The International Ovarian Tumour Analysis (IOTA) criteria

Similar documents
Accepted Manuscript. Ultrasound and adnexal pathology: what is the evidence? Wouter Froyman, MD, Lil Valentin, MD, PhD, Dirk Timmerman, MD, PhD

Adnexal Masses in Menopausal Women

ISUOG Basic Training Typical Ultrasound Appearances of Common Pathologies in the Adnexae

Adnexal Masses in Menopausal Women Surgery or Surveillance?

IOTA and Models for Screening for Ovarian Cancer

Gynaecological cancers. Mr Vivek Nama MD MRCOG Consultant Gynaecological Oncologist

Terminology Estimate the risk of malignancy in adnexal masses - Overview

Top Tips for Gynaecological Ultrasound. Catherine Kirkpatrick Consultant Sonographer Dublin Oct 2018

A Quality Improvement Initiative to Reduce Unnecessary Followup Imaging for Adnexal Lesions

Diagnostics guidance Published: 15 November 2017 nice.org.uk/guidance/dg31

A new scoring model for characterization of adnexal masses based on two-dimensional gray-scale and colour Doppler sonographic features

Gynaecology: Diagnosis and management of ovarian and / or adnexal masses. 1, Introduction and who the guideline applies to:

Ovarian Lesion Benign vs Malignant?

National Institute for Health and Clinical Excellence

American Journal of Oral Medicine and Radiology

JMSCR Vol 05 Issue 06 Page June 2017

Clinical, ultrasound parameters and tumor marker-based mathematical models and scoring systems in pre-surgical diagnosis of adnexal tumors

Hereditary Breast and Ovarian Cancer (HBOC) Information for individuals and families

West Midlands Sarcoma Advisory Group

Sonographic Prediction of Ovarian Malignancy in Adnexal Mass

Surveillance report Published: 17 March 2016 nice.org.uk

Alliance Diagnostic Hub for NEL. Cancer Collaborative Annual Review event

PhD Summary. J. Kaijser 1,2 Promotor:T. Bourne 1,2,3 Co-promotors: B. Van Calster 1, D. Timmerman 1,2. Abstract

USING R-SCAN TO IMPROVE ADHERENCE TO CHOOSING WISELY RECOMMENDATIONS FOR SIMPLE ADNEXAL CYSTS

CA125 in the diagnosis of ovarian cancer: the art in medicine

North Trent Cancer Network. Referral Guidelines, Head & Neck Cancer (including Thyroid), for Primary Care Practitioners

Gynaecology Cancer Red Flags. Dr Dina Bisson Consultant Obstetrician and Gynaecologist Southmead Hospital North Bristol NHS Trust 27 April 2017

Assessment of benefit of ultrasound monitoring of adnexal masses <10 cm on ovarian cancer early detection

Appendix 5. EFSUMB Newsletter. Gastroenterological Ultrasound

Evaluation of the Ovarian Crescent Sign in the Preoperative Determination of the Nature of Adnexal Masses

ISUOG Basic Training Examining the Uterus: Myometrium

The key contribution of MRI in adnexal mass evaluation is in: 1. Identifying benign features. 2. Identifying malignant features.

Successful Implementation of a Performance-Related Audit Tool. Pamela Parker Lead Sonographer

Comparison of Lerner score, Doppler ultrasound examination, and their combination for discrimination between benign and malignant adnexal masses

Are We Ordering Tumor Markers Appropriately?

P. SLADKEVICIUS and L. VALENTIN ABSTRACT

Gynecologic Ultrasound. Sujata Ghate, MD Associate Professor of Radiology Duke University Medical Center

Simple ultrasound-based rules for the diagnosis of ovarian cancer

RESEARCH. Simple ultrasound rules to distinguish between benign and malignant adnexal masses before surgery: prospective validation by IOTA group

Renal psychology service. Information for patients Department of Psychological Services

Original Article Risk of Malignancy Index (Adnexal Masses) Pak Armed Forces Med J 2014; 64 (4): Qurratulain Mushtaq, Mona Zafar, Sarwat Navid

Pathway Gynaecology Cancer & Diagnostic Protocol for Inter Trust transfer

OVARIAN MASSES : MANAGEMENT CHALLENGE

Prospective evaluation of three different models for the pre-operative diagnosis of ovarian cancer

Title of Guideline (must include the word Guideline (not protocol, policy, procedure etc)

New York Science Journal 2017;10(3) Mahmoud Sayed El Edessy, Hesham Saleh mohammed, and Abd Alsttar Alwaziry

The diagnosis of endometriomas using colour Doppler energy imaging

Investigate the Pelvis or the Patient?

Title of Guideline (must include the word Guideline not protocol, policy, procedure etc)

Because ovarian cancer is usually diagnosed

Original Research Article

Ultrasound screening of soft tissue masses in the trunk and extremity - a BSG guide for ultrasonographers and primary care

Health Board/Region: All-Wales

Serum Biomarker Human Epididymis Protein 4. Description

Clinical correlation of ovarian mass with ultrasound findings and histopathology report

The Virtual Lung Nodule Clinic

A NEW QUANTITATIVE METHOD TO EVALUATE ADNEXAL TUMORS

Ultrasound characteristics of different types of adnexal malignancies.

Is It Time To Implement Ovarian Cancer Screening?

Public Statement: Medical Policy Statement: Limits: Medical Policy Title: OVA1, Detection of Ovarian Cancer. ARBenefits Approval: 10/26/2011

controversial topics in surgery

Valentin, Lil; Ameye, L; Jurkovic, D; Metzger, U; Lécuru, F; Van Huffel, S; Timmerman, D

Supervisor Handbook for the Diploma of Diagnostic Ultrasound (DDU)

The Adnexal Mass. Handout NCUS 3/18/2017 Suzanne Dixon, MD

Audit of two-week rule referrals for suspected testicular cancer in Cornwall,

Preoperative evaluation of ovarian masses with color Doppler and its correlation with pathological finding

American Journal of Obstetrics and Gynecology

Haematuria Clinic. Information for patients Urology PROUD TO MAKE A DIFFERENCE SHEFFIELD TEACHING HOSPITALS NHS FOUNDATION TRUST

Ask the Experts Obstetrics & Gynecology

West Midlands Sarcoma Advisory Group

Practical guidance for applying the ADNEX model from the IOTA group to discriminate between different subtypes of adnexal tumors

1. The Initial Referral Protocol (09-7A-113)

PLASTICS Referral Guidelines

Acute Oncology Induction Training Specification

Risk of Malignancy Index in the Preoperative Evaluation of Patients with Adnexal Masses among Women of Perimenopausal and Postmenopausal Age Group

Isolated Choroid Plexus Cyst

Plastic Surgery Referral Guidelines

SCREENING FOR OVARIAN CANCER: A SYSTEMATIC REVIEW 1998

Reliability of preoperative evaluation of postmenopausal ovarian tumors

Postmenopausal bleeding (PMB) guidelines for women with abnormal vaginal bleeding

Abdominal aortic aneurysm. Information for patients Sheffield Vascular Institute

Clinical guideline Published: 27 April 2011 nice.org.uk/guidance/cg122

WOLFSON FERTILITY CENTRE. Wolfson Fertility Centre

Pregnancy With Huge Ovarian Cyst

SKIN CANCER SCREENING AT UPMC. Laura K. Ferris, MD, PhD Associate Professor of Dermatology

Waiting Times for Suspected and Diagnosed Cancer Patients

Breast Cancer Screening and Treatment Mrs Belinda Scott Breast Surgeon Breast Associates Auckland

Ultrasound is not able to fully evaluate the stomach or bowel, as sound waves are unable to travel through gas and air.

Research & Teaching AWARDS. Morris F. Collen Research Awards Teaching Awards for Excellence

Triage of Ovarian Masses. Andreas Obermair Brisbane

Title: Symptoms, CA125 and HE4 for the preoperative prediction of ovarian malignancy in Brazilian women with ovarian masses

The Incidental Renal lesion

M. J. KUDLA* and J. L. ALCÁZAR ABSTRACT

Improving diagnostic pathways for patients with vague symptoms

External validation of IOTA simple descriptors and simple rules for classifying adnexal masses

Diagnosis of adnexal malignancies by using color Doppler energy imaging as a secondary test in persistent masses

Multimodal approach to predict ovarian malignancy prior to laparoscopy

Everolimus. Information for patients Sheffield Kidney Institute (Renal Unit)

Using patient data to improve. cancer waiting times. May 2018

Transcription:

The International Ovarian Tumour Analysis (IOTA) criteria Elizabeth Bullivant Specialist Sonographer Sheffield Teaching Hospitals NHS Foundation Trust

Contents Ultrasound reports. What is IOTA? What the IOTA rules can t do. Analysis criteria. Benign features. Malignant features. The rules. IOTA group. Conclusion.

Ultrasound reports - Are they useful? - Are we potentially patient anxiety where urgent gynaecology referral is advised? Set protocol Patient anxiety Fast track appointment capacity

The IOTA Group The simple rules were developed by clinicians and statisticians from the IOTA group Rules based on clinical and ultrasound data from 1066 women recruited at 9 centres in 5 countries (Italy, Belgium, Sweden, France and UK). All patients included required surgery as judged by a local clinician. The parameters used in the Simple Rules are based on the terms and definitions as published by the IOTA group (Timmerman D, et al. Ultrasound Obstet Gynecol 2000;16:500-505. ). This had led to further studies including the ROCKeTS (Refining Ovarian Cancer Test Accuracy Scores - ongoing).

The manuscript describing the Simple Rules is published in Ultrasound in Obstetrics and Gynaecology, Timmerman et al, 2008.

What the simple rules can t do. The simple rules cannot replace training and experience in ultrasonography. The simple rules cannot compensate for poor quality of ultrasound equipment.

The International Ovarian Tumour Analysis criteria - IOTA Preoperative classification system for ovarian tumours consisting of: - 5 features typical for benign tumours (B-features). - 5 features typical for malignant tumours (M-Features). Based on which of the B-features and M-features that apply, tumours can be classified as benign, malignant or inconclusive: - Benign only B Features - Malignant only M Features - Inconclusive no features apply or both B- and M- features apply.

The simple Ultrasound rules BMUS 2018 Ultrasound reports categorising adnexal masses Helps with patient referral pathways Helps to reduce unnecessary patient anxiety

Benign features U/S report:.as per IOTA simple rules these are benign features. Using IOTA a mass is classified as benign if at least one B-Feature is present and no M- features are present.

Malignant features U/S report:.as per IOTA simple rules these are malignant features. Using IOTA Rules a mass is classified as malignant if at least one M-feature is present and no B- features are present.

The Rules Rule 1: If one or more M features are present in the absence of B feature(s), the mass is classified as malignant. Rule 2: If one or more B features are present in the absence of M feature(s), the mass is classified as benign. Rule 3: If both M features and B features are present, or if no B or M features are present, the result is inconclusive and a second stage test is recommended.

Conclusion When the rules are applied it makes it much easier to classify ovarian tumours. Studies have found that when the simple rules were applied they were conclusive in approximately 75% of adnexal masses, therefore approximately 25% indeterminate = fast track referrals to gynaecology, patient anxiety in benign cases. Several trials are ongoing which will be used to validate this system (ROCKeTS). It will probably change the way ultrasound scans are reported in the future, which in turn will help with patient referral pathways and also help reduce unnecessary patient anxiety..back to the ultrasound report example, if IOTA rules were applied in this case.. B4 smooth multilocular tumour with largest diameter <100mm

Was the urgent gynaecology referral necessary?

Questions