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ID # COMPLETED: YES 1 DATE NO 2 NEUROLOGICAL EXAM "Normal, Abnormal, Other, Can't execute or Missing for each question. If you circle "Abnormal" or Other, also check the appropriate reason why or explain in comment field. For each question, "Can't Execute and Missing" will mean the following: -Can't Execute: subject will not/cannot attempt task secondary to dementia. -Missing: examiner omits task, subject refuses (not secondary to dementia), or subject unable to do task secondary to physical reason. 1. VISUAL FIELDS BY CONFRONTATION NORMAL No field cut in any quadrant 1 ABNORMAL Field cut (SPECIFY) 2 CAN T EXECUTE 8 SPECIFY/COMMENT: 2. RANGE/EXTENT OF LATERAL GAZE NORMAL Complete gaze to left/right 1 ABNORMAL Incomplete left or right gaze (Specify left or right) 2 Complete absence of left or right gaze (Specify left or right) 3 CAN T EXECUTE 8 SPECIFY/COMMENT: 3. RANGE/EXTENT OF VERTICAL GAZE NORMAL Complete up & down gaze 1 ABNORMAL Incomplete up & down gaze 2 Complete absence of up & down gaze 3 CAN T EXECUTE 8 SPECIFY/COMMENT: ADAMS1NeuroExamFormAB.pdf - 1 -

4. PUPILLARY REFLEX NORMAL PERRLA 1 ABNORMAL Re: pupil size, reaction time (Specify left or right) 2 5. CLOSE EYES, RESIST OPENING BY EXAMINER NORMAL No weakness of upper eyelid on either side 1 ABNORMAL Unilateral or bilateral weakness (Specify left or right) 2 6. OPENING AND CLOSING JAW NORMAL No deviation of mandible 1 ABNORMAL (SPECIFY) 2 7. PHARYNGEAL MOVEMENTS (subject opens mouth, says "ah") NORMAL No deviation of uvula or tongue 1 ABNORMAL Deviation to left or right (Specify left or right) 2 ADAMS1NeuroExamFormAB.pdf - 2 -

8. BLOW OUT CHEEKS WITH MOUTH CLOSED NORMAL Can perform evenly bilateral 1 ABNORMAL Cannot perform evenly (Specify left or right) 2 Cannot perform with mouth closed 3 9. WIDE SMILE- SHOW TEETH NORMAL No weakness noted 1 ABNORMAL Flattened nasolabial fold 2 Inability to raise corner of mouth on left or right (Specify left or right) 3 10. RAISE EYEBROWS NORMAL No weakness noted 1 ABNORMAL Inability to raise eyebrow 2 Inability to wrinkle forehead on left or right (Specify left or right) 3 11. WINK WITH OTHER EYE OPEN NORMAL Can perform with either eye 1 Can perform with one eye only (Specify left or right) 2 ABNORMAL Cannot perform 3 SPECIFY/ COMMENTS ADAMS1NeuroExamFormAB.pdf - 3 -

12. RAPID TONGUE MOVEMENT NORMAL 4 touches/second 1 ABNORMAL < 4 touches/second or arrhythmic 2 13. MOTOR IMPERSISTENCE A. Eye closure x 20 seconds NORMAL Maintains act for 20 seconds 1 ABNORMAL Opens eyes before 20 seconds 2 B. Tongue protrusion x 20 seconds NORMAL Maintains act for 20 seconds 1 ABNORMAL Pulls tongue in before 20 seconds 2 14. ACOUSTIC NERVE A. Rubbing of fingers NORMAL Able to hear 1 1 ABNORMAL Unable to hear 2 2 3 8 9 ADAMS1NeuroExamFormAB.pdf - 4 -

B. Whispering NORMAL Able to hear 1 1 ABNORMAL Unable to hear 2 2 3 8 9 15. CHIN RESISTANCE NORMAL No weakness noted on either side 1 ABNORMAL Unilateral weakness (Specify left or right) 2 Bilateral weakness 3 16. SHOULDER ELEVATION (shrug) NORMAL No weakness noted 1 ABNORMAL Unilateral weakness (Specify left or right) 2 Bilateral weakness 3 17. IS SUBJECT MUTE? YES 1 (GO TO 21) NO 2 ADAMS1NeuroExamFormAB.pdf - 5 -

18. REPEAT A). "La, La, La, La, La" NORMAL Regular rate, rhythm and > 4 syllables/second, each syllable clear 1 ABNORMAL Arrhythmic 2 < 4 syllables/second 3 Slurred words 4 B). "Go, Go, Go, Go, Go" NORMAL Regular rate, rhythm and > 4 syllables/second, each syllable clear 1 ABNORMAL Arrhythmic 2 < 4 syllables/second 3 Slurred words 4 C). "Kitty, Kitty, Kitty, Kitty, Kitty" NORMAL Regular rate, rhythm and > 4 syllables/second, each syllable clear 1 ABNORMAL Arrhythmic 2 < 4 syllables/second 3 Slurred words 4 19. RATE OF CONVERSATION NORMAL Normal speed 1 ABNORMAL Too fast 2 Too slow 3 ADAMS1NeuroExamFormAB.pdf - 6 -

20. CLARITY OF CONVERSATION NORMAL Normally understandable 1 ABNORMAL Examiner must listen carefully 2 Subject must repeat to be understood 3 Almost incomprehensible 4 21. FINGER -TO-NOSE TOUCHING NORMAL Quickly, smooth and accurate 1 1 ABNORMAL Slow but accurate 2 2 Dysmetria noted 3 3 4 8 9 SPECIFY/ COMMENTS: 22. FINGER-THUMB TAPPING NORMAL 4 taps/second 1 1 ABNORMAL 3 taps/second or faster but arrhythmic 2 2 < 3 taps/second 3 3 4 8 9 23. DIADOCHOKINESIS NORMAL At least 3 pats/second and smooth 1 1 ABNORMAL Right = <3 pats/second =1, Arrhythmic =2, Both = 3 2 2 Left = <3 pats/second =1, Arrhythmic =2, Both = 3 4 8 9 ADAMS1NeuroExamFormAB.pdf - 7 -

24. HAND PRAXIS TASKS A). Inter-locking thumbs NORMAL Performs correctly 1 ABNORMAL Performs incorrectly 2 B). Mirrored fingers NORMAL Performs correctly 1 ABNORMAL Performs incorrectly 2 25. GRASP NORMAL Absent 1 1 ABNORMAL Subject grasps examiners hand on stimulation 2 2 Grasps after verbal request not to do so 3 3 4 8 9 26. MUSCLE TONUS (passive flexion/extension at elbow and wrist) NORMAL Normal muscle tone, no rigidity 1 1 ABNORMAL Rigidity or stiffness present 2 2 3 8 9 ADAMS1NeuroExamFormAB.pdf - 8 -

27. COGWHEEL PHENOMENON NORMAL No cogwheeling noted 1 1 ABNORMAL Slight or noticeable rhythmicity throughout 2 2 3 8 9 SPECIFY/COMMENT: 28. PRIMITIVE REFLEXES A). Snout (tap closed lips with reflex hammer) NORMAL Absent 1 ABNORMAL Present 2 B). Visual suck NORMAL Absent 1 ABNORMAL Present 2 C). Tactile suck NORMAL Absent 1 ABNORMAL Present 2 ADAMS1NeuroExamFormAB.pdf - 9 -

29. DEEP TENDON REFLEXES ABSENT REDUCED NORMAL BRISK, NO CLONUS BRISK, W/ CLONUS CAN T EXECUTE MISSING Biceps, R 0 1 2 3 4 8 9 Biceps, L 0 1 2 3 4 8 9 BR., R 0 1 2 3 4 8 9 BR., L 0 1 2 3 4 8 9 Knees, R 0 1 2 3 4 8 9 Knees, L 0 1 2 3 4 8 9 AJ, R 0 1 2 3 4 8 9 AJ, L 0 1 2 3 4 8 9 SPECIFY: 30. ANKLE CLONUS NORMAL Absent 1 1 ABNORMAL Present 2 2 3 8 9 31. PROPRIOCEPTION PRESENT 1 1 ABSENT 2 2 CAN T EXECUTE 8 8 9 SPECIFY/COMMENT: 32. VIBRATING SENSATION PRESENT 1 1 ABSENT 2 2 CAN T EXECUTE 8 8 9 SPECIFY/COMMENT ADAMS1NeuroExamFormAB.pdf - 10 -

33. PLANTAR RESPONSE NORMAL Plantar flexion of great toe 1 1 ABNORMAL Extension of great toe 2 2 No reflex present 3 3 4 8 9 SPECIFY/COMMENT 34. HEEL - TO - KNEE TEST NORMAL Moving foot is dorsiflexed and motion down shin is 1 1 smooth, slow and accurate ABNORMAL Path of heel is shaky, jerky, wavering 2 2 Knee is overshot 3 3 Slide down skin accompanied by action tremor 4 4 5 CAN T EXECUTE 8 8 9 35. ROMBERG'S SIGN (stand with feet together for 10-15 seconds) NORMAL Normally still or slight weaving 1 ABNORMAL Falls to one side with eyes closed (Specify left or right) 2 Falls to one side with eyes open (Specify left or right) 3 Needs widend base to stay in one place 4 36. GAIT ACTIVITIES A). Walking down a hall at least 10 paces NORMAL Normal gait, narrow base 1 ABNORMAL Deviation from straight line 2 ADAMS1NeuroExamFormAB.pdf - 11 -

B). Pivot while turning NORMAL Pivots on narrow base 1 ABNORMAL Hesitates 2 Widens base or moves feet 3 Turns slowly or awkwardly 4 CAN' T EXECUTE 8 C). Stopping on unexpected command NORMAL Stops on command or takes one small step 1 ABNORMAL Stops but body lurches forward 2 Takes > 1 step before stopping 3 D). Festination NORMAL None 1 ABNORMAL Slow start 2 Shuffling gait 3 E). Accessory movements NORMAL Normal 1 ABNORMAL Decrease of arm swings 2 Trunk/neck rigid and flexed 3 Width of gait gets smaller 4 ADAMS1NeuroExamFormAB.pdf - 12 -

38. TREMOR AT REST NORMAL None 1 ABNORMAL Slight/occassional 2 Moderate to severe 3 CAN T EXECUTE 8 39. TREMOR WITH ARMS OUTSTRETCHED NORMAL None 1 ABNORMAL Slight/ occasional 2 Moderate to severe 3 CAN T EXECUTE 8 40. PRONATOR DRIFT (arms outstretched, palms up, eyes closed) NORMAL Absence of drift 1 ABNORMAL Spontaneous drift of either/both hands (Specify left or right) 2 41. STRENGTH DIFFERENCE WITH DOWNWARD PRESSURE AND THEN SUDDEN RELEASE BY EXAMINER (arms outstretched, resists examiner's pressure) NORMAL No strength difference, equal rebound 1 ABNORMAL Unequal rebound (Specify left or right) 2 CAN' T EXECUTE 8 ADAMS1NeuroExamFormAB.pdf - 13 -

42. UPPER EXTREMITY MOTOR STRENGTH. GRIP STRENGTH OR BICEPS PULL. STRENGTH DIFFERENCE BETWEEN L AND R FINGER GRASP OR BICEPS PULL. SUBJECT GRASPS EXAMINER S EXTENDED FINGERS (2 digits) WITH R AND L TRIALS. Grip strength = 1 Biceps pull = 2 NORMAL No strength difference between R and L trials 1 ABNORMAL Specify weakness (L or R) 2 CAN' T EXECUTE 8 SPECIFY/ COMMENT 43. BRADYKINESIA NORMAL Voluntary movements are normal 1 ABNORMAL Mild or marked slowness 2 CAN' T EXECUTE 8 SPECIFY/ COMMENT 44. MYOCLONUS NORMAL Absent 1 ABNORMAL Mild myoclonus 2 Occasional myoclonus 3 Frequent myoclonus 4 Severe myoclonus 5 OTHER (SPECIFY) 6 45. POSTURE NORMAL Normal, erect 1 ABNORMAL Slightly stooped 2 Very stooped 3 Leans to one side (Specifiy left or right) 4 CAN T EXECUTE 8 ADAMS1NeuroExamFormAB.pdf - 14 -

46. PRAXIS TASKS (PRETEND TO) NORMAL ABNORMAL PERFORMS (SPECIFY) CORRECTLY OTHER (SPECIFY) CAN T EXECUTE MISSING Comb your hair 1 2 3 8 9 Hammer a nail 1 2 3 8 9 Brush your teeth 1 2 3 8 9 SPECIFY/COMMENT: COMMENTS This neurological examination was modified from similar instruments for assessment of Huntington's disease(folstein,se et al., Neurobehavioral Toxicology and Teratology,1983,5:605-609) and the CERAD exam for AD (Morris,JC et al., Neurology, 1989, 39:1159-1165.) ADAMS1NeuroExamFormAB.pdf - 15 -