UCSF RADIATION ONCOLOGY UPDATE: MANAGEMENT OF

Department of Radiation University of California, School of Medicine University of California UCSF RADIATION ONCOLOGY UPDATE: MANAGEMENT OF RECURRENT DISEASE FRIDAY - SUNDAY April 30 - May 2, 2010, CA COURSE CHAIRS Catherine C. Park, MD Associate Professor Department of Radiation University of California, Helen Diller Family Comprehensive Cancer Center Mack Roach III, MD Professor and Chair Department of Radiation University of California, Helen Diller Family Comprehensive Cancer Center

UCSF RADIATION ONCOLOGY UPDATE: MANAGEMENT OF RECURRENT DISEASE This course will address the optimal radiotherapeutic and multi-disciplinary management of recurrent cancers. Updates on the most advanced technology in stereotactic radiosurgery, brachytherapy, intraoperative radiotherapy and hyperthermia and their application to recurrent disease will be highlighted. Course attendants will able to treat patients more effectively, and counsel patients and their families as to the most currently available treatment options. TARGET AUDIENCE The course is intended for a national audience of practicing radiation oncologists. Content is targeted to enhance delivery of state-of-the-art patient care., CA April 30 - May 2, 2010 ACCREDITATION The University of California, School of Medicine (UCSF) is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. UCSF designates this educational activity for a maximum of 15.5 AMA PRA Category 1 Credit(s). Physician should only claim credit commensurate with the extent of their participation in the activity. This CME activity meets the requirements under California Assembly Bill 1195, continuing education and cultural and linguistic competency. For the purpose of recertification, the American Nurses Credentialing Center accepts AMA PRA Category 1 Credit issued by organizations accredited by the ACCME. OBJECTIVES Upon completion of this program, participants should be able to: Define the major treatment options for locally recurrent cancers of the breast, prostate, head and neck, brain, and gynecologic malignancies; Improve practice by applying the appropriate imaging techniques to diagnose recurrent cancers; Understand the indications, contraindications, pros and cons for using IORT, cyberknife, brachytherapy or hyperthermia modalities for treatment of recurrences; Identify where combined systemic therapies or systemic therapies alone may be preferred over re-irradiation; Describe the biology of recurrence and future potential therapies.

UCSF RADIATION ONCOLOGY UPDATE: MANAGEMENT OF RECURRENT D FRIDAY, APRIL 30, 2010 12:00 pm Registration 1:00 Opening Remarks Mack Roach III, MD HEAD AND NECK TUMORS MODERATOR: NANCY Y. LEE, MD 1:10 Local Recurrence in the Nasopharynx and Nancy Y. Lee, MD other Non-NP Head and Neck Sites 1:30 Use of PET-CT in Evaluation of Local Andrew Quon, MD Recurrence and in Post-IR Surveillance 1:50 Surgical Considerations in Recurrent Disease TBA 2:10 Case Presentations and Panel Discussion Nancy Y. Lee, MD 2:55 Break GI/LUNG/SARCOMA TUMORS MODERATOR: ALEX R. GOTTSCHALK, MD, PHD 3:10 Stereotactic Radiosurgery for Thoracic and Alexander R. Gottschalk, MD, PhD Soft Tissue Malignancies 3:30 Surgical Salvage for Thoracic Recurrences Michael Mann, MD 3:45 Anti-angiogenic Therapies and Radiation Christopher G. Willett, MD for GI Recurrences 4:05 Case Presentations and Panel Discussion Alexander R. Gottschalk, MD, PhD 4:30 Phillips Lecture: The Use of IORT for Christopher G. Willett, MD Recurrent Disease 5:30 - Reception 7:30 pm SATURDAY, MAY 1, 2010 7:00 am Continental Breakfast 8:00 Opening Remarks CENTRAL NERVOUS SYSTEM TUMORS MODERATOR: IGOR J. BARANI, MD 8:05 Session Overview Igor J. Barani, MD 8:15 Imaging Techniques for Differential Christopher Hess, MD Diagnosis of Recurrent Brain Lesions 8:40 Treatment of Recurrent Brain Metastases Penny K. Sneed, MD 9:00 Clinical Trials for Recurrent GBM Jennifer Clarke, MD, PhD 9:15 Molecular Predictors and Concurrent Daphne Haas-Kogan, MD Biologic Therapies for Recurrent CNS Disease 9:30 Case Presentations and Panel Discussion Penny K. Sneed, MD 10:15 Break CENTRAL NERVOUS SYSTEM TUMORS (CONT D) MODERATOR: JEAN L. NAKAMURA, MD 10:30 Surgical Management of Recurrent Dean Chou, MD Spine Tumors 10:45 Stereotactic Radiosurgery for Recurrent Arjun Sahgal, MD Spine Tumors 11:00 Biology of Radiation Induced Tumors Jean L. Nakamura, MD 11:15 Case Presentations and Panel Discussion Igor J. Barani, MD 11:45 - Lunch (provided) 12:45 pm BREAST TUMORS MODERATOR: CATHERINE C. PARK, MD 12:45 The Role of Radiation in the Treatment of Barbara L. Fowble, MD Locally-regionally Recurrent Breast Cancer 1:00 Local Recurrence and Molecular Phenotypes: Laura van't Veer, PhD Ready for Prime-time? 1:15 Surgical Issues in Management of Local Shelley Hwang, PhD Recurrence: Sentinel Nodes, Reconstruction 1:30 Chemotherapy for Isolated Recurrence: Hope Rugo, MD NSABP Trial 1:45 The Role of the Cancer Associated Stroma Catherine C. Park, MD in Predicting Local Recurrence 2:00 Case Presentations and Panel Discussion Catherine C. Park, MD 2:45 Break

ISEASE, CA SATURDAY, MAY 1, 2010 (CONT D) HYPERTHERMIA MODERATOR: CHRIS J. DEIDERICH, PHD 3:00 Overview of Hyperthermia Mark W. Dewhirst, DVM, PhD 3:25 UCSF Hyperthermia Chris J. Deiderich, PhD 3:40 Case Presentations and Panel Discussion Chris J. Deiderich, PhD 4:00 Buschke Lecture: The Relationship Between Jay R. Harris, MD Local Recurrence and Survival in Breast Cancer 5:00 Adjourn SUNDAY, MAY 2, 2010 7:00 am Continental Breakfast PROSTATE TUMORS MODERATOR: ALEXANDER R. GOTTSCHALK, MD, PHD 8:00 Radiation after Post-operative Local Recurrence Alexander R. Gottschalk, MD, PhD 8:15 Salvage Radiation for Local Recurrence: Mack Roach III, MD HDR and Brachytherapy 8:40 Surgical Salvage for Recurrence after James A. Eastham, MD Radiotherapy 9:00 Systemic Management of Hormone Charles J. Ryan, MD Refractory Disease 9:15 Nomograms Predicting Recurrence Michael W. Kattan, PhD 9:30 Case Presentations and Panel Discussion Mack Roach III, MD 10:15 Break GYNECOLOGIC TUMORS MODERATOR: I-CHOW (JOE) HSU, MD 10:30 Management of Recurrent Cervical Cancer I-Chow (Joe) Hsu, MD 10:45 Approaches for Endometrial Recurrence Phillip M. Devlin, MD, FACR 11:00 Surgical Salvage for Ovarian Cancers Lee-May, Chen, MD 11:15 Case Presentations and Panel Discussion 12 Noon Adjourn GENERAL INFORMATION Advanced registration closes one (1) business day prior to start of course. HOW TO ENROLL Tuition: $560 Physicians $460 Nurses/Allied Health Professionals/ Residents/Fellows Payment can be made by Visa, MasterCard, AmEx or check. REGISTER VIA: Online: www.cme.ucsf.edu Mail: Complete course registration form and send with payment to: UCSF Office of CME P.O. Box 45368, CA 94145-0368 Fax: Fax completed registration form to: (415) 502-1795 (be sure to include your credit card number) Phone: To register by phone or to inquire about registration status, please call UCSF s CME Registration Office at (415) 476-5808. Please check our website for up-to-date information on the course: www.cme.ucsf.edu REFUND POLICY Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. CONFERENCE LOCATION Enjoy s renowned attractions such as the historic cable cars, shopping in Union Square, or visit s culinary hub at the Ferry Building. The A block of guestrooms has been reserved at the special UCSF conference rate of $295/night. You are urged to make your reservations early. The cut off date is March 30, 2010, or until the group room block is filled. After this date, rooms will be provided on a space-available basis only. To make hotel reservations on-line, go to http://starwoodmeeting.com/book/ucsfradiation. If you prefer to telephone in your reservation, call (415) 284-4000, please identify yourself as a member of this UCSF conference to receive the special rate. By staying at the host hotel, you help UCSF meet its contractual obligations and keep registration fees reasonable. RENTAL CAR Hertz is offering special rates for participants of this conference; simply call 800-654-2240 and refer to identification number #03BW0129, or call your travel agent. You may also make reservations at www.hertz.com. Advance reservations are recommended. AIR TRANSPORTATION Special arrangements have been made with Montgomery Travel; simply call (800) 391-2287 8:30-5:30pm PST or complete the form on the UCSF web page at www.montgomerytravel.com. In addition to offering lower rates than published airfares, ticketed passengers may take advantage of the after hours emergency service. There is a $40 service fee. UCSF has negotiated special fares with American and United Airlines for our course attendees. You may use the following tour codes to book on your own: American (800) 433-1790 code: 1310SS United (800) 521-4041 code: 510CF

0569 University of California, Office of Continuing Medical Education UCSF Box 0742, CA 94143-0742 E Printed on Recycled Paper For more information or to register online visit our website at www.cme.ucsf.edu. You may also reach us by calling the Office of CME at (415) 476-4251 or emailing: info@ocme.ucsf.edu. COURSE CO-CHAIRS Catherine C. Park, MD Associate Professor of Radiation University of California, Helen Diller Family Comprehensive Cancer Center Mack Roach III, MD Professor and Chair of Radiation University of California, Helen Diller Family Comprehensive Cancer Center GUEST FACULTY Phillip M. Devlin, MD, FACR Chief, Division of Brachytherapy Dana Farber/Brigham and Women's Cancer Center Harvard Medical School Mark W. Dewhirst, DVM, PhD Professor of Radiation Duke University Medical Center James A. Eastham, MD Chief, Urology Service; Florence and Theodore Baumritter/Enid Ancell Chair of Urologic Memorial Sloan-Kettering Cancer Center Jay R. Harris, MD Professor of Radiation, Harvard Medical School Chief of Radiation, Dana- Farber Cancer Institute Michael W. Kattan, PhD Chair, Quantitative Health Sciences Cleveland Clinic GUEST FACULTY (CONT D) Nancy Lee, MD Associate Attending of Radiation, Memorial Sloan-Kettering Cancer Center Andrew Quon, MD Assistant Professor of Nuclear Medicine, Stanford University Arjun Sahgal, MD Assistant Professor, Radiation, Princess Margaret Hospital and the Sunnybrook Health Sciences Centre, University of Toronto Laura van't Veer, PhD Netherland Cancer Institute Christopher G. Willett, MD Chair of Radiation Duke University Medical Center UCSF FACULTY University of California,, School of Medicine Igor J. Barani, MD Assistant Professor of Radiation Lee-May Chen, MD Associate Professor of Obstetrics, Gynecology, and Reproductive Sciences Dean Chou, MD Associate Professor of Neurosurgery Jennifer Clarke, MD, PhD Assistant Professor of Neurology Chris J. Deiderich, PhD Professor of Radiation ; Director, Thermal Therapy Research Group & Clinical Hyperthermia Physics UCSF FACULTY (CONT D) Barbara L. Fowble, MD Professor of Radiation Alexander R. Gottschalk, MD, PhD Associate Professor of Radiation Daphne Haas-Kogan, MD Professor of Radiation Christopher Hess, MD Assistant Professor of Radiology I-Chow (Joe) Hsu, MD Associate Professor of Radiation Eun-Sil (Shelley) Hwang, MD Associate Professor of Surgery David A. Larson, MD, PhD Professor Emeritus, Radiation and Neurological Surgery Michael Mann, MD Associate Professor of Surgery Jean L. Nakamura, MD Assistant Professor of Radiation Hope Rugo, MD Professor of Medicine Director, Breast Clinical Trials Program Charles J. Ryan, MD Assistant Professor of Medicine and Urology Patricia (Penny) K. Sneed, MD Professor and Vice Chair of Radiation

Course Registration Form www.cme.ucsf.edu UCSF RADIATION ONCOLOGY UPDATE April 30 - May 2, 2010, California Mail to : UCSF Office of CME P.O. Box 45368, CA 94145-0368 Fax: (415) 502-1795 æ Dr. æ Mr. æ Mrs. æ Ms. Last Name First M.I. Degree Specialty Address City State Zip Daytime Phone Fax Email Address Label Code (see address label: example, A, B, C, D, etc.) Would you like to be on our priority email list? Yes No Date of birth to be used as OCME registrant number: / / X X Month Day Please indicate if you have any special needs: REGISTRATION FEES (Receipt/Confirmation will be mailed within two to four weeks): $560 Physicians $460 Nurses/Pharmacist/Allied Health Professionals/Residents/Fellows Make checks payable to UC Regents MRO10001 Please charge my credit card: Visa MasterCard AmEx for $ / Card # Expiration date Name on Card (Please Print) Authorized Signature Refund Policy: Cancellations received in writing before the first day of the course will be refunded, less a $75 administrative fee. No refunds will be made on cancellations received after that date. Please check our website for up-to-date information on the course: www.cme.ucsf.edu The St. Regis 125 Third Street, CA 94103 (877) ST-REGIS (877-787-3447) toll-free (415) 284-4000 phone http://www.starwoodhotels.com/stregis Line Jackson St NOB HILL GRACE CATHEDRAL Leavenworth St Landmarks Neighborhoods Jones St MASONIC AUDITORIUM FRANCISCO Online registration: www.cme.ucsf.edu Registration Information: (415) 476-5808 Course Information: (415) 476-4251 Points of Interest Parks Cable Car Lines Taylor St Mason St Powell St St Stockton St CHINATOWN UNION SQUARE O Farrell St Ellis St umbus Av PORTSMOUTH SQUARE BANK OF AMERICA BLDG. Grant Av Pine St Bush St Kearny St Post St Geary St Market St POWELL ST. STATION TRANSAMERICA PYRAMID BLDG. FINANCIAL DISTRICT Montgomery St CROCKER GALLERIA Clay St Sansome St Washington St Sacramento St California St New Montgomery St St. Regis Battery St 2nd St PARK TRANS TERMI GOLDEN GATE UNIV. CENTER FOR THE ARTS AT YERBA BUENA GARDENS MOSCONE CONVENTION EMBARCAD SHOPPING C MONTGOMERY ST. STATION SF MUSEUM OF MODERN ART 1