April 26 th April 29 th, 2017 Kibbutz Hagoshrim, Israel WEDNESDAY, APRIL 26, rd International Congress on Molecular Targeting Therapy

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3 rd International Congress on Molecular Targeting Therapy April 26 th April 29 th, 2017 Kibbutz Hagoshrim, Israel WEDNESDAY, APRIL 26, 2017 Update: Mar. 12 14:00-21:00 Registration & Check-In 16:00-17:00 Cocktail Reception & Exhibition 17:00-17:15 Opening Ceremony - Oren hall Dr. Salman Zarka, Director, Ziv Medical Center, Safed Prof. Ran Tur-Kaspa, Dean, Faculty of Medicine in the Galilee, Bar Ilan University Dr. Wilmosh Mermershtain, President of ISCORT Prof. Eliezer Robinson, Chairman of Israel Cancer Association Prof. Jamal Zidan, Congress President 17:15-17:30 Educational Lecture - Oren hall Molecular Targeting Therapy and Immunotherapy: Where We Are? Prof. J. Zidan, Ziv M.C, Safed, Israel 17:30-18:00 Educational Lecture - Oren hall BRCAness / Homologous Recombination Deficiency in Defining PARPi Patient Prof. M.H Stern, Curie Center, Paris, France 18:00-18:30 Educational Lecture - Oren hall Assembly of Tumor Vasculature and Vasculogenic Mimicry; Fusion Proteins Prof. J. Rosenblatt, Miami University, Miami, Fl, USA 18:30-19:00 Educational Lecture - Oren hall Cancer Therapy 2017: The Challenges Ahead Prof. Y. Yarden, Weizmann Institute of Science, Rehovot, Israel 19:00-19:30 Educational Lecture - Oren hall Why Do Cancers Become Metastatic and What Can We Do About It? Prof. H. Ostrer, Albert Einstein University, New-York, NY, USA 19:30-20:30 Dinner 20:30-23:30 Social Event

THURSDAY, APRIL 27, 2017 07:00 Breakfast 08:00-20:00 Registration & Exhibition 08:00-08:30 Educational Lecture - Oren hall Integration of EGFR Targeting with Chemotherapy Prof. D. Hochhauser, UCL Cancer Center, London, UK 08:30-09:00 Invited Lecture - Oren hall (Roche) Targeted Molecular Therapy in HER2 Positive Early Breast Cancer DR. K. Drumea, Rambam M.C, Haifa, Israel 09:00-09:30 Educational Lecture - Oren hall Molecular Targeted and Immunotherapy Conjugated Radiotherapy Lecturer: 09:30-10:00 Invited Lecture - Oren hall (Boehringer-Ingelheim; BI) EGFR Targeting Therapy in NSCLC: Current and Future Approaches Prof. A. Onn, Sheba M.C, Tel-Hashomer, Israel 10:00-10:30 Invited Lecture - Oren hall (Nanostring) Bringing the Next Generation of Immuno-Oncology Biomarkers to the Clinic Dr. A. Cesano, Chief Medical Officer, Nanostring Technologies, Seattle, Wa, USA 10:30-11:00 Coffee Break & Exhibition 11:00-11:30 Educational Lecture - Oren hall PARP inhibitors in Breast Cancer: Past-Present-Future Prof. B. Kaufman, Sheba M.C, Tel-Hashomer, Israel 11:30-12:00 Educational Lecture - Oren hall A Critical Appraisal of Anti-Angiogenic Therapy in Gynaecological Cancers Prof. J. Ledermann, UCL Cancer Center, London, UK 12:00-12:20 Invited Lecture - Oren hall (Roche) Updates in the Treatment of Bladder Cancer Dr. A. Peer, Rambam M.C, Haifa, Israel

12:20-12:40 Educational Lecture - Oren hall Colorectal Cancer Biology and Therapy Prof. D. Hochhauser, UCL Cancer Center, UK 12:40-13:00 Educational Lecture - Oren hall Molecular Targeted Therapy and Immunotherapy in Head & Neck Malignancies Prof. G. Lopes, Associate director for Global Oncology, Miami University, Miami, Fl, USA 13:10-14:00 Lunch Buffet & Exhibition 14:00-14:30 Educational Lecture - Oren hall Modern Technologies in the Treatment of Advanced Melanoma as Predictors of a New Paradigm in the Therapy of Solid Tumors Prof. J. Schachter, Sheba M.C, Tel-Hashomer, Israel 14:30-15:00 Invited Lecture - Oren hall (BMS) Immunotherapy and Novel Combinations in Oncology: Current Landscape, Challenges and Opportunities Prof. G. Markel, Sheba M.C, Tel-Hashomer, Israel 15:00-15:30 Educational Lecture- Oren hall Novel Targeted Therapies in Malignant lymphomas Prof. Izidore Lossos, University of Miami, US 15:30-16:00 Invited Lecture-Oren Hall (Astra Zeneca) Circulating Tumor DNA: ctdna Where We Are. Prof. M.H Stern, Curie Center,Paris, France 16:00-16:30 Coffee Break & Exhibition 16:30-17:00 Educational Lecture - Oren hall Balancing the immunological response and treatment efficacy to cancer therapy : The double-edged sword. Prof. Y. Shaked, Faculty of Medicine, Technion, Haifa, Israel 17:00-17:30 Educational Lecture-Oren Hall Updating in Diagnosis of Detective Factors for Targeted Therapy and Immunotherapy, Pathology Testing Prof. D. Hershkovitz, Sourasky M.C, Tel-Aviv, Israel 17:30-18:00 Abstracts presentations Oren hall

SCIENTIFIC SESSION: Yasmin hall Faculty of Life Sciences, Bar-Ilan University 14:00-14:30 Targeting the Energy managing System of Cancer Cells Prof. U. Nir, Bar-Ilan University, Rama- Gan, Israel 14:30-15:00 T-Cell Mediated Anti-Tumor Immunity - Bridging Between Immunotherapy and Personalized Medicine Prof. C. Cohen, Bar-Ilan University, Ramat-Gan, Israel 15:00-15:30 Photodynamic Therapy and Photo Diagnosis of Cancer Prof. Z. Malik, Bar-Ilan University, Ramat-Gan, Israel 15:30-16:00 Tracking Down the Footprints of Viral Induced Oncogenesis Dr. M. Gal-Tanami, Bar-Ilan University, Safed, Israel 16:00-16:30 RNA Mutations-Alterations of RNA Editing and Alternative Splicing in Cancer Dr. E. Levanon, Bar-Ilan University, Ramat-Gan, Israel 16:30-17:00 Targeting the Stem Cell Pool in Pediatric Malignancies Prof. B. Dekel, Sackler School of Medicine, Tel Aviv University, Tel-Aviv, Israel 19:00-23:00 Gala Dinner & Social Event FRIDAY, APRIL 28, 2017 07:00- Breakfast 08:00-14:00 Registration & Exhibition 08:00-08:30 Educational Lecture - Oren hall Summary of Molecular Targeting Therapy in Colon Cancer Prof. D. Aderka, Sheba M.C, Tel-Hashomer, Israel 08:30-09:00 Invited Lecture - Oren hall (Roche) Immunotherapy in Advanced NSCLC: Practical Aspects Dr. E. Dudnik, Davidoff Cancer Center, Rabin M.C, Petach-Tikva, Israel 09:00-09:20 Educational Lecture - Oren hall Increased incidence of HCC and Other Malignancies in Patients Treated with Direct Antiviral Agents (DAA) for Hepatitis C Prof. R. Tur-Kaspa, Dean Faculty of Medicine in the Galilee, Bar-Ilan University, Safed, Israel Liver Institute, Rabin M.C, Israel 09:20-09:40 Invited lecture - Oren hall (MSD) Immunotherapy in lung Cancer Dr. Y. Bar, Sheba M.C, Tel-Hashomer, Israel

09:40-10:10 Educational Lecture - Oren hall Summary of Molecular Targeted Therapy in Breast Cancer Prof. T. Perez, Hadassah M.C, Jerusalem, Israel 10:10-10:30 Educational Lecture - Oren hall Side Effects of Targeted Agents in Solid Tumors lecturer 10:30-10:50 Educational Lecture - Oren hall (Session Supported by Eli Lilly) Soft Tissue Sarcomas Updating Prof. Breelyn Wilky, Miami University, Miami, FL, USA 10:50-11:10 Coffee Break & Exhibition 11:10-11:40 Invited Lecture-Oren Hall (Roche) Current and Future Perspectives of Comprehensive Genomic Profiling Prof. N. Peled, Rabin M.C, Petach-Tikva, Israel 11:40-12:00 Educational Lecture - Oren hall Imaging in Targeted Therapy: Should We Resist the RECIST? lecturer 12:00-12:20 Educational Lecture - Oren hall BRCA Mutations and PARP Inhibitors Open the Gate to Biomarker-Driven Therapy of Ovarian Cancer Prof. J. Ledermann, UCL Cancer Center, London, UK 12:20-12:30 Educational Lecture-Oren Hall Summary of Molecular Targeting Therapy in Ovarian Cancer Prof. T. Safra, Sourasky M.C, Tel-Aviv, Israel 12:30-13:00 Educational Lecture - Oren hall Summary of Molecular Targeting Therapy and Immunotherapy in Non-Small Cell Lung Cancer Prof. G. Lopes, Associate director for Global Oncology, Miami University, Miami, USA 13:00-13:20 Educational Lecture - Oren hall Targeted Therapy in Prostate and Bladder Cancer Lecturer 13:20-13:30 Closings Remarks - Oren hall Prof. Jamal Zidan, Congress President

13:40-14:30 Lunch Buffet 14:00-18:30 Galilee Sightseeing Tour 18:30-21:00 Dinner & Entertainment Entrance of Sabbath (Saturday): 18:53 SATURDAY, APRIL 29, 2017 07:00-10:00 Breakfast 07:00-12:00 Morning Walk / Bike Happening 11:00-12:00 Plenary Lecture - Oren hall Controversial Issues in Oncology Ethics Lecturer 13:00-14:30 Lunch 14:30- Check Out Exit of Sabbath (Saturday): 20:03