CURRICULUM VITAE Bong Sook Jhun, Ph.D. EDUCATION AND TRAINING UNDERGRADUATE SCHOOL DATES MONTH/YEAR DEGREE/YR/SUBJECT Kyung Hee University 03/1995 02/1999 BS, 1999, Chemistry GRADUATE SCHOOL Kyung Hee University 03/1999 02/2001 MS, 2001, Biochemistry School of Medicine Kyung Hee University 03/2003 02/2006 Ph.D., 2006, Biochemistry PROFESSIONAL EXPERIENCES 03/2000 02/2001: Research Assistant Kyung Hee University 12/2000 12/2001: Researcher, Bioneer Corporation, Daejeon, Korea 02/2002 02/2003: Researcher, Sam s Bio Corporation, 03/2003 04/2006: Research Assistant School of Medicine Kyung Hee University 10/2006 08/2007: Postdoctoral Fellow Department of Pediatrics, Division of Allergy and Immunology Harbor-UCLA Medical Center Torrance, CA, USA 09/2007 12/2009: Postdoctoral Research Associate Aab Cardiovascular Research Institute 1
University of Rochester School of Medicine and Dentistry Rochester, NY, USA 01/2010 Present: Postdoctoral Research Associate Department of Anesthesiology University of Rochester School of Medicine and Dentistry Rochester, NY, USA ACADEMIC HONORS AND AWARDS 11/27/2000: Excellent Graduate Award, Kyung Hee University, 2003/2004: President Scholarship, Kyung Hee University, 2004/2005: Superiority Scholarship, Kyung Hee University, 2004/2005: Academic Research Scholarship, Kyung Hee University, 2004/2005: Research Presentation Scholarship, Kyung Hee University, 07-08/2005: Research Abroad Scholarship (Visiting University of British Columbia, Canada) Kyung Hee University, 10/26/2005: Excellent Poster Presentation Award, 2005 Fall International Conference of Korean Society of Medical Biochemistry and Molecular Biology, 09/07/2011: Mitochondrial Symposium Traveling Award, 65 th Annual Meeting and Symposium of the Society of General Physiologists, Woods Hole, Massachusetts, USA PUBLICATIONS PEER-REVIEWED ARTICLES 1. Jhun BS, Lee H, Yoon Y: Mitochondrial fission is an essential cellular process for glucosestimulated insulin secretion in pancreatic β cells. 2011. [Manuscript in preparation] 2. Galloway CA, Lee H, Nejjar S, Jhun BS, Yu T, Hsu W, Yoon Y: Transgenic control of mitochondrial fission induces mitochondrial uncoupling and relieves diabetic oxidative stress in mice. 2011, [Review pending] 3. Jhun BS*, O-Uchi Jin*, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG: Adrenergic signaling controls RGK-dependent trafficking of cardiac voltagegated L-type Ca 2+ channels through PKD1. Circulation Research Published online before print November 10, 2011 (* Equal Contribution) 4. Yoon Y, Galloway CA, Jhun BS, Yu T: Mitochondrial Dynamics in Diabetes. Antioxidants & Redox Signaling 2011, 14(3): 439-457. 2
5. Yu T, Jhun BS, Yoon Y: High-Glucose Stimulation Increases Reactive Oxygen Species Production Through the Calcium and Mitogen-Activated Protein Kinase-Mediated Activation of Mitochondrial Fission. Antioxidants & Redox Signaling 2011, 14(3): 425-437. 6. Ha CH, Kim JY, Zhao J, Wang W, Jhun BS, Wong C, Jin ZG: PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proceedings of the National Academy of Sciences of the United States of America 2010, 107(35): 15467-15472. 7. Wang W, Ha CH, Jhun BS, Wong C, Jain MK, Jin ZG: Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and enos. Blood 2010, 115(14): 2971-2979. 8. Ha CH, Jhun BS, Kao HY, Jin ZG: VEGF stimulates HDAC7 phosphorylation and cytoplasmic accumulation modulating matrix metalloproteinase expression and angiogenesis. Arterioscleosis Thrombosis and Vascular Biology 2008, 28(10): 1782-1788. 9. Ha CH, Wang W, Jhun BS, Wong C, Hausser A, Pfizenmaier K, Mckinsey TA, Olson EN, Jin ZG: Protein kinase D-dependent phosphorylation and nuclear export of histone deacetylase 5 mediates vascular endothelial growth factor-induced gene expression and angiogenesis. Journal of Biological Chemistry 2008, 283(21): 14590-14599. 10. Xu X, Jhun BS, Ha CH, Jin ZG: Molecular mechanisms of Ghrelin-mediated endothelial nitric oxide synthase activation. Endocrinology 2008, 149(8): 4183-4192. 11. Ma Z., Jhun B, Oh CK: Binding of USF-1 to the E-Box regulates the 4G/5G polymorphismdependent PAI-1 expression in mast cells. Journal of Allergy and Clinical Immunology 2008, 121(4): 1006-1012. 12. Ma Z, Jhun B, Oh CK: Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. FEBS Letters 2007, 581: 4485-4490. 13. Jhun BS, Lee JY, Oh YT, Lee JH, Choe W, Baik HH, Kim SS, Yoon KS, Ha J, Kang I: Inhibition of AMP-activated protein kinase suppresses IL-2 expression through downregulation of NF-AT and AP-1 activation in Jurkat T cells. Biochemical and Biophysical Research Communications 2006, 351(4): 986-992. 14. Lee JY, Jhun BS, Oh YT, Lee JH, Choe W, Baik HH, Ha J, Yoon KS, Kim SS, Kang I: Activation of adenosine A 3 receptor suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of PI3-kinase/Akt and NF-kB activation in murine BV2 microglial cells. Neuroscience Letter 2006, 396(1): 1-6. 15. Jhun BS, Oh YT, Lee JY, Kong Y, Yoon KS, Kim SS, Baik HH, Ha J, Kang I: AICAR suppresses IL-2 expression through inhibition of GSK-3 phosphorylation and NF-AT activation in Jurkat T cells. Biochemical and Biophysical Research Communications 2005, 332(2): 339-346. 16. Jhun BS, Jin Q, Oh YT, Kim SS, Kong Y, Cho YH, Ha J, Baik HH, Kang I: 5- Aminoimidazole-4-carboxamide riboside suppresses lipopolysaccharide-induced TNF-alpha production through inhibition of phosphatidylinositol 3-kinase/Akt activation in RAW 264.7 murine macrophages. Biochemical and Biophysical Research Communications 2004, 318(2): 372-380. 17. Jin Q, Jhun BS, Lee SH, Lee J, Pi Y, Cho YH, Baik HH, Kang I: Differential regulation of phosphatidylinositol 3-kinase/Akt, mitogen-activated protein kinase, and AMP-activated protein kinase pathways during menadione-induced oxidative stress in the kidney of young and old rats. Biochemical and Biophysical Research Communications 2004, 315(3): 555-561. 3
18. Lim JI, Bae BN, Jhun BS, Kang I. Kim SJ: A simple preparative polyacrylamide gel electrophoresis for the purification of chymotrypsin inhibitor isoforms from ganoderma lucidum. Bulletin of the Korean Chemical Society 2003, 24(10): 1531-1534. 19. Hong F, Kwon SJ, Jhun BS, Kim SS, Ha J, Kim SJ, Sohn NW, Kang C, Kang I: Insulin-like growth factor-1 protects H9c2 cardiac myoblasts from oxidative stress-induced apoptosis via phosphatidylinositol 3-kinase and extracellular signal-regulated kinase pathways. Life Sciences 2001, 68(10): 1095-1105. 20. Kim SJ, Kim YJ, Seo MR, Jhun BS: Regulatory mechanism of L-alanine dehydrogenase from bacillus subtilis. Bulletin of the Korean Chemical Society 2000, 21(12): 1217-1221. ABSTRACTS 1. Jhun BS, Lee H, Yoon Y. Mitochondrial fission is an essential process for glucosestimulated insulin secretion in pancreatic β cells. 65 th Annual Meeting and Symposium of the Society of General Physiologists, September 7-11, 2011, Woods Hole, Massachusetts, USA 2. Wang W, Ha CH, Jhun BS, Wong W, Jin ZG. Fluid shear stress stimulates HDAC5 phosphorylation modulating KLF2 expression and endothelial inflammation. 48 th Annual Meeting of the American Society for Cell Biology, December 13-17, 2008, San Francisco, CA, USA 3. Jin ZG, Jhun BS, Wang W, Ha CH, Wong C. Reactive oxygen species inhibit flow-mediated endothelial nitric oxide synthase activation. 48 th Annual Meeting of the American Society for Cell Biology, December 13-17, 2008, San Francisco, CA, USA 4. Jin ZG, Xu XB, Jhun BS, Wong C, Ha CH. Ghrelin stimulates endothelial nitrite oxide synthase activation through AMP-activated protein kinase in vascular endothelium. 9 th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, April 16-18, 2008, Atlanta, GA, USA 5. Ma Z, Jhun B, Oh CK. USF-1 regulates the 4G/5G polymorphism-dependent PAI-1 expression in human mast cells 64th Annual Meeting of the American-Academy-of-Allergy- Asthma-and-Immunology, March 14-18, 2008, Philadelphia, PA, USA 6. Jhun BS, Baik HH, Yoon KS, Kang I. Role of AMP-Activated Protein Kinase in Interleukin- 2 Production from PMA/Ionomycin and anti-cd3/anti-cd28 Stimulated Human T Lymphocytes. 2005 Fall International Conference of Korean Society of Medical Biochemistry and Molecular Biology, October 26, 2005, Seoul Kyoyuk Munhwa Heokwan,. 7. Jhun BS, Baik HH, Yoon KS, Kang I. 5-Aminoimidazole-4-carboxamide riboside suppresses interleukin-2 expression through inhibition of nuclear factor of activated T cells in human leukemic Jurkat T cells. The 13 th International Conference of Women Engineers and Scientists, August 27, 2005, Ewha Womens University,. 8. Jhun BS, Yoon KS, Baik HH, Kang I. AICAR suppresses IL-2 expression through inhibition of NF-AT and AP-1 activations in Jurkat T cells. 62 nd KSBMB Annual Meeting in 2005 of Korean Society for Biochemistry and Molecular Biology, May 20, 2005, COEX, Seoul, Korea. 9. Jhun BS, Yoon KS, Baik HH, Kang I. 5-Aminoimidazole-4-carboxamide riboside suppresses interleukin-2 expression through inhibition of GSK-3 phosphorylation and NF- AT and AP-1 activations in human leukemic Jurkat T cells. The 13 th Federation Meeting of Korean Basic Medical Scientists, May 13, 2005, Grand Hilton Seoul Hotel,. 10. Jhun BS, Lee JY, Cho YH, Yoon KS, Baik HH, Kang I. Effects of Adenosine, ATP and its Analogs on LPS-induced TNF-alpha Production in Microglia. The 16 th Annual Meeting of 4
The Korean Society for Molecular and Cellular Biology, October 15, 2004, Seoul Kyoyuk Munhwa Heokwan,. 11. Jhun BS, Yoon KS, Cho YH, Baik HH, Kang I. AICAR suppresses LPS-induced TNF-α productions through inhibition of phosphatidylinositol 3-kinase/Akt activation in Raw 264.7 murine macrohages. The 61 st Annual Meeting 2004 of Korean Society for Biochemistry and Molecular Biology, May 28, 2004, COEX,. 12. Jhun BS, Yoon KS, Cho YH, Baik HH, Lee JH, Kang I. AICA riboside suppresses lipopolysaccharide-induced TNF-α productions through inhibition of phosphatidylinositol 3- kinase/akt activation in murine macrohages. The 12 th Federation Meeting of Korean Basic Medical Scientists, May 8, 2004, Korea University,. 13. Jhun BS, Lee JH, Cho YH, Baik HH, Kang I. AMPK Activation Stimulates DNA Synthesis and Protects Jurkat T Lymphocytes from Oxidative Stress-induced Apoptosis. The 14 th Annual Meeting of The Korean Society for Molecular and Cellular Biology, October 17, 2002, Seoul Kyoyuk Munhwa Heokwan,. 14. Jhun BS, Kim MS, Kim SJ. Isolation and characterization of a proteinase inhibitor from Ganoderma Lucidum. 2000 Fall Scientific Meeting and General Assembly of The Biochemical Society of The Republic of Korea, October 7, 2000, inbionet Co., Taejon, Korea. 5