Table updated 15 th February Sodium valporate 15 th February Ramipril & Felodipine 15 th February 2019

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This table contains information on shortages of human medicines notified to the Health Products Regulatory Authority that have been resolved in the last 6 months. Table updated 15 th February 2019 Product name Authorisation number Active Ingredient Date normal supply resumed Epilim 100mg Crushable Tablet Sodium valporate 15 th February 2019 PA0540/150/001 Triapin 2.5mg/2.5mg Prolonged Release Tablet Ramipril & Felodipine 15 th February 2019 PA0540/082/001 Sinemet 25mg/250mg Tablet Carbidopa & Levodopa 14 th February 2019 PA1286/009/005 Hycamtin 4mg for Powder for Concentrate for Solution for Infusion Topotecan hydrochloride 12 th February 2019 EU/1/96/027/001 Parlodel 2.5mg Bromocriptine mesilate 12 th February 2019 PA2010/042/001 Syntocinon Ampoules 10IU/ml Concentrate for Infusion or Solution for Intramuscular Oxytocin 12 th February 2019 PA2206/003/002 Clopidogrel 75mg Tablet Clopidogrel besilate 11 th February 2019 1/7

PA1380/057/001 Fluorouracil 25mg/ml Solution for or Infusion Fluorouracil sodium 11 th February 2019 PA0822/223/001 Losartan 25mg Film Coated Tablet Losartan potassium 8 th February 2019 PA1390/003/001 Coversyl Arginine 5mg Film Coated Perindopril arginine 4 th February 2019 PA0568/002/005 Lopid 300mg Capsules (100 pack size) Gemfibrozil 31 st January 2019 PA0822/014/001 Methotrexate 5mg/2ml Methotrexate 29 th January 2019 PA0822/206/001 Betaloc 1mg/ml Solution for Metoprolol tartrate 30 th January 2019 PA0970/032/001 Blopress 2mg Candesartan cilexetil 30 th January 2019 PA2229/001/001 Perindopril Tosilate Teva 5mg Film Coated Tablet Perindopril tosilate 29 th January 2019 <DOCUMENT NUMBER>-<VERSION NUMBER> 2/7

PA0749/168/002 Perindopril Tosilate / Amlodipine 5mg/5mg Tablet Perindopril tosilate & Amlodipine 29 th January 2019 PA0749/197/001 Perindopril Tosilate / Amlodipine 10mg/5mg Tablet Perindopril tosilate & Amlodipine 29 th January 2019 PA0749/197/003 Simvastatin 10mg Film Coated Simvastatin 29 th January 2019 PA0749/052/002 Tavanic 250mg Film Coated Levofloxacin hemihydrate 29 th January 2019 PA0540/077/002 Tavanic 500mg Film Coated Levofloxacin hemihydrate 29 th January 2019 PA0540/077/003 Tracrium 10mg/ml Solution for or Infusion (Ampoules 25ml x 2 pack size) Atracurium besilate 29 th January 2019 PA1691/029/001 Stesolid Rectal Solution 10mg Diazepam 25 th January 2019 PA1390/141/002 Doxatan 1mg Tablet Doxazosin 23 rd January 2019 <DOCUMENT NUMBER>-<VERSION NUMBER> 3/7

PA0126/202/001 Eumovate Ointment 0.05% w/w Clobetasone butyrate 22 nd January 2019 PA1077/006/002 Caverject 20mcg Powder and Solvent for Solution for Alprostadil 21 st January 2019 PA0822/115/003 Minims Prednisolone Sodium Phosphate 0.5% w/v Eye Drop Solution Prednisolone sodium phosphate 18 th January 2019 PA0555/023/001 Aciclovir 25mg/ml Concentrate for Solution for Infusion Aciclovir sodium 17 th January 2019 (500mg/20ml presentation only) PA0822/215/001 Clopidogrel Teva 75mg Film Coated Clopidogrel hydrogen sulphate 17 th January 2019 EU/1/09/540/001-016 Bupivacaine hydrochloride 0.25% w/v Solution for Bupivacaine hydrochloride 10 th January 2019 PA/0073/091/001 Bupivacaine hydrochloride 0.5% w/v Solution for Bupivacaine hydrochloride 10 th January 2019 PA/0073/091/002 <DOCUMENT NUMBER>-<VERSION NUMBER> 4/7

Sinemet Plus 25/100mg Carbidopa & Levodopa 7 th January 2019 PA1286/009/004 Sastravi 125/31.25/200mg Film Coated Levodopa, Carbidopa & Entacapone 21 st December 2018 PA1380/154/004 Glucose IV Infusion BP 10% w/v Solution for Infusion Anhydrous Glucose 19 th December 2018 PA0179/001/028 Naltrexone Hydrochloride 50mg Film Coated Tablet Naltrexone Hydrochloride 18 th December 2018 PA1390/020/001 Quinine Sulphate 300mg Film Coated Quinine Sulphate 13 th December 2018 PA1986/052/001 Amoxil 500mg Vials Powder for Solution for or Infusion Amoxicillin 5 th December 2018 PA1077/033/004 Imuran 50mg Powder for Solution for /Infusion Azathioprine sodium 5 th December 2018 PA1691/003/001 Surmontil 50mg Hard Capsules Trimipramine maleate 29 th November 2018 PA0540/128/003 Fortum 500mg Powder for Solution for Ceftazidime pentahydrate 28 th November 2018 PA1077/007/001 <DOCUMENT NUMBER>-<VERSION NUMBER> 5/7

Ativan 4mg/ml Solution for Lorazepam 26 th November 2018 PA0822/090/002 Bactroban 2.0% w/w Nasal Ointment Mupirocin calcium 14 th November 2018 PA1077/094/002 Valsartan Krka 160mg Valsartan 14 th November 2018 PA1347/010/008 Amikin 100mg/2ml Solution for Amikacin sulphate 13 th November 2018 PA2255/001/001 Diovan 160mg Valsartan 2 nd November 2018 PA0896/009/002 Fludrocortisone acetate 0.1mg Fludrocortisone acetate 2 nd November 2018 PA1691/018/001 Morphine Sulphate 10mg/ml Solution for Morphine Sulphate 30 th October 2018 PA0073/020/001 Diovan 80mg Valsartan 18 th October 2018 PA0896/009/001 Xylocaine 10mg/Dose Oromucosal Spray Lidocaine 14 th September 2018 PA1691/028/001 Sotoger 80mg Sotalol 13 th September 2018 PA0577/021/041 Stesolid 5mg Rectal Solution Diazepam 4 th September 2018 <DOCUMENT NUMBER>-<VERSION NUMBER> 6/7

PA1390/141/001 Marcain 0.5% with Adrenaline 0.5%/0.55% v/v Solution for Bupivacaine hydrochloride & Epinephrine bitartrate 30 th August 2018 PA1691/025/002 Phenergan 25mg Film Coated Tablet Promethazine hydrochloride 27 th August 2018 PA0540/121/003 <DOCUMENT NUMBER>-<VERSION NUMBER> 7/7