REGISTER NOW! Registration and additional course information can be found on our NEW course website : ce.mayo.edu/node/6581

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Mayo School of Continuous Professional Development 26th Annual Mayo Clinic Hematology/Oncology Reviews 17th Annual Fellows Research Presentations July 27-30, 2016 The Ritz-Carlton Amelia Island, FL Course Directors Gerardo Colon-Otero, M.D. Ruben A. Mesa, M.D. Joseph R. Mikhael, M.D. Steven R. Alberts, M.D. Mark R. Litzow, M.D. REGISTER NOW! Registration and additional course information can be found on our NEW course website : ce.mayo.edu/node/6581

COURSE DESCRIPTION This course is a comprehensive review of hematology/oncology that focuses on the clinical application of new research developments over the preceding year. Didactic presentations will be case-based. Attendees will leave with up-to-date, practical information which will have immediate clinical application. The most important clinical management questions in hematology/oncology will be addressed in highly interactive sessions. COURSE LEARNING OBJECTIVES Upon conclusion of this program, participants should be able to: List new practice changing developments in hematology and medical oncology in 2015 2016 Select the appropriate clinical conditions in oncology and hematology where new treatments were developed in 2015 and 2016 Identify risks and benefits of new treatments approved by the FDA Address the most important management issues in hematology/ oncology and select the best treatments based on current evidence Attendance at this Mayo course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course. INTENDED AUDIENCE This course is intended for practicing hematologists, medical oncologists, scientists, researchers, nurses, physician assistants, pharmacists and clinical research associates. CREDIT Mayo Clinic College of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. Mayo Clinic College of Medicine designates this live activity for a maximum of 20.75 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. AOA This program has been accredited by the American Osteopathic Association for 20.75 credits of AOA Category 2-A. Other Health Care Professionals A certificate of attendance will be provided to other health care professionals for requesting credits in accordance with state nursing boards, specialty societies, or other professional associations. GRANTS AND EXHIBITS At the time of this printing, a complete listing of commercial supporters was not available. Appropriate acknowledgment will be given to all supporters at the time of the meeting. Exhibits will be available for viewing at all scheduled breaks. REGISTRATION Register online at ce.mayo.edu/node/6581 The registration fee includes tuition, comprehensive course syllabus (electronic), continental breakfasts, break refreshments, and lunches. Although it is not Mayo School of Continuous Professional Development (CPD) policy to limit the number of registrants for a course, conference room facilities may necessitate closing of enrollment; therefore, early registration is advised. A letter of confirmation will be sent upon receipt of payment and completed registration form. SIMULATION CENTER EDUCATIONAL SESSION Mayo Clinic Simulation Center Wednesday, July 27, 2016, 1:30-5:30 pm Additional Fee This optional hands-on workshop in the Mayo Clinic Simulation Center will engage participants in interactive education sessions covering errors in oncology, hematopathology diagnostic challenges, marrow procedures, gynecologic oncology procedures, chemotherapy administration, lymphoma, AML, MDS, CMPN and coagulation. Registration Fees Physician/Scientists On or before 06/27/15 $600 After 06/27/15 $675 Residents, Retirees, PAs and NPs On or before 06/27/15 $475 After 06/27/15 $550 Simulation Center Educational Session (Wednesday, July 27, 2016) $50 Transportation from Ritz provided CANCELLATION POLICY If you cancel your participation in this course, your registration fee, less a $75 administrative fee, will be refunded when written notification is received by Mayo School of CPD on or before July 12, 2016 (cme-jax@mayo.edu). No refunds will be made after July 12, 2016. Canceled registrations are non-transferable. Mayo School of CPD reserves the right to cancel or postpone any course due to unforeseen circumstances. In the unlikely event Mayo School of CPD must cancel or

postpone this course, Mayo School of CPD will refund the registration fee, but is not responsible for any related costs, charges, or expenses to participants, including fees assessed by airline/travel/lodging agencies. For additional information, contact: Mayo School of Continuous Professional Development Website: ce.mayo.edu E-mail: cme-jax@mayo.edu Phone: 800-462-9633 TRAVEL AND LODGING ACCOMODATIONS Ritz-Carlton 4750 Amelia Island Parkway Amelia Island, Florida 32034 866-763-2960 The Ritz-Carlton is offering coastal view hotel rooms for attendees and their guests at the group rate of $249 per night plus applicable taxes. In order to receive the special rate, identify yourself as a participant of the Mayo Clinic Hematology/Oncology Reviews or register online at https://resweb.passkey.com/go/foundations26thannual. Reservations must be made by Tuesday, July 5, 2016 or before the room block is filled, whichever comes first. The hotel has extended the special rate three days before and three days after the meeting. There is limited guest room availability at the special rates; early reservations are based on availability. The standard hotel reservations cancellation policy will apply to all reservations. Attendees are responsible for their own reservations. Guests receive complimentary in-room internet service. Rooms are limited so we encourage early booking. All parking at the resort is provided by valet service. Overnight parking at the resort is $14 per night. Day guest parking is complimentary. Jacksonville International Airport (JAX) is located 35 minutes from The Ritz-Carlton at Amelia Island. Mayo School of CPD is not responsible for expenses incurred by an individual who is not confirmed and for whom space is not available at the meeting. Costs incurred by the registrant such as airline or hotel fees or penalties are the responsibility of the registrant. FACULTY Course Director(s) Gerardo Colon-Otero, M.D.; Ruben A. Mesa, M.D.; Joseph R. Mikhael, M.D.; Steven R. Alberts, M.D.; Mark R. Litzow, M.D. Mayo Faculty Sikander Ailawadhi, M.D. Thorvardur R. Halfdanarson, M.D. Kabir Mody, M.D. Steven R. Alberts, M.D. Kathleen M. Hebenstreit, R.N. Donald W. Northfelt, M.D. Steven Attia, D.O. Joleen M. Hubbard, M.D. Grzegorz S. Nowakowski, M.D. Alan H. Bryce, M.D. Kurt A. Jaeckle, M.D. Katharine A. Price, M.D. Asher A. Chanan-Khan, M.D. Richard W. Joseph, M.D. Helen J. Ross, M.D. Gerardo Colon-Otero, M.D. Mark R. Litzow, M.D. Kathryn J. Ruddy, M.D. Roxana S. Dronca, M.D. Yanyan Lou, M.D., Ph.D. Lisa Vigil Schattinger, M.S.N. James M. Foran, M.D. Ariela L. Marshall, M.D. Taimur Sher, M.D. Matthew P. Goetz, M.D. Michael E. Menefee, M.D. Winston Tan, M.D. Thomas M. Haberman, M.D. Ruben A. Mesa, M.D. David D. Thiel, M.D. Tufia C. Haddad, M.D. Joseph R. Mikhael, M.D. Guest Faculty Sharlene Gill, M.D. BC Cancer Agency Vancouver Center Mrinal M. Gounder, M.D. Memorial Sloan Kettering Cancer Center Nasser H. Hanna, M.D. Indiana University Medical Center William K. Oh, M.D. Mount Sinai Hospital Hope S. Rugo, M.D. UCSF Helen Diller Family Comprehensive Cancer Center Ken Brummel-Smith, M.D. Florida State University College of Medicine David P. Steensma, M.D. Dana-Farber Cancer Institute Brady L. Stein, M.D., M.H.S. Robert H. Lurie Comprehensive Cancer Center of Northwestern University Martin S. Tallman, M.D. Memorial Sloan Kettering Cancer Center Jason Robert Westin, M.D. MD Anderson Cancer Center Neil S. Young, M.D. National Institute of Health

PROGRAM AGENDA Wednesday, July 27, 2016 1:00 p.m. Transportation Departs Ritz-Carlton, Amelia Island 2:30 Simulation Center Educational Session (choice of four) 1. Marrow procedures: Posterior electric drill 2. Intrathecal Chemotherapy 3. Lymphoma Case Discussions 4. AML, ALL Case Discussion 5. MDS-CMPN Case Discussion 6. Coagulation Case Discussions 5:30 p.m. Transportation Departs Mayo Clinic Thursday, July 28, 2016 Session: Hematology Consultative Hematology: Benign Hematology and Hematologic Malignancies Moderator: Gerardo Colon-Otero, M.D. 7:00 a.m. Registration and Continental Breakfast 8:00 Welcome - Gerardo Colon-Otero, M.D. 8:20 Aplastic Anemia and PNH - Neal Young, M.D. 8:40 Thrombosis Update - Ariela L. Marshall, M.D. 9:00 Case Presentations, Q&A, Post-Test 9:20 Break Chronic Myeloid Disorders (CMPN and MDS) Moderator: James M. Foran, M.D. 9:40 CMPN - Ruben A. Mesa, M.D. 10:00 CML - Brady L. Stein, M.D., M.H.S. 10:20 MDS - David P. Steensma, M.D. 10:40 Case Presentation, Q&A, Post-Test 11:00 Break Acute Leukemias Moderator: James M. Foran, M.D. 11:20 AML - Martin S. Tallman, M.D. 11:40 ALL - Mark R. Litzow, M.D. 12:00 p.m. Case Presentations, Q&A, Post-Test 12:20 Lunch Session: CLL Myeloma Moderator: Sikander Ailawhadi, M.D. 1:20 CLL - Asher A. Chanan-Khan, M.D. 1:40 Myeloma - Joseph R. Mikhael, M.D. 2:00 Waldenstrom s Macroglobulinemia - Sikander Ailawhadi, M.D. 2:20 Case Presentations, Q&A, Post-Test 2:40 Break Lymphomas Moderator: Thomas M. Haberman, M.D. - MCR 3:00 Mantle Cell Lymphoma - Thomas Habermann, M.D. 3:20 Non Hodgkins Lymphoma - Grzegorz S. Nowakowski, M.D. 3:40 Aggressive Lymphomas - Jason Robert Westin, M.D. 4:00 Case Presentations, Q&A, Post-Test 4:20 Adjourn

Friday, July 29, 2016 Session: Solid Tumor Oncology GI and GYN Oncology Moderator: Winston Tan, M.D. 7:30 a.m. Continental Breakfast 8:00 Prostate Cancer - David Thiel, M.D. 8:20 Prostate Cancer - William K. Oh, M.D. 8:40 Case Presentations, Q&A, Post-Test 9:00 Renal and Bladder Cancers - Alan H. Bryce, M.D. 9:20 Ovarian Cancer - Gerardo Colon-Otero, M.D. 9:40 Case Discussion 10:00 Break Melanomas and Sarcomas Moderator: Steve Attia, D.O. and Richard W. Joseph, M.D. 10:20 Metastatic Melanoma - Roxana S. Dronca, M.D. 10:40 Sarcomas - Mrinal M. Gounder, M.D. 11:00 Case Presentations, Q&A, Post-Test End of Life Controversies Moderator: Gerardo Colon-Otero, M.D. 11:20 Aid in Dying for Individuals with Terminal Illness - Ken Brummel-Smith, M.D. 11:40 Personal Experience with a Loved One Who Ends His Life with the Help of the Death with Dignity Law - Lisa Vigil Schattinger, M.S.N. and Jan Rowe, R.N. 12:00 p.m. Case Presentations, Q&A, Post-Test 12:30 Lunch Session: GI Oncology Moderator: Steven R. Alberts, M.D. 1:30 Metastatic Gastroesophageal Cancers - Helen J. Ross, M.D. 1:50 Metastatic Pancreatic Cancers - Kabir Mody, M.D. 2:10 Case Discussions 2:30 Neuroendocrine Cancers - Thorvardur R. Halfdanarson, M.D. 2:50 Metastatic Cholangiocarcinoma - Steven R. Alberts, M.D. 3:10 Case Discussions 3:50 Rectal Cancer - Joleen M. Hubbard, M.D. 4:10 Metastatic Colorectal Cancer - Sharlene Gill, M.D. 4:30 Case Discussion 5:00 p.m. Adjourn Saturday, July 30, 2016 Session: Cancer Survivorship Moderator: Kathryn J. Ruddy, M.D. 7:30 a.m. Continental Breakfast 8:00 Toxicities in Cancer Survivors - Kathryn J. Ruddy, M.D. 8:20 Nutrition and Integrative Medicine - Katherine A. Price, M.D. 8:40 Communication and Care Coordination - Tufia C. Haddad, M.D. 9:00 Case Discussion 9:20 Break Non-Small Cell Lung Cancers and Head and Neck Cancers Moderators: YanYan Lou, M.D., Ph.D. 9:40 Non-Small Cell Lung Cancer - YanYan Lou, M.D., Ph.D. 10:00 Metastatic Non-Small Cell Lung Cancer - Nasser Hannah, M.D. 10:20 Head and Neck Cancers - Michael E. Menefee, M.D. 10:40 Case Discussions Breast Cancers Moderators: Alvaro Moreno-Aspitia, M.D. and Sara Chumsri, M.D. 11:00 Triple Negative Breast Cancer - Donald Northfelt, M.D. 11:20 HER2 Based Treatments - Hope S. Rugo, M.D. 11:40 Hormone Receptor Positive Disease - Matthew Goetz, M.D. 12:00 Case Discussion 12:30 Adjourn and Box Lunches

4500 San Pablo Road Jacksonville, Florida 32224 FACULTY DISCLOSURE As a provider accredited by ACCME, Mayo Clinic College of Medicine (Mayo School of Continuous Professional Development) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so those participants in the activity may formulate their own judgments regarding the presentation. NATIONAL PHYSICIAN PAYMENT TRANSPARENCY PROGRAM Mayo Clinic College of Medicine complies with the requirements of the National Physician Payment Transparency Program OPEN PAYMENTS (Physician Payments Sunshine Act). 2017 SAVE THE DATE 27th Annual Mayo Clinic Hematology/Oncology Reviews August 16-19, 2017 Ritz-Carlton Amelia Island, FL MC8100-05 NON-PROFIT ORG. U.S. POSTAGE PAID MAYO CLINIC