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Internal Medicine Confident and Conclusive Diagnosis with Flexible Solutions ALPINION MEDICAL SYSTEMS We are Ultrasound Professionals

Ultrasound is widely used as the gold-standard for internal medicine diagnostic procedures such as abdominal, thyroid, carotid, echo, vascular, prostate, kidney, musculoskeletal and breast examinations. The core values of ultrasound are used for lesion detection, follow-up procedures, preventive screenings, FNA (fine needle aspiration), and FNAB (fine needle aspiration biopsy). Ultrasound must provide a uniform image quality (regardless of patient case dependency) and high-resolution images that visualize targeted lesions and surrounding tissue structures. Application-specific software is also a key ultrasound component to maximize patient throughput with an efficient and confident diagnosis. High-definition image for diagnostic confidence Application software to enhance diagnostic efficiency Intuitive and simple workflow for maximal patient throughput ALPINION s E-CUBE 15 was developed to satisfy these three major customer core values. Internal Medicine

IMAGING TECHNOLOGY ALPINION s imaging technology provides uniform high-resolution image performance, regardless of patient type that retains a uniform image performance during whole life cycle of the system. ALPINION s unique acoustic engineering controls the ultrasound signals to produce qualified ultrasound beam patterns for axial, lateral, and spatial resolution. Calibrated beams are processed with ALPINION s unique Optimal Imaging Suite (OIS) technology and converted into primary sources that generate a uniform and high-resolution image with detailed tissue characteristics. Unique technology that enables a high-resolution image function: SensitiView Technology TM and Clear Signal Amplifier (CSA TM ) SensitiView Technology TM consists of advanced sub-technologies and the application of innovative materials (i.e. high performance active materials, low transmission inter-element materials, and tightly controlled passive materials) in the acoustic module. Technology optimally integrates the acoustic module and electrical module to optimize the impedance mismatch of the acoustic module and cabling. In addition, ALPINION applied the CSA TM (Clear Signal Amplifier) technology to maximize the amplified Rx signal and optimally match networks. Reflected Wave Signal Converted by Element Signal Amplified by LNA Signal Amplified by Matching Network CSA (Clear Signal Amplifier) Low Loss Cable Matching Network High Efficiency Piezo- Electric Material Optimal Imaging Suite Optimal Imaging Suite, ALPINION s unique image processing technology, contributes to image clarity by the edge enhancement of internal organ images. This technology provides users more choices to optimize images that provide high-resolution, deeper penetration, and uniform images in near and far field zones through the combination of different image parameters, algorithms, and advanced image filtering to reduce artifacts. Crystal Signature TM Research/manufacturing technology The unique design and manufacturing technology of piezoelectric materials by ALPINION ranges from conventional PZT composite ceramics to advanced materials like single crystal ceramics. ALPINION s single crystal technology (Crystal Signature) is unique in the creation of highresolution and wide bandwidth images for the daily practice of internal medicine. ALPINION s single crystal generates calibrated beam patterns even in the long depth that benefit practitioners with a clear scan image that reaches deep into the abdomen to examine the liver, pancreas, kidney, appendix and bowels. Competitor ALPINION Elevation [mm] Elevation [mm] 30 20 10 0-10 -20 10-20 30 20 9 0-10 Beam field(normalized at each depth) 20 40 60 80 100 120 140 Depth [mm] 20 40 60 80 100 120 140 Magnitude (db) 0-5 -10-20 -25 5-40 Frequency Domain Spectrum Crystal Signature TM General PZT A B C 1 2 3 4 5 6 7 8 MHz

IMAGE GALLERY Liver Lt. Lobe Renal Doppler Renal Power Doppler Small Bowel Thyroid Mass Thyroid Mass

Breast Mass Breast Hypoechoic Mass MV M-mode Tricuspid Valve Regurgitation TDI CCA Triplex

CubeStrain TM ALPINION s proprietary core imaging technology for Conclusive Diagnosis. CubeStrain TM Application specified software to support diagnostic confidence Design technology for diagnostic efficiency Stress Echo

SIMPLE AND INTUITIVE WORKFLOW TO IMPROVE PATIENT THROUGHPUT Ultrasound diagnosis is an essential to the internal medicine application in daily practice. Essential requirements for ultrasound systems are high-definition images and ease-of-use workflow. Furthermore, fast workflow and system preparation, and effective data management (transmission, restore, back-up) are essential as well. One-Button Automation Technology Xpeed TM The Xpeed TM feature enables instant and optimal images in 2D, color, and Doppler modes with a simple one-button operation that improve diagnostic speed and accuracy. Quick ID, Quick Image Preset The Quick ID function quickly preps the scanning mode with basic patient information data input. The Quick image preset feature allows clinicians to assign preferred image settings and parameters per transducer and application that help users promptly prepare an optimal scan mode. System Design Technology The E-CUBE15 s design science focuses on a quality ultrasound design that contributes to diagnostic efficiency and an optimal diagnostic environment. Finger tip Control Panel Up-down The E-CUBE 15 is designed for single finger-tip use that facilitates the easy operation of the control panel up-down function to match the user s preferable system height. Lightweight and best grip transducer ALPINION s innovative design technology of transducer, MicroFit Technology TM complements perfectly optimized scanning conditions and enhanced customer design ergonomics. MicroFit Technology TM enables ALPINION s miniaturized transducer design. The results are a light-weight transducer with the control boards, Clear Signal Amplifier (CSA TM ) and multi-flex circuits to control active technologies, embedded inside the transducer main body. MicroFit Technology TM maximizes user comfort through the minimization of operational strain. 10.4 Full touch screen Full touch screen provides an easy and intuitive operation for a convenient diagnosis.

APPLICATION SOFTWARE TO SUPPORT DIAGNOSTIC CONFIDENCE E-CUBE 15 s diagnostic software improves the diagnostic efficiency and confirmation of abdomen, thyroid, carotid, cardio-vascular and thyroid FNA. E-CUBE 15 s application-specific software effectively diagnoses disease and efficiently facilitates follow-up treatments for high-risk patients. Auto IMT A carotid scanning observes early stage arterial sclerosis. ALPINION s Auto IMT software for carotid scan, provides simple operation and accurate measurement results by calibrating the thickness of the upper and lower intima-media with a single line near the intima. TDI, Cube Strain TDI software helps in the quantitative and objective assessment of left ventricle wall motion function. Cube Strain, ALPINION s Strain imaging software, enables a quantitative and objective evaluation of myocardial contractions. It detects velocity gradients and helps clinicians analyze regional myocardial function. TDI and Cube Strain software help diagnose heart diseases such as coronary artery disease and myocardial deformation. Fine Needle Visualization ALPINION s Fine Needle Visualization software enables a precise needle tip visual during a thyroid FNA procedure and accurate lesion targeting. The simple on-off function provides the clinician a precise target location that increases FNA efficiency and accuracy. > Before After

E 3 Extreme Accuracy Efficient Workflow Ergonomic Design ALPINION promises to provide these three values to customers We are Ultrasound Professionals Internal Medicine Real Time Ultrasound, Real Time Customer Service ALPINION s E-CUBE system can be accessed by Net CUBE CARE TM service anytime. It contributes to the efficient troubleshooting of system software. Net CUBE CARE TM efficiently upgrades (based on customer needs) the E-CUBE system by accessing and upgrading the system software. ALPINION s intuitive customer service, Net CUBE CARE TM, is optional for further inquiries, please contact at service@alpinion.com ALPINION MEDICAL SYSTEMS Verdi Tower, 222-22, Guro 3-dong Guro-gu, Seoul, 152-848, Korea TEL +82-2282-0903 FAX +82-2-851-5593 www.alpinion.com Copyright 2013 ALPINION MEDICAL SYSTEMS, Inc. All rights reserved.