The ability of isolated and combined ACL reconstruction and/or lateral monoloop tenodesis to restore intact knee laxity in the presence of isolated

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The ability of isolated and combined ACL reconstruction and/or lateral monoloop tenodesis to restore intact knee laxity in the presence of isolated and combined injuries in- vitro. K.C. Lagae, M.D., Antwerp Orthopaedic Centre Monica Hospitals, Antwerp, Belgium J. Robberecht M.D., (Co-first author, Presenter) Antwerp Orthopaedic Centre Monica Hospitals, Antwerp, Belgium Department of Orthopaedic Surgery, Antwerp University Hospital (UZA) K. K. Athwal PhD, Biomechanics Group, Department of Mechanical Engineering, Imperial College, London, UK. Prof. Verdonk P. M.D. PhD, Professor or Orthopaedic Surgery, Antwerp Orthopaedic Centre Monica Hospitals and Department of Orthopaedic Surgery, Antwerp University Hospital (UZA), Antwerp, Belgium Prof Andrew A. Amis FREng, DSc(Eng), PhD, Department of Mechanical Engineering, Imperial College London, London, UK. Musculoskeletal Surgery Group, Imperial College London School of Medicine, Charing Cross Hospital, London, UK

Acknowledgements Study Supported by research grants paid by Smith & Nephew Endoscopy Co to Imperial College London. Smith & Nephew also lent surgical instruments and provided surgical consumables for the experiment. K.C. Lagae, M.D., Consultant with Smith & Nephew J. Robberecht M.D., No financial conflicts to disclose. K. K. Athwal PhD, Supported by research grants paid by Smith & Nephew Endoscopy Co to Imperial College London. Prof. Verdonk P. M.D. PhD, Consultant with Smith & Nephew, Depuy-Synthes, Active Implants, Cartiheal, Conmed Prof Andrew A. Amis FREng, DSc(Eng), PhD, Received research funding from Smith & Nephew and royalties from Smith& Nephew, Paid speaker for Smith & Nephew.

Study This controlled laboratory study examined The influence on knee laxity after sequentially sectioning different structures Anterior cruciate ligament (ACL) Anterolateral ligament (ALL) Harvesting a iliotibial band (ITB) midportion strip Releasing the deep fibres of the ITB Isolating the ALL through a fibre splitting incision of the ITB. The effect of the reconstructions on the laxity ACL reconstruction alone, with hamstring tendon grafts ACL reconstruction in combination with a lateral monoloop tenodesis, Isolated Monoloop tenodesis without ACL reconstruction Harvesting the ITB strip.

Lateral Monoloop tenodesis 20N 4 During the section phase a midportion ITB strip is harvested. The attachment to Gerdy s tubercle is preserved (1) and an ITB strip of 10 x 150 mm is taken. 3 When performing the monoloop procedure, the tibia is locked in the initial neutral rotation, the ITB strip is routed deep to the LCL (2) and fixed with a 12 x 23 mm staple posterior and proximal to the femoral insertion of the LCL (3). 2 1 Based upon a previous study, this tenodesis was fixed at an applied tension of 20 N 1 (4)

Methods 12 cadaveric left knees Installed in a 6 degrees of freedom rig using an optical tracking system to record the kinematics through 0 to 100 of knee flexion with different forces applied No load Anterior drawer (90N) Posterior drawer (90N) External rotation (5Nm) Internal rotation (5Nm) Combined anterior drawer (90N) and internal rotation (5Nm). The knees were sequentially tested in intact state and the different states of injury and reconstructions Statistics Two-way repeated-measures analyses of variance were used to compare the laxity data across knee states and flexion angles. When differences were found between knee states, paired t tests with Bonferroni correction were performed.

CHANGE IN ANTERIOR TRANSLATION (MM) Section states - Graphics 1. Intact 2. ACL cut 3. ALL + ACL cut 4. ITB graft harvest + ALL + ACL cut 5. Deep ITB + ALL + ACL cut Response to a 90-N anterior drawer force Cutting the ACL significantly increased anterior translation laxity by a mean of 4 to 7 mm compared to the intact knee at all flexion angles (p<0.01 from 0-90, p=0.013 at 100 ). Further sectioning of the ALL increased anterior translation laxity by <1 mm, significant at 20-30 knee flexion compared to the ACL-deficient knee (p<0.05). Harvesting the midportion ITB strip did not affect anterior translationlaxity significantly. Additional sectioning of the deep ITB significantly increased anterior translation laxity by up to 3 mm, significant at 40 to 100 flexion compared to the ACL and ALLdeficient knee (p<0.05). After the cutting stages, the knees with combined soft-tissue damage were significantly more lax in tibial anterior translation than the intact knee, by 7 to 10 mm across 0 to 100 flexion (p<0.004).

CHANGE IN INTERNAL ROTATION ( ) 3 3 Section states - Graphics 1. Intact 2. ACL cut 3. ALL + ACL cut 4. ITB graft harvest + ALL + ACL cut 5. Deep ITB + ALL + ACL cut Response to a 5-Nm internal torque Cutting the ACL did not increase tibial internal rotation laxity significantly compared to the intact knee at any flexion angle (mean changes 1 to 4 ). Further sectioning of the ALL did not increase tibial internal rotation laxity significantly compared to either the intact knee or the ACL-deficient knee at any flexion angle, with mean changes <1. Harvesting the midportion ITB strip increased tibial internal rotation laxity significantly when compared to the ACL plus ALL-deficient state at 90 and 100 flexion (mean changes <2 ), and the knee was now significantly more lax than when intact across the range 20-100 flexion. Additional sectioning of the deep ITB significantly increased internal rotation laxity at 20 to 100 flexion compared to the ACL and ALL-deficient knee (p<0.012), with a maximum mean change of 5 at 70 knee flexion. Thus, after the cutting stages, the knees with combined soft-tissue damage were significantly more lax in tibial internal rotation than the intact knee, across 10 100, p<0.017, with mean laxity increases of 4 to 7.

Section states - Graphics Response in anterior translation to a 5-Nm internal torque combined with a 90-N anterior drawer force CHANGE IN ANTERIOR TRANSLATION (MM) 3-1. Intact 2. ACL cut 3. ALL + ACL cut 4. ITB graft harvest + ALL + ACL cut 5. Deep ITB + ALL + ACL cut CHANGE IN INTERNAL ROTATION ( ) Response in internal rotation to a 5-N m internal torque combined with a 90-N anterior drawer force 3 3 When applying a combined anterior drawer and internal torque, cutting the ACL significantly increased anterior translation laxity compared to the intact knee from 0-60 flexion (p<0.05), but did not increase internal rotation. Cutting the ALL did not change either the anterior translation or internal rotation at any angle of knee flexion (p>0.05). Sectioning the ITB significantly increased both anterior translation laxity and internal rotation at 20 to 100 and 30 to 100, respectively (p<0.05) compared to the ACL and ALLdeficient knee.

CHANGE IN ANTERIOR TRANSLATION (MM) Reconstruction states - Graphics 1. Intact 5. Deep ITB + ALL + ACL cut 6. ACL graft 7. Monoloop + ACL graft 8. ACL graft out, monoloop intact Response to a 90-N anterior drawer force After isolated ACL reconstruction, anterior translation laxity did not differ significantly from the intact knee at any angle of knee flexion from 0 to 100 (p>0.053), with residual changes from 1 to 3 Addition of the monoloop tenodesis to the ACL reconstruction maintained anterior translation laxity that did not differ significantly (P> 0.085) from the intact values at all angles of knee flexion examined. => ACL + MONOLOOP restores normal anterior translation stability

CHANGE IN INTERNAL ROTATION ( ) 3 3 Reconstruction states - Graphics 1. Intact 5. Deep ITB + ALL + ACL cut 6. ACL graft 7. Monoloop + ACL graft 8. ACL graft out, monoloop intact Response to a 5-Nm internal torque After the isolated ACL reconstruction, significant differences remained in internal rotation at 30 to 100 knee flexion (p<0.008) With the combined ACL reconstruction plus Monoloop tenodesis, there were no significant differences in internal rotation compared to the intact knee. Thus, there was a significant decrease in internal rotation laxity after monoloop reconstruction compared to isolated ACL reconstruction at 20 to 100 knee flexion (p<0.01), and the combined procedure had not overconstrained the internal rotation compared to the intact knee at any angle of knee flexion => ACL + MONOLOOP restores normal rotational stability

Reconstruction states - Graphics Tibial anterior translation in response to a 5-Nm internal torque combined with a 90- N anterior drawer force CHANGE IN ANTERIOR TRANSLATION (MM) 3-1. Intact 5. Deep ITB + ALL + ACL cut 6. ACL graft 7. Monoloop + ACL graft 8. ACL graft out, monoloop intact Change of tibial internal rotation in response to a 5-N m internal torque combined with a 90-N anterior drawer force CHANGE IN INTERNAL ROTATION ( ) 3 3 After isolated ACL reconstruction there were still significant differences compared to the intact knee in anterior drawer at 30-100 flexion (p<0.035) and internal rotation at 20-100 flexion (p<0.042). With combined anterior drawer and internal torque, after additional Monoloop reconstruction no significant differences remained in anterior drawer or internal rotation compared to the intact knee. There was significant decrease in anterior laxity after adding the monoloop reconstruction compared to the isolated ACL reconstruction at 20-80 flexion (p<0.027), and internal rotation at 20-100 flexion (p<0.016). Without the ACL graft, the knee with an isolated monoloop lateral tenodesis remained significantly more lax in anterior translation than the native knee throughout 0-100 knee flexion (p<0.009) and in internal rotation from 30-100 (p<0.020). These trends were also found under combined anterior drawer and internal torque loading (Anterior translation p<0.037, internal rotation p<0.044, except at 20, p=0.070).

Conclusion This study found that cutting the deep fibres of the ITB caused large increases in tibial internal rotation laxity across the range of knee flexion, while cutting the ALL did not. In case of an ACL deficiency combined with increased rotational laxity caused by cutting both the ALL and deep fibres of the ITB, an ACL reconstruction alone was insufficient to restore normal knee laxity. However, adding a lateral extra-articular ITB Monoloop tenodesis procedure restored the normal knee laxity.

References Inderhaug E, Stephen JM, El-Daou H, Williams A, Amis AA. The Effects of Anterolateral Tenodesis on Tibiofemoral Contact Pressures and Kinematics. The American journal of sports medicine 2017;45:3081-8. Ferretti A, Monaco E, Vadala A. Rotatory instability of the knee after ACL tear and reconstruction. J Orthop Traumatol 2014;15:75-9. Inderhaug E, Stephen JM, Williams A, Amis AA. Biomechanical Comparison of Anterolateral Procedures Combined With Anterior Cruciate Ligament Reconstruction. The American journal of sports medicine 2017;45:347-54. Samuelson M, Draganich LF, Zhou X, Krumins P, Reider B. The effects of knee reconstruction on combined anterior cruciate ligament and anterolateral capsular deficiencies. The American journal of sports medicine 1996;24:492-7. Yamamoto Y, Hsu WH, Fisk JA, Van Scyoc AH, Miura K, Woo SL. Effect of the iliotibial bandon knee biomechanics during a simulated pivot shift test. J Orthop Res 2006;24:967-73.