Vascular & Interventional Education Days Thomas M Griglock, Ph.D., DABR Chief Diagnostic Imaging Physicist, OHSU

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Vascular & Interventional Education Days - 2018 Thomas M Griglock, Ph.D., DABR Chief Diagnostic Imaging Physicist, OHSU

In the beginning. Experimenters circa 1890s

In the beginning. Advertisement for General Electric, early 1900s

In the beginning. Thoracic fluoroscopy circa 1909

In the beginning. Battlefield fluoroscopy during operation in WWI

In the beginning. Pediatric X-Ray, 1942

In the beginning. Thoracic fluoroscopy circa 1940

In the beginning. National Chiropractors Convention, Chicago, 1956

In the beginning. Fluoroscopic shoe fitting, 1920-1970

In the beginning. we knew a lot less than we do now!

In the beginning. Experimenters circa 1890s If photons were mosquitos, everyone would be a radiation safety master!

And as a result of that? Hands of Radiologist 33 years old in first picture 40 years old in fourth Died shortly after last picture c.1910 c.1915 What s the point? X-rays are indispensible in medicine and must be applied with a great deal of respect for their potential hazards. c.1916 c.1917

And as a result of that? The Frank Balling Case (IL, 1897) 09/02/1895 Frank Balling thrown from his buggy and broke his ankle Continued pain/stiffness for over a year 09/19/1896 referred for a new type of examination X-ray photography 3 exposures: 35-40 minutes each, with tube 5-6 from skin surface Developed erythema, followed by blistering & ulceration 11/28/1896 amputation of foot 08/27/1897 amputation of leg First successful litigation for x-ray burn Retired a $10,000-aire, which was a millionaire in todays terms

What s YOUR point, Tom? For safe use, fluoroscopy requires training! Proper machine operation Patient positioning X-ray tube positioning Image Quality vs. Radiation Dose HIGHEST Quality LOWEST Dose Scattered radiation Personnel positioning in room Shielding

Safe Use: Patient vs. Staff Lower patient exposures = Lower staff exposure Risk vs. Benefit for Interventional Patients Risks are generally skin effects (deterministic) Cross a threshold risk becomes reality (or Risk > Benefit if you cross a line) Proper Radiation Safety practices IMMENSELY decreases chance of crossing the threshold for effects (or Benefit > Risk if you Step Gently ) Effects are still possible in some cases Larger patients, longer/more complex procedures, etc. BUT these are minimized with good safety practices Good practice lower exposures all around!

Aside: Radiobiological Effects Stochastic (statistical) Effects Radiation-induced cancer. Probability of occurrence increases with dose. Severity does not increase with dose. No dose threshold for this type of effect. Deterministic Effects Skin effects (erythema, epilation, etc) & cataracts. A dose threshold exists for this type of effect. Severity increases with dose. Fluoroscopy normally concerned with these.

What s wrong with these pictures? What s the point? X-rays are indispensible in medicine and must be applied with a great deal of respect for their potential hazards. ~20Gy from Coronary Angiography ~18Gy from 3 separate AVM Embolizations (17 months after procedure)

What s wrong with these pictures? 120 minutes. Coronary Angiography 6 weeks later 16 weeks later 18 months later What s the point? X-rays are indispensible in medicine and must be applied with a great deal of respect for their potential hazards.

What s wrong with these pictures? Other than seeing bone??? What type of procedure was performed? What bad practice resulted in this injury?

What s wrong with these pictures? Arm is in the beam!!! What does this do to the image? What does the x-ray tube do?

Radiation-Induced Injuries No sensation during procedure! Threshold dose 2Gy Latent period between procedure and effects Need to know about high exposures

IAEA Patient Safety https://rpop.iaea.org/rpop/rpop/conte nt/documents/whitepapers/posterpatient-radiation-protection.pdf

Dose Rates and Dose Fluoro Dose Rates Patient Dose Staff Dose Greatest where x-rays enter patient (skin) Vary from <10 mgy/min to >500 mgy/min 30 min procedure (low): 300 mgy 30 min procedure (high): 15000 mgy = 15 Gy We need to minimize the doses

Control Your Dose Continuous vs. Pulsed Fluoroscopy Things to consider: 1. How much do I need to see? 2. How true do I need to see? 3. Last Image Hold! 4. The more you give, the more you get.

Patient Safety vs. Staff Safety Lower patient exposures = Lower staff exposure Risk vs. Benefit for Interventional Patients Risks are generally skin effects (deterministic) Cross a threshold risk becomes reality (or Risk > Benefit if you cross a line) Proper Radiation Safety practices IMMENSELY decreases chance of crossing the threshold for effects (or Benefit > Risk if you Step Gently ) Effects are still possible in some cases Larger patients, longer/more complex procedures, etc. Risks from Occupational Exposures Risks are cataracts (deterministic) and increased cancer incidence (stochastic) Both associated with repeated chronic exposure to radiation Proper Radiation Safety practices IMMENSELY decreases chance of crossing the threshold for cataracts, or probability for cancer incidence

What s wrong with these pictures? What s the point? X-rays are indispensible in medicine and must be applied with a great deal of respect for their potential hazards. Lens injuries induced by occupational exposure in nonoptimized interventional radiology laboratories. http://bjr.birjournals.org/content/71/847/728.full.pdf+html Or as Spiderman would say, With great power comes great responsibility.

Radiation Induced Cataracts?

Cancer? Biological Exposure to Ionizing Radiation, Report VII, Phase 2 Used data from Japanese atomic bomb survivors Created the Linear-No- Threshold (LNT) model LNT says: There is no safe radiation dose. Any amount of radiation may initiate cancer.

Cancer Risks from Radiation Exposure Proponents of BEIR VII say: Excess Cancers = Dose (mgy) x BEIR VII factor (cancers/mgy) Boy I m lucky I never had one of these done! I was always skeptical of this procedure. It was my intuition that told me don t go there!.usa Today

Cancer Risks from Radiation Exposure Used data from Japanese atomic bomb survivors Critics of BEIR VII say: o o o Doses too high (shouldn t extrapolate to low doses used in imaging) Committee ignored at least four other data sets that showed lower cancer incidence Ignored any repair mechanism for radiationinduced DNA damage Medical dose range

What is the truth? Attributing these risks to individual patients is inappropriate. One photon is all it takes Attributing these risks to large populations leads to sensationalized results. The numbers that BEIR VII predicted have not panned out. A little radiation is good for you Current and ongoing research is increasingly leaning toward a slightly nonlinear risk under 100mGy nearly all imaging exams result in doses well under 50mGy.

IAEA Staff Safety https://rpop.iaea.org/rpop/rpop/conte nt/documents/whitepapers/poster-staffradiation-protection.pdf

Conclusions? Lower patient exposures = Lower staff exposure Risk vs. Benefit for Interventional Patients Risks are generally skin effects (deterministic) Cross a threshold risk becomes reality (or Risk > Benefit if you cross a line) Proper Radiation Safety practices IMMENSELY decreases chance of crossing the threshold for effects (or Benefit > Risk if you Step Gently ) Effects are still possible in some cases Larger patients, longer/more complex procedures, etc. Risks from Occupational Exposures Risks are cataracts (deterministic) and increased cancer incidence (stochastic) Both associated with repeated chronic exposure to radiation Proper Radiation Safety practices IMMENSELY decreases chance of crossing the threshold for cataracts, or probability for cancer incidence

Always Practice ALARA What does this mean for YOU? 1. Follow pearls for patient and staff safety 2. Wear quality, comfortable leaded glasses 3. Don t be overly worried about cancer risk 4. Whatever you do, don t fall out of your buggy