Cedars-Sinai Medical Center Harvey Morse Conference Center Plaza Level, South Tower 8701 Gracie Allen Drive Los Angeles, CA 90048

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10 th Annual Women and Ischemic Heart Disease Symposium Friday, May 13, 2016 Offered in cooperation with the California Chapter of the American College of Cardiology and WomenHeart: The National Coalition for Women with Heart Disease Conference Location Medical Center Harvey Morse Conference Center Plaza Level, South Tower 8701 Gracie Allen Drive Los Angeles, CA 90048 For the latest course information and to register, visit cedars-sinai.edu/cme and click on CME courses.

Activity Information COURSE DESCRIPTION AND STATEMENT OF NEED This in-depth educational symposium will explore gender-specific cardiac issues of prevalence, risk factors, screening modalities, and medical management strategies, including exercise and stress management, cholesterol management, hypertension, postural orthostatic tachycardia syndrome (POTS), reproductive hormone therapy, heart failure, and coronary microvascular dysfunction (CMD). The purpose of this conference is to close the knowledge gap for physicians and allied healthcare professionals regarding gender-specific differences in cardiovascular disease and the impact these differences have on treatment options, and also to highlight the importance of identifying women at risk for cardiovascular disease and using the most current evidence-based treatment strategies for improved patient outcomes. TARGET AUDIENCE This symposium is intended for clinicians who provide cardiovascular care for adult female patients. EDUCATIONAL OBJECTIVES Recognize the clinical presentation of cardiac disease in women and how it differs from men Recommend strategies for risk reduction and management based on exercise, nutrition, and stress guidelines Develop a gender-specific approach to identifying and diagnosing non-obstructive disease and coronary microvascular dysfunction in women Review guidelines to reduce hypertension in women Understand CVD risks and the benefits of reproductive hormone therapy Review heart failure with preserved ejection fraction, which is more prevalent in women, with regard to prevention and treatment ACCREDITATION STATEMENT Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT DESIGNATION STATEMENT Medical Center designates this live activity for a maximum of 6.5 AMA PRA Category 1 Credit(s). Physicians should claim only the credit commensurate with the extent of their participation in the activity. NURSES The California State Board of Registered Nursing accepts courses approved by the ACCME for Category 1 credit as meeting the continuing education requirements for license renewal. POLICY ON DISCLOSURE It is the policy of Medical Center to ensure balance, independence, objectivity, and scientific rigor in all its educational activities. Medical Center assesses conflicts of interest with its faculty, planners, and managers of CME activities. Conflicts of interest that are identified are resolved by reviewing that presenter s content for fair balance and absence of bias, scientific objectivity of studies utilized in this activity, and patient care recommendations. While Medical Center endeavors to review faculty content, it remains the obligation of each physician or other healthcare practitioner to determine the applicability or relevance of the information provided from this course in his or her own practice. ACKNOWLEDGMENT OF COMMERCIAL SUPPORT Commercial support for this conference is pending and will be acknowledged at the conference. PARKING Self-parking is available in parking lots 1, 2, and 4. HOTEL ACCOMMODATIONS For a detailed list of hotels convenient to the medical center, please visit cedars-sinai.edu/visitors, select Patient & Visitor Information from the left navigation bar, and then select Los Angeles Area Resources and then Lodging. When making reservations at any of these hotels, please be sure to mention that you are attending a conference at to ensure you are receiving the best current reservation rate.

Agenda 10 th Annual Women and Ischemic Heart Disease Symposium FRIDAY, MAY 13, 2016 7:15 7:45 a.m. Registration, Breakfast, and Exhibits 7:45 Introduction C. Noel Bairey Merz, MD, FACC, FAHA 8:00 Keynote: Why medicine often has dangerous side effects in women Alyson J. McGregor, MD 9:00 Break & Exhibits 9:15 Coronary microvascular dysfunction Update 2016 CHAIR: C. Noel Bairey Merz, MD, FACC, FAHA SPEAKER: Bina Ahmed, MD, FACC 9:40 Question & Answer 9:50 What is new in heart failure in women including atrial fibrillation, Takotsubo cardiomyopathy, contraception in patients with CVD, and cardio-oncology CHAIR: Michelle Kittleson, MD, FACC, PhD SPEAKER: Janet Wei, MD, FACC Case presentation given by Sofy Landes, MD 10:50 Question & Answer 11:00 Exercise and stress management: How to prevent and reverse heart disease, including how much exercise is too much CHAIR: Christina Economides, MD SPEAKER: Puja Mehta, MD, FACC 11:25 Question & Answer 11:35 Update on hormones and heart disease: The ELITE and KEEPS trial results, and alternatives for hot flashes CHAIR: Margareta Pisarska, MD SPEAKER: Chrisandra Shufelt, MD, MS 12:00 p.m. Question & Answer 12:10 Lunch 1:00 Overview of WomenHeart: The National Coalition for Women with Heart Disease SPEAKER: Barbara Fleeman 1:25 Cholesterol 2016: How to maximize statin therapy, manage statin intolerance and the new PSCK9 inhibitors CHAIR: Prediman K. Shah, MD, MACC SPEAKER: Margo Minissian, PhDc, ACNP, CLS, AACC, FAHA Case presentation given by Ahmed Al-Badri, MD 2:25 Question & Answer 2:35 Hypertension, dysautonomias, POTS, and inappropriate sinus tachycardia in women CHAIR: Florian Rader, MD, FACC SPEAKER: Ronald Victor, MD, FACC 3:00 Question & Answer 3:10 Post-test 3:15 p.m. Adjourn

REGISTRATION 10 th Annual Women and Ischemic Heart Disease Symposium FRIDAY, MAY 13, 2016 Registration Methods Online registration: csmc.edu/cme and click on CME Courses Mail form to: Medical Center Office of Continuing Medical Education Attn: Registration 8797 Beverly Blvd., Suite 250 Los Angeles, CA 90048 Fax form to: 310-423-8596 For additional course or registration information, call 310-423-5548. Registration Fees Physician Allied Health *Resident/Fellow PROFESSIONAL Received by 4/29/16 $185 $145 $25 Received after 4/29/16 $235 $185 $25 *Residents/Fellows are eligible to attend for a reduced registration fee. In order to receive this reduced fee, please send the written proof of residency (e.g., letter from Program Director) along with your completed registration form, or upload the written proof of residency if registering online. Please print clearly Last Name First Name Degree Specialty Address City State Zip Phone Fax Email * An email address is required to register for the conference. Check enclosed payable to CSMC for $ Please charge my credit card Visa MasterCard AmEx for $ CC Number CCV Exp Date / Authorized Signature How did you learn about this CME activity? Brochure/Other Printed Materials Website Email Internet Search Colleague Past Participant Internal Communication Other CONFIRMATION In order to receive a registration confirmation, please provide your email address. If you do not receive a confirmation, please call 310-423-5548 to confirm your registration. REFUND POLICY All cancellations must be submitted in writing, and refunds will be subject to a $45 administrative charge. No refunds will be given after April 29, 2016. CANCELLATION POLICY reserves the right to cancel or reschedule programs due to circumstances beyond its control, or close registration when programs are oversubscribed. Registrants are advised against purchasing nonrefundable airline tickets until they receive registration confirmation. is not responsible for penalties incurred as a result of cancelled transportation costs.

Faculty COURSE DIRECTOR C. Noel Bairey Merz, MD, FACC, FAHA Women s Guild Endowed Chair in Women s Health Director, Barbra Streisand Women s Heart Center Director, Linda Joy Pollin Women s Heart Health Program Director, Preventive Cardiac Center Professor of Medicine Medical Center Los Angeles, CA GUEST FACULTY Bina Ahmed, MD, FACC Assistant Professor, Interventional Cardiology University of New Mexico Albuquerque, NM Alyson J. McGregor, MD Associate Professor of Emergency Medicine Director, Division of Sex and Gender in Emergency Medicine Warren Alpert Medical School of Brown University Providence, RI Puja Mehta, MD, FACC Director, Women s Translational Cardiovascular Research Emory Women s Heart Center Emory Clinical Cardiovascular Research Institute Assistant Professor of Medicine in Cardiology Emory University School of Medicine Atlanta, GA CEDARS-SINAI COURSE FACULTY Christina Economides, MD Cardiologist Michelle Kittleson, MD, FACC, PhD Cardiologist Margo Minissian, PhDc, ACNP, CLS, AACC, FAHA Cardiology Nurse Practitioner, Barbra Streisand Women s Heart Center Margareta Pisarska, MD Associate Professor, Obstetrics and Gynecology Director, Division of Reproductive Endocrinology and Infertility Florian Rader, MD, FACC Co-Director, Clinic for Hypertrophic Cardiomyopathy and Aortopathies Staff Cardiologist Assistant Professor of Cardiology Prediman K. Shah, MD, MACC Director, Oppenheimer Atherosclerosis Research Center Director, Atherosclerosis Prevention and Management Center Chrisandra Shufelt, MD, MS Associate Director, Barbra Streisand Women s Heart Center Director, Women s Hormone and Menopause Program Associate Professor, Heart Institute Ronald Victor, MD, FACC Professor of Medicine Burns and Allen Chair in Cardiology Research Director, The Hypertension Center Director, Translational Research Associate Director, Heart Institute Janet Wei, MD, FACC Cardiologist CEDARS-SINAI FELLOWS Ahmed Al-Badri, MD Sofy Landes, MD

8797 Beverly Blvd., Suite 250 Los Angeles, CA 90048 Register Now! 10 th Annual Women and Ischemic Heart Disease Symposium Friday, May 13, 2016 Medical Center Los Angeles, CA In-depth symposium exploring gender-specific differences in cardiovascular disease, including: Why medicine often has dangerous side effects in women Coronary microvascular dysfunction Update 2016 What is new in heart failure in women Exercise and stress management Update on hormones, testosterone, and heart disease Cholesterol 2016 Hypertension, dysautonomias, POTS, and inappropriate sinus tachycardia in women Non-Profit Org. U.S. Postage PAID Los Angeles, CA Permit #22328