Contents. Welcome to EULAR 2012 Berlin... iii AbstractsReviewers... iv. Speakers Abstracts

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vii Welcome to EULAR 2012 Berlin... iii AbstractsReviewers... iv Speaker Presentations Speakers Abstracts Wednesday, 6 June 2012 SP0001 Pre-conference outlook... 2 SP0002 WIN Session 1... 2 SP0003 SP0005 Health economics of RA in 2012: Can we afford to treat? Can we afford not to treat?...... 2 SP0006 SP0007 Interstitial lung disease in rheumatic disease: an update...... 3 SP0008 How to manage 1... 3 SP0009 SP0010 Long-term outcomes of modern treatment... 3 SP0011 Seronegative rheumatoid arthritis..... 4 SP0012 SP0014 Transition for teenagers and young adults with arthritis: what does it need?... 4 SP0015 SP0018 How to run an osteoarthritis clinic in daily practice... 5 SP0019 SP0022 Meet the ADAM s family: ADAM, MMP s, ADAMTS... 6 SP0023 SP0025 Talking microparticles... 6 SP0026 SP0027 Political campaigning... 7 SP0028 SP0030 Lupus in little and big folks... 7 SP0031 SP0033 RADAR RAre Diseases Associated with Rheumatology... 8 SP0034 SP0035 How to manage 2... 9 SP0036 Equitable or equal? To what or to whom? Equity issues in rheumatology... 10 SP0037 Two difficult SLE patient cases...... 10 SP0038 SP0039 Aseptic bone inflammation... 10 SP0040 SP0042 Crossing boundaries of primary to secondary care... 11 SP0043 SP0045 From joint development to osteoarthritis... 11 SP0046 SP0048 Fibroblasts transforming rheumatology.... 12 SP0049 MRI Workshop basic 1..... 12 SP0050 SP0053 Less well-known but just as important: some other rare musculoskeletal diseases... 13 SP0054 SP0056 MicroRNA macro effect... 14 SP0057 SP0058 New developments in the pre-clinical phases of rheumatoid arthritis... 14 SP0059 WIN Session 2... 15 SP0060 SP0061 How to manage 3... 15 SP0062 How to get a job and how to keep it...... 15 SP0063 SP0064 Hot topics for primary care: what s new?..... 16 SP0065 SP0067 Vasculitis: new therapies changing outcomes... 16 SP0068 SP0069 Molecular targets for therapy in fibrotic diseases... 17 SP0070 SP0071 How to manage 4... 18 SP0072 SP0074 Soft predictors of hard outcomes..... 18 SP0075 SP0077 Autoinflammation 2: Linking autoinflammation to autoimmunity... 19 SP0078 SP0080 Supporting self management in OA: the role of primary care...... 20 SP0081 SP0084 Patient involvement in research. Past, present and future... 21 SP0085 SP0086 EULAR-EFIS Session: B regulatory cells... 21 SP0087 SP0090 Collateral damage in muscles...... 22 SP0091 MRI Workshop advanced 1..... 23 SP0092 What s new: latest advances in treatment and management... 23 SP0093 SP0095 New insights in osteoarthritis... 23 SP0096 SP0097 How to manage 5... 24

viii SP0098 Update on ACR/EULAR RA classification criteria: what have we learned?... 25 SP0099 SP0101 Underrecognized and challenging manifestations in systemic sclerosis... 25 SP0102 SP0103 Macrophage activation syndrome.... 26 SP0104 Work and workability in rheumatic diseases: what does it mean for primary care...... 26 SP0105 SP0108 Promotion of physical activity in rheumatology targeting patients, providers and the public... 26 SP0109 SP0110 Immunological memory...... 27 SP0111 SP0114 Innate lymphoid cells: straddling innate and adaptive immunity... 28 SP0115 SP0117 Comorbidity... 28 SP0118 SP0119 Bugs in autoimmunity...... 29 SP0120 SP0121 Osteoimmunology: links to systemic and juvenile diseases... 30 SP0122 WIN Session 5... 30 SP0123 How to manage 6... 30 SP0124 SP0125 WIN Session 6... 31 SP0126 SpA throughout life...... 31 SP0127 SP0129 Vascular imaging in rheumatic diseases... 31 SP0130 SP0131 How to manage 7... 32 SP0132 SP0133 Patient Reported Outcome (PRO) assessment in rheumatology... 33 SP0134 Multi-drug resistant RA... 33 SP0135 Resolution and control of inflammation...... 33 SP0136 SP0137 Primary and secondary care: working in partnership in autoimmune rheumatic diseases... 34 SP0138 SP0139 Challenges in health professionals, practice: how to develop and execute a treatment plan for a patient with a rheumatic condition and comorbidities... 34 SP0140 SP0141 Casting NET s and catching autoimmunity: the role of neutrophils in inflammation... 34 SP0142 SP0143 Novel signalling molecules...... 35 SP0144 SP0145 Impact of RMDs on families/partners/friends..... 35 SP0146 SP0148 Non anti-tnf biologics on SpA and PsA...... 36 SP0149 How to implement technical improvements in existing imaging modalities in clinical practice... 36 SP0150 SP0153 It s good but it may be dangerous... 37 SP0154 SP0156 Autoinflammation 1: News form IL-1 driven diseases... 37 SP0157 SP0160 Clinical update in connective tissue diseases... 38 SP0161 SP0163 New lights on translational models... 39 SP0164 Biomechanics meets immunology (in spondyloarthritis)..... 40 SP0165 SP0167 Working in partnership... 40 Saturday, 9 June 2012 SP0168 WIN Session 8... 41 SP0169 SP0170 RA treatment: small molecules.... 41 SP0171 SP0173 Does everbody need stronger bones?... 41 SP0174 SP0176 Measuring outcomes in different settings... 42 SP0177 SP0178 Infections and arthritis...... 43 SP0179 SP0180 I ve been asked to review a clinical guideline where do I start?..... 44 SP0181 SP0182 Angiogenesis in health and disease...... 44 SP0183 SP0185 Move, groove and improve exercise and RMDs... 44 SP0186 WIN Session 9... 45 SP0187 SP0188 RA remission: prediction and imaging..... 45 SP0189 SP0191 ILAR Advancing rheumatology in developing countries ILAR projects past, present and future... 46 SP0192 How to manage 10... 47 SP0193 SP0195 Vaculitis...... 47 SP0196 SP0199 Cardiovascular health in rheumatic diseases.... 48 SP0200 SP0202 Auto antibodies actually cause disease: targeting the vasculature...... 48 SP0203 SP0204 Breathing new life into rheumatology... 49 SP0205 SP0207 Inclusive design..... 50 SP0208 Health Professionals Highlight Session... 50

ix Scientific Abstracts Oral Presentations Wednesday, 6 June 2012 OP0001 Interstitial lung disease in rheumatic disease: an update... 52 OP0002 OP0003 Long-term outcomes of modern treatment... 52 OP0004 Transition for teenagers and young adults with arthritis: what does it need?... 53 OP0005 Beginning and succeding as a clinical academic researcher..... 53 OP0006 OP0008-HPR EULAR criteria work to improve rheumatologic care... 54 OP0009-PARE OP0010-PARE Political campaigning... 55 OP0011 Equitable or equal? To what or to whom? Equity issues in rheumatology...... 55 OP0012 Aseptic bone inflammation... 56 OP0013 OP0014 From joint development to osteoarthritis... 56 OP0015 OP0016 Fibroblasts transforming rheumatology... 57 OP0017 OP0018 MicroRNA macro effect...... 58 OP0019 OP0020 New developments in the pre-clinical phases of rheumatoid arthritis... 59 OP0021 OP0028 Abstract Session: Update on non anti-tnf biologics..... 59 OP0029 OP0036 Abstract Session: Osteoarthritis..... 62 OP0037 OP0044 Abstract Session: Osteoporosis... 65 OP0045 OP0052 Abstract Session: RA prognosis, predictors, outcomes..... 68 OP0053 OP0058 PReS Abstract Session: Basic science in paediatric rheumatology...... 71 OP0059 OP0066 Abstract Session: Lupus and Sjögren s; basics diagnosis treatment...... 73 OP0067 OP0074 Abstract Session: Regional pain and fibromyalgia: understanding mechanisms and effective management...... 76 OP0075-HPR OP0082 HPR Abstract Session: Progress in rehabilitation the future is bright...... 78 OP0083 OP0090 Abstract Session: Early pathogenic mechanisms; clues for targeted therapies in arthritis... 81 OP0091 OP0098 Abstract Session: Spondyloarthritis translational science..... 83 OP0099 OP0106 Abstract Session: Metabolic and crystal diseases of joints and bone... 86 OP0107 OP0113 Abstract Session: Don t forget the orphans... 89 OP0114 OP0121 Abstract Session: Epidemiololgy and health services... 91 OP0122-PARE OP0123-PARE How to get a job and how to keep it...... 94 OP0124 OP0125 Vasculitis: new therapies changing outcomes... 95 OP0126 Soft predictors of hard outcomes..... 95 OP0127 OP0128 Personalised medicine... 96 OP0129 OP0130 New insights in osteoarthritis... 97 OP0131 OP0134 Update on ACR/EULAR RA classification criteria: what have we learned?... 97 OP0135 Macrophage activation syndrome... 99 OP0136 OP0137-PC Work and workability in rheumatic diseases: what does it mean for primary care..... 99 OP0138 OP0139 Immunological memory..... 100 OP0140-PARE Comorbidity... 100 OP0141 OP0142 Osteoimmunology: links to systemic and juvenile diseases... 101 OP0143 OP0149 Abstract Session: RA anti-tnf.... 101 OP0150 OP0157 Abstract Session: Treatment strategy in RA..... 104 OP0158 OP0165 Abstract Session: Psoriatic arthritis... 107 OP0166 OP0172 Abstract Session: Spondyloarthritis clinical aspects and treatment..... 110 OP0173 OP0178 PReS Abstract Session: Clinical science in paediatric rheumatology... 113 OP0179 OP0186 Abstract Session: Vasculitis... 115 OP0187-PC OP0193 Primary Care Abstract Session: From epidemiology to effective practice... 118 OP0194-HPR OP0201-HPR HPR Abstract Session: Evidence into clinical practice the way forward... 120 OP0202 OP0088 Abstract Session: Molecules small and smart... 123 OP0208 OP0215 Abstract Session: Genomics, genetics and epigenetics of rheumatic diseases... 126 OP0216 OP0223 Abstract Session: Innate and adaptive immunity... 129 OP0224 OP0231 Abstract Session: Clincal and translational scleroderma.... 131 OP0232 OP0239 Abstract Session: Diagnostics and imaging procedures...... 134

x OP0240-PARE OP0246-PARE PARE Abstract Session... 137 OP0247 SpA throughout life..... 139 OP0248 OP0249 Vascular imaging in rheumatic diseases...... 139 OP0250 OP0251 Patient Reported Outcome (PRO) assessment in rheumatology... 140 OP0252 Resolution and control of inflammation...... 141 OP0253-PC OP0254 Primary and secondary care: working in partnership in autoimmune rheumatic diseases... 141 OP0255 Casting NET s and catching autoimmunity: the role of neutrophils in inflammation... 142 OP0256 OP0257 Novel signalling molecules...... 142 OP0258-PARE OP0259-PARE Impact of RMDs on families/partners/friends.... 143 OP0260 Autoinflammation 1: News form IL-1 driven diseases...... 144 OP0261 OP0262 Biomechanics meets immunology (in spondyloarthritis).... 144 Saturday, 9 June 2012 OP0263 RA treatment: small molecules... 145 OP0264 OP0265 Does everbody need stronger bones?... 145 OP0266 Measuring outcomes in different settings... 146 OP0267 OP0268 Infections and arthritis...... 146 OP0269 OP0270 EULAR ESSR Session: Imaging in arthritis: the radiologist s perspective... 147 OP0271 Angiogenesis in health and disease...... 148 OP0272 OP0273 Inhibitory checkpoints in inflammation... 148 OP0274 OP0275 RA remission: prediction and imaging..... 149 OP0276 OP0277 Vaculitis..... 150 Late Breaking Abstracts LB0001 LB0005 Late Breaking Abstract Session... 150 Poster Presentations Guided Poster Tours THU0001 THU0009 (Epi)-Genetics and genomics 1: where are we?.... 154 THU0020 THU0025 Novel aspects of joint homeostasis and pathology... 160 THU0086 THU0097 B cells and beyond... 209 THU0127 THU0134 RA small molecules old and new...... 198 THU0158 THU0166 SLE, APS, Sjörgren s... 209 THU0231 THU0240 Clinical scleroderma 1 and inflammatory myopathy... 233 THU0260 THU0266 Spondyloarthritis treatment... 242 THU0287 THU0296 PReS basic research in paediatric rheumatology..... 252 THU0368 THU0379 Orphan diseases and infectious arthritis... 280 THU0001 THU0019 Genomics, genetics and epigenetics of rheumatic diseases... 154 THU0020 THU0042 Cartilage, synovium and osteoimmunology... 160 THU0043 THU0085 Rheumatoid arthritis comorbidity and clinical aspects... 167 THU0086 THU0126 Rheumatoid arthritis other biologic treatment... 182 THU0127 THU0157 Rheumatoid arthritis non-biologic treatment and small molecules... 198 THU0158 THU0197 SLE, Sjögren s and APS clinical aspects (other than treatment)... 209 THU0198 THU0230 Vasculitis...... 222 THU0231 THU0259 Scleroderma, myositis and related syndromes clinical aspects and treatment... 233 THU0260 THU0286 Spondyloarthritis treatment... 242 THU0287 THU0296 Basic science in paediatric rheumatology... 252 THU0297 THU0340 Paediatric rheumatology... 256 THU0341 THU0359 Fibromyalgia and pain in rheumatic diseases... 271 THU0360 THU0370 Infection-related rheumatic diseases... 277 THU0371 THU0410 Other orphan diseases...... 281 THU0411 THU0447 Diagnostics and imaging procedures..... 294 THU0448 THU0458 Education... 306

xi Guided Poster Tours FRI0059 FRI0067 RA prognosis, predictors, outcomes...... 329 FRI0142 FRI0152 RA anti-tnf... 358 FRI0209 FRI0216 Vasculitis... 384 FRI0241 FRI0250 Clinical scleroderma 2... 395 FRI0270 FRI0279 Spondyloarthritis clinical aspects other than treatment..... 405 FRI0299 FRI0306 Osteoarthritis... 415 FRI0324 FRI0333 PReS clinical research in paediatric rheumatology... 423 FRI0367 FRI0376 Metabolic and crystal diseases of joints and bones... 438 FRI0404 FRI0411 Epidemiology and health services... 451 FRI0459 OT PT (see page xiii)... 469 FRI0001 FRI0015 Adaptative immunity (T cells and B cells) in rheumatic diseases... 311 FRI0016 FRI0024 Innate immunity in rheumatic diseases... 315 FRI0025 FRI0058 Cytokines and inflammatory mediators... 318 FRI0059 FRI0098 Rheumatoid arthritis prognosis, predictors and outcome... 329 FRI0099 FRI0141 Rheumatoid arthritis comorbidity and clinical aspects.... 343 FRI0142 FRI0178 Rheumatoid arthritis anti-tnf therapy.... 358 FRI0179 FRI0208 Rheumatoid arthritis other biologic treatment...... 372 FRI0209 FRI0240 Vasculitis... 384 FRI0241 FRI0269 Scleroderma, myositis and related syndromes clinical aspects and treatment..... 395 FRI0270 FRI0298 Spondyloarthritis clinical aspects (other than treatment)... 405 FRI0299 FRI0323 Osteoarthritis... 415 FRI0324 FRI0366 Paediatric rheumatology...... 423 FRI0367 FRI0403 Bone diseases other than osteoporosis, metabolic diseases and crystal diseases.... 438 FRI0404 FRI0448 Epidemiology, health services and outcome research... 451 FRI0449 FRI0459 Rehabilitation...... 466 Saturday, 9 June 2012 Guided Poster Tours SAT0001 SAT0010 (Epi)-Genetics and genomics 2: where are we?... 471 SAT0021 SAT0031 The mystery of SSc pathophysiology... 478 SAT0038 SAT0049 Pathogenesis of RA...... 483 SAT0181 SAT0186 Lupus nephritis bench to bedside..... 532 SAT0203 SAT0210 Lupus and Sjörgren s clinical... 540 SAT0245 SAT0254 SpA basic and translational highlights... 554 SAT0287 SAT0293 Psoriatic arthritis from assessment to imaging...... 569 SAT0340 SAT0350 Osteoporosis... 587 SAT0383 SAT0392 Diagnostics and imaging procedures...... 601 SAT0440 SAT0447 Musculoskeletal health in Europe... 621 SAT0001 SAT0020 Genomics, genetics and epigenetics of rheumatic diseases.... 471 SAT0021 SAT0037 Scleroderma, myositis and related syndromes etiology, pathogenesis and animal models...... 478 SAT0038 SAT0079 Rheumatoid arthritis etiology, pathogenesis and animal models.... 483 SAT0080 SAT0119 Rheumatoid arthritis prognosis, predictors and outcome... 497 SAT0120 SAT0157 Rheumatoid arthritis anti-tnf therapy.... 511 SAT0158 SAT0183 SLE, Sjögren s and APS etiology, pathogenesis and animal models...... 525 SAT0184 SAT0204 SLE, Sjögren s and APS treatment... 533 SAT0205 SAT0244 SLE, Sjögren s and APS clinical aspects (other than treatment)... 541 SAT0245 SAT0256 Spondyloarthritis etiology, pathogenesis and animal models...... 554 SAT0257 SAT0286 Spondyloarthritis clinical aspects (other than treatment)... 558 SAT0287 SAT0315 Psoriatic arthritis.... 569 SAT0316 SAT0339 Osteoarthritis... 579 SAT0340 SAT0382 Osteoporosis... 587 SAT0383 SAT0419 Diagnostics and imaging procedures...... 601

xii SAT0420 SAT0439 Back pain, mechanical musculoskeletal problems, local soft tissue disorders.... 614 SAT0440 SAT0484 Epidemiology, health services and outcome research... 621 Abstracts accepted for publication AB0001 AB0036 Genomics, genetics and epigenetics of rheumatic diseases.... 637 AB0037 AB0057 Adaptative immunity (T cells and B cells) in rheumatic diseases... 639 AB0058 AB0072 Innate immunity in rheumatic diseases... 641 AB0073 AB0113 Cytokines and inflammatory mediators... 641 AB0114 AB0145 Cartilage, synovium and osteoimmunology... 644 AB0147 AB0185 Rheumatoid arthritis etiology, pathogenesis and animal models..... 646 AB0186 AB0192 Spondyloarthritis etiology, pathogenesis and animal models... 648 AB0193 AB0224 SLE, Sjögren s and APS etiology, pathogenesis and animal models...... 648 AB0225 AB0248 Scleroderma, myositis and related syndromes etiology, pathogenesis and animal models 650 AB0249 AB0254 Basic science in paediatric rheumatology...... 651 AB0255 AB0348 Rheumatoid arthritis prognosis, predictors and outcome... 652 AB0349 AB0448 Rheumatoid arthritis comorbidity and clinical aspects.... 657 AB0449 AB0503 Rheumatoid arthritis anti-tnf therapy.... 663 AB0504 AB0592 Rheumatoid arthritis other biologic treatment... 666 AB0593 AB0614 Rheumatoid arthritis non-biologic treatment and small molecules... 672 AB0615 AB0634 SLE, Sjögren s and APS treatment..... 673 AB0635 AB0738 SLE, Sjögren s and APS clinical aspects (other than treatment)... 675 AB0739 AB0778 Vasculitis... 680 AB0779 AB0846 Scleroderma, myositis and related syndromes clinical aspects and treatment... 683 AB0847 AB0861 Spondyloarthritis treatment..... 687 AB0862 AB0922 Spondyloarthritis clinical aspects (other than treatment).... 688 AB0923 AB0949 Psoriatic arthritis.... 691 AB0950 AB1008 Osteoarthritis..... 693 AB1009 AB1046 Osteoporosis... 696 AB1047 AB1084 Bone diseases other than osteoporosis, metabolic diseases and crystal diseases.... 698 AB1085 AB1088 Infection-related rheumatic diseases.... 700 AB1090 AB1099 Fibromyalgia and pain in rheumatic diseases... 700 AB1100 AB1106 Back pain, mechanical musculoskeletal problems, local soft tissue disorders.... 701 AB1107 AB1220 Paediatric rheumatology... 701 AB1221 AB1234 Other orphan diseases.... 707 AB1235 AB1310 Diagnostics and imaging procedures...... 708 AB1311 AB1396 Epidemiology, health services and outcome research... 712 AB1397 AB1402 Rehabilitation...... 717 AB1403 AB1416 Education... 718 Oral Presentations Primary Care Abstracts OP0137-PC Work and workability in rheumatic diseases: what does it mean for primary care...... 720 OP0187-PC OP0191-PC Primary Care Abstract Session: From epidemiology to effective practice... 720 OP0253-PC Primary and secondary care: working in partnership in autoimmune rheumatic diseases.. 721 Poster Presentations Guided Poster Tour PC0001 PC0006 Primary care... 723 PC0001 PC0007 Primary care... 723

xiii Abstracts accepted for publication AB1417-PC AB1418-PC Primary care..... 726 Health Professionals in Rheumatology Abstracts Oral Presentations Wednesday, 6 June 2012 OP0008-HPR EULAR criteria work to improve rheumatologic care... 728 OP0069-HPR Abstract Session: Regional pain and fibromyalgia: understanding mechanisms and effective management..... 728 OP0075-HPR OP0079-HPR HPR Abstract Session: Progress in rehabilitation the future is bright... 729 OP0194-HPR OP0201-HPR HPR Abstract Session: Evidence into clinical practice the way forward... 730 Poster Presentations Guided Poster Tour THU0466-HPR THU0472-HPR, THU0481-HPR THU0482-HPR Clinical aspects of care... 736 THU0459-HPR THU0467-HPR Nursing...... 734 THU0468-HPR THU0480-HPR Psychology/socialsciences... 737 THU0481-HPR THU0492-HPR Miscellaneous forms of clinical care..... 741 Guided Poster Tour FRI0459, FRI0477-HPR FRI0484-HPR OT PT... 469 FRI0460-HPR FRI0481-HPR Physiotherapy...... 745 FRI0482-HPR FRI0492-HPR Occupational therapy..... 752 Abstracts accepted for publication AB1419-HPR AB1425-HPR Nursing...... 756 AB1426-HPR AB1439-HPR Psychology/socialsciences... 756 AB1440-HPR AB1455-HPR Physiotherapy...... 757 AB1456-HPR AB1461-HPR Occupational therapy..... 758 AB1462-HPR AB1477-HPR Miscellaneous forms of clinical care..... 758 Oral Presentations People with Arthritis and Rheumatism in Europe Abstracts Wednesday, 6 June 2012 OP0009-PARE OP0010-PARE Political campaigning...... 762 OP0122-PARE OP0123-PARE How to get a job and how to keep it... 762 OP0140-PARE Comorbidity... 763 OP0240-PARE OP0246-PARE PARE Abstract Session..... 763 OP0258-PARE OP0259-PARE Impact of RMDs on families/partners/friends... 766

xiv Poster Presentations Saturday, 9 June 2012 PARE0001 PARE0006 Patient information and education... 767 PARE0007 Building patient led organisations... 768 PARE0008 Work and rehabilitation... 769 Author Index... 771 Ann Rheum Dis: first published as on 1 June 2013. Downloaded from http://ard.bmj.com/ on 2 April 2019 by guest. Protected by copyright.