MultiPulse PRO - CO 2 Laser -

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MultiPulse PRO - CO 2 Laser -

Specifications Laser: CO 2 RF-PSD, class 4 Wavelength: Power: Pulse duration: Pulse modes: Handpieces: Accessories*: Display: Dimensions: Weight: 10,600 nm Max. 40 W or Max. 60 W 0.01 0.9 s SP, UP, HP, DP, CW Handpieces with different focal lengths and spot sizes of 0.125 20 mm Ø available (depending on power and handpiece) HiScan DOT for dermatology HiScan SURG for surgery Micromanipulator EasySpot for surgery EndoScan for surgery 8.4 LCD with Touchscreen 55 cm x 49 cm x 112 cm (W x D x H) without arm approx. 68 kg * optional available MP PRO 100 0518 EN 2

Experiences and Features Clinical success In 1998, Asclepion launched its first CO 2 laser system. Asclepion is the only laser manufacturer, who has been offering both Er:YAG and CO 2 lasers in its portfolio since the 90s and is always offering the optimum solution for its customers. More than 20 years experience Features Max. 60 watts of power Numerous treatment modes Various handpieces for DERMA Numerous accessories for surgery Scanner for full and fractional ablation PSD technology for optimal pulse Spring-balanced articulated mirror arm Smoke evacuation system optional available MP PRO 100 0518 EN 3

Modern design Elegant, mobile and space-saving spring-balanced articulated mirror arm easy to transport (arm can be folded down) no consumables MP PRO 100 0518 EN 4

Easy user interface 8.4 LCD with Touchscreen High brightness and contrast for better visibility Large buttons and icons for easy use One screen for all necessary information User database for individual treatments Indication-based database Database Free Hand menu Scanner menu MP PRO 100 0518 EN 5

Handpieces The handpieces with the different optics allow an optimal adaptation to the needs of the doctor. All handpieces can easily be changed, cleaned and sterilised. Focus 1.5 Ø 0.125 mm* Optics Spacer for 1.5 and 2 Focus 2 Ø 0.155 mm* Focus 4 Ø 0.267 mm* Focus 7 Ø 0.489 mm* Focus Ø 1.5 mm* Ø 2 mm** Handpiece Spacer for 4, 7 and collimated ( ) MP PRO 100 0518 EN * Spot size @ 63% of output power ** Spot size @ 83% of output power 6

Handpieces The handpiece with the different tips is tailored to the various disciplines areas. Straight tip with backstop Straight tip 120 Tip 90 Tip with handpiece 5 (spot size Ø 0.325 mm) MP PRO 100 0518 EN 7

HiScan SURG for ENT, gynecology* The scanner HiScan Surgical is used for surgical applications. Simple and intuitive functions guarantee speed of action and perfect compatibility to the majority of colposcopes and microscopes. Max. Scanning Area Dwell Time Ablation Depth Scanning Modes Scanning Shapes Emission Mode 6.3 mm x 6.3 mm @ 400 mm EFL From 0.1 ms to 45 ms (power mode) From 0.2 μm to 2 mm (depth mode) Power mode and depth Mode Point and line Arcs of circles up to full circle Spiral Hexagon (progressive and interlaced) Ellipsoid Continuous Wave (cw) Ultimate Pulse (UP) MP PRO 100 0518 EN * optional for surgical model 8

Micromanipulator for ENT, gynecology* The MultiPulse PRO features an innovative micromanipulator EasySpot for microsurgery that combines holographic lenses and mirrors in a unique way - hybrid technology and laser optics at the highest level. Optical Technology Spot Size Operative Field @ 400 mm EFL Joystick control Focal Length: from 200 mm to 400 mm Min. 140 μm (200 mm EFL) Max. 4.5 mm (400 mm EFL) Min. 20 x 18 mm Max. 55 x 40 mm Rotation and size of the ablation figure, Scan-ON / Scan-OFF, fine-tune of the centering MP PRO 100 0518 EN * optional for surgical model 9

EndoScan for gynecology, general surgery* The scanner system EndoScan is for ENT, laparoscopic gynaecological surgery and general surgery. Max. Scanning Area Dwell Time Ablation Depth Scanning Shapes Emission Mode 5 mm x 5 mm @ 300 mm EFL 6.3 mm x 6.3 mm @ 400 mm EFL From 0.1 ms to 1 ms From 0.2 mm to 2 mm Point (Cut mode), Circle, Clover Continuous Wave (cw) Ultimate Pulse (UP) MP PRO 100 0518 EN * optional for surgical model 10

HiScan DOT for dermatology The HiScan DOT is the ideal scanner for dermatological applications and can work full ablative as well as fractional. Scan size Pitch (Spacing) Dwell Time Modes Emission 15 mm x 15 mm 0 2,000 µm, in 50 µm steps 100 2,000 µs, in 100 µs steps Normal, Interlaced, SmartTrack SP, DP, HP, CW MP PRO 100 0518 EN 11

HiScan DOT for dermatology The MultiPulse PRO with the Scanner DOT enables a precise selection of all treatment parameters, so that all types of aesthetic and dermatological treatments can be carried out in the most efficient way, which facilitates the postoperative recovery of the patient. Mode ABLATION Pitch (Spacing) = 0 (full ablation) Mode FRACTIONAL Pitch (Spacing) = 0 2000 µm (fractional ablation) MP PRO 100 0518 EN 12

Power (kw) Power (kw) Power (kw) HiScan DOT PSD technology Ablation S-pulse D-pulse H-pulse Ablation Ablation Thermal effect Thermal effect Pulse duration (ms) Pulse duration (ms) Pulse duration (µs) The exclusive Pulse Shape Design technology provides maximum flexibility of the pulse shape: S-pulse, D-pulse, H-pulse and the CW mode significantly expand the treatment options of the MultiPulse PRO. This allows for an always perfect adaptation of the ablation and thermal denaturation effects to the needs of the patient. MP PRO 100 0518 EN 13

HiScan DOT SmartStack The SmartStack feature guarantees maximum precision in controlling skin penetration and thermal effects by allowing subsequent pulse emissions from 1 to 5 to be varied at the same point (DOT). This makes therapy with the MultiPulse PRO safer and more effective compared to other pulsed lasers. This leads to faster recovery times and increases patient comfort. MP PRO 100 0518 EN 14

HiScan DOT Penetration depth 0 µm 100 µm 200 µm HP Erbium SP 300 µm HP Ultrapulse 400 µm DP 200 100 0 100 200 Single micropulse (Stack 1) The MultiPulse PRO with the HiScan DOT is a high performance CO 2 fractional system that can give consistent ablation channels to over 1 mm in depth. The depth is correlated with peak power and pulse width. MP PRO 100 0518 EN 15

HiScan DOT Scanning shapes Ratio 10/10 8/10 6/10 4/10 10/10 8/10 6/10 4/10 Rectangle Triangle Hexagon Parallelogram Line Point Standard Fractional MP PRO 100 0518 EN 16

HiScan DOT Scanning modes Normal Interlaced Autofill Start already lasered need to be lasered In Normal mode, the area is treated by scanning the lines from left to right and then from right to left. In Interlaced mode, the odd and even lines are scanned alternately. This mode is advisable for reducing the thermal effects during treatment. In SmartTrack mode, the area is treated, scanning the dots with random order. This minimizes the tissue overheating and then the thermal damage. MP PRO 100 0518 EN 17

HiScan DOT Coverage Percentage of treated skin dependent on pitch The scanner offers 38 density levels ranging from 2% to 100% Variable thermal pulse modulation of each single DOT (0.1 20 ms in 100 µs steps) Personalized parameters tailored to the individual needs of each patient Pitch* 2000 1500 1000 750 600 500 400 300 200 0 Density 1.7% 2.8% 5.3% 8.0% 10.7% 13.3% 17.1% 22.5% 31.8% 100% * Pitch (Spacing) can be varied by 50 µm increments; Pitch = 0 is for full resurfacing only 2000 µm 1500 µm 1000 µm 500 µm MP PRO 100 0518 EN 18

Selective absorption 100000 10000 1000 Desoxy-Hemoglobin Absorption Coefficient [cm -1 ] 100 10 1 0.1 Protein Oxy-Hemoglobin Melanin Water 0.01 0.001 Scattering 0.0001 100 200 300 400 500 1000 2000 3000 4000 5000 10000 Wavelength [nm] MP PRO 100 0518 EN 19

Epidermis Epidermis CO 2 vs. Er:YAG Ablation (Vaporization) Necrosis Warming CO 2 Er:YAG* Penetration depth in water 20 µm 1 µm Ablation depth per pulse 50-80 µm 5-50 µm Range of thermal injury 75-150 µm 10-30 µm Histological effect Safety of treatment Precision of treatment Thermal effects Coagulation-crater around the ablated area (necrosis, deep thermal effect) Necrosis makes control of ablation depth difficult Treatment is not restricted to the epidermis because of thermal effect Collagen shrinkage because of thermal effect is maintained, cutting without bleeding Precise and safe ablation (limited thermal effect) High visibility of treatment range, ablation depth can easily be controlled Superficial ablation of epidermal lesions Very limited thermal effect Wound healing longer wound healing due to necrosis areas Short healing process Patient comfort High patient impairment Anesthesia indispensable Higher risk of side effects (scarring, hyperpigmentation) * short pulses Low patient impairment Mostly no anesthesia required Low risk of side effects for epidermal treatments MP PRO 100 0518 EN 20

Indications Removal of dermal and epidermal lesions Actinic precancers, Cheilitis actinica, epidermal nevi, Seborrheic keratosis, papillom. dermal nevi, (benign) lentigines, Xanthelasma Fractional laser therapy Wrinkles, acne scars MP PRO 100 0518 EN 21

Indications Dermablation - Handpiece Fibroma before during treatment 3 weeks after Xanthelasma before immediately after 3 weeks after MP PRO 100 0518 EN By courtesy of Dr. K. Kykalova, Prague, Czech Republic 22

Indications Dermablation - Handpiece Naevus Naevocellularis Cave: Histologically confirmed diagnosis; long term follow up necessary! MP PRO 100 0518 EN By courtesy of Dr. K. Kykalova, Prague, Czech Republic 23

Indications Dermablation - Handpiece Naevus verrucosus MP PRO 100 0518 EN By courtesy of Dr. K. Kykalova, Prague, Czech Republic 24

Indications Dermablation - Handpiece Naevus verrucosus MP PRO 100 0518 EN By courtesy of Dr. K. Kykalova, Prague, Czech Republic 25

Indications Dermablation - Handpiece Rhinophyma MP PRO 100 0518 EN By courtesy of Dr. Andreas Ott, Rehau, Germany 26

Indications Dermablation - Handpiece Rhinophyma MP PRO 100 0518 EN By courtesy of Dr. Andreas Ott, Rehau, Germany 27

Indications Dermablation - Handpiece Naevus sebaceus CO 2 -Laser MP PRO 100 0518 EN By courtesy of PD Dr. Peter Arne Gerber, Dept. of Dermatology, University Hospital Dusseldorf, Germany 28

Indications Dermablation - Scanner Cheilitis actinica MP PRO 100 0518 EN By courtesy of PD Dr. Peter Arne Gerber, Dept. of Dermatology, University Hospital Dusseldorf, Germany 29

Indications Fractional laser therapy MP PRO 100 0518 EN 30

Indications Fractional - Scanner Elastose rejuvenation MP PRO 100 0518 EN By courtesy of Dr. Andreas Britz, Hamburg, Germany 31

Indications Fractional - Scanner OP scar MP PRO 100 0518 EN By courtesy of Dr. Andreas Britz, Hamburg, Germany 32

Indications Fractional - Scanner Acne scars MP PRO 100 0518 EN By courtesy of Dr. Andreas Ott, Rehau, Germany 33

Indications Fractional - Scanner Acne scars MP PRO 100 0518 EN By courtesy of Dr. Andreas Ott, Rehau, Germany 34

Indications Fractional - Scanner Accident scar MP PRO 100 0518 EN By courtesy of Dr. Andreas Ott, Rehau, Germany 35

Indications Fractional - Scanner Skin rejuvenation MP PRO 100 0518 EN By courtesy of Dr. Wood and Dr. Elvers, Bad Homburg, Germany 36

Indications Fractional - Scanner Skin rejuvenation MP PRO 100 0518 EN By courtesy of Dr. Wood and Dr. Elvers, Bad Homburg, Germany 37

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