SmartSensor Home OGTT Kit For Detection Of Diabetes

SmartSensor Home OGTT Kit For Detection Of Diabetes

Background to Diabetes

Global diabetes epidemic 50% of type 2 undiagnosed; 183m people Prediabetes affects over 350m people 18% of pregnancies affected by gestational diabetes UK: 1m with undiagnosed type 2; 7m with prediabetes

Preventing type 2 diabetes and its complications Type 2 usually diagnosed several years after onset 50% of new patients already have complications Earlier diagnosis reduces severity of complications Type 2 follows several years of prediabetes Prediabetes can be reversed by diet, lifestyle changes

Isle of Man Perspective

IOM perspective type 2 diabetes Chance of developing type 2 diabetes increases substantially when aged over 45 years 46% of IOM population aged 45+ years 32% of IOM population aged 55+ years

Proposed IOM screening demonstrator Assess glucose tolerance in IOM population Identify prediabetes Identify undiagnosed type 2 diabetes Study could be a precursor to prevention of diabetes and diabetes complications, using well established interventions SmartSensor s other planned trials at two London clinics: Gestational diabetes in pregnancy Monitoring cystic fibrosis patients

OGTT Oral Glucose Tolerance Test

Oral Glucose Tolerance Test: OGTT Measures body s insulin response after glucose The Gold Standard test for all forms of diabetes The only test for gestational diabetes (pregnancy) The most sensitive test for prediabetes and type 2

Glucose levels during an OGTT procedure

Alternative tests compared to OGTT type 2 risk OGTT is the gold standard test, with >90% sensitivity and almost no false positives OGTT finds type 2 diabetes and prediabetes earlier than the alternative tests

Applications of OGTT

OGTT in pregnancy (screen for gestational diabetes) OGTT is the only test recommended for gestational diabetes WHO and other bodies recommend screening of all pregnancies using OGTT

Performing a home OGTT test

Before supply, the home OGTT kit can be personalized to the patient

Personalising a packaged OGTT kit OGTT device ID can be tied to patient ID in database OGTT Home Test Wireless Read unique OGTT device ID USB NFC reader attached to PC or POS terminal Smartphone with NFC Link to database Add a personal ID NFC is the wireless system used in payment cards for transport (eg London Underground) and for access to offices and hotel rooms

Using the OGTT test device

The OGTT device removed from its protective package Start at the top Icons, text and audible feedback guide the untrained user through the test procedure I mean, in terms of its design, I can t really see how somebody could make it more straightforward. Subject, Oxford University Study, 2011 Finish at the bottom

Wash hands, remove cover A for first glucose test

Prick finger to obtain a blood spot

Add blood spot to glucose sensor Device records a glucose measurement

Take all of the glucose drink Glucose drink

Press SET to start the 2 hour timer

Rest for 2 hours read a book, or watch TV

2 hours is up time to complete the test 2:00

Press OFF to cancel timer

Wash hands, remove cover B for second glucose test

Prick finger again, add blood spot to glucose sensor Device records a glucose measurement

The device beeps when the test is completed

Snap off the Data Record

All test information is stored in the Data Record Take the Data Record to your healthcare professional or send the information by Mail Mobile Phone Hand Held Device Computer

Benefits of home OGTT Provides the Gold Standard test en mass Easier and more convenient for patients No facilities needed; do more tests at lower cost Improves access; speeds up diagnosis has the potential to impact long-standing strategies for diabetes screening and diagnosis. American Diabetes Association, June 2013,