University of Groningen Apoptosis in (pre-) malignant lesions in the gastro-intestinal tract Woude, Christien Janneke van der IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2004 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Woude, C. J. V. D. (2004). Apoptosis in (pre-) malignant lesions in the gastro-intestinal tract Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 11-02-2018
APOPTOSIS IN (PRE-) MALIGNANT LESIONS IN THE GASTRO-INTESTINAL TRACT JANNEKE VAN DER WOUDE
The studies described in this thesis were performed at the Gastroenterology and Hepatology Research Laboratory, Department of Gastroenterology and Hepatology, University Hospital Groningen, and they were financially supported by an unrestricted grant from AstraZeneca, The Netherlands. Financially Support for the publication of this thesis is gratefully acknowledged and was received from: AstraZeneca, Nederland Schering-Plough, Nederland Ferring, Nederland Rijksuniversiteit Groningen Apoptosis in (pre-) malignant lesions in the gastro-intestinal tract Thesis University Hospital Groningen ISBN 90-9018057-5 Printed by Haveka, Alblasserdam 2004 Janneke van der Woude
RIJKSUNIVERSITEIT GRONINGEN Apoptosis in (pre-) malignant lesions in the gastro-intestinal tract Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts in het openbaar te verdedigen op woensdag 26 mei 2004 om 14.45 uur door Christien Janneke van der Woude geboren op 4 maart 1966 te Groningen
Promotores: Copromotor: Beoordelingscommissie prof. dr. P. L. M. Jansen prof. dr. J. H. Kleibeuker dr. H. Moshage prof. dr. C. G. Kallenberg prof. dr. P. M. Kluin prof. dr. E. J. Kuipers Paranimfen: Marieke van der Woude Tanja van der Woude
CONTENTS Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 General introduction...1 Chronic inflammation, apoptosis and (pre-) malignant lesions in the gastro-intestinal tract Adapted from Apoptosis 2004, 9: 123-130...7 Expression of apoptosis-related proteins in Barrett s metaplasia-dysplasia-carcinoma sequence: a switch to a more resistant phenotype Human Pathology 2002;33:686-92..17 Apoptosis and expression of inos, COX-1 and COX-2 in gastritis and intestinal metaplasia: inducible nitric oxide synthase is highly specific for intestinal metaplasia......27 Diffuse and intestinal type gastric carcinomas differ in their expression of apoptosis-related proteins Journal of Clinical Pathology 2003;56:699-702...37 Active celiac disease induces an anti-apoptotic phenotype which limits apoptosis... 47 Expression of apoptosis-related proteins during malignant progression in chronic ulcerative colitis submitted....57 Summary, general discussion and future perspectives...67 Addendum 1 Nederlandse samenvatting..75 Addendum 2 Dankwoord.83 Addendum 3 Figuren