University of Groningen Proteinuria-associated renal injury and the effects of intervention in the renin-angiotensinaldosterone system Kramer, Andrea Brechtsje IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2006 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Kramer, A. B. (2006). Proteinuria-associated renal injury and the effects of intervention in the reninangiotensin-aldosterone system s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
Proteinuria-associated renal injury and the effects of intervention in the renin-angiotensin-aldosterone system
Chapter 1 CJP-gegevens Koninklijke Bibliotheek, Den Haag Kramer, A.B. Proteinuria-associated renal injury and the effects of intervention in the reninangiotensin-aldosterone system Proefschrift Groningen, met literatuur opgave en samenvatting in het Nederlands ISBN 90-367-2599-2 A.B. Kramer 2006 All rights are reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, or otherwise, without the written permission of the author. Typesetting and layout: A.B. Kramer Printed by: Stichting Drukkerij C. Regenboog Groningen 2
General introduction RIJKSUNIVERSITEIT GRONINGEN Proteinuria-associated renal injury and the effects of intervention in the renin-angiotensin-aldosterone system Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 17 mei 2006 om 14:45 uur door Andrea Brechtsje Kramer geboren op 18 juli 1978 te Wymbritseradeel 3
Chapter 1 Promotor Copromotor : Prof. dr. G.J. Navis : Dr. H. van Goor Beoordelingscommissie : Prof. dr. J.H. Berden Prof. dr. T.H. The Prof. dr. J.J. Weening 4
General introduction Paranimfen : Drs. J.W. Brinkman Drs. M.M. van Timmeren The research presented in this thesis was supported by grants from the research school GUIDE (Groningen University Institute for Drug Exploration) and the Dutch Kidney Foundation. Financial support by the Dutch Kidney Foundation, Rijksuniversiteit Groningen, GUIDE and the Faculty of Medical Sciences for publication of this thesis is gratefully acknowledged. Further financial support was kindly provided by: Amgen BV, Baxter BV, Bristol-Myers Squibb, Harlan BV, Novo Nordisk Farma BV 5
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General introduction Contents Chapter 1: General Introduction 9 Partly published in American Journal of Kidney Disease 2002; 40 (3): 664-666 Chapter 2: Inter-individual differences in antiproteinuric response to ACEi in 21 established adriamycin nephrotic rats are predicted by pretreatment renal damage Journal of Pathology 2003; 201: 160-167 Part I: Intrarenal factors during therapy resistance Chapter 3: Modulation of osteopontin in proteinuria-induced renal interstitial fibrosis 39 Journal of Pathology 2005; 207: 483-492 Chapter 4: De novo induction of Kidney injury molecule-1 in proteinuria-induced 57 tubular injury is attenuated by RAS blockade Submitted Chapter 5: Induction of glomerular heparanase expression in rats with adriamycin 73 Nephropathy is regulated by reactive oxygen species and the renin-angiotensin system Provisionally accepted by the Journal of the American Society of Nephrology Part II: Strategies to overcome the renal resistance to RAAS blockade Chapter 6: Sodium intake modifies the negative prognostic value of renal damage 91 prior to treatment with ACE-inhibitors on proteinuria induced by adriamycin Nephron Physiology 2006; 103: 43-52 Chapter 7: Effect of combining ACE inhibition with aldosterone blockade on 107 proteinuria and renal structural damage in experimental nephrosis In revision for Kidney International Chapter 8: General discussion 123 Nederlandse samenvatting 137 Curriculum vitae 145 List of publications 147 Dankwoord 149 7
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