University of Groningen Albuminuria as a laboratory risk marker Brinkman, Jacoline Willijanne IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2007 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Brinkman, J. W. (2007). Albuminuria as a laboratory risk marker: Methods evaluated s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 10-02-2018
ALBUMINURIA AS A LABORATORY RISK MARKER METHODS EVALUATED
CIP-GEGEVENS KONINKLIJKE BIBLIOTHEEK, DEN HAAG Brinkman JW. Albuminuria as a laboratory risk marker. Methods evaluated. Proefschrift Groningen. Met literatuuropgave en samenvatting in het Nederlands. ISBN 978-90-367-3090-7 Copyright 2007, JW Brinkman All rights reserved. No part of this publication may be reproduced, or transmitted in any form or by any means, without permission of the author. The research described in this thesis was technically supported by AusAm Biotechnologies Inc., New York, USA, and Dade Behring, Marburg, Germany. Financial support by the Netherlands Kidney Foundation, and the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. Further financial support for the printing and distribution of this thesis was kindly provided by: the University of Groningen, the University Medical Center Groningen, the Groningen University Institution for Drug Exploration (GUIDE), Abbott Laboratories BV, Bristol-Myers Squibb BV, Boehringer Ingelheim BV, HemoCue Diagnostics BV, Merck Sharpe & Dohme BV, Roche Diagnostics Nederland BV, and Servier Nederland Farma BV. Cover design: Frank Holtkamp. Typesetting and lay-out: Jacoline Brinkman. Printed by: Gildeprint BV, Enschede, the Netherlands.
RIJKSUNIVERSITEIT GRONINGEN ALBUMINURIA AS A LABORATORY RISK MARKER METHODS EVALUATED Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. F. Zwarts, in het openbaar te verdedigen op woensdag 24 oktober 2007 om 14:45 uur door Jacoline Willijanne Brinkman geboren op 1 december 1976 te Hasselt
PROMOTORES Prof. dr. D. de Zeeuw Prof. dr. P.E. de Jong COPROMOTORES Dr. S.J.L. Bakker Dr. R.T. Gansevoort Dr. I.P. Kema BEOORDELINGSCOMMISSIE Prof. dr. P.C. Limburg Prof. dr. R.P. Stolk Prof. dr. R.J. Vonk
PARANIMFEN Drs. Mirjan M. van Timmeren Ing. Michel A. Hoogenkamp
CONTENTS Chapter 1 Introduction and aims of the thesis. 9 PART I Chapter 2 Chapter 3 Chapter 4 Chapter 5 ALBUMINURIA AND STORAGE OF SPECIMENS Falsely low urinary albumin concentrations after prolonged frozen storage of urine samples. Clinical Chemistry 2005;51(11):2181-2183. 17 Prolonged frozen storage of urine reduces the predictive value of albuminuria for mortality. Clinical Chemistry 2007;53(1):153-154. 27 Urinary ph affects concentrations of immunochemically reactive albumin after prolonged frozen storage. Nephrology Dialysis Transplantation; accepted for publication. 37 Apparent loss of urinary albumin during long-term frozen storage; HPLC versus immunonephelometry. Clinical Chemistry 2007; 53(8):1520-1526. 41 PART II Chapter 6 Chapter 7 Chapter 8 ALBUMINURIA AND METHODS OF ANALYSIS Evaluation of measures of urinary albumin excretion in epidemiological studies. American Journal of Epidemiology 2006;164(8):725-727. 57 Which method for quantifying urinary albumin excretion gives what outcome? A comparison of immunonephelometry with HPLC. Kidney International 2004; 66 Suppl 92:S69-S75. 65 HPLC-measured urine albumin improves prediction of mortality by standard measured urine albumin. Submitted. 81
Chapter 9 General discussion. Published in adapted form in Current Opinion in Nephrology and Hypertension 2006;15(6):631-636. 95 Summary 111 Nederlandse samenvatting 117 Dankwoord 123 List of publications 129 Curriculum Vitae 131