See it! Trust it! Treat it!

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Flexible soft tissue Marker for IGRT, SBRT & PT See it! Trust it! Treat it! THORACIC GI GU CERVIX

See it! Improved Marker Visibility by Design Conventional gold seeds VISICOIL linear fiducial marker 1) Visibility during Marker Placement More accurate marker placement: With TRUS / EUS / EBUS through highly echogenic VISICOIL surface 2) Better Visibility for Better Target Definition VISICOIL aids in accurate target delineation particularly when tightening margins. CT: Reduced artifact for improved contouring MRI: Compatible and visible with MRI for planning & fusion 1) 3) Better Visibility for More Precise Image-Guided Patient Setup Linear profile: Non-anatomic structure provides easy detection Flexible marker design: Conforms with tissue motion Conventional Seed VISICOIL VISICOIL is Compatible with all Common Imaging Modalities Ultrasound Prostate CBCT Prostate X-ray Lung MRI Prostate PET/CT Esophagus MV Prostate 1) Jonsson JH, Garpebring A, Karlsson MG, et al. Internal fiducial markers and susceptibility effects in MRI-simulation and measurement of spatial accuracy. Int J Radiat Oncol Biol Phys 2012;1612-1618. IBA DOSIMETRY // 2

Trust it! VISICOIL Ideal for IGRT, SBRT, Proton Therapy & Robotic Radiosurgery NON-MIGRATING DESIGN Helical shape increases surface area to anchor VISICOIL into tissue 1) LINEAR MARKER = MORE INFORMATION, LESS NEEDLES FLEXIBLE MARKER ABSORBS TISSUE MOTION THINNER NEEDLE = IMPROVED PATIENT COMFORT Ideal for use with 22g FNA OVER 75,000 PATIENTS TREATED WITH VISICOIL The VISICOIL fiducials did not migrate and are easily identified on kilovoltage fluoroscopy using modern on-board imaging. Creach KM, Azar R, Bradley JD, et al. Tumor localization with Visicoil ultra-thin fiducials for abdominal radiation therapy. Int J Radiat Oncol Biol Phys 2009;75:S589 In the current study, fiducials implanted into a lung tumor showed no substantial migration during the entire course of treatment. Kupelian PA, Forbes A, Willoughby TR, et al. Implantation and stability of metallic fiducials within pulmonary lesions. Int J Radiat Oncol Biol Phys 2007;777-785. The type of fiducial marker that we are employing has several advantages. One is the flexibility of the coiled marker. The other is the length. Together these characteristics allow ease of radial placement. We feel the coiled design lessens potential for migration. McGuire FR, Kerley JM, Ochran T, et al. Radiotherapy monitoring device implantation into peripheral lung cancers: A therapeutic utility of electromagnetic navigational bronchoscopy. J Broncol 2007;189-192. IBA DOSIMETRY // 3

Treat it! VISICOIL s Proven Efficiency and Ease of Use Enables you to Focus on your Patients Faster, Easier and Safer Marker Placement Less needles = Less measuring = Faster implantations* Pre-loaded needles or loose VISICOIL = Easy to use VISICOIL products are stocked = Same day shipment available *see implantation video at YouTube (ibadosimetry) Patient Setup Efficiency & Reliability Faster Setup through unambiguous marker detection VISICOIL is indicated for use to radiographically mark soft tissue for future therapeutic procedures VISICOIL Support Dedicated team specializing in fiducial markers Local availability with vast experience Support your team through every step including placement and use As a courtesy, our partner Revenue Cycle is available for any reimbursement questions* EDUCATION TRAINING SUPPORT NETWORKING *Revenue Cycle is only available in the United States. IBA DOSIMETRY // 4

Innovations Designed for Interventional Radiology Approved by Interventional Radiology VISICOIL s 0.50mm and 0.35mm markers are now available pre-loaded in 21 and 22 gauge 15cm needles. Ideal for Interventional Radiology allowing for easier access with improved patient comfort and safety due to the smaller needle size. Implantation Safety Reduced risk of pneumothorax Reduced risk of bleeding / edema Improved safety and comfort for patient Implantation Efficiency Shorter 15cm needle ideal for standard bore CT Steerable needle aids in accurate marker placement Centimeter marks for depth placement VISICOIL Needle Size 17g 21g 22g VISICOIL is also available Pre-Loaded in new 21g and 22g x 15cm needles for increased safety. These are designed for Interventional Radiology. NEW VISICOIL 0.5mm 21g Needle 15cm NEW VISICOIL 0.35mm 22g Needle 15cm VISICOIL can be loaded into both 19g and 22g FNA for EUS/EBUS/Bronchoscope placement. IBA DOSIMETRY // 5

What you see is what you treat! VISICOIL is the original flexible linear marker for use with today s most accurate image guided radiotherapy treatment plans. CONTACT DETAILS For more information or to order VISICOIL, please contact us: NORTH AMERICA LATIN AMERICA RadioMed Corporation 3150 Stage Post Drive, Suite 110 Bartlett, TN 38133 Tel: +1 901 432 7202 Fax: +1 901 432 7206 Toll Free: 866 429 0922 E-mail: visicoil@iba-group.com EUROPE MIDDLE EAST AFRICA IBA Dosimetry GmbH Bahnhofstr. 5 90592 Schwarzenbruck, Germany Tel: +49 9128 607 0 Fax: +49 9128 607 10 E-mail: info@iba-dosimetry.com ASIA PACIFIC IBA Dosimetry Asia Pacific No. 6, Xing Guang Er Jie Beijing OPTO-mechatronics Industrial Park (OIP) Tel: +86 10 8080 9288 Fax: +86 10 8080 9299 E-mail: visicoil@iba-group.com IM-BR-E-VISICOIL-Rev.2-1014 IBA 2013 All rights reserved VISICOIL is a trademark of IBA Distribed by IBA Manufactured by RadioMed Corporation, an IBA Company VISICOIL.com