Lésions du tronc commun: Reste t il une place pour la chirugie? Pierre Deharo, CHU TIMONE, Marseille
Disclosure Statement of Financial Interest I currently have, or have had over the last two years, an affiliation or financial interests or interests of any order with a company or I receive compensation or fees or research grants with a commercial company : Speaker's name: Pierre, Deharo, MARSEILLE I do not have any potential conflict of interest
Guidelines: indications ESC guidelines, Eur Heart J 2014
Methods of revascularisation ESC guidelines, Eur Heart J 2014
LMS: evidence 5-y PRECOMBAT + SYNTAX LMS analyse Subgroup of negative study! Cavalcante, JACC 2016
SYNTAX calculator = a very complicated tool!
New evidence for LMS: What is the source of dilemna? EXCEL STUDY Everolimus-Eluting Stents or Bypass Surgery for Left Main Coronary Artery Disease. PCI non inferior to CABG Stone G et al. N Engl J Med Dec. 2016 NOBLE STUDY Percutaneous coronary angioplasty versus coronary artery bypass grafting in treatment of unprotected left main stenosis (NOBLE): a prospective, randomised, open-label, non-inferiority trial. PCI NOT non inferior to CABG and CABG superior to PCI Mäkikallio T et al. Lancet Dec. 2016
EXCEL Study PCI non inferior to CABG for LM disease LM and SYNTAX<32 Xience stent, 28% BIMA CABG vs PCI, n= 1905 PEP= Death, MI, stroke Stone et al, NEJM 2016
NOBLE Study PCI not non-inferior to CABG for LM disease (HR>1.35) Left Main Biomatrix stent (>90%) CABG vs PCI, n= 1201, 8% BIMA PEP= Death, non procedural MI, stroke + Revasc Mäkikallio et al, Lancet 2016
Why different results? EXCEL study NOBLE study PEP without repeat revasc. PEP: All MI PEP with repeat revasc. PEP: Only non procedural MI 3 years FU 5 years FU Positive Study Non Inferiority of PCI Negative study No Non inferiority of PCI Superiority of CABG Stone et al, NEJM 2016 Mäkikallio et al, Lancet 2016
How study design impacts study results! EXCEL study: PEP NOBLE study: PEP CABG PCI CABG PCI Difference in KM curves Earlier (MI Definition / Early Hazard) Faster (Repeat Revasc. In PEP) Larger (Longer follow-up) Stone et al, NEJM 2016 Mäkikallio et al, Lancet 2016
EXCEL NOBLE All cause death Higher Higher CV death Equal Equal Periprocedural MI Lower* Lower Non Periprocedural MI Higher Higher* Revasc Higher* Higher* Stroke Lower Higher ST/SGO Lower* Lower PCI as reference * p<0,05 Stone, NEJM 2016 Makikallio, Lancet 2016
EXCEL NOBLE AF Lower* Lower* Transfusion Lower* Lower* Anemia Lower* Lower* PCI as reference * p<0,05 Stone, NEJM 2016 Makikallio, Lancet 2016
Revascularization strategy ESC guidelines, Eur Heart J 2014
Revascularization strategy STS Age SCA vs. SCAD Diabetes Compliance DAPT SYNTAX Ostial vs. Bifurcation Downstream bed CTO Previous failure All arterial Delays Imaging
Revascularization strategy SYNTAX Ostial vs. Bifurcation Downstream bed CTO Previous failure STS Age SCA vs. SCAD Diabetes Compliance DAPT CABG PCI - Hybride Final tailored decision All arterial Delays Imaging
One patient is one patient... 63 yo Current smoker EF 50% No comorbidity egfr 80 = RIMA to LCX + LIMA to LAD 86 yo COPD PAD Frail EF 30% egfr 40 = PCI to LMS/LAD 1 DES
Remaining questions in 2018
SYNTAX score 2016 Stone, NEJM 2016 Makikallio, Lancet 2016
Score SYNTAXII
Constant devices improvement Last generation stents in LMS - diabetes Systematic use of intracoronary imaging in LMS procedures Less invasive PCI (6 Fr radial) Complete revascularisation (CTOs)
Conclusions LMS PCI: validated alternative except for complex anatomy Is there still a place for CABG: YES!... But if well done: all arterial
Graft patency Tranbaugh et al, Annals of thoracic surgery 2017
Conclusions Heart Team Expert centers Patient-based decision instead of SYNTAX based Need for optimization of PCI outcomes (OCT/IVUS, newer DES, bifurcations techniques, CTOs)