Supporting Information. First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: orthoalkynylaniline-based

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Supporting Information First synthetic entry to the trimer stage of 5,6-dihydroxyindole polymerization: orthoalkynylaniline-based access to the missing 2,7 :2,7 -triindole Luigia Capelli, Paola Manini,* Alessandro Pezzella and Marco d Ischia Department of Organic Chemistry and Biochemistry, University of aples Federico II, Complesso Universitario Monte S. Angelo, via Cintia 4, I-80126 aples Table of contents Materials and methods, experimental procedures and spectroscopic data References Table1. Cyclization of ortho-ethynylanilines under different reaction conditions Copies of 1 MR, 13 C MR, 1, 13 C SQC and 1, 13 C MBC spectra of 12a Copies of 1 MR, 13 C MR, 1, 13 C SQC and 1, 13 C MBC spectra of 12b Copies of 1 MR, 13 C MR, 1, 13 C SQC and 1, 13 C MBC spectra of 13 Copies of 1 MR, 13 C MR, 1, 13 C SQC and 1, 13 C MBC spectra of 14 Copies of 1 MR, 13 C MR, 1, 13 C SQC and 1, 13 C MBC spectra of 15 S2-S7 S8 S9 S10-S13 S14-S17 S18-S25 S26-S31 S32-S39 Copies of 1 MR, 13 C MR, 1, 1 COSY, ROESY, 1, 13 C SQC and 1, 13 C MBC spectra of 6-Ac S40-S53 LC-MS elutograms of the oxidation mixture of 1, after work up and acetylation, and of the coinjection of the same oxidation mixture with synthetic 6-Ac S54 ESI(+)-MS spectra of the peak A in the oxidation mixture of 1, after work up and acetylation, and in the coinjection of the same oxidation mixture with synthetic 6-Ac S55 S1

Materials and methods. All commercially available reagents were used as received. Anhydrous solvents were purchased from commercial sources and withdrawn from the container by syringe under a slight positive pressure of argon. All the solvents were of analytical grade quality. Compounds 8, 10a and 10b were prepared according to reported procedures. 1 MR spectra were recorded with 400 Mz instrument. 1 and 13 C MR spectra were recorded in (CD 3 ) 2 CO using TMS as the internal standard; J values are given in z. Assignments with identical superscripts may be interchanged. 1, 1 COSY, 1, 13 C SQC, 1, 13 C MBC and ROESY experiments were run at 400.1 Mz using standard pulse programs. Mass spectra and high resolution mass spectra were registered in the electrospray ionization-positive ion (ESI+) mode. ESI analysis were performed with the cone and the fragmentator voltages set at 4 kv and 80 V, respectively; nitrogen was used as carrier gas at a flow of 8 ml/min and the nebulizer pressure was set at 50 psi. Analytical and preparative TLC analyses were performed on F 254 silica gel plates (0.25 and 0.5 mm, respectively). TLC plates were visualised using a UV lamp (λ= 254 nm) and a fluorescence lamp (λ= 366 nm). Liquid chromatography was performed on silica gel (60-230 mesh). LC-MS analyses were carried out on an instrument equipped with an ESI ion source; an octadecylsilane-coated column (4.6 150 mm, 3.5 μ) at 0.4 ml/min was used. The eluant system was 0.1% formic acid (eluant A) and methanol (eluant B), starting with 40% solvent B for 1 minute, and then from 40% to 50% solvent B gradient, for 4 minutes, from 50% to 60% solvent B gradient, for 35 minutes, and finally with 60% solvent B for 20 minutes. Mass spectra were registered in the electrospray ionization-positive ion (ESI+) mode with the cone and the fragmentator voltages set at 4 kv and 70 V, respectively. Ultrasound experiments were performed in a sonic bath at 320 W and at 45 C. Synthesis of 5,6-diacetoxy-7-iodoindole (11) A solution of 10a (900 mg, 2.5 mmol) in dry C 2 Cl 2 (63 ml) was treated with Cu() 2 (300 mg, 1.5 mmol) at 55 C under an argon atmosphere. After 18 h the reaction mixture was brought to S2

room temperature and extracted with ethyl acetate and water. The organic layers were collected, dried over anhydrous sodium sulfate and evaporated under reduced pressure to afford pure 11 (720 mg, 80%). 1 and 13 C MR resonances were in good agreement with data reported in the literature. 1 Synthesis of 5,6-diacetoxy-7-(trimethylsilylethynyl)indole (12a) A solution of (11) (700 mg, 1.9 mmol) in a mixture of triethylamine (16.3 ml), toluene (11.1 ml) and tetrahydrofuran (5.2 ml) was treated with PPh 3 (51.1 mg, 0.19 mmol), CuI (37 mg, 0.19 mmol), (PPh 3 ) 2 PdCl 2 (68.4 mg, 0.1 mmol) and trimethylsilylacetylene (278 μl, 1.9 mmol) at 60 C under an argon atmosphere. After 30 min the reaction mixture was extracted with a 10% water solution of 4 Cl and chloroform. The organic layers were collected, dried over anhydrous sodium sulfate, evaporated under reduced pressure and the residue fractionated on silica gel (petroleum ether/ethyl acetate, gradient from 90:10 to 85:15) to afford pure 12a (450 mg, 70%, R f = 0.75 eluant: chloroform/ethyl acetate 95:5 (v/v)). 12a: δ (400 Mz; (CD 3 ) 2 CO) 0.28 (9, s, Si(C 3 ) 3 ), 2.28 (3, s, C 3 ), 2.33 (3, s, C 3 ), 6.55 (1, t, J 2.6, 3-), 7.40 (1, t, J 2.6, 2-), 7.45 (1, s, 4-), 10.53 (1, br s, ); δ C (50 Mz, (CD 3 ) 2 CO) 0.3 (Si(C 3 ) 3 ), 20.1 (C 3 ), 20.3 (C 3 ), 96.6 (C C-Si), 102.3 (C C-Si), 103.3 (C-3), 103.9 (C-7), 115.7 (C-4), 126.8 (C-4a), 127.6 (C-2), 134.8 (C-7a), 137.5 (C-5), 140.1 (C-6), 168.2 (C=O), 169.1 (C=O); MS (ESI+) m/z 330 ([M+] + ), 352 ([M+a] + ), 368 ([M+K] + ); RMS (ESI+) m/z C 17 20 O 4 Si [M+] + calcd 330.1161, found 330.1164. Synthesis of 5,6-diacetoxy-7-ethynylindole (12b) A solution of (12a) (500 mg, 1.5 mmol) in DMF (15 ml) was treated with KF (61.5 mg, 1.1 mmol) under vigorous stirring. After 30 min the reaction mixture was extracted with water and chloroform. The organic layers were collected, dried over anhydrous sodium sulfate and evaporated under S3

reduced pressure to afford pure 12b (383 mg, 98% R f = 0.50 eluant: chloroform/ethyl acetate 95:5 (v/v)). 12b: δ (400 Mz; (CD 3 ) 2 CO) 2.27 (3, s, C 3 ), 2.32 (3, s, C 3 ), 4.13 (1, s, C C- ), 6.56 (1, t, J 2.6, 3-), 7.44 (1, t, J 2.6, 2-), 7.47 (1, s, 4-), 10.63 (1, br s, ); δ C (50 Mz, (CD 3 ) 2 CO) 20.1 (C 3 ), 20.3 (C 3 ), 74.5 (C C-), 87.6 (C C-), 103.3 (C-3), 104.1 (C-7), 115.9 (C-4), 125.9 (C-4a), 127.7 (C-2), 134.8 (C-7a), 137.5 (C-5), 140.1 (C-6), 168.8 (C=O), 169.1 (C=O); MS (ESI+) m/z 258 ([M+] + ), 280 ([M+a] + ), 296 ([M+K] + ); RMS (ESI+) m/z C 14 12 O 4 [M+] + calcd 258.0766, found 258.0762. Synthesis of 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) A solution of 12b (500 mg, 1.9 mmol) in a mixture of triethylamine (17 ml), toluene (7 ml) and tetrahydrofuran (10 ml) was treated with 8 (897 mg, 1.9 mmol), PPh 3 (51 mg, 0.19 mmol), CuI (37 mg, 0.19 mmol) and (PPh 3 ) 2 PdCl 2 (68.3 mg, 0.1 mmol) at 60 C under an argon atmosphere. After 20 min the reaction mixture was extracted with a 10% water solution of 4 Cl and dichloromethane. The organic layers were collected, dried over anhydrous sodium sulfate, evaporated under reduced pressure and the residue fractionated on silica gel (petroleum ether/ethyl acetate, gradient from 70:30 to 65:35) to afford pure 13 (1 g, 90%, R f = 0.35 eluant: chloroform/ethyl acetate 98:2 (v/v)). 13: δ (400 Mz; (CD 3 ) 2 CO) 2.25 (3, s, C 3 ), 2.30 (3, s, C 3 ), 2.36 (3, s, C 3 ), 2.37 (3, s, C 3 ), 5.43 (2, br s, 2 ), 6.59 (1, t, J 2.9, 3 -), 7.33 (1, s, 5-), 7.46 (1, t, J 2.9, 2 -), 7.49 (1, s, 4 -), 10.92 (1, br s, ); δ C (100 Mz, (CD 3 ) 2 CO) 20.3 (4 C 3 ), 80.5 (C-2), 87.2 (C-2 ), 93.4 (C-1 ), 103.4 (C-3 ), 103.6 (C-7 ), 104.3 (C-6), 115.9 (C-4 ), 125.8 (C-4a ), 127.1 (C- 5), 127.6 (C-2 ), 133.8 (C-1), 134.7 (C-7a ), 137.5 (C-5 ), 140.0 (C-6 ), 146.0 (C-4), 149.0 (C-3), 167.5 (C=O), 168.6 (C=O), 169.0 (C=O), 169.2 (C=O); MS (ESI+) m/z 613 ([M+a] + ); RMS (ESI+) m/z C 24 19 I 2 ao 8 [M+a] + calcd 613.0084, found 613.0087. S4

Synthesis of 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) A solution of 13 (900 mg, 1.5 mmol) in dry ethanol (18 ml) was treated with AuCl 3 (60 mg, 0.15 mmol) under an argon atmosphere and kept in an ultrasound bath at 320 W and 45 C. After 1h and 30 min the mixture was extracted with a 10% water solution of 4 Cl and chloroform. The organic layers were collected, dried over anhydrous sodium sulfate and evaporated under reduced pressure to afford pure 14 (720 mg, 80%, R f = 0.70 eluant: chloroform/ethyl acetate 7:3 (v/v)). 14: δ (400 Mz; (CD 3 ) 2 CO) 2.20 (3, s, C 3 ), 2.31 (2 3, s, C 3 ), 2.40 (3, s, C 3 ), 6.59 (1, t, J 2.5, 3 -), 6.87 (1, d, J 1.7, 3-), 7.43 (1, t, J 2.5, 2 -), 7.48 (1, s, 4-), 7.50 (1, s, 4 - ), 10.37 (1, br s, ), 10.67 (1, br s, ); δ C (100 Mz, (CD 3 ) 2 CO) 20.0 (C 3 ), 20.3 (2 C 3 ), 20.4 (C 3 ), 73.4 (C-7), 102.6 (C-3 ), 104.8 (C-3), 111.1 (C-7 ), 114.6 (C-4, C-4 ), 126.0 (C- 4a, C-4a'), 127.5 (C-2 ), 127.8 (C-2), 133.0 (C-7a, C-7a ), 137.4 (C-O), 137.5 (C-O), 137.6 (C-O), 140.4 (C-O), 168.2 (C=O), 169.0 (2 C=O), 169.1 (C=O); MS (ESI+) m/z 591 ([M+] + ), 613 ([M+a] + ); RMS (ESI+) m/z C 24 20 I 2 O 8 [M+] + calcd 591.0264, found 591.0261. Synthesis of 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]- aniline (15) A solution of 14 (200 mg, 0.34 mmol) in triethylamine (3 ml) and tetrahydrofuran (3 ml) was treated with 10b (130.4 mg, 0.56mmol), PPh 3 (8.9 mg, 0.034 mmol), CuI (6.4 mg, 0.034 mmol) and (PPh 3 ) 2 PdCl 2 (12 mg, 0.017 mmol) at 60 C under an argon atmosphere. After 1h the reaction mixture was extracted with a 10% water solution of 4 Cl and chloroform. The organic layers were collected, dried over anhydrous sodium sulfate, evaporated under reduced pressure and the residue fractionated on silica gel (eluant chloroform/ethyl acetate 1:1 (v/v)) to afford pure 15 (118 mg, 50%, R f = 0.50 eluant: chloroform/ethyl acetate 6:4 (v/v)). 15: δ (400 Mz; (CD 3 ) 2 CO) 2.17 (3, s, C 3 ), 2.21 (3, s, C 3 ), 2.23 (3, s, C 3 ), 2.30 (3, s, C 3 ), 2.33 (3, s, C 3 ), 2.40 (3, s, C 3 ), 5.33 (2, br s, 2 ), 6.58 (1, t, J 2.3, 3 -), 6.66 (1, s, 6-), 6.73 (1, d, J 1.7, 3 -), 7.19 (1, s, 3-), 7.43 (1, t, J 2.3 z, 2 -), 7.48 (1, s, S5

4 -), 7.51 (1, s, 4 -), 10.80 (1, br s, ), 11.05 (1, br s, ); δ C (100 Mz, (CD 3 ) 2 CO) 20.1 (C 3 ), 20.2 (2 C 3 ), 20.3 (2 C 3 ), 20.6 (C 3 ), 86.3 (C-2 ), 94.4 (C-1 ), 102.4 (C-7 ), 102.7 (C-3 ), 104.3 (C-3 ), 104.5 (C-2), 109.1 (C-6), 111.5 (C-7 ), 114.7 (C-4 ), 115.2 (C-4 ), 126.2 (C-4a ), 126.4 (C-4a ), 126.8 (C-3), 127.6 (C-2 ), 133.1 (C-7a, C-7a ), 133.4 (C-1), 135.4 (C-2 ), 136.6 (C-5 ), 137.7 (C-5, C-6 ), 140.1 (C-6 ), 144.9 (C-4), 148.7 (C-5), 168.2 (C=O), 168.7 (C=O), 168.9 (C=O), 169.1 (C=O), 169.3 (2 C=O); MS (ESI+) m/z 696 ([M+] + ), 718 ([M+a] + ), 734 ([M+K] + ); RMS (ESI+) m/z C 36 30 3 O 12 [M+] + calcd 696.1829, found 696.1831. Synthesis of 5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -triindole (6-Ac) A solution of 15 (200 mg, 0.29 mmol) in dry ethanol (4 ml) was treated with AuCl 3 (66.7 mg, 0.17 mmol) under an argon atmosphere and kept in an ultrasound bath at 320 W and 45 C. After 30 min the mixture was extracted with a 10% water solution of 4 Cl and chloroform. The organic layers were collected, dried over anhydrous sodium sulfate and evaporated under reduced pressure to afford pure 6-Ac (160 mg, 80%, R f = 0.54 eluant: chloroform/ethyl acetate 1:1 (v/v)). 6-Ac: 3 δ (400 Mz; (CD 3 ) 2 CO) 2.17 (3, s, C 3 ), 2.22 (3, s, C 3 ), 2.26 (3 3, s, C 3 ), 2.33 (3, s, C 3 ), 6.56 (1, t, J 2.8, 3 -), 6.76 (1, s, 3 -), 6.87 (1, s, 3-), 7.32 (1, s, 7-), 7.39 (1, s, 4-), 7.41 (1, t, J 2.8, 2 -), 7.45 (1, s, 4 -), 7.51 (1, s, 4 -), 10.66 (1 2, br s,, ), 10.80 (1, br s, ); δ (400 Mz; (CD 3 ) 2 CO plus 1% of 4 Cl (10% in 2 O)) 2.15 (3, s, C 3 ), 2.21 (3, s, C 3 ), 2.27 (3 3, s, C 3 ), 2.33 (3, s, C 3 ), 6.56 (1, t, J 2.8, 3 -), 6.76 (1, s, 3 -), 6.85 (1, s, 3-), 7.32 (1, s, 7-), 7.38 (1, s, 4-), 7.40 (1, t, J 2.8, 2 -), 7.43 (1, s, 4 -), 7.50 (1, s, 4 -), 10.64 (1, br s, ), 10.71 (1, br s, ), 10.74 (1, br s, ); δ C (100 Mz, (CD 3 ) 2 CO) 20.3 (6 C 3 ), 102.7 (C-3 ), 103.7 (C-3), 104.2 (C-3 ), 106.2 (C- 7), 111.7 (C-7 ), 112.1 (C-7 ), 114.1 (C-4), 114.4 (C-4 ), 114.6 (C-4 ), 126.1 (C-4a"), 126.5 (C-4a), 127.0 (C-4a'), 127.3 (C-2 ), 129.5 (C-7a ), 132.8 (C-2), 133.1 (C-7a'), 133.5 (C-2 ), 134.7 (C-7a), 136.5 a (C-5 ), 136.6 a (C-5 ), 137.4 b (C-6 ), 137.6 b (C-6 ), 138.1 (C-6 ), 139.3 (C-5), 169.0 (2 S6

C=O), 169.2 (2 C=O), 169.3 (2 C=O); MS (ESI+) m/z 696 ([M+] + ), 718 ([M+a] + ); RMS (ESI+) m/z C 36 30 3 O 12 [M+] + calcd 696.1829, found 696.1826. Intramolecular cyclization of 15 to 6-Ac 4 A solution of 15 (150 mg, 0.22 mmol) in ethanol (1.8 ml) was treated with aaucl. 4 2 2 O (3.3 mg, 8.4 μmol) under an argon atmosphere. After 5 h the mixture was extracted with a 10% water solution of 4 Cl and ethyl acetate. The organic layers were collected, dried over anhydrous sodium sulfate and evaporated under reduced pressure to afford pure 6-Ac (125 mg, 83%, R f = 0.54 eluant: chloroform/ethyl acetate 1:1 (v/v)). LC-MS analysis of the oxidation mixture of 1 The oxidative polymerization of 1 under biomimetic conditions has been carried out as previously reported. 2 In brief, a solution of 1 in 0.05 M phosphate buffer, p 7.4, was treated with horseradish peroxidase (36 U/mL) and hydrogen peroxide (1.1 molar equivalents). After 25 s reaction time, the oxidation mixture was halted by the addition of a solution of sodium dithionite in water and worked up. After acetylation with acetic anhydride and pyridine overnight at r.t., the mixture was subjected to LC-MS analysis. S7

References 1 L. Capelli, P. Manini, A. Pezzella, A. apolitano and M. d'ischia, J. Org. Chem., 2009, 74, 7191-7194. 2 A. Pezzella, L. Panzella, O. Crescenzi, A. apolitano, S. avaratman, R. Edge, E. J. Land, V. Barone and M. d Ischia, J. Am. Chem. Soc., 2006, 128, 15490-11221. 3 Structural assignment was secured by comparing 1D and 2D MR spectra registered in (CD 3 ) 2 CO with or without the addition of 5 μl of a 10% solution of 4 Cl in 2 O. 4 A. Arcadi, G. Bianchi and F. Marinelli, Synthesis, 2004, 610-618. S8

Table1. Cyclization of ortho-ethynylanilines under different reaction conditions. Substrate Product Reaction conditions T ( C) Time (h) Yield (%) FeCl3/PdCl2/dry C2Cl2 55 4 - CuI/DMF 110 5 30 2 AuCl3/dry ethanol/(ultrasound bath) 10a 11 aaucl4. 22O/ethanol CuI/TEA/toluene 130 1.5 50 25 rt 1.5 4 30 70 Cu()2/C2Cl2 55 18 80 Cu()2/C2Cl2 55 24 - CuI/TEA/toluene 130 4 - CuI (2 eq)/dmf 110 4 20 2 CuI (5 eq)/dmf Cu()2/dry methanol/(ultrasound bath) LiCl/toluene 110 70 110 3 5 2 5 10 30 13 14 AlCl3/toluene 110 3.5 50 AuCl3/dry ethanol/(ultrasound bath) 45 1.5 80 aaucl4. 22O /ethanol rt 5 82 S9 I I I I

Si(Me) 3 5,6-diacetoxy-7-(trimethylsilylethynyl)indole (12a) 1 MR (400 Mz; (CD 3 ) 2 CO) S10

Si(Me) 3 5,6-diacetoxy-7-(trimethylsilylethynyl)indole (12a) 13 C MR (400 Mz; (CD 3 ) 2 CO) S11

Si(Me) 3 5,6-diacetoxy-7-(trimethylsilylethynyl)indole (12a) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) S12

Si(Me) 3 5,6-diacetoxy-7-(trimethylsilylethynyl)indole (12a) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) S13

5,6-diacetoxy-7-ethynylindole (12b) 1 MR (400 Mz; (CD 3 ) 2 CO) S14

5,6-diacetoxy-7-ethynylindole (12b) 13 C MR (400 Mz; (CD 3 ) 2 CO) S15

5,6-diacetoxy-7-ethynylindole (12b) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) S16

5,6-diacetoxy-7-ethynylindole (12b) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) S17

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1 MR (400 Mz; (CD 3 ) 2 CO) S18

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1 MR (400 Mz; (CD 3 ) 2 CO) Expanded region S19

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 13 C MR (400 Mz; (CD 3 ) 2 CO) S20

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 13 C MR (400 Mz; (CD 3 ) 2 CO) Expanded region S21

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1, 13 C SQC(400 Mz; (CD 3 ) 2 CO) S22

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1, 13 C SQC(400 Mz; (CD 3 ) 2 CO) Expanded region S23

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1, 13 C MBC(400 Mz; (CD 3 ) 2 CO) S24

2 I 3,4-diacetoxy-6-[2 -(5,6 -diacetoxy-indol-7 -yl)-1 -ethynyl]-2-iodoaniline (13) 1, 13 C MBC(400 Mz; (CD 3 ) 2 CO) Expanded region S25

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 1 MR(400 Mz; (CD 3 ) 2 CO) S26

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 1 MR(400 Mz; (CD 3 ) 2 CO) Expanded region S27

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 13 C MR(400 Mz; (CD 3 ) 2 CO) S28

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 13 C MR(400 Mz; (CD 3 ) 2 CO) Expanded region S29

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) S30

I 5,5,6,6 -tetraacetoxy-7-iodo-2,7 -biindole (14) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) S31

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1 MR (400 Mz; (CD 3 ) 2 CO) S32

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1 MR (400 Mz; (CD 3 ) 2 CO) igh field region S33

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1 MR (400 Mz; (CD 3 ) 2 CO) Low field region S34

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 13 C MR (400 Mz; (CD 3 ) 2 CO) S35

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 13 C MR (400 Mz; (CD 3 ) 2 CO) Expanded region S36

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) S37

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) S38

2 4,5-diacetoxy-2-[2 -(5,5,6,6 -tetraacetoxy-2,7 -biindol-7 -yl)-1 -ethynyl]-aniline (15) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) Expanded region S39

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -triindole (6-Ac) 1 MR (400 Mz; (CD 3 ) 2 CO) S40

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1 MR (400 Mz; (CD 3 ) 2 CO) igh field region S41

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1 MR (400 Mz; (CD 3 ) 2 CO) Low field region S42

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1 MR (400 Mz; (CD 3 ) 2 CO plus 1% of 4 Cl (10% in 2 O)) Low field region S43

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 13 C MR (400 Mz; (CD 3 ) 2 CO) S44

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 13 C MR (400 Mz; (CD 3 ) 2 CO) Expanded region S45

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1, 1 COSY (400 Mz; (CD 3 ) 2 CO plus 1% of 4 Cl (10% in 2 O)) Expanded region S46

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) ROESY (400 Mz; (CD 3 ) 2 CO) S47

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) ROESY (400 Mz; (CD 3 ) 2 CO) Expanded region S48

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) ROESY (400 Mz; (CD 3 ) 2 CO plus 1% of 4 Cl (10% in 2 O)) Expanded region S49

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) S50

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1, 13 C SQC (400 Mz; (CD 3 ) 2 CO) Expanded region S51

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) S52

5,5,5,6,6,6 -esaacetoxy-2,7 :2,7 -terindolyl (6-Ac) 1, 13 C MBC (400 Mz; (CD 3 ) 2 CO) Expanded region S53

LC-MS elutograms of the oxidation mixture of 1, after work up and acetylation, (UV 254nm trace; ESI(+)-MS trace) and of the coinjection of the same oxidation mixture with synthetic 6-Ac (UV 254nm trace; ESI(+)-MS trace). 1-Ac O-Acetylated dimers of 1,O-Acetylated trimers of 1 O-Acetylated trimers of 1 Expanded region 4-Ac A 5-Ac Unknown tetramer of 1 S54

ESI(+)-MS spectra of the peak A (31.8 min) in the oxidation mixture of 1, after work up and acetylation, and in the coinjection of the same oxidation mixture with synthetic 6-Ac. Oxidation mixture of 1: Peak A, 31.8 min Coinjection of the reaction mixture of 1 with synthetic 6-Ac: Peak A, 31.8 min S55