Medicine summary - citalopram (to end January 2009)

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734 13 493 Blood and lymphatic system disorders Iron deficiency anaemia 1 0 1 Anaemia 1 0 1 Pancytopenia 2 0 0 Thrombocytopenia 3 0 2 Lymphadenopathy 1 0 1 Eosinophilia 2 0 1 Leukocytosis 1 0 0 Leukopenia 3 0 1 Neutropenia 4 0 1 Blood and lymphatic system disorders 18 0 8 Cardiac disorders Atrioventricular block 1 0 0 Arrhythmia 1 0 0 Bradycardia 4 0 4 Extrasystoles 1 0 1 Tachycardia 16 0 9 Arrhythmia supraventricular 1 0 1 Sick sinus syndrome 1 0 1 Sinus bradycardia 1 0 1 Supraventricular tachycardia 1 0 0 Cardiac arrest 3 2 1 Torsade de pointes 3 1 1 Ventricular tachycardia 1 0 0 Cyanosis 1 1 0 Palpitations 23 0 18 Myocardial infarction 1 0 0 Myocardial ischaemia 1 1 1 Cardiomyopathy 1 1 0 Cardiac disorders 61 6 38 Congenital, familial and genetic disorders Ventricular hypoplasia 1 1 1 Ventricular septal defect 1 0 0 Fallot's tetralogy 1 0 0 Congenital anomaly 1 1 1 Congenital, familial and genetic disorders 4 2 2 Ear and labyrinth disorders Ear pain 1 0 1 Deafness unilateral 1 0 1 Hearing impaired 1 0 1 Hyperacusis 1 0 1 Tinnitus 5 0 5 Vertigo 1 0 1 Ear and labyrinth disorders 10 0 10 Endocrine disorders Hyperprolactinaemia 2 0 1 25/09/2009-1 - 10:31:03 AM

Endocrine disorders Inappropriate antidiuretic hormone secretion 13 0 11 Endocrine disorders 15 0 12 Eye disorders Eye pain 2 0 1 Eye swelling 2 0 2 Glaucoma 3 0 2 Conjunctival haemorrhage 1 0 1 Keratitis 1 0 1 Blepharospasm 1 0 1 Strabismus 1 0 1 Mydriasis 6 0 4 Photophobia 1 0 1 Accommodation disorder 2 0 1 Diplopia 3 0 2 Photopsia 1 0 1 Vision blurred 7 0 6 Visual impairment 16 0 14 Eye disorders 47 0 38 Gastrointestinal disorders Abdominal hernia 1 0 1 Anorectal disorder 1 0 1 Tooth disorder 1 0 0 Toothache 1 0 1 Tooth discolouration 1 0 0 Gingivitis 1 0 1 Gingival bleeding 1 0 1 Pancreatitis 1 0 0 Rectal haemorrhage 1 0 0 Gastrointestinal haemorrhage 2 1 0 Haematemesis 3 0 2 Melaena 2 1 0 Colitis 1 0 0 Gastritis 3 1 1 Crohn's disease 1 0 1 Diarrhoea 36 0 25 Constipation 3 0 2 Gastrointestinal motility disorder 1 0 1 Ileus paralytic 2 0 0 Dyspepsia 6 0 6 Eructation 1 0 1 Abdominal distension 3 0 3 Flatulence 7 0 6 Abdominal pain 14 0 9 Abdominal pain upper 4 0 3 25/09/2009-2 - 10:31:03 AM

Gastrointestinal disorders Abdominal discomfort 1 0 1 General disorders and administration site conditions Breath odour 2 0 1 Dysphagia 3 0 2 Nausea 96 0 69 Vomiting 33 0 22 Intestinal obstruction 2 0 0 Duodenal ulcer 1 0 0 Lip oedema 1 0 1 Lip swelling 4 0 2 Hypoaesthesia oral 1 0 1 Oral discomfort 1 0 1 Mouth ulceration 2 0 2 Dry mouth 15 0 12 Salivary hypersecretion 1 0 0 Glossitis 1 0 1 Swollen tongue 2 0 1 Gastrointestinal disorders 264 3 181 Hypothermia 1 0 1 Pyrexia 13 0 7 1 1 0 Sudden death 3 3 0 Asthenia 6 0 5 Fatigue 26 0 18 Malaise 12 0 9 Gait disturbance 6 0 2 Condition aggravated 1 0 0 Influenza like illness 2 0 2 Irritability 4 0 3 Swelling 1 0 1 Face oedema 4 0 4 Generalised oedema 3 0 2 Oedema 3 0 1 Oedema peripheral 3 0 3 Chest pain 12 0 9 Pain 4 0 4 Chest discomfort 3 0 2 Chills 2 0 1 Feeling abnormal 2 0 1 Feeling cold 1 0 0 Feeling hot 2 0 0 Feeling jittery 2 0 1 Thirst 3 0 2 25/09/2009-3 - 10:31:03 AM

General disorders and administration site conditions Drug interaction 3 0 0 Drug ineffective 14 0 13 Drug tolerance increased 1 1 0 Therapeutic response decreased 1 0 1 Therapeutic response unexpected 1 0 1 Drug withdrawal syndrome 2 0 2 Drug withdrawal syndrome neonatal 3 0 3 General disorders and administration site conditions 145 5 98 Hepatobiliary disorders Vanishing bile duct syndrome 2 0 2 Hepatitis cholestatic 4 0 3 Jaundice 2 0 1 Jaundice cholestatic 1 0 1 Liver disorder 1 0 1 Hepatic function abnormal 1 0 1 Hepatic failure 1 0 1 Hepatomegaly 1 0 0 Hepatitis 3 0 0 Hepatobiliary disorders 16 0 10 Immune system disorders Hypersensitivity 1 0 1 Immune system disorders 1 0 1 Infections and infestations Vaginal infection 1 0 1 Infection 1 0 1 Bronchitis 1 0 1 Pneumonia 2 0 1 Rash pustular 1 0 1 Pharyngitis 2 0 2 Rhinitis 3 0 3 Sinusitis 1 0 1 Upper respiratory tract infection 2 0 2 Herpes simplex 1 0 1 Influenza 1 0 1 Infections and infestations 16 0 15 Injury, poisoning and procedural complications Drug exposure during pregnancy 4 2 2 Fall 3 0 1 Contusion 3 0 2 Intentional overdose 2 0 2 Overdose 4 0 2 Injury, poisoning and procedural complications 16 2 9 Investigations Electrocardiogram QT prolonged 4 0 1 Electrocardiogram T wave inversion 1 0 0 25/09/2009-4 - 10:31:03 AM

Investigations Electrocardiogram abnormal 1 0 0 Blood pressure increased 2 0 1 Blood creatine phosphokinase increased 6 0 1 Prothrombin time prolonged 1 0 0 Gamma-glutamyltransferase increased 1 0 1 Liver function test abnormal 5 0 1 Oxygen saturation decreased 1 0 1 Blood glucose decreased 1 0 0 Blood glucose increased 1 0 1 Electroencephalogram abnormal 1 0 0 Apgar score low 1 0 1 Respiratory rate increased 1 0 0 Weight decreased 11 0 9 Weight increased 5 0 4 C-reactive protein increased 1 0 1 Blood creatinine increased 1 0 1 Drug level decreased 1 0 0 Drug level increased 4 2 0 Investigations 50 2 23 Metabolism and nutrition disorders Decreased appetite 11 0 8 Musculoskeletal and connective tissue disorders Tetany 2 0 0 Hypomagnesaemia 1 0 0 Electrolyte imbalance 1 0 0 Polydipsia 1 0 1 Hyperkalaemia 3 0 2 Hypokalaemia 3 0 1 Hypernatraemia 2 0 2 Hyponatraemia 64 0 33 Dehydration 2 0 1 Alcohol intolerance 1 0 0 Diabetes mellitus 1 0 0 Hyperinsulinaemia 2 0 2 Hypoglycaemia 1 0 1 Hypoglycaemia neonatal 1 0 1 Metabolism and nutrition disorders 96 0 52 Exostosis 1 0 1 Bone pain 1 0 1 Sjogren's syndrome 1 0 1 Arthralgia 4 0 4 Joint stiffness 1 0 1 Myalgia 13 0 11 Muscle spasms 4 0 4 25/09/2009-5 - 10:31:03 AM

Musculoskeletal and connective tissue disorders Neoplasms benign, malignant and unspecified (incl cysts and polyps) Muscle twitching 6 0 4 Muscle rigidity 3 0 0 Trismus 2 0 2 Muscular weakness 1 0 1 Rhabdomyolysis 1 0 0 Musculoskeletal stiffness 1 0 0 Back pain 3 0 2 Pain in extremity 1 0 1 Musculoskeletal and connective tissue disorders 43 0 33 Langerhans' cell granulomatosis 1 0 1 Lymphoma 1 0 0 Neoplasms benign, malignant and unspecified (incl cysts and polyps) 2 0 1 Nervous system disorders Cerebral haemorrhage 1 0 0 Cerebrovascular disorder 1 0 1 Drug withdrawal headache 1 0 1 Headache 43 0 31 Migraine 3 0 2 Brain oedema 1 0 1 Dementia 1 0 0 Amnesia 6 0 5 Memory impairment 2 0 2 Cognitive disorder 1 0 0 Disturbance in attention 8 0 7 Chorea 1 0 0 Akathisia 5 0 3 Bradykinesia 1 0 1 Clumsiness 1 0 1 Dyskinesia 4 0 1 Extrapyramidal disorder 7 0 6 Hyperkinesia 5 0 4 Hypokinesia 3 0 0 Tardive dyskinesia 3 0 1 Dystonia 8 0 5 Opisthotonus 1 0 1 Paresis 1 0 0 Tremor 48 0 30 Hyperreflexia 6 0 2 Ataxia 5 0 3 Balance disorder 1 0 0 Coordination abnormal 5 0 4 25/09/2009-6 - 10:31:03 AM

Nervous system disorders Nystagmus 2 0 0 Pregnancy, puerperium and perinatal conditions Coma 4 0 3 Coma hepatic 1 0 1 Aphasia 1 0 0 Consciousness fluctuating 3 0 1 Depressed level of consciousness 4 0 2 Lethargy 4 0 3 Loss of consciousness 5 0 2 Sedation 1 0 0 Somnolence 20 0 12 Syncope 12 1 6 Dizziness 34 0 24 Myoclonus 6 0 1 Crying 2 0 2 Burning sensation 2 0 2 Formication 2 0 2 Paraesthesia 23 0 20 Ageusia 2 0 2 Dysgeusia 2 0 2 Hypoaesthesia 7 0 6 Restless legs syndrome 1 0 1 Sensory disturbance 1 0 1 Dysarthria 7 0 4 Speech disorder 1 0 1 Hypertonia 14 0 6 Neuroleptic malignant syndrome 4 0 0 Serotonin syndrome 35 0 10 Muscle contractions involuntary 1 0 1 Myasthenic syndrome 2 0 2 Neuropathy peripheral 1 0 1 Grand mal convulsion 5 0 4 Convulsion 23 0 13 Epilepsy 1 0 0 Nervous system disorders 406 1 247 Intra-uterine death 1 1 0 Stillbirth 1 1 0 Foetal cardiac disorder 1 1 1 Foetal disorder 1 1 1 Foetal distress syndrome 1 0 1 Pre-eclampsia 1 0 1 Neonatal disorder 2 0 2 Meconium stain 1 0 1 25/09/2009-7 - 10:31:03 AM

Pregnancy, puerperium and perinatal conditions Pregnancy, puerperium and perinatal conditions 9 4 7 Psychiatric disorders Agitation 44 0 29 Agitation neonatal 1 0 1 Anxiety 28 0 17 Nervousness 6 0 3 Tension 1 0 1 Fear 1 0 0 Panic attack 5 0 4 Panic disorder 1 0 0 Neurosis 4 0 4 Restlessness 3 0 3 Automatism 1 0 0 Bruxism 8 0 6 Screaming 1 0 1 Confusional state 52 0 28 Disorientation 2 0 2 Delirium 8 0 2 Depression 8 0 5 Depersonalisation 9 0 9 Dissociation 1 0 0 Delusion 2 0 2 Hallucination 25 0 13 Hallucination, auditory 3 0 2 Hallucination, visual 2 0 2 Thinking abnormal 2 0 2 Eating disorder 1 0 0 Hypomania 1 0 1 Mania 10 0 8 Affect lability 3 0 2 Anger 2 0 1 Euphoric mood 1 0 1 Mood altered 2 0 1 Mood swings 3 0 2 Aggression 13 0 6 Homicidal ideation 5 0 1 Indifference 1 0 1 Paranoia 2 0 2 Violence-related symptom 1 0 0 Abnormal behaviour 4 0 1 Hypervigilance 1 0 1 Mental disorder 1 0 1 25/09/2009-8 - 10:31:03 AM

Psychiatric disorders Withdrawal syndrome 12 0 8 Acute psychosis 1 0 0 Psychotic disorder 2 0 2 Anorgasmia 4 0 4 Libido decreased 7 0 7 Insomnia 18 0 12 Sleep attacks 1 0 1 Abnormal dreams 1 0 1 Abnormal sleep-related event 2 1 0 Nightmare 17 0 12 Sleep disorder 6 0 5 Completed suicide 3 3 1 Intentional self-injury 1 0 1 Self injurious behaviour 1 0 1 Self-injurious ideation 1 0 0 Suicidal ideation 16 0 10 Suicide attempt 18 0 9 Psychiatric disorders 380 4 239 Renal and urinary disorders Tubulointerstitial nephritis 4 0 2 Anuria 1 0 0 Renal failure 2 0 2 Renal failure acute 5 0 1 Renal impairment 1 0 0 Renal tubular necrosis 1 0 1 Urethral disorder 1 0 0 Dysuria 3 0 2 Pollakiuria 3 0 2 Urethral pain 1 0 1 Urinary hesitation 2 0 1 Urinary incontinence 3 0 2 Urinary retention 5 0 4 Chromaturia 1 0 0 Haematuria 1 0 1 Nocturia 1 0 1 Polyuria 2 0 2 Renal pain 1 0 0 Renal and urinary disorders 38 0 22 Reproductive system and breast disorders Breast enlargement 1 0 1 Gynaecomastia 1 0 1 Breast pain 1 0 1 Galactorrhoea 6 0 6 Suppressed lactation 1 0 1 25/09/2009-9 - 10:31:03 AM

Reproductive system and breast disorders Premenstrual syndrome 1 0 1 Amenorrhoea 1 0 0 Penile size reduced 1 0 1 Penis disorder 1 0 1 Genital ulceration 1 0 1 Perineal pain 1 0 1 Ejaculation delayed 1 0 1 Ejaculation disorder 1 0 1 Ejaculation failure 3 0 3 Erectile dysfunction 9 0 6 Priapism 1 0 0 Sexual dysfunction 2 0 2 Uterine haemorrhage 1 0 1 Vaginal haemorrhage 1 0 1 Vulval ulceration 1 0 1 Vulval erythema 1 0 1 Reproductive system and breast disorders 37 0 32 Respiratory, thoracic and mediastinal disorders Asthma 2 0 1 Interstitial lung disease 1 0 1 Pulmonary fibrosis 1 0 1 Pulmonary hypertension 1 0 0 Pulmonary embolism 1 1 0 Apnoea 1 0 1 Dyspnoea 18 1 11 Hyperventilation 3 0 3 Hypoventilation 1 0 1 Respiratory depression 1 1 0 Hypoxia 2 1 0 Cough 9 0 8 Sputum increased 1 0 1 Hiccups 1 0 1 Respiratory failure 1 1 0 Aspiration 1 0 1 Respiratory disorder 2 0 2 Dysphonia 1 0 1 Sneezing 1 0 1 Snoring 1 0 1 Throat irritation 1 0 1 Yawning 3 0 3 Stridor 1 0 0 Nasal congestion 1 0 0 Epistaxis 1 0 1 25/09/2009-10 - 10:31:03 AM

Respiratory, thoracic and mediastinal disorders Nasal dryness 1 0 1 Pharyngeal oedema 1 0 1 Respiratory, thoracic and mediastinal disorders 59 5 42 Skin and subcutaneous tissue disorders Angioedema 5 0 5 Periorbital oedema 5 0 5 Urticaria 16 0 16 Mechanical urticaria 1 0 1 Blister 2 0 0 Dry skin 3 0 3 Skin burning sensation 1 0 1 Skin discolouration 1 0 1 Dermatitis 1 0 1 Drug eruption 1 0 1 Erythema 2 0 1 Rash erythematous 5 0 5 Dermatitis exfoliative 1 0 0 Exfoliative rash 1 0 1 Skin exfoliation 1 0 1 Lichen sclerosus 1 0 0 Rash papular 1 0 1 Photosensitivity reaction 1 0 1 Pruritus 21 0 14 Rash pruritic 2 0 2 Psoriasis 1 0 1 Fixed eruption 1 0 1 Rash 27 0 19 Rash generalised 1 0 0 Rash macular 1 0 0 Rash maculo-papular 5 0 2 Erythema nodosum 1 0 1 Acne 1 0 0 Alopecia 6 0 3 Cold sweat 2 0 1 Hyperhidrosis 43 1 27 Nail disorder 1 0 1 Henoch-Schonlein purpura 1 0 1 Increased tendency to bruise 1 0 1 Purpura 4 0 4 Skin and subcutaneous tissue disorders 168 1 122 Social circumstances Walking disability 1 0 0 Social circumstances 1 0 0 25/09/2009-11 - 10:31:03 AM

Surgical and medical procedures Abortion induced 1 1 1 Drug therapy changed 12 0 10 Therapy regimen changed 6 0 3 Surgical and medical procedures 19 1 14 Vascular disorders Peripheral ischaemia 2 0 1 Circulatory collapse 5 0 1 Hypotension 5 1 3 Orthostatic hypotension 4 0 1 Deep vein thrombosis 1 1 0 Flushing 6 0 4 Hot flush 5 0 4 Pallor 1 1 0 Hypertension 9 0 6 Arteritis 1 0 0 Vasculitis 1 0 0 Vascular disorders 40 3 20 1961 39 1276 25/09/2009-12 - 10:31:03 AM

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