ALPHA BLOCKERS. Products Affected Step 1: Details. Step 2: Rapaflo 4 mg capsule Rapaflo 8 mg capsule

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CHRISTUS Health Plan Generations (HMO) CHRISTUS Health Plan Generations Plus (HMO) 2018 Premier Performance Standard Step Therapy PLEASE READ: THIS DOCUMENT CONTAINS INFORMATION ABOUT SOME OF THE DRUGS WE COVER IN THIS PLAN. HPMS Approved Formulary File Submission ID 00018064, Version Number 16 This step therapy criteria was updated on 10/25/2018. For questions, please contact CHRISTUS Health Plan Generations (HMO), CHRISTUS Health Plan Generations Plus Member Services, at 1-844-282-3026 or, for TTY users, 711, 8 a.m. 8 p.m. local time, seven days a week, from October 1 March 31, and 8 a.m. 8 p.m. local time, Monday Friday, from April 1- September 30, or visit https://www.christushealthplan.org/ H1189_MC930_C 10/31/2018 1

ALPHA BLOCKERS alfuzosin ER 10 mg tablet,extended tamsulosin 0.4 mg capsule release 24 hr terazosin 1 mg capsule doxazosin 1 mg tablet terazosin 10 mg capsule doxazosin 2 mg tablet terazosin 2 mg capsule doxazosin 4 mg tablet terazosin 5 mg capsule doxazosin 8 mg tablet Rapaflo 4 mg capsule Rapaflo 8 mg capsule may be given. 2

COLCRYS-PST Mitigare 0.6 mg capsule Colcrys 0.6 mg tablet If the patient has tried one Step 1 product, authorization for a Step 2 product may be given. Exceptions can be made for a step 2 drug (without a trial of a step 1 drug) for the treatment of Familial Mediterranean Fever and for the treatment of gout flares (i.e, prophylaxis of gout flares requires a trial of a step 1 drug). 3

DPP-4 INHIBITORS-PST Janumet 50 mg-1,000 mg tablet Janumet 50 mg-500 mg tablet Janumet XR 100 mg-1,000 mg tablet,extended release Janumet XR 50 mg-1,000 mg tablet,extended release Janumet XR 50 mg-500 mg tablet,extended release Januvia 100 mg tablet Januvia 25 mg tablet Jentadueto 2.5 mg-1,000 mg tablet Jentadueto 2.5 mg-500 mg tablet Jentadueto 2.5 mg-850 mg tablet Jentadueto XR 2.5 mg-1,000 mg tablet, extended release Jentadueto XR 5 mg-1,000 mg tablet, extended release Januvia 50 mg tablet Kombiglyze XR 2.5 mg-1,000 mg tablet,extended release Kombiglyze XR 5 mg-1,000 mg tablet,extended release Kombiglyze XR 5 mg-500 mg tablet,extended release Onglyza 2.5 mg tablet Onglyza 5 mg tablet Kazano 12.5 mg-1,000 mg tablet Kazano 12.5 mg-500 mg tablet Nesina 12.5 mg tablet Nesina 25 mg tablet Nesina 6.25 mg tablet Tradjenta 5 mg tablet may be given. 4

HIGH RISK MEDICATIONS - SEDATIVE HYPNOTICS Rozerem 8 mg tablet eszopiclone 1 mg tablet eszopiclone 2 mg tablet eszopiclone 3 mg tablet zaleplon 10 mg capsule zaleplon 5 mg capsule zolpidem 10 mg tablet zolpidem 5 mg tablet zolpidem ER 12.5 mg tablet,extended release,multiphase zolpidem ER 6.25 mg tablet,extended release,multiphase may be given. This step therapy program applies to patients greater than 64 years of age only.authorization for a step 2 drug may be given in patients aged less than 65 years. 5

OPHTHALMIC PROSTAGLANDINS-PST bimatoprost 0.03 % eye drops latanoprost 0.005 % eye drops Lumigan 0.01 % eye drops Travatan Z 0.004 % eye drops Zioptan (PF) 0.0015 % eye drops in a dropperette may be given. Authorization for Zioptan may be given if the patient has a known benzalkonium chloride (BAK) sensitivity or a known sensitivity to other ophthalmic preservatives. 6

ORAL BISPHOSPHONATES alendronate 10 mg tablet alendronate 35 mg tablet alendronate 40 mg tablet alendronate 5 mg tablet alendronate 70 mg tablet alendronate 70 mg/75 ml oral solution ibandronate 150 mg tablet risedronate 150 mg tablet risedronate 30 mg tablet risedronate 35 mg tablet risedronate 35 mg tablet (12 pack) risedronate 35 mg tablet (4 pack) risedronate 35 mg tablet,delayed release risedronate 5 mg tablet Fosamax Plus D 70 mg-2,800 unit tablet Fosamax Plus D 70 mg-5,600 unit tablet may be given. 7

RAPID-ACTING INSULIN-PST Humalog Junior KwikPen (U-100) 100 unit/ml subcutaneous half-unit pen Humalog KwikPen (U-100) Insulin 100 unit/ml subcutaneous Humalog KwikPen U-200 Insulin 200 unit/ml (3 ml) subcutaneous Humalog Mix 50-50 (U-100) Insulin 100 unit/ml subcutaneous suspension Humalog Mix 50-50 KwikPen U-100 Insulin 100 unit/ml subcutaneous pen Apidra SoloStar U-100 Insulin 100 unit/ml subcutaneous pen Apidra U-100 Insulin 100 unit/ml subcutaneous solution Novolog Flexpen U-100 Insulin aspart 100 unit/ml subcutaneous Novolog Mix 70-30 FlexPen U-100 Insulin 100 unit/ml subcutaneous pen Humalog Mix 75-25 (U-100) Insulin 100 unit/ml subcutaneous suspension Humalog Mix 75-25 KwikPen U-100 insulin 100 unit/ml subcutaneous pen Humalog U-100 Insulin 100 unit/ml subcutaneous cartridge Humalog U-100 Insulin 100 unit/ml subcutaneous solution Novolog Mix 70-30 U-100 Insulin 100 unit/ml subcutaneous solution NOVOLOG PENFILL U-100 INSULIN ASPART 100 UNIT/ML SUBCUTANEOUS CARTRIDGE Novolog U-100 Insulin aspart 100 unit/ml subcutaneous solution may be given. 8

TOPICAL ACTINIC KERATOSIS-PST Carac 0.5 % topical cream diclofenac 3 % topical gel fluorouracil 2 % topical solution fluorouracil 5 % topical cream fluorouracil 0.5 % topical cream Zyclara 2.5 % topical cream pump fluorouracil 5 % topical solution imiquimod 5 % topical cream packet Picato 0.015 % topical gel Picato 0.05 % topical gel Zyclara 3.75 % topical cream pump may be given. 9

ULORIC allopurinol 100 mg tablet allopurinol 300 mg tablet Uloric 40 mg tablet Uloric 80 mg tablet may be given. Authorization may be given for Uloric if the patient has renal insufficiency or decreased renal function. Authorization may be given for Uloric if the patient is receiving concomitant medications that have significant drug-drug interactions with allopurinol, which are not noted with Uloric (eg, cyclosporine, chlorpropamide). 10

Index A alendronate 10 mg tablet... 7 alendronate 35 mg tablet... 7 alendronate 40 mg tablet... 7 alendronate 5 mg tablet... 7 alendronate 70 mg tablet... 7 alendronate 70 mg/75 ml oral solution... 7 alfuzosin ER 10 mg tablet,extended release 24 hr... 2 allopurinol 100 mg tablet... 10 allopurinol 300 mg tablet... 10 Apidra SoloStar U-100 Insulin 100 unit/ml subcutaneous pen... 8 Apidra U-100 Insulin 100 unit/ml subcutaneous solution... 8 B bimatoprost 0.03 % eye drops... 6 C Carac 0.5 % topical cream... 9 Colcrys 0.6 mg tablet... 3 D diclofenac 3 % topical gel... 9 doxazosin 1 mg tablet... 2 doxazosin 2 mg tablet... 2 doxazosin 4 mg tablet... 2 doxazosin 8 mg tablet... 2 E eszopiclone 1 mg tablet... 5 eszopiclone 2 mg tablet... 5 eszopiclone 3 mg tablet... 5 F fluorouracil 0.5 % topical cream... 9 fluorouracil 2 % topical solution... 9 fluorouracil 5 % topical cream... 9 fluorouracil 5 % topical solution... 9 Fosamax Plus D 70 mg-2,800 unit tablet... 7 Fosamax Plus D 70 mg-5,600 unit tablet... 7 H Humalog Junior KwikPen (U-100) 100 unit/ml subcutaneous half-unit pen... 8 Humalog KwikPen (U-100) Insulin 100 unit/ml subcutaneous... 8 Humalog KwikPen U-200 Insulin 200 unit/ml (3 ml) subcutaneous... 8 Humalog Mix 50-50 (U-100) Insulin 100 unit/ml subcutaneous suspension... 8 Humalog Mix 50-50 KwikPen U-100 Insulin 100 unit/ml subcutaneous pen... 8 Humalog Mix 75-25 (U-100) Insulin 100 unit/ml subcutaneous suspension... 8 Humalog Mix 75-25 KwikPen U-100 insulin 100 unit/ml subcutaneous pen... 8 Humalog U-100 Insulin 100 unit/ml subcutaneous cartridge... 8 Humalog U-100 Insulin 100 unit/ml subcutaneous solution... 8 I ibandronate 150 mg tablet... 7 imiquimod 5 % topical cream packet... 9 J Janumet 50 mg-1,000 mg tablet... 4 Janumet 50 mg-500 mg tablet... 4 Janumet XR 100 mg-1,000 mg tablet,extended release... 4 Janumet XR 50 mg-1,000 mg tablet,extended release... 4 Janumet XR 50 mg-500 mg tablet,extended release... 4 Januvia 100 mg tablet... 4 Januvia 25 mg tablet... 4 Januvia 50 mg tablet... 4 Jentadueto 2.5 mg-1,000 mg tablet... 4 Jentadueto 2.5 mg-500 mg tablet... 4 Jentadueto 2.5 mg-850 mg tablet... 4 Jentadueto XR 2.5 mg-1,000 mg tablet, extended release... 4 Jentadueto XR 5 mg-1,000 mg tablet, extended release... 4 K Kazano 12.5 mg-1,000 mg tablet... 4 Kazano 12.5 mg-500 mg tablet... 4 Kombiglyze XR 2.5 mg-1,000 mg tablet,extended release... 4 Kombiglyze XR 5 mg-1,000 mg tablet,extended release... 4 Kombiglyze XR 5 mg-500 mg tablet,extended release... 4 11

L latanoprost 0.005 % eye drops... 6 Lumigan 0.01 % eye drops... 6 M Mitigare 0.6 mg capsule... 3 N Nesina 12.5 mg tablet... 4 Nesina 25 mg tablet... 4 Nesina 6.25 mg tablet... 4 Novolog Flexpen U-100 Insulin aspart 100 unit/ml subcutaneous... 8 Novolog Mix 70-30 FlexPen U-100 Insulin 100 unit/ml subcutaneous pen... 8 Novolog Mix 70-30 U-100 Insulin 100 unit/ml subcutaneous solution... 8 Novolog PenFill U-100 Insulin aspart 100 unit/ml subcutaneous cartridg... 8 Novolog U-100 Insulin aspart 100 unit/ml subcutaneous solution... 8 O Onglyza 2.5 mg tablet... 4 Onglyza 5 mg tablet... 4 P Picato 0.015 % topical gel... 9 Picato 0.05 % topical gel... 9 R Rapaflo 4 mg capsule... 2 Rapaflo 8 mg capsule... 2 risedronate 150 mg tablet... 7 risedronate 30 mg tablet... 7 risedronate 35 mg tablet... 7 risedronate 35 mg tablet (12 pack)... 7 risedronate 35 mg tablet (4 pack)... 7 risedronate 35 mg tablet,delayed release... 7 risedronate 5 mg tablet... 7 Rozerem 8 mg tablet... 5 T tamsulosin 0.4 mg capsule... 2 terazosin 1 mg capsule... 2 terazosin 10 mg capsule... 2 terazosin 2 mg capsule... 2 terazosin 5 mg capsule... 2 Tradjenta 5 mg tablet... 4 Travatan Z 0.004 % eye drops... 6 U Uloric 40 mg tablet... 10 Uloric 80 mg tablet... 10 Z zaleplon 10 mg capsule... 5 zaleplon 5 mg capsule... 5 Zioptan (PF) 0.0015 % eye drops in a dropperette... 6 zolpidem 10 mg tablet... 5 zolpidem 5 mg tablet... 5 zolpidem ER 12.5 mg tablet,extended release,multiphase... 5 zolpidem ER 6.25 mg tablet,extended release,multiphase... 5 Zyclara 2.5 % topical cream pump... 9 Zyclara 3.75 % topical cream pump... 9 12

This step therapy criteria was updated on 10/25/2018. For questions, please contact CHRISTUS Health Plan Generations (HMO), CHRISTUS Health Plan Generations Plus Member Services, at 1-844-282-3026 or, for TTY users, 711, 8 a.m. 8 p.m. local time, seven days a week, from October 1 March 31, and 8 a.m. 8 p.m. local time, Monday Friday, from April 1- September 30, or visit https://www.christushealthplan.org/ 13