Chapter 6: Hippocampal Function In Cognition From Mechanisms of Memory, second edition By J. David Sweatt, Ph.D.
Grid Cell
The Hippocampus Serves a Role in Multimodal Information Processing and Memory Consolidation
Functions of the Hippocampus Cognitive Processing: Space Timing Relationships Memory Consolidation
Hippocampal Connectivity in the CNS Visual Somatosensory Olfactory Sensory Regions Of Cortex Auditory Perirhinal/ Entorhinal Cortex Hippocampal Formation Perirhinal Cortex Entorhinal Cortex CA3 Dentate Gyrus CA1
Theta Pattern in Hippocampal EEG
Functions of the Hippocampus Cognitive Processing: Space Time Relationships
Virtual Maze Burgess N, Maguire EA, O'Keefe J. The human hippocampus and spatial and episodic memory Neuron. 2002 35:625-41.
MRI of Hippocampus fmri in Virtual Maze Navigation Morphometry of London Taxi Drivers Right Posterior Hippocampal Volume Correlates with Time Spent Driving Burgess N, Maguire EA, O'Keefe J. The human hippocampus and spatial and episodic memory. Neuron. 2002 35:625-41.
Hippocampal Output Pathway & Intrinsic Circuit A Entorhinal Cortex Perforant Pathway B CA3 CA1 Dentate Gyrus Entorhinal Cortex CA1 Outputs CA3 Mossy Fibers Schaffer Collaterals C CA1 Axon CA1 GABAergic Interneuron Norepinephrine Subiculum/ Entorhinal Cortex Lateral Septum Amygdala, Cortex Acetylcholine Serotonin Schaffer Collaterals
Hippocampal Output Pathway & Intrinsic Circuit A Entorhinal Cortex Perforant Pathway B CA3 CA1 Dentate Gyrus Entorhinal Cortex CA1 Outputs CA3 Mossy Fibers Schaffer Collaterals C CA1 Axon CA1 GABAergic Interneuron Norepinephrine Subiculum/ Entorhinal Cortex Lateral Septum Amygdala, Cortex Acetylcholine Serotonin Schaffer Collaterals
Figure 3 Comparative Views
Place Cell Firing Patterns
Types of Rodent Mazes Lashley Maze Finish 4 Arm Radial (Plus) Maze 8 Arm Radial Maze Start Triangle Maze T Maze Y Maze
Direction Selectivity in Place Cell Firing
Types of Rodent Mazes Lashley Maze Finish 4 Arm Radial (Plus) Maze 8 Arm Radial Maze Start Triangle Maze T Maze Y Maze
Courtesy Emma Wood and Howard Eichenbaum
Rotation of Visual Cues C B B Place Field D Rotate Visual Cues 90 A Place Field C A N D N Figure 7
Place Cells Fire in Corresponding Location Figure 8
Experience-Dependent Changes in Place Cell Firing A B Figure 9
Functions of the Hippocampus Cognitive Processing: Space Timing Relationships
Eye-Blink Conditioning in Rabbits Corneal Air Puff Elicits Eyeblink Response Corneal Air Puff Given with Tone Tone Given Alone Elicits Eyeblink Response
Courtesy of David Linden. JHU
Increased Hippocampal Neuron Firing during Trace Eyeblink Conditioning Mean Number of Spikes Time CS US
Increased Connectivity in Pyramidal Neurons with Eye-blink Conditioning A B a b Figure 11 c d
Functions of the Hippocampus Cognitive Processing: Space Time Relationships
4-arm Radial Maze with Local and Distal Cues
Double Rotation 4-arm Maze Experiment
Continuous Odor-guided Non- Matching to Sample
Task Related Firing Patterns of Hippocampal Pyramidal Neurons
Functions of the Hippocampus Cognitive Processing: Space Time Relationships
Percent Arc-positive CA1 neurons (mean ± s.e.) Arc and Cellular Reactivation Caged Context A, Context A, Context A Context A Context A Immediate delay re-place in A then Context B then context B, delayed Blue Box 2
Blue Box 1 Grid Cells in the Entorhinal Cortex
Functions of the Hippocampus Cognitive Processing: Space Time Relationships Memory Consolidation
Human Studies
MRI of HM s Brain lesions Surgeon s Estimate of H.M. s lesions Revised Estimate based on MRI
Functions of the Hippocampus Cognitive Processing: Space Timing Relationships Memory Consolidation