Experts News Source. Introducing Clinpro % Sodium Fluoride Anti-Cavity Toothpaste. News. A Formula for Success. Breakthrough Formulas

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Espertise December 2008 Experts News Source In this issue News......................... Introducing Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste Update........................ 3M ESPE Expands the Availability of Lava Chairside Oral Scanner C.O.S. News...................................... Vanish XT Extended Contact Varnish will Debut in 2009 News............................................ 3M ESPE Works to Serve the Dental Community Clinical Study............ Two 3M ESPE Restorative Products Receive Top Ratings from The Dental Advisor Results........................... Launch of Pentamix 3 Automatic Mixing Unit Exceeds Expectations Product Information Visit 3MESPE.com/preventivecare to learn more about these exciting new products. Introducing Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste News Developed with expertise of dental industry leaders, 3M ESPE Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste (Clinpro Tooth Crème 0.21% w/w Sodium Fluoride Anti- Cavity Paste with Tri-Calcium Phosphate) is an advanced prescription formula containing an innovative tri-calcium phosphate ingredient launching on January 15, 2009. A nonprescription version of the formula, Clinpro Tooth Crème, will be released internationally beginning February 2009. Both products are examples of 3M ESPE s commitment to creating and launching new products that target the specific needs of the market. Prevention is a key concern of both patients and dentists, and 3M ESPE is continually working on new solutions to promote oral health. Breakthrough Formulas These formulas represent a major breakthrough in anti-cavity toothpaste technology. Clinpro 5000 toothpaste contains fluoride as well as calcium and phosphate, which are components naturally found in saliva. During the manufacturing process, a protective barrier is created around the calcium allowing it to coexist with the fluoride ions. As the toothpaste comes in contact with saliva during brushing, the barrier breaks down and makes the calcium, phosphate and fluoride readily available to the tooth. The tooth naturally absorbs these Continued on page 7 A Formula for Success

Espertise Experts News Source 3M ESPE Expands the Availability of Lava Chairside Oral Scanner C.O.S. Update 3M ESPE is expanding the availability of its Lava Chairside Oral Scanner C.O.S., a digital impression system that enables the high-speed capture of accurate and precise impressions. A new business model, new indications, expansion into new regions, and distribution agreements make it possible for more dentists and labs to use the system and participate in the digital workflow. Product Information For more information and to register for seminars, go to www.3mespe.com/lavacos The latest on products, trends and techniques for dental industry leaders worldwide Published by 3M ESPE The opinions expressed in Espertise Experts News Source are not necessarily those of the publisher. We welcome your feedback and article proposals. Please submit them to the editor for consideration. Jean T. Madden, Editor, 3M ESPE Scientifi c Marketing Communications Manager 651-736-5281 phone 651-733-2481 fax jtmadden@mmm.com 3MESPE.com/espertise 3M ESPE Customer Care 1-800-634-2249 New Business Model, Additional Indications Widens Availability 3M ESPE s business model lets any dentist or lab in active regions participate in the digital workflow by utilizing a business model that requires no capital investment from a lab and allows doctors to work with their existing lab. This process is very similar to the highly successful business model labs have used for years to outsource their 3M ESPE Lava Copings to an Authorized Lava Milling Center. Additionally, with the release of 3M ESPE Lava Software 1.5 for Chairside Oral Scanner, the system is now indicated for single unit crowns, multiple adjacent units, inlay/onlays and three- or four-unit bridges. New Regions Offer New Opportunities 3M ESPE continues the launch of the Lava C.O.S. by expanding into the Mid-Atlantic, Southern Florida and Texas regions. These regions will complement existing operations in the Northeast, Upper Midwest, Pacific Northwest and Southern California regions. Additionally, Henry Schein, Burkhart Dental and Benco Dental are the first distributors of the device, and are responsible for installing, maintaining and servicing the Lava C.O.S. for dentists. 3M ESPE will continue discussions with additional qualified distributors as part of the non-exclusive distribution arrangement for the Lava C.O.S. 2

New Sprayer and Powder We are excited to announce our 3M ESPE Lava C.O.S. Sprayer and Powder is now available. This system supports our light dusting protocol by providing an even distribution of powder and enabling you to control the flow using the sprayer s trigger. Replacement powder or parts can be ordered through distributors. New Educational Opportunities Lava C.O.S. seminars are now open to any doctor practicing in the regions where we are currently active. If you attend a local study club, or have a colleague who is interested, help us spread the word on this exciting technology. Anyone interested in attending a seminar can visit our website for registration and a full listing of locations. Vanish XT Extended Contact Varnish Will Debut in 2009 News 3M ESPE is excited to announce the upcoming introduction of Vanish XT Extended Contact Varnish. Scheduled to become available in 2009, Vanish XT varnish is a site-specific, durable coating that forms an immediate layer of protection to relieve hypersensitivity without the need for isolation of the preparation. It releases fluoride, calcium and phosphate and the coating provides long-term protection against acid challenges. Dentin Permeability Occluding dentinal tubules in-office provides immediate relief from pain associated with the movement of fluid through open tubules. Laboratory studies demonstrate Vanish XT varnish penetrates dentin tubules and reduces dentin permeability by 88 percent. The coating remains on the tooth for 6 months or longer, giving long-lasting protection. fig. 1 Application of 3M ESPE Vanish XT Extended Contact Varnish 3

Espertise Experts News Source 3M ESPE Works to Serve the Dental Community News 3M ESPE is committed to supporting charitable initiatives as well as serving dental professionals and their patients by contributing to the field with new and innovative products. Dedicated to providing the very best in service and uncompromised quality in every step of development and production, 3M ESPE puts the resources of 3M to work for the dental field. 3M ESPE has the unique ability to combine innovative 3M technologies from across 45 technology platforms with dental practitioner insight to solve problems and come up with innovative, groundbreaking solutions. 3M ESPE Provides Value In a U.S. Omnibus study conducted in August 2008, a random sample of 250 dentists across the country were asked to assess the overall price and value of 3M ESPE along with several competitors. The results confirm that 3M ESPE is among the dental community s most trusted and valued partners. How would you rate each of the following dental manufacturers on the value they provide relative to the price of their products? Company Mean Top Two Ratings 3M ESPE 4.04 77% Dentsply 3.74 60% GC 3.90 70% Kulzer 3.49 48% Ivoclar 3.65 58% Ultradent 4.06 77% Volco 3.50 51% 0 10 20 30 40 50 60 70 80 90 100 Percentage (%) fig. 2 Results of the U.S. Omnibus Study 3M ESPE Supports the Causes that Matter to Our Customers 3M ESPE supports many philanthropic organizations that promote dental health and access to care research across the country and around the world. A recent donation to Oral Health America s Smiles Across America program will support their initiatives to help communities build infrastructure for community-based oral health services. We have had a longstanding partnership with Oral Health America, and are committed to helping them help care providers who are preventing oral disease and educating children about oral health s importance to overall health, said Steve Bonfig, Global Communications Manager, 3M ESPE. 4

Two 3M ESPE Restorative Products Receive Top Ratings from The Dental Advisor Clinical Study Both 3M ESPE Z100 and 3M ESPE Filtek Z250 Universal Restorative have received excellent (+++++) clinical ratings from The Dental Advisor, the highest rating the publication gives. The Dental Advisor ratings are based on the following clinical categories: resistance to fracture, esthetics, wear resistance and resistance to marginal discoloration. 3M ESPE Z100 restorative is an all-purpose, light-cured composite with zirconia filler particles. In the study, it was reviewed at 15 years and given a 96 percent clinical rating. Almost 130 restorations placed in 1992 1993 were recalled. After 15 years, more than 80 percent of the restorations showed no fractures or chipping. Less than 20 percent showed some minor chipping, but none of the restorations had required replacement. Very little shade change took place over the 15-year period, and more than 70 percent of the restorations still exhibited excellent shade match. 3M ESPE Z100 Universal Restorative Resistance to Fracture 81% 12% 7% 3M ESPE Filtek Z250 Universal Restorative Esthetics 72% 24% 4% Resistance to Marginal Discoloration 81% 15% 4% Wear Resistance 84% 16% 0 10 20 30 40 50 60 70 80 90 100 Percentage (%) Excellent Very Good Good Product Information For complete results see: www.dentaladvisor.com/publications Look in the Issue Archive for the June, 2008 issue. fig. 3 Clinical performance of Filtek Z100 at 15 years Filtek Z250 universal restorative is a direct universal composite for anterior and posterior use. For this study, more than 560 restorations were recalled and reviewed at nine years. Results showed that almost 95 percent of restorations recalled showed no chips or fractures. In addition, 98 percent were rated very good to excellent for esthetics; restorations remained smooth with stable color. Nearly 90 percent of the restorations showed no marginal discoloration at recall. Resistance to Fracture 94% 4% Esthetics 88% 10% 2% Resistance to Marginal Discoloration 88% 10% 2% Wear Resistance 93% 7% 0 10 20 30 40 50 60 70 80 90 100 Percentage (%) Excellent Very Good Good Fair fig. 4 3M ESPE Filtek Z250 rating at 9 years For complete results, see The Dental Advisor, June 2008. 5

Espertise Experts News Source Product Information For more information please go to www.3mespe.com/greatimpressions Launch of Pentamix 3 Automatic Mixing Unit Exceeds Expectations Results The recent launch of the 3M ESPE Pentamix 3 Automatic Mixing Unit was extremely successful. With the input and participation of dental industry leaders in the development of the Pentamix 3 unit, 3M ESPE developed a tool that truly meets the needs of practitioners. [fig. 5] High Ratings from Users In an evaluation which began last spring, Pentamix 3 units and surveys were sent to dental opinion leaders around the world. One hundred and eight questionaires were returned by October. In terms of overall satisfaction, the surveys showed that 93 percent of respondents found the Pentamix 3 better or much better than current mixing procedures. One hundred percent of respondents would recommend this device, and 99 percent would recommend the 3M ESPE impression materials used with the Pentamix 3 unit. fig. 5 The 3M ESPE Pentamix 3 Automatic Mixing Unit takes up less space and offers clinicians more usable working time with their impression material than other available mixers. About the Pentamix 3 Unit The Pentamix 3 unit is a new generation automatic mixer based on the success and experience gained with Pentamix 2 Unit, as well as the valuable input of practitioners throughout its development. The new device offers improved handling, speed, convenience and accuracy. It dispenses all Penta Materials from 3M ESPE, including Impregum Polyether, Imprint 3 VPS Impression Material and Express VPS Impression Materials, twice as fast as its predecessor Pentamix 2 unit and faster than any other automatic mixing unit on the market. 6

Introducing Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste continued from front page components, helping to prevent the initiation and further progression of demineralization by allowing remineralization to occur. To learn more about Clinpro 5000 toothpaste and its breakthrough technology, visit 3MESPE.com/preventivecare. F CaO CaO CaO CaO F F fig. 6 Saliva activates the calcium compound, breaking down the protective coating and making it available to the tooth. Developed with Top Experts The development of these formulas is the result of a relationship between 3M ESPE and Indiana Nanotech scientists. 3M ESPE enlisted world-renowned and expert caries researchers to become part of the development team. Key players included Dr. George Stookey, a pioneer in caries research and key contributor to developing the world s first clinically proven fluoride toothpaste, Dr. Robert Karlinsey, an emerging leader in developing dental and biomedical technology applications and the 3M ESPE Prevention Research Team led by Aaron Pfarrer. 7

New products APRIL 3M ESPE Filtek LS Low Shrink Posterior Restorative (North America); Filtek P90 Low Shrink Posterior Restorative (Latin America/Asia); Filtek Silorane Low Shrink Posterior Restorative (WE/EE/ Australia/New Zealand) JULY 3M ESPE Avagard D Instant Hand Antiseptic with Moisturizers 3M ESPE Pentamix 3 Automatic Mixing Unit AUGUST 3M ESPE Protemp Plus Temporization Material COMING IN 2009 Vanish XT Extended Contact Varnish 3M ESPE Clinpro 5000 1.1% Sodium Fluoride Anti-Cavity Toothpaste (Clinpro Tooth Créme 0.21% w/w Sodium Fluoride Anti-Cavity Paste with Tri-Calcium Phosphate) Dental Products 3M Center Building 275-2SE-03 St. Paul, MN 55144-1000 USA 3M Canada Post Offi ce Box 5757 London, Ontario N6A 4T1 Canada 1 888 363-3685 3M, Adper, Avagard, Clinpro, ESPE, Espertise, Expess, Filtek, Impregum, Lava, Penta, Pentamix, Protemp, Vanish, Z100 and Z250 and are trademarks of 3M or 3M ESPE AG. Please recycle. Printed in U.S.A. 3M 2008. All rights reserved.