1 Revised 3/7/2013 Curriculum Vitae Yosef Jose Greenspon, M.D. Personal Information Professional Address Phone 314-577-5629 Fax 314-268-6454 Current Position, Institution and start date Include faculty appointment with rank as well as administrative roles Assistant Professor of Surgery; Pediatric Surgery SSM Cardinal Glennon Children s Medical Center 1465 South Grand Boulevard St. Louis, MO 63104 Education Postgraduate Clinical training: Pediatric Surgery Fellow 07/10-06/12 St. Louis Children s Hospital/Washington University SOM Role of sphingolipids (S1P) and polyamines in intestinal epithelial cell integrity and apoptosis Cell Physiology Laboratory Department of Surgery University Chief Resident of Surgical Education 07/09-06/10 University of Maryland Medical System Resident in Surgery 07/04-06/05 University of Maryland Medical System 07/07-06/09 Categorical Intern in Surgery 07/03-06/04 University of Maryland Medical System
2 Postgraduate Research: Research Fellow 06/05-06/07 Role of sphingolipids (S1P) and polyamines in intestinal epithelial cell integrity and apoptosis Cell Physiology Laboratory Department of Surgery University of Maryland School of Medicine and Baltimore VA Medical Center Graduate degree and major, University George Washington University School of Medicine 07/99-05/03 Washington, D.C. Doctor of Medicine Undergraduate degree and major, University University of Maryland, College Park 07/96-06/99 College Park, MD B.S. in Microbiology Languages English, Spanish Board Certification and Licensure Certification organization(s) American Board of Surgery, General Surgery American Board of Surgery, Pediatric Surgery 3/2011 3/2013 Licensure(s) Missouri State Medical License 07/10-pres District of Columbia Medical License, inactive 5/06-7/08 Maryland State Medical License, inactive 5/06-7/08
3 Professional Society memberships National American Pediatric Surgical Association, Candidate Member 2011 American College of Surgeons, Resident Member 2005-2009 Honorary Societies, Honors and Awards Named Lectureships as well as other honors 1. Sponseller Surgical Research Award, Second Place 2008 University of Maryland School of Medicine 2. Sponseller Surgical Research Award 2007 University of Maryland School of Medicine 3. NIH Research Training Fellowship in Gastroenterology 2006-2007 Principal Investigator: Jean-Pierre Raufman, M.D. (two-year fellowship award) 4. Department of Surgery Education Award 2006 5. Arnold P. Gold Humanism and Honor Society Resident Award 2006 6. Humanism and Excellence in Teaching Resident Award 2005 University of Maryland School of Medicine 7. Alpha Omega Alpha Medical Honor Society 2005 8. Sigma Alpha Omicron Microbiology Honor Award 1999 University of Maryland, College Park 9. Who's Who Among American College Students 1998 10. OMSE Academic Excellence Honors 1997-1999 University of Maryland, College Park 11. Dean s List (five semesters), University of Maryland, College Park 1995-1999 Professional Services (Note: in reverse chronological order) Committee memberships (include in the following order): Department
4 Clinical Information Systems, Committee on Perioperative Care, 2007-2010 UMSOM General Surgery Curriculum Committee, UMSOM 2005-2010 Webmaster University of Maryland General Surgery Resident Site, 2005-2008 UMSOM Current and Past Teaching Responsibilities (Note: in reverse chronological order) (Note: reference Clinical Educator Portfolio, if appropriate) Courses and lectures or topics Medical Student General Surgery Clerkship Lecturer, UMSOM 2004-2010 Anatomy Instruction. University of Maryland School of Medicine 2003-2008 (UMSOM) Participated in medical student instruction of abdominal and thoracic gross anatomy Thalamus Club, George Washington University School of Medicine 1999-2001 Instructed underclassmen in dissection anatomy/neuroanatomy Research Support (Note: in reverse chronological order) Current funding: NONE start/end dates (mm/yy) University of Maryland School of Medicine, Dept of Surgery, 2006-2008 Division of Pediatric Surgery. Samuel Alaish, M.D., Terez Shea-Donohue, Ph.D. Studied the role of genetic polymorphisms in response to cholestatic injury in mice. University of Maryland School of Medicine & Baltimore VA 2005-2007 Medical Center, Jin-Yiang Wang, M.D., Ph.D., Douglas J. Turner, M.D., Terez Shea-Donohue, Ph.D. George Washington University Medical Center 2002-2003 Bruce A. Orkin, M.D. Studied the role of surgical versus expectant management in recurrence of thrombosed external hemorrhoids. George Washington University Medical Center 2002 Bruce A. Orkin, M.D. Worked on characterization of anal carcinoma - in situ progression in HIV-positive versus noninfected patients.
5 National Institute of Child Health and Human Development, NIH 1999 Doug J. Fields, M.D., Ph.D. Explored the effects of impulse activity on gene expression, myelination, and synaptic function of neurons. National Institute of Neurological Disorders and Stroke, NIH 07/98-04/99 John Hallenbeck, M.D. Studied the role of NF-κB with intranuclear p300, to chemical (TNF-α exposure) and hypoxic tolerance in astrocytes and neurons. University of Maryland, College Park Summer 1998 Stephen Hutcheson, Ph.D. Developed protocols for the use of mutant strains of Xanthomonas in surveillance of plant pathogens in the environment.
6 Bibliography (Note: numbered & in chronological order here only, underline your name in the reference) Peer reviewed articles: Papers published, in press, or accepted for publication in peerreviewed journals; all authors, full title, journal, per PubMed format 1. Ginis I, Jaiswal R, Klimanis D, Liu J, Greenspon J, Hallenbeck JM. TNF-alpha-induced tolerance to ischemic injury involves differential control of NF-kappaB transactivation: the role of NF-kappaB association with p300 adaptor. J Cereb Blood Flow Metab. 2002 Feb;22(2):142-152. 2. Greenspon J, Williams SB, Young HA, Orkin BA. Thrombosed external hemorrhoids: outcome after conservative or surgical management. Dis Colon Rectum. 2004 Sep;47(9):1493-1498. 3. Williams SB, Greenspon J, Young HA, Orkin BA. Small bowel obstruction: conservative vs. surgical management. Dis Colon Rectum. 2005 Jun;48(6):1140-1146. 4. Liu L, Guo X, Rao, JN, Zou, TT, Marasa BS, Greenspon J, Casero RA, Wang J-Y. Polyamine-Modulated c-myc Regulates p21 Transcription through proximal region of its promoter in normal intestinal epithelium. Biochem J. 2006 Sep 1;398(2):257-67. 5. Turner DJ, Martin PC, Rao JN, Greenspon J, Zou T, Bass BL, Wang JY, Strauch ED. Substance P regulates migration in rat intestinal epithelial cells. Ann Surg. 2007 Mar; 245(3):408-414. 6. Greenspon J, Li R, Rao JN, Strauch ED, Wang JY, Turner DJ. Sphingosine-1-Phosphate upregulates E-cadherin and enhances intestinal mucosal permeability. J Surg Res. 2007;137(2):256. 7. Greenspon J, Li R, Rao JN, Marasa BS, Zhang AH, Strauch ED, Wang JY, Turner DJ. Sphingosine-1-Phosphate protects intestinal epithelial from apoptosis through Akt activation. Dig Dis Sci 2009 Mar;54(3):499-510. Epub 2008 Jul 25. 8. Alaish SM, Greenspon J, Strauch ED, Sun CC. Intraabdominal pulmonary sequestration presenting with elevated urinary normetanephrine levels. J Pediatr Surg. 2009 Mar;44(3):e11-4. 9. Greenspon J, Perrone E, Alaish SM. Shoshin Beriberi mimicking central line sepsis in a child with short bowel syndrome. World J Pediatr. 2010 Nov;6(4):366-368. Book chapters, monographs, case reports, electronic media, non-peer reviewed articles (mm/yy) 1. Greenspon J, Fialkowski E, Warner BW. Necrotizing Enterocolitis in Pediatric Gastroenterology: A Color Handbook. In preparation.
7 Abstracts include dates (mm/yy) 1. Liu L, Guo X, Rao JN, Zou TT, Marasa BS, Greenspon J, Casero RA, Wang J-Y. Induced c-myc regulates p21 transcription through proximal region of its promoter following increased polyamines in normal intestinal epithelial cells. Gastroenterology 2006;130:A540. 2. Marasa BS, Rao JN, Zou TT, Liu L, Greenspon J, Casero RA, Wang JY. Induced TRPC- 1 expression sensitizes intestinal epithelial cells to apoptosis by inhibiting NF-κB signaling pathway through a process involving Ca 2+ influx. Gastroenterology 2006;130:A330. 3. Marasa BS, Rao JN, Zou TT, Liu L, Greenspon J, Xiao L, Zhang AH, Chen J, Turner DJ, Wang JY. Induced TRPC-1 expression in intestinal epithelial cells increases protein phosphatase-2a through Ca 2+ influx leading to inhibition of NF-κB activation. Gastroenterology 2006;130:A000. Presentations & Posters Clarify accepted as Posters/Oral Presentations National/International Meetings 1. Greenspon J, Li R, Rao JN, Strauch ED, Wang JY, Turner DJ. Sphingosine-1-phospate Regulates Intestinal Epithelial Cell Apoptosis Via Akt Activation. Presentation #26- GI/Small Bowel I. 2 nd Annual Academic Surgical Congress, Phoenix, AZ. February 6-9, 2007. 2. Greenspon J, Li R, Rao JN, Strauch ED, Wang JY, Turner DJ. Sphingosine-1-phospate Upregulates E-cadherin & Enhances Intestinal Epithelial Barrier Function. Oral Poster #P46. 2 nd Annual Academic Surgical Congress, Phoenix, AZ. February 6-9, 2007. 3. Greenspon J, Rao JN, Li R, Strauch ED, Marasa BS, Wang JY, Turner DJ. Enhancement of Intestinal Epithelial Cell Barrier Function by Sphingosine-1-Phosphate. Poster #S1563/AGA Institute. Digestive Disease Week 2007, Washington, D.C. May 19-24, 2007. 4. Shah P, Greenspon J, Cunningham S, Daly B. Widening Spectrum of Causes for Portal Venous Gas in the Interventional Era. Presentation G15031. Radiological Society of North America Convention. Chicago, IL. November 25-30, 2007. 5. Greenspon J, Li R, Rao JN, Strauch ED, Wang JY, Turner DJ. Sphingosine-1-phospate Enhances Intestinal Barrier Function Through Paracellular Protein Manipulation. Presentation #412-GI IV: Small Bowel & Colon. 3 rd Annual Academic Surgical Congress, Huntington Beach, CA February 12-15, 2008.