University of Groningen Neurodevelopmental outcome of children born following assisted reproductive technology Middelburg, Karin Janette IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2011 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Middelburg, K. J. (2011). Neurodevelopmental outcome of children born following assisted reproductive technology: 0-2 years. Groningen: s.n. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 12-04-2019
NEURODEVELOPMENTAL OUTCOME OF CHILDREN BORN FOLLOWING ASSISTED REPRODUCTIVE TECHNOLOGY 0-2 YEARS
The studies in this thesis have been carried out with financial support from the University Medical Center Groningen (grant 754510), the Dutch Organisation for Health Research and Development, (ZonMw grant 945-03-013 follow-up), the Research School of Behavioural and Cognitive Neurosciences and the Cornelia Stichting. Publication of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, Origio Benelux B.V., Goodlife Fertility B.V., Ferring B.V., Memidis Pharma B.V., MDT Artworks B.V. and Merck Sharp & Dome B.V.. Their support is gratefully acknowledged. K.J. Middelburg, 2011 All rights are reserved. No parts of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means - electronic, mechanical, photocopy, recording or otherwise - without prior written permission of the author or the corresponding journal. ISBN: 978-90-367-5096-7 Cover and lay-out by Michiel Mellens, NetzoDruk Groningen. Printed by NetzoDruk, Groningen.
NEURODEVELOPMENTAL OUTCOME OF CHILDREN BORN FOLLOWING ASSISTED REPRODUCTIVE TECHNOLOGY 0-2 YEARS Proefschrift ter verkrijging van het doctoraat in de Medische Wetenschappen aan de Rijksuniversiteit Groningen op gezag van de Rector Magnificus, dr. E. Sterken, in het openbaar te verdedigen op woensdag 28 september 2011 om 16.15 uur door Karin Janette Middelburg geboren op 24 juli 1979 te Assen
Promotores Prof. dr. M. Hadders-Algra Prof. dr. M.J. Heineman Prof. dr. A.F. Bos Beoordelingscommissie Prof. dr. F.M. Helmerhorst Prof. dr. J.H. Kok Prof. dr. C.M. Bilardo
CONTENTS Chapter 1 General Introduction 7 Part I Chapter 2 Literature review Neuromotor, cognitive, language and behavioural outcome in children born following IVF or ICSI a systematic review 17 17 Part II Chapter 3 Chapter 4 Chapter 5 Chapter 6 The Groningen ART cohort study Ovarian hyperstimulation and the in vitro fertilization procedure do not influence early neuromotor development, a history of subfertility does Ovarian hyperstimulation and the in vitro procedure do not affect neurological outcome in infancy The effects of ovarian hyperstimulation and the IVF laboratory procedures on neurological condition at 2 years Developmental status and behaviour at 2 years 41 41 59 75 93 Part III Chapter 7 Chapter 8 Follow-up of children born after IVF with Preimplantation Genetic Screening Neurological condition of infants born after IVF with preimplantation genetic screening Mental, psychomotor, neurological, and behavioural outcome of 2-year-old children born following preimplantation genetic screening: follow-up of a randomised controlled trial 107 107 121 Part IV Chapter 9 Chapter 10 General discussion, future perspectives and summary General discussion and future perspectives Summary & Samenvatting 133 133 143 References Dankwoord Over de auteur List of publications 153 166 171 173
endless forms most beautiful and most wonderful have been, and are being evolved from so simple a beginning adapted from Charles Darwin, Origin of Species, 1859 Voor mijn ouders