University of Groningen A geriatric perspective on chronic kidney disease Bos, Harmke Anthonia IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2019 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Bos, H. A. (2019). A geriatric perspective on chronic kidney disease: The three M's. [Groningen]: Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 12-04-2019
A geriatric perspective on chronic kidney disease The three M s Harmke A. Polinder-Bos
Harmke A. Polinder-Bos A geriatric perspective on chronic kidney disease. The three M s PhD dissertation University of Groningen, The Netherlands Financial support by the University of Groningen, Graduate School of Medical Sciences, Alzheimer Nederland, Beter Healthcare B.V., Chipsoft, Dialysis Center Groningen, Dutch Kidney Foundation, Fresenius Medical Care B.V., HMZ Fashiongroup B.V. (Lemon & Soda), and Nekst IT B.V. for the printing of this thesis is gratefully acknowledged. ISBN: 978-94-034-1174-3 (printed version) ISBN: 978-94-034-1173-6 (digital version) Cover design: Ilse Modder, www.ilsemodder.nl Lay out and printed by: Gildeprint, Enschede Copyright 2018 H.A. Polinder-Bos. All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording or otherwise, without the permission of the author.
A geriatric perspective on chronic kidney disease The three M s Proefschrift A geriatric perspective on chronic kidney disease ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen The three M s op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties De openbare verdediging Proefschrift zal plaatsvinden op woensdag 9 januari 2019 om 12.45 uur ter verkrijging van de graad van doctor aan de door Rijksuniversiteit Groningen op gezag van de rector Harmke magnificus Anthonia prof. dr. Bos E. Sterken en volgens besluit van het College voor Promoties geboren op 14 juni 1984 De openbare verdediging te Zeist zal plaatsvinden op woensdag 9 januari 2019 om 12.45 uur door Harmke Anthonia Bos geboren op 14 juni 1984 te Zeist
Promotores Prof. dr. C.A.J.M. Gaillard Prof. dr. R.T. Gansevoort Copromotor Dr. C.F.M. Franssen Beoordelingscommissie Prof. dr. S.E.J.A. de Rooij Prof. dr. S.J. Berger Prof. dr. P.M. ter Wee Paranimfen E.A. Luitwieler-Blok, MSc Drs. A.C. Slotboom-Bosker
CONTENTS Chapter 1 Introduction 7 PART I Muscle Chapter 2 Lower body mass index and mortality risk in older adults starting dialysis Sci Rep 2018; 8(1):12858 31 Chapter 3 Low urinary creatinine excretion is associated with selfreported frailty in patients with advanced chronic kidney disease Kidney Int Rep 2017;2:676-685 55 Chapter 4 PART II Creatinine synthesis rate and associations with muscle strength and self-reported physical health in dialysis patients Submitted Mobility 83 Chapter 5 High fall incidence and fracture rate in elderly dialysis patients 107 Neth J of Med 2014;72(10):509-515 PART III Mind Chapter 6 Hemodialysis induces an acute decline in cerebral blood flow in elderly patients J Am Soc Nephrol 2018;4:1317-1325 125 Chapter 7 Changes in cerebral oxygenation and cerebral blood flow during hemodialysis a simultaneous near-infrared spectroscopy and positron emission tomography study Accepted for publication in J Cereb Blood Flow Metab 155 Chapter 8 Summary, general discussion and future perspectives 185 Nederlandse samenvatting - summary in Dutch 213 Dankwoord - Acknowledgements 225 About the author 233 List of publications 237