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Infectious Diseases Weekly Report TOKYOIDWR Tokyo Metropolitan Infectious Disease Surveillance Center 11 April / Number 14 Surveillance System in Tokyo, Japan The infectious diseases which all physicians must report All physicians must report to health centers the incidence of the diseases which are shown at page one. Health centers electronically report the individual cases to Tokyo Metropolitan Infectious Disease Surveillance Center. The infectious diseases required to be reported by the sentinels The numbers of patients who visit the sentinel clinics or hospitals during a week are reported to health centers in Tokyo. And they electronically report the numbers to Tokyo Metropolitan Infectious Disease Surveillance Center. We have about 500 sentinel clinics and hospitals in Tokyo. Tokyo Metropolitan Institute of Public Health TEL:81-3-3363-3213 FAX:81-3-5332-7365 e-mail:www@tokyo-eiken.go.jp URL:idsc.tokyo-eiken.go.jp/

Number of patients with the diseases which all physicians must report Category I II III IV Diseases 11th 12th 13th 14th Japan 14th Ebola hemorrhagic fever Crimean-Congo hemorrhagic fever Smallpox South American hemorrhagic fever Plague Marburg disease Lassa fever Acute poliomyelitis Tuberculosis 57 54 61 58 755 324 5,260 Diphtheria Severe Acute Respiratory Syndrome(SARS) Middle East Respiratory Syndrome (MERS) Avian influenza H5N1 Avian influenza H7N9 Cholera 1 1 1 Shigellosis 1 6 1 28 Enterohemorrhagic Escherichia coli infection 1 2 6 36 15 274 Typhoid fever 1 2 9 Paratyphoid fever 1 1 5 Hepatitis E 3 2 3 1 30 8 121 West Nile fever Hepatitis A 1 2 1 2 20 6 120 Echinococcosis 2 Yellow fever Psittacosis 1 2 8 Omsk hemorrhagic fever Relapsing fever Kyasanur forest disease Q fever Rabies Coccidioidomycosis 1 Monkeypox Zika virus infection Severe Fever with Thrombocytopenia Syndrome 1 7 Hemorrhagic fever with renal syndrome Western equine encephalitis Tick-borne encephalitis Anthrax Chikungunya fever 2 Scrub typhus(tsutsugamushi disease) 1 42 Dengue fever 2 1 2 2 28 6 78 Eastern equine encephalitis Avian influenza (excluding H5N1 and H7N9) Nipah virus infection Japanese spotted fever 1 8 Japanese encephalitis Hantavirus pulmonary syndrome Herpes B virus infection Glanders Brucellosis 1 Venezuelan equine encephalitis Hendra virus infection Epidemic typhus Botulism 1 Malaria 2 1 10 Tularemia Lyme disease Lyssavirus infection(excluding rabies) Rift valley fever Melioidosis Legionellosis 2 2 3 34 20 351 Leptospirosis 1 1 1 Rocky mountain spotted fever Tokyo 1

Category V Diseases Tokyo 11th 12th 13th 14th Japan 14th Amebiasis 6 2 3 3 48 13 228 Viral hepatitis(excluding hepatitis A and E) 6 3 3 26 1 84 CRE infection 2 5 5 4 56 26 494 Acute Flaccid Paralysis (excluding Acute poliomyelitis) 1 1 14 Acute encephalitis(excluding JE and WNE) 1 1 36 9 331 Cryptosporidiosis 1 1 4 Creutzfeldt-Jakob disease 1 8 3 40 Severe invasive streptococcal infections(tsls) 4 2 1 26 11 255 Acquired immunodeficiency syndrome (AIDS) 12 12 6 11 117 14 307 Giardiasis 1 3 9 Invasive Haemophilus influenzae disease 2 1 1 27 3 175 Invasive meningococcal disease 1 15 Invasive pneumococcal disease 7 7 5 5 123 50 1,015 Varicella (limited to hospitalized case) 3 1 2 2 17 6 111 Congenital rubella syndrome 1 Syphilis 36 30 30 25 447 64 1,627 Disseminated cryptococcosis 1 2 5 1 40 Tetanus 1 1 1 13 Vancomycin-resistant S. aureus infection Vancomycin-resistant Enterococcus infection 1 1 2 1 25 Pertussis 39 23 42 19 521 226 4,342 Rubella 27 33 29 26 370 71 1,202 Measles 6 2 6 2 44 10 382 MDRA infection 2 11 Number of patients with the diseases to be reported by the designated clinics and hospitals Diseases Tokyo 11th 12th 13th 14th /sentinel Respiratory syncytial virus infection 81 101 57 69 0.27 Pharyngoconjunctival fever 59 49 43 36 0.14 Group A streptococcal pharyngitis 689 570 432 411 1.61 Infectious gastroenteritis 1,775 1,591 1,526 1,578 6.19 Chickenpox 113 128 118 102 Hand, foot, and mouth disease 30 22 16 15 6 Erythema infectiosum 162 145 115 156 0.61 Exanthem subitum 105 112 99 110 0.43 Herpangina 3 2 4 6 2 Mumps 11 17 16 20 8 Kawasaki disease 6 1 1 6 2 Cold with exanthems 14 10 16 5 2 Influenza 525 406 345 439 1.07 Acute hemorrhagic conjunctivitis Epidemic keratoconjunctivitis 11 6 6 8 0.22 Bacterial meningitis 2 1 2 8 Aseptic meningitis 2 Mycoplasma pneumonia 2 3 Chlamydial pneumonia (excluding psittacosis) 1 2 2 3 0.12 Infectious gastroenteritis (only by Rotavirus) 8 7 6 11 0.44 Influenza-Associated Hospitalizations 10 8 10 8 0.32 ( Blank means 0. ) 2

Disease Trend Graph (weekly reported cases per sentinel in comparison) Respiratory syncytial virus infection Pharyngoconjunctival fever 5.00 Group A streptococcal pharyngitis 35.0 Infectious gastroenteritis 3 25.0 2 15.0 5.0 5.00 Chickenpox 2 Hand, foot, and mouth disease 15.0 5.0 3

2.50 Erythema infectiosum Exanthem subitum 12.0 Herpangina Mumps 8.0 6.0 4.0 2.0 0 Kawasaki disease Cold with exanthems 75 50 25 0 4

8 7 6 Influenza 5 4 3 2 Acute haemorrhagic conjunctivitis Epidemic keratoconjuncitivitis Bacterial meningitis Aseptic meningitis 5

2.50 Mycoplasma pneumonia Chlamydia Pneumonia Infectious gastroenteritis (only by Rotavirus) 1 Influenza-Associated Hospitalizations 1.20 8.00 0.90 6.00 0.60 Number of sentinel facilities for weekly reporting Types of sentinels Number of sentinels Sentinels having reported Pediatric 264 255 Influenza 419 409 Ophthalmic 39 37 Speciallydesignated 25 25 6