Hamilton Regional Laboratory Medicine Program

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Created: April 2002 of Review: February 2004 of Review: June 2006 of Review: July 2007, St. Joseph s Healthcare went live with Meditech as of June18, 2007. of Review: August 2009 of Review: December 2011; updates made June 2012; further updates made due to New Chemistry Instrument November 2012 of Review: December 2014 of Review: December 2016 of Review: January 2019 Leukocytes 4.0-11.0 x10 9 /L Erythrocytes 4.50-6.50 3.80-5.80 x10 12 /L x10 12 /L Male Hemoglobin 130-180 115-165 g/l g/l Male Hematocrit 0.400-0.540 0.370-0.470 L/L L/L Male MCV 82-99 fl MCH 27-32 pg MCHC 315-353 g/l 20/04/17 R.D.W. 11.5-15.0 % 31/01/08 Platelets 150-400 x10 9 /L M.P.V. 9.3-12.5 fl 20/04/17 Page 1 of 10 Printed on 15-Mar-19

Absolute Neutrophils 2.0-7.5 x10 9 /L 24/01/08 Absolute Lymphocytes 1.5-4.0 x10 9 /L Absolute Monocytes 0.2-0.8 x10 9 /L Absolute Eosinophils 0.0-0.4 x10 9 /L Absolute Basophils 0.0-0.1 x10 9 /L Reticulocyte Count 10-86 x10 9 /L Erythrocyte Sedimentation Rate 0-15 mm/h Male 28/06/07 0-20 mm/h Vitamin B12 138-652 ERC Folate <317 nmol/l Deficient 17/01/13 PT in INR 0.8-1.2 Therapeutic Range: 2.0-3.0 Mechanical mitral and high-risk aortic values: 2.5-3.5 Page 2 of 10 Printed on 3/15/2019 23/02/05 (Mechanical valve 06/06/06) APTT 22-35 s Heparin Therapeutic Range: 60-85s 17/11/04 Clauss Fibrinogen 1.6-4.2 g/l TCT 2 unit 20-30 s D-Dimer <500 ug/l FEU Quantitative Method 06/07/11 Albumin 35-50 g/l Alkaline Phosphatase 40-120 U/L Alpha Fetoprotein <10 ug/l 20/01/13 ALT 40 U/L Male 28 U/L Ammonia 18-72 Amylase <100 U/L Apolipoprotein A1 0.99-1.86 1.09-2.04 g/l g/l 27/06/14 Male Ratio of Apo B/Apo A1 is important for CVD risk

Apolipoprotein B g/l Intermediate and High Risk CVD target Apo B is <0.80g/L 27/06/14 AST <35 U/L Beta-hCG, Total <5 IU/L Bile Acid, Total <6.7 21/04/11 Bilirubin, Conjugated 9.0 25/01/13 Bilirubin, Total <21 Blood Gases: H+ Arterial 35-45 nmol/l ph Arterial 7.35-7.45 pco2 Arterial 35-45 mmhg po2 Arterial 80-100 mmhg Bicarbonate Calculated 22-26 mmol/l 23/10/09 Base Excess -2 to +3 mmol/l O2 Saturation Measured Arterial 0.94-0.98 Fract Carboxyhemoglobin, Arterial 0.00-0.04 Fract Heavy smokers may show up to 0.10 Methemoglobin 0.000-0.020 Fract Methemoglobin levels >0.1 are compatible with cyanosis CA125 35 ku/ml 20/01/13 Calcium (total) 2.15-2.55 mmol/l Carotene 0.9 3.7 06/01/09 Chloride 98-107 mmol/l Cholesterol mmol/l Target Values: Desirable Total Cholesterol: <5.20 mmol/l High Risk / 20/06/12 CK (Creatine Kinase) <200 <168 U/L U/L Secondary CVD Prevention: 4.00 mmol/l Male Page 3 of 10 Printed on 15-Mar-19

ug/l Male ug/l CK-2 (CKMB) 7.2 3.4 Study use only. No longer available. Total CO2 22-29 mmol/l Cortisol 200-660 nmol/l 0800h Specimen 80-400 nmol/l 1600h Specimen <140 nmol/l 2400h Specimen C-Peptide 298-2350 15/10/07 Creatinine 64-111 Male 50-98 C-Reative Protein 5.0 mg/l DHEA-Sulphate 2.8-12.4 2.1-9.1 1.5-6.6 1.1-4.8 0.8-3.5 0.0-2.6 1.0-8.7 0.0-6.7 0.0-5.1 0.0-3.9 0.0-3.0 0.0-2.3 Male, 19-29 years Male, 30-39 years Male, 40-49 years Male, 50-59 years Male, 60-69 years Male, 70 years, 19-29 years, 30-39 years, 40-49 years, 50-59 years, 60-69 years, 70 years Digoxin nmol/l Therapeutic Range in Heart Failure: 0.7-1.4 nmol/l Toxic (>6 hours post-ingestion): 2.6 nmol/l 06/10/15 Page 4 of 10 Printed on 3/15/2019

Estradiol <162 Male Follicular: 77-921 Mid Cycle: 139-2382 05/01/17 Luteal: 77-1145 Post Menopausal (no HRT): <103 Post Menopausal (on HRT): <529 Ferritin <23 ug/l Probably iron deficient 12/07/04 24-50 ug/l Possibly iron deficient 51-140 ug/l Probably not iron deficient 141-400 ug/l Not iron deficient >400 ug/l Possibly iron overload Follicle Stimulating Hormone 1.0-12.0 IU/L Male Follicular: 3.0-8.1 IU/L Mid-cycle: 2.6-16.7 IU/L Luteal: 1.4-5.5 IU/L Postmenopausal: 26.7-133.4 IU/L Fructosamine 205-285 03/07/14 Gastrin, Fasting 13-115 ng/l 01/12/04 GGT (Gamma Glutamyl Transpeptidase) <65 U/L Male <37 U/L Glucose, Fasting 3.8-6.0 mmol/l 3.8 6.0 Normal 6.1 6.9 Impaired FBG 7.0 Abnormal FBG Glucose, Random 3.8-11.0 mmol/l 20/06/12 HbA1C 0.040-0.060 Fract. Page 5 of 10 Printed on 3/15/2019

HDL -Cholesterol mmol/l Target Values: 20/06/12 1.30 mmol/l Desirable <1.04 mmol/l Low HDL-C (Increases risk of CVD) 1.55 mmol/l High HDL-C (Optimal) Human Growth Hormone 3.0 ug/l Male 19/04/11 8.0 ug/l IgA 0.70-3.52 g/l IgD 7.7-132.1 mg/l 19/08/13 IgE <87 KIU/L 21/11/18 IgG 6.35-14.65 g/l IgM 0.41-2.07 g/l Insulin <120 Fasting 21/07/10 Iron 12-31 Male 08/05/12 9-30 Iron Binding Capacity 40-80 Lactate 0.5-2.2 mmol/l LD (Lactate Dehydrogenase) 100-220 U/L LDL - Cholesterol mmol/l Target Values: 25/01/13 Desirable Total Cholesterol: <5.20 mmol/l High Risk/Secondary CVD Prevention: 4.00 mmol/l Lipase <79 U/L Lithium 0.5-1.1 mmol/l Toxic: >1.5 mmol/l 20/06/12 Magnesium 0.66-1.07 mmol/l Osmolality 280-300 mmol/kg Page 6 of 10 Printed on 3/15/2019

Parathyroid Hormone (PTH Intact) 2.0-9.4 07/07/14 Phosphate 0.80-1.45 mmol/l Potassium 3.5-5.0 mmol/l Prealbumin 0.18 0.38 g/l 20/06/14 Progesterone <0.7 nmol/l Male Progesterone reference interval varies with menstrual cycle. Folicular Phase: <1.0 nmol/l Luteal Phase: 3.8-50.6 nmol/l Postmenopausal: <0.7 nmol/l 1st Trimester: 8.9-468.4 nmol/l 2nd Trimester: 71.6-303.1 nmol/l 3rd Trimester: 88.7-771.2 nmol/l 17-Hydroxy Progesterone 1.5 6.4 nmol/l Male Reproductive age: Folicular: 0.3 2.4 mmol/l 24/08/10 Luteal: 1.8 7.0 mmol/l Ovulation: 0.9 4.2 mmol/l Post Menopausal: 0.4 1.5 mmol/l PSA, Total <4.0 ug/l Male Sodium 135-145 mmol/l Calculated Testosterone, Free 320-800 250-700 210-600 190-500 170-500 160-400 Male, 20-29 years Male, 30-39 years Male, 40-49 years Male, 50-59 years Male, 60-69 years 70 years, Menstrual Cycle: Oral Contraceptive Use: 3-26 No Oral Contraceptive Use: 7-53 Page 7 of 10 Printed on 3/15/2019 20/02/15

nmol/l Male, 20-49 years 17/03/11 nmol/l Male, 50 years nmol/l, Ovulating nmol/l, Post-menopausal Testosterone, Total 5.5 25.2 4.5-26.6 2.5 1.5 Theophylline Bronchodilation: 55-110 Premature Apnea: 33-70 Toxic: >110 26/02/18 Thyroxine (T4) 58-154 nmol/l Thyroxine, Free 9.0-19.0 T3 Triiadothyronine, Free (T3, Free) 2.76-6.45 26/02/14 T3 Triiadothyronine (Total T3) 0.9-2.4 nmol/l Total Protein 60-80 g/l Transferrin 1.74-3.64 g/l Male 1.80-3.82 g/l Triglycerides <1.70 mmol/l High Triglycerides increases risk for CVD; 20/06/12 >10 mmol/l increases risk for pancreatitis Troponin T Not available Troponin I Not available 25/11/14 Troponin I - HS ng/l 30 ng/l No evidence of Myocardial Injury 25/11/14 >30 ng/l Evidence of Myocardial Injury TSH (Thyrotropin) 0.35-4.90 miu/l 16/10/14 Urate (Uric Acid) 208-428 Male 155-357 Urea 3.2-7.4 2.5-6.7 3.0-9.2 3.5-7.2 mmol/l mmol/l mmol/l mmol/l Male, 19-49 years, 19-49 years Male, 50 years, 50 years 14/12/12 Valporic Acid 350-700 Page 8 of 10 Printed on 3/15/2019

25-Hydroxy Vitamin D nmol/l <25 nmol/l Vitamin D deficiency 01/04/12 25-75 nmol/l Sub-optimal Vitamin D Status >75 nmol/l Desirable Vitamin D Status >250 nmol/l Potential Adverse Effects Urinalysis: Routine: Glucose Ketones Specific Gravity 1.005-1.030 20/06/12 Blood ph 5.0-8.0 Protein Nitrates Leukocyte Screen Microscopic: Ercs 0-3 /HPF Lkcs 0-5 /HPF Epithelial Cells No Defined Reference Range Urine Bilirubin Urobilinogen EU/dL Normally present in urine at concentrations up to 1 EU/dL Page 9 of 10 Printed on 3/15/2019

Sputum No Defined Cultures are processed and reported for Reference pathogens clinically significant for the site Range collected; normal (colonizing) flora is not considered clinically significant. Josephine Baldwin Josephine Baldwin Laboratory Research Coordinator Page 10 of 10 Printed on 3/15/2019