The HPTN Scholars Program: Enabling independent investigators in the HIV prevention research field. Linda-Gail Bekker The Desmond Tutu HIV Centre UCT CTU, Cape Town.
Interest and investment History of Prevention Combination, tailored, population/risk specific 1980 2005/6 2010 2017 Time
Protection and justice Microbicides for women Abdool Karim Q, Science 2010 Harm Reduction Male circumcision Auvert BPloS Med 2005 Gray R,Lancet 2007 Bailey R, Lancet 2007 Treatment of STIs Grosskurth H, Lancet 2000 Female Condoms Oral pre-exposure prophylaxis Grant R, NEJM 2010 (MSM) Baeten J, NEJM 2012 (Couples) Paxton L, NEJM 2012 (Heterosexuals) Choopanya K, Lancet 2013 (IDU) Post Exposure prophylaxis (PEP) Scheckter M, 2002 (Un)conditional cash transfers Kohler HP, 2002 HIV INNOVATION PREVENTION Treatment for prevention Cohen M, NEJM, 2011 Donnell D, Lancet 2010 Tanser, Science 2013 Male Condoms +Lube HIV Counselling and Testing Coates T, Lancet 2000 Sweat M, Lancet 2011 Behavioural Intervention - Abstinence - Be Faithful PMTCT Karim S, 2014
Clinical Laboratory/Basic Behavioural Pharmacological Prevention Science Social Ethical Statistical Epidemiological
Exciting clinical science attracts new young talent
Odds of Success : first R01
Desperate need for opportunities to : Participate in interim funding opportunities Less fiercely competitive Practice some skills Grant writing, project management, budget management, manuscript writing. Develop a network Give a leg up to get pilot data Build CV Without giving up the day job!
Welcome EPICENTRE OF to TUBERCULOSIS The UCTCTU! AND HIV
UCTCTU CRSs GSH CRS CIDRI CRS HPTN 083 AMP/HPTN 081 HVTN 702 EMA CRS HPTN 084 HVTN 702 HVTN 705 ASPIRE ECHO HVTN 702 Protocol Specific SATVI CRS MASI CRS UCT LI CRS TB Drugs TB Vaccines Drug Resistance The RING HVTN 705 Protocol Specific TB Drugs Drug Resistance
none ring gel öral prep vaccine none ring gel öral prep vaccine none ring gel öral prep vaccine 0 percent 20 40 60 Choice! HPTN 067, AMP, 075, 076, More people get their preferences met Choice is important from a behavioural perspective leads to better uptake and persistence 082, 083, 084 Allows reach to the whole population, including traditionally hard-to-reach populations Mimics what toolbox approach to prevention may be like... Questionnaire: TUPP study, CT 48.8 55.3 28.4 31.5 33.2 17.0 17.0 19.4 6.1 10.2 6.5 2.1 12.4 2.4 10.6 adolescents adults Msm Atujuna M et al., 2016
So, you would like to be an HPTN scholar? Making a successful application: Choosing a project Choosing a mentor Increasing the chances of success
Choosing a project Get to know what studies are out there Attend the HPTN meetings...hear about the studies- understand the project objectives and get familiar with the protocol chairs, protocol numbers and protocol project support. Protocols are on the HPTN web sites Make contact with chair and discuss possibilities Think what interests you, what your capabilities are and when your cycle would be Consider projects that are 1. recently finished 2. will have data available in your cycle
Think about topics... That are not the primary objectives protocol team has first tabs on those! Explore angles or ideas with existing data Review exploratory objectives Explore sub-populations within the data Particular age group, sub-population Use the data in new ways Use the data in modeling study
Challenges Timing, timing, timing... Steer away from primary objectives and discuss secondary objectives- think about exploratory objectives.
Think about mentor... Where are they located? Co-located, at another site, another time zone? What is their role on the parent study? Will they be able to influence decisions and do they know the parent study? How available are they? How busy? How expert? Able to offer mentorship? May still need assistance in particular areas How supportive are they? Willing to go out to bat for you?
The case of Dr. Jesne Kistan and ADAPT/HPTN 067 in Cape Town An International HPTN Scholar in Cycle 1.
A Phase II, Randomized, Open-label, Pharmacokinetic And Behavioral Study Of The Use Of Intermittent Oral Emtricitabine/Tenofovir Disoproxil Fumarate Preexposure Prophylaxis (Prep) Alternative Dosing to Augment PrEP Pill Taking
Overall Purpose: A Behavioral study to evaluate the feasibility of non daily PrEP regimens. Recommendations for intermittent usage, compared with daily usage, to provide comparable coverage of risk exposures with preand post-exposure dosing, decreased pill requirements, and decreased symptoms.
Overall PI: Robert Grant Harlem Prevention Centre 179 HIV-uninfected at risk MSM/TGW NYC (Harlem), USA Dec 2014 Silom Community Clinic 178 HIV-uninfected at risk MSM/TGW Bangkok, Thailand March 2014 Emavundleni Prevention Centre 179 HIV-uninfected at risk WSM Cape Town, South Africa June 2013
Primary Objective: To test the hypothesis that recommending nondaily PrEP, compared with recommending daily usage, will be associated with: Equivalent coverage of sex events with pre- and post-exposure dosing Lower number of pills needed for coverage and fewer pills used Decreased self-reported symptoms/side effects (both severity and frequency) during 24 weeks of self-administered use
Secondary Objectives To describe safety outcomes including adverse events among all participants and drug resistance and plasma HIV RNA levels among participants who seroconvert Assess differences between arms in the acceptability of different PrEP regimens and in perceptions of advantages and disadvantages of different regimens Assess differences by arm in adherence Develop objective measures of drug exposure by obtaining steady state pre-dose trough drug concentration in several biological matrices for participants during a lead-in period of weekly DOT Evaluate the potential influence of PrEP usage on: changes in sexual behavior, planning for sex, prediction of risky situations, and recognition of possible HIV exposure from baseline to final on-drug assessment in relation to PrEP optimism
HPTN 067 Design Wk 0 Wk 34 TDF/FTC D Daily- Once daily dosing Time driven- 2 doses/week with post coital boost Event driven- pre and post coital dosing No more than 1 dose daily and 7 doses/week 191 6 weeks DOT Randomized T 24 weeks self-administered dosing 4 weeks off drug Final Study Visit Screening Enrollment 1 dose Weekly for 4 weeks PK steady State E Qualitative : Staff 60 Participants IDIs and FGs Sex coverage
294 screened 103 not enrolled* 12 not randomized HIV + rapid 2/ 16.7% Relocated 3/ 25% Pregnant 1/ 8.3% Lost contact 2/ 16.7% Other 4/ 33.3% 191 enrolled 179 randomized Dot Phase HIV + rapid 7/ 6.8% Pregnant 3/ 2.9% Lab abnormality 3/ 2.9% Not Hep B immune 29/ 28.2% Other medical/mental12/ 11.7% Low HIV risk 26/ 25.2% Withdrew consent 1/ 1% Not enrolled in window 14/ 13.6% Other 10/ 9.7% Self-Administered Phase 60 Daily usage 59 Timedriven usage 60 Eventdriven usage
PrEP for Younger Women? Jesne s question... To assess differences in acceptability of PrEP between young African woman (age:18-24) and older African woman (age: 25) within the Assess differences between arms in the acceptability of different PrEP regimens Assess different differences PrEPby dosing arm adherence regimens. To assess differences in adherence between young African women (age:18-24) and older African woman (age 25) within the different PrEP dosing regimens ADAPT HPTN 067: An open label of oral PrEP use by 179 women in Cape Town, South Africa. Majority of women took oral PrEP when made available in open label. Daily dosing resulted in good adherence (higher drug levels) & better coverage of sex acts, compared to intermittent use. Daily dosing may foster better habit formation and provide the most forgiveness for missed doses at observed adherence levels. Bekker, et al Lancet HIV 2017 24
Tips to a successful application Sit down with protocol chair and mentor preferably face to face... Consider feasibility, timing, scope Clarify which permissions, approvals will be needed and time line for these Start early to allow time for : Initial drafting of proposal Back and forth with mentor- use this feedback Submission to protocol team see if mentor can endorse Further potential back and forth - using mentor support Be politely persistent and engaged Trouble shoot with mentor support if things get stuck
In the application, articulate How this proposal plays to your strengths and capabilities Make a compelling case for : Why this? Why you? Why now? How it will enhance the overall study, site, HPTN? Be honest about any risks and provide mitigating solutions In the mentorship plan: show feasibility, compatibility, realistic expectations
During the project Remain in touch and engaged with mentor Watch timelines carefully Be politely persistent and seek help early if things seem stuck Use networking opportunity to seek help in other quarters keeping mentor informed Try for F2F mentorship sessions where possible but skype and tele calls also ok Long distance mentorship possible but more challenging Take responsibility: Remind mentor, others about timelines, tasks and milestones Give enough time for inputs, be responsive to guidance and apologise when timelines are tight! Leave sufficient time for report backs and manuscript writing
Extraordinary opportunity. To make a difference and translate good ideas into great work..and saved lives! Your ordinary acts of love and hope point to the extraordinary promise that every human life is of inestimable value.
Thanks The UCTCTU and its CRSs Giuseppe, Jill, Christie, Ntando, Lulu, Danielle, Zoh, the CRS leaders Other CTUs: PHRU, Aurum, CAPRISA Kathy, Fatima, Glenda, Gavin The Networks and Core teams : HVTN, HPTN, MTN, INSIGHT, ACTG, IMPAACT Their support teams: LAB, SHARP, FHI The DAIDS, NIH program COMMUNITIES OF VOLUNTEERS IN SOUTH AFRICA