Chapter 5 ~ Infections: Special Section 1 of 6 Chapter 5 ~ Infections Please refer to The Hillingdon Hospitals NHS Trust Antibiotic Guidelines, Policy number 233, and Surgical Prophylaxis Policy, Policy number 234 Notifiable diseases Doctors must notify the consultant in communicable disease control when attending a patient suspected of suffering from any of the diseases listed below: Anthrax Measles Rubella Cholera Meningitis Scarlet fever Diphtheria Meningococcal septicaemia Smallpox Dysentry (amoebic or bacillary) (without meningitis) Tetanus Encephalitis, acute Mumps Tuberculosis Food poisoning Ophthalmia neonatorum Typhoid fever Haemorrhagic fever (viral) Paratyphoid fever Typhus Hepatitis, viral Plague Whooping cough Leprosy Poliomyelitis, acute Yellow fever Leptospirosis Rabies Malaria Relapsing fever 5.1 Antibacterial drugs 5.1.1 Penicillins 5.1.1.2 Penicillinase-resistant penicillins TEMOCILLIN Injection 1g Non Policy Antibiotic Requires 5.1.1.3 Broad-spectrum penicillins AMOXICILLIN Powder SF 3 g For ENT CO-AMOXICLAV Suspension SF 400/57 in 5.1.1.4 Antipseudomonal penicillins PIPERACILLIN with tazobactam (TAZOCIN ) TICARCILLIN with clavulanic acid (TIMENTIN ) Injection 2g/250mg; 4g/500mg Injection 3g/200mg 5.1.2 Cephalosporins and other beta-lactams CEFIXIME Suspension 100mg in Tablet 200 mg For use in Cystic Fibrosis For Obstetrics and Gynaecology For Obstetrics and Gynaecology CEFTAZIDIME Injection 500mg; 1g; 2g CEFTRIAXONE Injection 250mg; 1g CEFUROXIME Injection 250mg; 1.5g ERTAPENEM 1g 500mg/500mg IMIPENEM with Cilastatin MEROPENEM Injection 500mg; 1g 5.1.3 Tetracyclines LYMECYCLINE Capsule 408mg (= For Dermatologist use 300mg tetracycline) MINOCYCLINE Modified release For Dermatologist use
Chapter 5 ~ Infections: Special Section 2 of 6 capsule 100mg Tablet 50mg; For Dermatologist use OXYTETRACYCLINE Tablet 250mg For Dermatologist use 5.1.3 Tetracyclines (contd.) TIGECYCLINE 50mg 5.1.4 Aminoglycosides AMIKACIN Injection 500mg in 2ml GENTAMICIN TOBRAMYCIN Intrathecal injection 5mg in 1ml Injection 40mg in 1ml; 80mg in 2ml Nebuliser solution 75mg/ml For use in Cystic Fibrosis Use in accordance with TA276 5.1.5 Macrolides AZITHROMYCIN Capsule 250mg For Obstetrics and Gynaecology For Paediatric use 5.1.6 Clindamycin CLINDAMYCIN Suspension 200mg in Suspension 75mg in For Paediatric use Unlicensed. 5.1.7 Some other antibacterials CHLORAMPHENICOL Capsule 250mg COLISTIN SULPHOMETHATE SODIUM DAPTOMYCIN FUSIDIC ACID LINEZOLID Injection 1g (as sodium succinate) Injection 1 million units Powder for nebuliser solution 1 million units 350mg; 500mg Suspension 250mg in (= 175mg sodium fusidate) 600mg in 300ml Suspension 100mg in Tablet 600 mg For use in Cystic Fibrosis Use in accordance with NICE TA276 RIFAXIMIN Tablet 550mg On Gastroenterology advice and in SODIUM FUSIDATE 500mg Tablet 250mg SPECTINOMYCIN Injection 2g Unlicensed TEICOPLANIN Injection 200mg; 400mg accordance with NICE TA 337 Genito Urinary Medicine VANCOMYCIN Capsule 125mg Injection 500mg; 1g 5.1.8 Sulphonamides and trimethoprim CO-TRIMOXAZOLE
Chapter 5 ~ Infections: Special Section 3 of 6 480mg in Suspension 240mg in ; 480mg in Tablet 480mg; SULFADIAZINE Injection 250mg in 1ml Tablet 500mg 5.1.9 Antituberculous drugs RIFABUTIN Capsule 150mg 5.1.10 Antileprotic drugs DAPSONE Tablet 50 mg For Dermatologist use 5.1.12 Quinolones MOXIFLOXACIN Tablet 400mg NALIDIXIC ACID Tablet 500mg OFLOXACIN Tablet 200mg; 400mg 5.2 Antifungal drugs AMPHOTERICIN CASPOFUNGIN (Liposomal) 50mg 50mg; 70mg ITRACONAZOLE Capsule 100mg For Haematologist use Solution 50mg in. For Haematologist use. TERBINAFINE Tablet 250mg For Dermatologist use VORICONAZOLE Tablet 200mg For Haematologist use. 5.3 Antiviral drugs 5.3.1 HIV infection Nucleoside reverse transcriptase inhibitors ABACAVIR Oral solution 100mg in ABACAVIR with lamivudine and zidovudine (TRIZIVIR ) DIDANOSINE Tablet 300mg Tablet 300mg abacavir / 150mg lamivudine / 300mg zidovudine Enteric coated capsule 250 mg; 400 mg EMTRICITABINE Capsule 200mg LAMIVUDINE Oral solution 50mg in Tablet 150mg Tablet 100mg For Chronic Hepatitis B Use in accordance with NICE (TA96) STAVUDINE Capsule 30mg; 40mg TENOFOVIR DISOPROXIL Tablet 245mg OR For chronic Hepatitis B, use in accordance with NICE (TA173) TENOFOVIR Tablet 245mg/100mg
Chapter 5 ~ Infections: Special Section 4 of 6 DISOPROXIL with Emtricitabine (TRUVADA ) ZIDOVUDINE Capsule 100mg; 250mg Injection 200mg in 20ml ZIDOVUDINE with lamivudine (COMBIVIR ) Oral solution 50mg in Tablet 300mg/150mg Protease inhibitors ATAZANAVIR Capsule 100mg; 150mg DARUNAVIR Tablet 300mg LOPINAVIR with ritonavir (KALETRA ) RITONAVIR SAQUINAVIR Capsule 133.3mg/33.3mg Film coated Tablet 200mg/50mg Oral solution 400mg/100mg in Oral solution SF 400mg in Soft capsule 100mg Tablet (Invirase ) 500mg Non-nucleoside reverse transcriptase inhibitors EFAVIRENZ Capsule 200mg NEVIRAPINE 5.3.2 Herpesvirus infections Oral solution SF 150mg in Tablet 600mg Suspension 50mg in Tablet 200mg 5.3.2.1 Herpes simplex and varicella-zoster infection FAMCICLOVIR Tablet 250mg For Ophthalmologist use 5.3.2.2 Cytomegalovirus FOSCARNET SODIUM 6g in 1ml GANCICLOVIR 500mg VALGANCYCLOVIR Tablet 450mg 5.3.3 Viral hepatitis 5.3.3.1 Chronic Hepatitis B ENTECAVIR Tablet 500mcg, 1mg Oral Solution 50mcg/ml Use in accordance with NICE (TA153) ADEFOVIR DIPIVOXIL Tablet 10mg Use in accordance with NICE (TA96) 5.3.3.2 Chronic Hepatitis C TELAPREVIR Tablet 375mg Use in accordance with NICE (TA252)
Chapter 5 ~ Infections: Special Section 5 of 6 BOCEPREVIR Capsule 200mg Use in accordance with NICE (TA253) SIMEPREVIR Capsule 150mg On Gastroenterology advice and in accordance with NICE TA 331 SOFOSBUVIR Tablet 400mg On Gastroenterology advice and in accordance with NICE TA 330 5.3.4 Influenza OSELTAMIVIR ZANAMIVIR Capsule 30mg, 45mg, 75mg Oral Suspension 60mg in Powder for inhalation 5mg/blister Use in accordance with NICE (TA168) (TA158) Use in accordance with NICE (TA168) (TA158) 5.3.5 Respiratory syncytial virus PALIVIZUMAB Injection 50mg; 100mg For Paediatric use RIBAVIRIN Tablet 200mg For Chronic Hepatitis C pegylated interferon, ribavirin and alfa interferon Use in accordance with NICE (TA75) For Hepatitis C peginterferon alfa and ribavirin) Use in accordance with NICE (TA200) Hepatitis C children and young people, peginterferon alfa and ribavirin Use in accordance with NICE (TA300) 5.4 Antiprotozoal drugs 5.4.1 Antimalarials CHLOROQUINE PHOSPHATE (AVLOCHLOR ) CHLOROQUINE SULPHATE Tablet 250mg (=155mg chloroquine base) Syrup 68mg (= 50mg chloroquine base) in Tablet 200mg (= 150mg chloroquine base) MEFLOQUINE Tablet 250mg PRIMAQUINE Tablet 7.5mg Unlicensed Medicine PROGUANIL Tablet 100mg PROGUANIL Tablet 100mg/250mg HYDROCHLORIDE with atovaquone (MALARONE ) PYRIMETHAMINE Tablet 25mg PYRIMETHAMINE with sulfadoxine (FANSIDAR ) QUININE DIHYDROCHLORIDE RIAMET (artemether 20mg, lumefantrine 120mg) Tablet 25mg/500mg Injection 300mg in 1ml, 3000mg in 10ml Tablet 5.4.8 Drugs for pneumocystis pneumonia PENTAMIDINE Injection 300mg Unlicensed Medicine
Chapter 5 ~ Infections: Special Section 6 of 6 ISETIONATE 5.5 Anthelmintics Nebuliser solution 300mg Unlicensed Medicine 5.5.5 Schistosomicides PRAZIQUANTEL Tablet 500mg Unlicensed Medicine 5.5.8 Drugs for stronyloidiasis ALBENDAZOLE Tablet 400mg Unlicensed Medicine IVERMECTIN Tablet 3mg; 6mg Unlicensed Medicine