Dear Valued Colleague, C4 Laboratories, LLC 1930 S. Alma School Rd Suite B202 Mesa, AZ 85210 www.c4lab.com "Patient protection through true science" Thank you for selecting C4 Laboratories. Our goal at C4 is to provide reliable data that is interpreted within the appropriate physiological context, to ultimately empower patients to use cannabis medicine more effectively. The data within this report are the result of various analytical methods that have been developed by the team of scientists at C4 Laboratories. For the characterization and quantification of 21 terpene compounds and residual solvents we use Head- Space Gas Chromatography with Flame Ionization Detection (HS- GC- FID). Additionally, Ultra High Performance Liquid Chromatography (UHPLC) is used for the characterization and quantification of the 10 major phytocannabinoids found in cannabis. All data are collected in concert with proper quality assurance/quality control measures (QA/QC), including the use of intermittent analytical blanks, sample spikes, and commercial standards. As an additional measure of quality control, we provide a historical reference (when available) to analytical results from an equivalent strain of cannabis/cannabis product to draw comparison. We understand that within an individual strain that results may vary as a result of variances in sample homogeniety, analytical methodology, crop conditions, genetic drift, and/or gene flow during hybridization. However, such a comparison can provide valuable insight into sample integrity and/or the phenotypic identity of the analyzed sample. Additionally, we have interpreted all data within the physiological context provided to us by the growing body of peer- reviewed scientific research studies. Key factors to consider when determing how to most appropriately use a particular strain of cannabis include, but are not limited to, an evaluation of the possible cannabinoid/terpene synergies and an analysis of the various cannabinoid ratios, particular the CBD- A/THC- A and CBG/CBN ratios. It is important to note that when analyzing cannabis there can exist natural variablity of cannabinoid and terpene concentrations within individual plants. Cannabinoid concentrations in cannabis flower have been found to increase distally with respect to the root mass. As such, the analysis of multiple samples from any plant of interest is recommended. Thank you again for your confidence in C4 Laboratories. We strive to be an authority on cannabis education, targeted therapies and patient protection. Also, as a research laboratory, we hope to discover novel cannabis constituents through our efforts with academic research programs in the C4 Cannabinomics Collaborative. For more information about how you can collaborate with our research team please visit our website at www.c4lab.com. Zacariah L. Hildenbrand, Ph.D. Chief Scientific Officer C4 Laboratories, LLC
PRODUCT SUMMARY ID: EC_XI8_121015 Analyte: Flower Strain: XI8 Client: Errl Cup Date: 12/10/15 Microbial Screen: PASS Foreign Material: PASS Pesticide Analysis: Not performed Residual Solvents: Not performed 18.08% Major 10 Cannabinoids: Total available THC: 15.50% Total THC Isomers: 15.50% Δ9 + Δ8 THC Total available CBD: 0.00% Highest Terpenes: Not performed Not performed Not performed Activated THC: 0.000 (mg) APPLICABLE TO MEDIBLES, TINCTURES AND SALVES Fresh product CBG/CBN > 1.0 denotes fresh product, CBG/CBN < 1.0 denotes high CBN 0.00 (CBG/CBN): strain and/or an oxidized product Targeted Use: Appetite stimulant (CBN), anti- inflammatory and analgesic (THC)
Potency Profile Value (%) Historical (%) CBDV Therapeutic properties CBD- A CBG CBD THCV CBN Δ9- THC Δ8- THC 0.58 #N/A 1.25 #N/A Appetite stimulant (Farrimond et al., 2012), analgesic (Zygmunt et al., 2002) and anti- tumorigenic against some forms of lung cancer (BiFulco et al., 2006) Anti- inflammatory and analgesic (Russo, 2011), neuroprotectant (Hampson et al., 1999), reduces intraocular pressure associated with glaucoma, spasticity and muscle tension (Pacher et al., 2006) CBC Δ9- THC- A 16.26 #N/A Total Available THC 15.50 #N/A Total THC Isomers 15.50 #N/A Total Available CBD CBD/Δ9- THC ratio CBG/CBN ratio Major 10 Total 18.08 #N/A See therapeutic properties of Δ9- THC for medicinal value upon activation through decarboxylation General Characteristics Δ9- THC- A + Δ9- THC (accounts for conversion rate) Δ9- THC- A + Δ9- THC + Δ8- THC (accounts for conversion rate) CBD- A + CBD (accounts for conversion rate) THC- dominant, psychoactive CBG/CBN > 1.0 denotes fresh product, CBG/CBN < 1.0 denotes high CBN strain and/or an oxidized product Historical measurements based on analysis of equivalent product N/A #N/A Blank cells denote cannabinoid concentrations below the limit of detection (0.01%) #N/A
Terpene Profile Value (%) Historical (%) Therapeutic properties alpha- Pinene Camphene beta- Pinene beta- Myrcene delta- 3- Carene alpha- Terpinene p- Cymene d- Limonene Ocimene gamma- Terpinene Terpinolene Linalool (- )- Isopulegol Geraniol beta- Caryophyllene alpha- Humulene Nerolidol Guaiol (- )- alpha- Bisabolol Eucalyptol (- )- Caryophyllene oxide Terpene Total #N/A * Based on historical measurements of equivalent strain/product Blank cells denote terpene concentrations below the limit of detection (0.001%)
Cannabinoid Ratios CBD- A/Δ9- THC- A ratio is outide of the optimal therapeutic range of 1-2 (Lemberger et al., 1976; Burnett, 2014) CBD- A/Δ9- THC- A ratio is below 1, user may experience tachycardia (increased heart rate) and difficulty walking, resulting from elevated THC (Burnett, 2014) CBG/CBN > 1.0 denotes fresh product and is useful for the treatment of gastrointestinal abnormalities (Borrelli et al., 2013), CBG/CBN < 1.0 denotes high CBN strain and/or an oxidized product Cannabinoid/Terpene Synergies (Russo, 2011) Additional Observations Terpene analysis was not performed Residual Solvents Not performed Pesticides Not performed
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12/11/2015 10:48:36 AM Page 1 / 1 C4 Laboratories, LLC 1930 S. Alma School Rd Suite B202 Mesa, AZ 85210 www.c4lab.com "Patient protection through true science" C4 Laboratories, LLC Sample Name : XI-8 Sample ID : MeOH blank Data Filename : XI-8_007.lcd Method Filename : 10 Cannabinoids Standard Method mgperlv4.lcm Batch Filename : Batch v1.lcb Vial # : 1-34 Sample Type : Flower Injection Volume : 5 ul Date Acquired : 12/11/2015 10:31:44 AM Acquired by : Aaron J. Hicks Date Processed : 12/11/2015 10:38:45 AM Processed by : Sean S. Jun Cannabinoids by HPLC mau 250 200 150 THC-A / 16.257 % PDA Multi 1 220nm,4nm 100 50 CBN / 0.580 % THC / 1.247 % 0 1.0 1.5 2.0 2.5 3.0 3.5 4.0 4.5 5.0 min Cannabinoids PDA Ret. Time 2.739 3.210 3.606 Area 20114 26020 389275 Conc. CBD-V CBD-A CBG CBD THC-V 0.580% CBN 1.247% THC d8-thc CBC 16.257% THC-A Name C: LabSolutions Data 11 Dec 2015 XI-8_007.lcd