Effective Date: TBD Version: 1.0 (Revised: 6/11/2014)

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Protocol Title: Hypertension Effective Date: TBD Version: 1.0 (Revised: 6/11/2014) Approval By: TBD Planned Review Date: TBD 1 Purpose & Objective This protocol provides evidence-based care recommendations in the screening and treatment of patients with Hypertension in the primary care setting. 2 Scope of Protocol Target Population This protocol was derived from clinical guidelines for individuals in the CCC population diagnosed with Hypertension, 18 years of age or older. Target Users This protocol is developed for use in primary care settings. Excluded Topics This protocol does not address the clinical management of patients with Pre-Hypertension or Malignant Hypertension. Related Guidelines James P.A. et al. (2014) Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA Understand Your Risk for High Blood Pressure. (2012, April 4).. Retrieved February 4, 2014, from http://www.heart.org/heartorg/conditions/highbloodpressure/understandyourriskforhighblood Pressure/Understand-Your-Risk-for-High-Blood-Pressure_UCM_002052_Article.jsp 1

1 Protocol Development & Review Process Protocol Development & Review Process This protocol originated in the CCC Clinical Protocol Subcommittee, led by a Cardiologist specializing in Hypertension. A group of clinical staff met and converged on the items in this document via a Rapid Design Session. In this session, a facilitator guided the group through the process to extract evidence-based elements to adequately care for the CCC population impacted by Hypertension. The above depiction describes the approval and subsequent review process for this protocol. Group Name Approval Date CCC Hypertension Protocol Subcommittee 2/4/2014 CCC Clinical Protocols Workgroup 3/6/2014 CCC Clinical Delivery System Steering Group 5/28/14 CCC Advisory Committee 5/20/2014 CCC Board of Directors 5/13/2014 2

2 Screening Criteria & Risk Factors Assessing Risk All CCC patients 18 years of age or older should have a blood pressure reading taken at every encounter within the healthcare system. Providers should check the health record for past blood pressure readings and review for trends. 1. Risk Factors: Family history Advanced age Gender-related risk patterns Lack of physical activity Poor diet, especially one that includes too much salt Overweight and obesity Drinking too much alcohol 2. Possible Contributing Factors: Stress Smoking and second-hand smoke Sleep apnea 3. Secondary Hypertension High blood pressure caused by a pre-existing problem (i.e. Kidney abnormality, structural abnormality of the aorta that has existed since birth, narrowing of certain arteries) 4. Risks Among Certain Groups Women African-Americans 3

Initial Screening & Diagnosis Other Considerations: Patients in pre-hypertensive range should receive lifestyle education (low salt diet). 4

3 Medication Treatment, Management & Referrals (Refer to Hypertension Medications Spreadsheet Attachment) Clinical Management Monitoring- Consider patient visit with Nurse at a 3 or 6 month interval once Blood Pressure in control Strategies to Dosing Strategy A o Start one drug, titrate to maximum dose, and then add a second drug. Strategy B o Start one drug and then add a second drug before achieving maximum dose of the initial drug. Strategy C o Begin with 2 drugs at the same time either as 2 separate pills or as a single pill combination. 5

Referrals Criteria When to Refer To Whom Resistant Hypertension* Within 30 days Cardiology or Nephrology (if at CKD stage 3) Chest pain Shortness of Breath with Clinical signs of Heart Failure (Jugular Vein Distention, Pulmonary Rales, Edema) Headache with changes in vision Neurological Deficit Abnormal EKG (with ischemic changes ie BP 180/100) *Resistant Hypertension- Patients who have failed to reach target BP on three anti-hypertensive medications (in three different drug categories) at maximum dose. Consider advising patients on 2 gram/day sodium diet and verification of medication adherence. Considerations for Mode of Transportation to Ability to maintain airway No focal neurologic changes No cardiac signs and symptoms If patient goes by private car, patient should not drive. 6

4 Protocol Development Team Name Mark Hernandez MD *Chief Medical Officer George Rodgers MD *Clinical Champion Lola Okunade MD Evelyn Burns RN Jason Jokerst PharmD Peter Miller MD Laura Miles, RD, LD, CDE Affiliation Community Care Collaborative (CCC) & Seton Healthcare Family Seton Healthcare Family Lone Star Circle of Care People s Community Clinic CommUnityCare Capital Nephrology Central Health / Community Care Collaborative 5 References James P.A. et al. (2014) Evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA Understand Your Risk for High Blood Pressure. (2012, April 4).. Retrieved February 4, 2014, from http://www.heart.org/heartorg/conditions/highbloodpressure/understandyourriskforhighblood Pressure/Understand-Your-Risk-for-High-Blood-Pressure_UCM_002052_Article.jsp 7

6 Glossary of Abbreviations Abbreviation A1C ACEI ARB BMP B/P BP Ca CCB CCC CKD CREAT DM ECG EKG GFR H & P HCT HTN K Na SBP Term Hemoglobin A1C Angiotensin-Converting Enzyme Inhibitor Angiotensin Receptor Blocker Basic Metabolic Panel Blood Pressure Blood Pressure Calcium Calcium-Channel Blocker Community Care Collaborative Chronic Kidney Disease Creatinine Diabetes Mellitus Electrocardiogram Electrocardiogram Glomerular Filtration Rate History and Physical Hematocrit Hypertension Potassium Sodium Systolic Blood Pressure 8

Tx UA Treatment Urinalysis 9