University of Groningen Understanding negative symptoms Klaasen, Nicky Gabriëlle IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 2017 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Klaasen, N. G. (2017). Understanding negative symptoms: Neuroimaging insights into the neurocognitive basis of negative symptoms in schizophrenia. [Groningen]: Rijksuniversiteit Groningen. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 19-04-2019
Understanding negative symptoms Neuroimaging insights into the neurocognitive basis of negative symptoms in schizophrenia Nicky Gabriëlle Klaasen
N.G. Klaasen, Groningen 2017 Understanding negative symptoms: neuroimaging insights into the neurocognitive basis of negative symptoms in schizophrenia Cover design: Ellen Beck www.ellenbeck.nl Layout: Nicky Klaasen Printed by: Netzodruk, 100% recycled paper ISBN printed version: 978-94-034-0170-6 ISBN digital version: 978-94-034-0169-0
Understanding negative symptoms Neuroimaging insights into the neurocognitive basis of negative symptoms in schizophrenia Proefschrift ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen op gezag van de rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties. De openbare verdediging zal plaatsvinden op woensdag 1 november 2017 om 12.45 uur door Nicky Gabriëlle Klaasen geboren op 12 oktober 1987 te Leiderdorp
Promotor Prof. dr. A. Aleman Copromotor Dr. E.M. Opmeer Beoordelingscommissie Prof. dr. S. Kaiser Prof. dr. J.M. Spikman Prof. dr. D.J. Veltman
Table of contents Chapter 1 General introduction 7 PART I Neural correlates of negative symptoms Chapter 2 Chapter 3 Negative symptoms and ventral striatal activation during reward processing in schizophrenia: a systematic review and meta-analysis Neural correlates of forecasting of positive emotional events in patients with schizophrenia 19 39 PART II Neural correlates of negative symptom dimensions: amotivation and expressive deficits Chapter 4 Chapter 5 Connectomics and negative symptom dimensions in schizophrenia: expressive deficits versus amotivation Intrinsic mesocorticolimbic connectivity is negatively associated with amotivation in people with schizophrenia 59 79 PART III Neural correlates of a single negative symptom: apathy Chapter 6 Chapter 7 Apathy is related to reduced activation in cognitive control regions during set-shifting Neural basis of self-initiative in relation to apathy in a student sample 99 123 Chapter 8 Summary and general discussion 147 References 160 Samenvatting (Summary in Dutch) 186 Dankwoord (Acknowledgements) 194 Curriculum vitae 198 Publications 199