under the aegis of cover picture: Chiostro d Onore University of Milan

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under the aegis of cover picture: Chiostro d Onore University of Milan Milan. 2,3 July 2012 Palazzo Visconti

MEETING AIM In the last year the therapeutic scenario of chronic hepatitis C has been subverted by the introduction of HCV protease inhibitors, that in combination with pegylated interferon plus ribavirin have become the standard of care treatment for patients with genotype 1 infection. Due to specific protease inhibitors related side effects and treatment algorithms that are far from being user-friendly, this important clinical breakthrough has increased the complexity in the clinical management of HCV-1 patients. Moreover there are still some areas of uncertainties that regard both the selection of patients for treatment as well as the optimal management of protease inhibitors based regimens. The present workshop aims to highlight these grey areas with the ultimate aim of translating treatment efficacy as seen in clinical trials, into effectiveness in the clinical practice. A panel of opinion leaders from Europe and the US will discuss these issues with specific lectures and case presentations followed by interactive discussion. We do hope that everybody will enjoy attending this meeting while providing his/her fruitful contribution in the discussion between panelists and audience. STEERING COMMITTEE Massimo Colombo Alessio Aghemo U.O. Gastroenterologia Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico Via Francesco Sforza, 35 - Milan (IT) Ph. +39 (0)2 55035432 alessio.aghemo@unimi.it

FACULTY Nezam Afdhal Professor of Medicine Beth Israel Deaconess Medical Center, Boston (MA, USA) Alessio Aghemo Dept. of of Medicine Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan (IT) Alfredo Alberti Dept. of Histology, Microbiology and Medical Biotechnology University of Padua (IT) Ferruccio Bonino Dept. of Internal Medicine University of Pisa (IT) Maurizia Brunetto Dept. of Hepatology Azienda Ospedaliero Universitaria Pisana (IT) Stéphane Chevaliez Dept. of Virology, French National Reference Center for Viral Hepatitis B, C and delta INSERM U955, Henri Mondor University Hospital, Créteil (FR) Alessia Ciancio Dept. of Gastroenterology San Giovanni Battista Hospital, Turin (IT) Massimo Colombo Dept. of Medicine Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico University of Milan (IT) Antonio Craxì Gastroenterology and Hepatology, DIBIMIS Policlinico Paolo Giaccone University of Palermo (IT) Vito Di Marco Gastroenterology and Hepatology, DIBIMIS Policlinico Paolo Giaccone University of Palermo (IT) Philippe Halfon Virology and Infectious Diseases Hôpital Ambroise Pare, Marseille (FR) Alessandra Mangia Dept. of Hepatology IRCCS Ospedale Casa Sollievo della Sofferenza San Giovanni Rotondo (IT) Patrick Marcellin Professor of Hepatology Hôpital Beaujon, Clichy (FR) Mario Rizzetto Dept. of Gastroenterology Ospedale San Giovanni Battista University of Turin (IT) Maria Grazia Rumi Dept. of Hepatology Ospedale San Giuseppe University of Milan (IT) Christoph Sarrazin Dept. of Internal Medicine J.W. Goethe University Hospital, Frankfurt (DE) Giovanni Squadrito Unit of Clinical and Molecular Hepatology Dept. of Internal Medicine University of Messina (IT)

Monday, July 2 13.00-14.00 Welcome Lunch 14.00-14.20 Meeting Introduction Massimo Colombo 14.20-14.50 Standard of care therapy in 2012 Alfredo Alberti Chairmen: Ferruccio Bonino, Antonio Craxì 14.50-15.20 From Guidelines to clinical practice Antonio Craxì 15.50-16.20 Management of specific side effects of DAAs Nezam Afdhal 16.20-17.20 Discussion 17.20-17.40 Coffee Break 17.40-19.00 Case presentations with discussion Alessia Ciancio, Vito Di Marco 15.20-15.50 IL28B genotype: useful or not useful? Stéphane Chevaliez

Tuesday, July 3 Chairmen: Massimo Colombo, Mario Rizzetto 09.00-09.30 Resistance to DAAs: are there any clinical implications? Philippe Halfon 09.30-10.00 DAAs in patients with cirrhosis Alessandra Mangia 10.00-10.30 Discussion 10.30-10.50 Coffee break 10.50-12.20 Case Presentations with discussion Alessio Aghemo, Giovanni Squadrito Chairmen: Massimo Colombo, Patrick Marcellin 14.00-14.30 Future therapies for HCV- 1: between myth and reality Christoph Sarrazin 14.30-15.00 Future therapies for other HCV genotypes Patrick Marcellin 15.00-15.30 Discussion 15.30-17.00 Case Presentations with discussion Maurizia Brunetto, Maria Grazia Rumi 12.20-14.00 Lunch

GENERAL INFORMATION MEETING VENUE Palazzo Visconti Via Cino del Duca, 8 - Milan (IT) REGISTRATION Free-registration for a fixed number participants. Online registration available on the website www.iec-srl.it, section Events and then selecting Application Form. A few delegates will be invited directly by the sponsor. CME CREDITS PROVIDER ITALIAN CME CREDITS: I&C srl (n. 1740) ID CME ITALIAN CREDITS: 34312 CME CREDITS: n. 7,5 CME credits for physicians have been requested, to be obtained by attending all sessions of the meeting (100% of attendance). Disciplines: Gastroenterology, Infectious Diseases, Internal Medicine, General Medicine. Checking Method: Multiple-choice test (75% of the answers must be correct). I&C S.r.l. assumes all responsibility for the content, quality and ethical correctness of this CME activity. FOR FURTHER INFORMATION ORGANIZING SECRETARIAT I&C srl Via Andrea Costa, 202/6 40134 Bologna (IT) Ph. +39 (0)51 6144004 Fax +39 (0)51 6142772 e-mail: federica.schiassi@iec-srl.it web: www.iec-srl.it with unrestricted contribution of MSD ITALIA S.R.L www.msd-italia.it