Impact of Depression on families, patients and professional lives

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MEP Initiative Depression in the Workplace Impact of Depression on families, patients and professional lives Detlef E. Dietrich, MD European Depression Association (EDA) and AMEOS Klinikum Hildesheim, Germany 18.06.2014 Prof. Dr. Detlef E. Dietrich 1

Content General aspects of depression Epidemiology, etiopathogenesis, symptoms, impact on subjects, families, society and work place European Depression Association (EDA) The IDEA-Study 18.06.2014 Prof. Dr. Detlef E. Dietrich 2

Epidemiology of mood disorders Studies Prevalence Major Depression Lifetime Prevalence Dysthymia Lifetime Bland et al., 1988 Edmonton, Canada 8.6 3.7 Wells et al., 1989; Oakley-Browne et al., 1989 Christchurch, New Zealand 12.6 6.4 Szadoczky et al., 1998 Hungary 15.1 4.5 Kessler et al., 1994; Blazer et al., 1994 USA (NCS) 17.1 6.4 Bijl et al., 1998 The Netherlands 15.4 6.3 Kringlen et al., 2001 Oslo (Norway) 17.8 10.0 Abou-Saleh et al., 2001 Al Ain (United Arab. Emirates) 3.4 - Andrade et al., 2002 Sao Paulo, Brazil 16.8 4.3 Jacobi et al., 2004 Germany 14.8 4.5 The ESEMeD-MHEDEA 2000, 2004 Belgium, France, Germany, Italy, The Netherlands, Spain 12.8 4.1 Wittchen & Jacobi (2005) 18.06.2014 Prof. Dr. Detlef E. Dietrich 3

Epidemiology of mood disorders Angst et al. (2005) 18.06.2014 Prof. Dr. Detlef E. Dietrich 4

WHO Global Burden of Disease Years lived with disability(mio.) 10 9 8 7 6 5 4 3 2 1 0 Major Depression, unipolar 8,39 Dementia a.o. deg. Disord. 6,33 Defective Hearing 5,39 Abuse of Alcohol 3,77 3,77 Osteoarthritis Cerebrovascular Disorders 3,46 Chronic Obstructive Pulmonary Disease 2,86 Diabetes mellitus 2,25 Endocrine Disorders 1,68 Age-related Visual Impairment 1,53 Lopez et al. (2006) 18.06.2014 Prof. Dr. Detlef E. Dietrich 5

Early retirement: mental disorders The four most common reasons for early retirement due to illness Malignoma Cardiovascular diseases Musculosceletal diseases Psychiatric disorders (Wedegärtner et al. 2007) 18.06.2014 Prof. Dr. Detlef E. Dietrich 6

Depression affects The individuum (mental and somatic health) The relatives (partners, children, parents ) Social environment Company (colleagues, supervisors, company physician, company, health insurance fund, productivity, economic situation ) Economy 18.06.2014 Prof. Dr. Detlef E. Dietrich 7

What is Depression? Karl Jaspers defined the core of depression as a deep sadness and an inhibition of all mental activity ( tiefe Traurigkeit und eine Hemmung allen seelischen Geschehens ) 18.06.2014 Prof. Dr. Detlef E. Dietrich 8

Symptoms of Depression Symptoms % Insomnia 100 Depressive mood 100 Loss of interest or pleasure 94 Lack of concentration 91 Negative thoughts 82 Fatigue / decrease of energy 76 Fractiousness 76 Psychomotor retardation 76 Lack of appetite 66 Daily fluctuations 64 Despair 51 Memory disturbance 35 Delusional ideas 33 Suicidal attempts 15 18.06.2014 Prof. Dr. Detlef E. Dietrich 9

Suicide WHO: > 1 mio. people commit suicide per year wordwide 10-20 mio. non-fetal suicide attempts estimated Leading cause of death among teenagers and adults under 35 y More than 50 % related to depression 15 % of recurrently depressed die of suicide 18.06.2014 Prof. Dr. Detlef E. Dietrich 10

Treatment options Psychotherapy Pharmacotherapy Sociotherapy Occupational therapy Physiotherapy Light therapy Sleep deprivation Electroconvulsive therapy (ECT) DeRubeis et al. (2008) 18.06.2014 Prof. Dr. Detlef E. Dietrich 11

Incidence and treatment reality Depressive persons in Germany Treated in general practice Diagnosed as being depressed Adequately treated ca. 4 mio. 2.4-2.8 mio. 1.2-1.4 mio. 400 tsd. 100% 60-70% 30-35% 10% Kompetenznetz Depression, 2001; Laux G. (ed.), Springer 2002 18.06.2014 Prof. Dr. Detlef E. Dietrich 12

European Depression Association (EDA) European Depression Association (EDA) Alliance of organisations, patients, researchers and healthcare professionals from 19 countries across Europe President: Dr. Vincenzo Costigliola EDA raises awareness and promotes better understanding of the impact of depression on people s lives, and to challenge stigma and discrimination More details: www.europeandepressionday.com 18.06.2014 Prof. Dr. Detlef E. Dietrich 13

IDEA: Impact of Depression at Work in Europe Audit Final report Prepared by: Fabrice Dussol Ipsos Healthcare FINAL /DRAFT Version 1 Strictly Confidential September 2012 2012 Ipsos. All rights reserved. Contains Ipsos' Confidential and Proprietary information and may not be disclosed or reproduced without the prior written consent of Ipsos.

7 Countries Covered In Europe Technical Note: The research was conducted using Ipsos MORI s online panel, between Thursday 30 th of August and 19 th September 2012. Questions were asked online of 7,065 adults aged 16-64 who are workers and managers, or have worked and managed within the last 12 months, across Europe. Results are weighted to ensure the sample was representative of this profile. Full data tables are available upon request. Where percentages do not add up to 100, this may be due to computer 15 rounding, multiple responses, or the exclusion of don t know categories. All figures are percentages based on the total sample (1000) unless otherwise stated.

Depression diagnosis By country Q2A. Have you ever personally been diagnosed as having depression by a doctor/medical professional? = significant difference on Yes with a 95% confidence interval 16 Base: 7065 Adults aged 16-64 September 2012 Source: Ipsos MORI

Time taken off work because of the depression By country Q3A. Have you personally ever taken time off work because of your depression? = significant difference on Yes with a 95% confidence interval 17 Base: 1407 Adults aged 16-64 who have been diagnosed with depression September 2012 Source: Ipsos MORI

Depression in the Workplace Symptoms % Insomnia 100 Depressive mood 100 Loss of interest or pleasure 94 Lack of concentration 91 Negative thoughts 82 Fatigue / decrease of energy 76 Fractiousness 76 Psychomotor retardation 76 Lack of appetite 66 Daily fluctuations 64 Despair 51 Memory disturbance 35 Delusional ideas 33 Suicidal attempts 15 18.06.2014 Prof. Dr. Detlef E. Dietrich 18

Symptoms associated with depression and impact at work Q5. Which, if any, of the following attributes/symptoms do you associate with depression in general? Tick all that apply. Q6A. Looking at the issues below, please select the 5 you think would have the most impact on your ability to perform tasks at work as normal. Q6B. Please select the 5 issues you think would be most likely to cause you to take time off from work. Most likely to take time off 3 1 4 Crying for no reason Trouble sleeping Low mood or sadness 6 5 2 Loss of interest in daily activities 7 Changes in weight and appetite 9 8 Difficulty planning Size of bubble= frequency associated with depression X Indecisiveness 19 Base: 7065 Adults aged 16-64 September 2012 Source: Ipsos MORI Forgetfulness Trouble Concentrating = Rank/ Associated with depression Most impact at work

Working days lost due to depression: by country Q3C. The last time you experienced depression, how many working days did you have to take off work because of your depression? Please write in the total number of days below Average number of working days = significant difference on Average number of days with a 95% confidence interval 20 Base: 722 Adults aged 16-64 who take time off work because of depression September 2012 Source: Ipsos MORI

Burden of Depression Significant socio-economic costs: 18.06.2014 Estimated costs of 113.4 billion in 2012 63 % being indirect (lost productivity, sick leave and early retirement) Prof. Dr. Detlef E. Dietrich 21

Working environment Conditions of work for 235 Mio. workers in the EU (European Foundation, 2011) 18.06.2014 Work at very high speed/tight deadlines: 50% Monotonous tasks: 45% Repetitive tasks of less than 1 minute: 27% Problems in work-life-balance: 18% Heavy loads at least ¼ of working time: 33% Work in tiring and painful positions: 46% Work in loud noise: 30% Prof. Dr. Detlef E. Dietrich 22

Depression and the Workplace Employment in a good working environment is beneficial to physical and mental health (antidepressive effects) Unemployment is related to a massive enhancement of physical and mental health problems! Reintegration into workplace which is supportive for mental health is essential! 18.06.2014 Prof. Dr. Detlef E. Dietrich 23

Carer required when off work due to depression By country Q3D. Thinking about the last time that you were off work due to depression, did you require a carer (i.e. a family member or friend) and if so, did they have to take time off work? = significant difference on Yes carer who did not have to take time off with a 95% confidence interval 24 Base: 715 Adults aged 16-64 who take time off work because of depression September 2012 Source: Ipsos MORI

Impact of Depression on families Depression in one family member is associated with 18.06.2014 an increased incidence of psychopathology in other family members an increased physical morbidity in their families imbalance of the family system Prof. Dr. Detlef E. Dietrich 25

Families of depressive patients Relatives / friends may be affected by 18.06.2014 Lack of understanding, helplessness Conflicts, feeling of anger Feeling of guilt and/or frustration Financial problems Social isolation Changed parenting behavior Stress Prof. Dr. Detlef E. Dietrich 26

Chronic stress Cortisol-enhancement sympathical activation inflammation Metabolic syndrome/ diabetes Musculosceletal disorders/ dysfunctions Cognitive disturbances (memory and learning) Hypertension coronar diseases/ ischemia 18.06.2014 Immunosuppression Sleep disturbances anxiety and/or depression Prof. Dr. Detlef E. Dietrich 27

Etiopathogenesis of Depression and treatment options Genetic factors Somatic factors Social support External factors Behavioural factors Depression Stressful life-events / trauma Behaviour Chronic stress and conflicts Personality Treatment 18.06.2014 Prof. Dr. Detlef E. Dietrich 28

Thank you for your attention! 18.06.2014 Prof. Dr. Detlef E. Dietrich 29