Vit. K2 A breakthrough in the treatment of OSTEOPOROSIS OSTEOPOROSIS is a systemic disease of the skeleton apparatus implying compromised bone mineral density and microarchitecture which increases fracture risks. The loss of bone connectivity is the biggest damage caused by Osteoporosis. For, even augmenting bone mineral density, bone microarchitecture integrity is not necessarily recovered, reducing fracture risks. It promotes bone mineral content and preserves bone quantity. It improves bone structural solidity and quality and increases fracture resistance.
Vit. K2 Ingredients: Menaquinone 7 (Vitamin K2), Calcium, Magnesium, Zinc and Manganese with Fructooligosaccharides (FOS), Vitamin D3, Citric acid, Fructooligosaccharides, Acesulfame K, Silica www.visualgraphic.com 05/2008 Bibliography L.J. Schurgers et Al. - Vitamin K2 improves bone strength in postmenopausal women - (ELSEVIER) International Congress series 1297 (2007)179-187 Gnosis - Effect of Vitamin in bone metabolism: in vitro and in vivo studies on Osteocalcin carboxylation in healty volunteers - 2007 Gnosis - Effect of MK 7 on PGE-2 synthesis in bone forming osteoblast - 2007 Jamie Adam and J. Pepping - Vitamin K in the treatment and prevention osteoporosis and arterial calcification- 2006 Yudiitiya et Al. - Vitamin K2 treatmant for postmenopausal osteoporosis - Japan Society of Obstretrics and Gynecology - Vol.32, No. 2:230-234, April 2006 Steven M. Plaza et Al. - Vitamin K2 in Bone Metabolism and Osteoporosis - Alt. Medicine Review- Vol10, No. 1:24-35 - 2005 Yamaguchi et Al. - Stimulatory effect of Menaquinone - 7 (Vitamin K2) on osteoblastic bone formation in vitro - Molecular and Cellular Biochemestry 223:131-137, 2001 Van den Heuvel et Al - Oligofructose stimulates calcium absorption in adolescents - Am. J. Clin. Nutr., 69 : 544-548 (1999) Ohta et Al. - Calcium and Magnesium absorption from the colon and rectum are increased in rats fed fructooligosaccharides - J. Nutr. 125: 2417-2424 (1995b) www.riverpharma.it
Vit. K2 A breakthrough in the treatment of OSTEOPOROSIS MAN RAY TRUST by SIAE 2008 It improves the bioavailability of Calcium and Magnesium It increases fracture resistance
Vit. K2 PLAYS A KEY ROLE IN - Menaquinone (Vit. K2) Vitamin K2 is a natural vitamine localised in bone tissues. It includes short and long-chain Menaquinone isomers. is biologically more active isomer. Mechanism of Action reductase reductase H2 Osteocalcina Glutammic acid oxide Osteocalcina γ carboxy Glutamic acid Glu carboxilase Binding Calcium intervenes as cofactor in the carboxylation reactions activating Osteocalcine, a protein synthetized by Osteoblasts that links Calcium and is indispensable in bone mineralization and growth.
REDUCING THE INCIDENCE OF FRACT Osteoblasts,, Calcium and Bone Osteoclasts Osteoclasts participating to bone homeostasis adhere to the bone. Osteoclasts release acids and enzymes degrading the bone. Osteoblasts Bone reconstruction starts thanks to the Osteoblasts activated by that synthesise Osteocalcine. Osteoblasts produce a Collagen base that adheres to the bone. Calcium made available by Osteocalcine adheres to Collagen to form new bone tissue. Vitamin D3 and Magnesium actions They favour Calcium fixing to bone tissues.
URES AND IN BONE HOMEOSTASIS Higher assimilation of Calcium with Fructooligosaccharides FOS Calcium 1,000 mg of Calcium per os Vit. K2 1.000 mg of Calcium + FOS per os 30% 300 mg absorbed 70% 700 mg in feces 30% 300 mg absorbed 70% 700 mg in feces 140 mg help strengthen bones 160 mg in urine and sweat 170 mg help strengthen bones 130 mg in urine and sweat Only 14% of Calcium, taken per OS is functional to bone structure. With 17% of Calcium is functional to bone structure, thanks to the association of Calcium and FOS, with a 20% increase if compared with sampling. FOS actions ph FOS are complex carbohydrates almost totally indigestible that improve mineral absorption. They have prebiotic effects, i.e. they are preferential food for intestinal flora. Faster fermentation Slower fermentation Normally, Calcium absorption takes place in the duodenum and terminates in the lower intestine, where the environment becomes alkaline. When the FOS contained in reach the proximal part of colon, fermentation rapidly increases and also continues in the most distal part of colon with consequent production of short-chain fatty acids. As a result, colon acidity significantly increases making Calcium and Magnesium more soluble and bioavailable.