Innovation in Science and Care June, Milan, Italy Auditorium GRUPPO 24 ORE Chair: Paolo Veronesi - Aron Goldhirsch.

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Innovation in Science and Care 22-23 June, 2017 Milan, Italy Auditorium GRUPPO 24 ORE Chair: Paolo Veronesi - Aron Goldhirsch www.breastmilan.com

WELCOME Umberto Veronesi, the Founding Father of the Milan Breast Cancer Conference, and a charismatic leader responsible for significant progress in research and care of women with breast cancer, left us on November 8th, 2016. The Milan Breast Cancer Conference, which he initiated almost 20 years ago, will now carry his name. It will continue to provide caregivers and scientists interested in breast cancer with results of current research. The faculty of international experts will present the most exciting areas of innovation in breast cancer and will discuss issues of significant controversy. The 2017 Umberto Veronesi MBCC will initiate a change to a biannual pace. The conference will continue to provide detailed information and debate on the most recent innovations in diagnosis and treatment to reach the users, women and health care professionals. The conference will include discussions of new developments in Genetics, Prevention, Diagnostics, Imaging, Tumor Pathology, Surgery, Radiation Therapy, Systemic Treatments and Patient Support. Faculty members will therefore be encouraged to promote discussions with the audience. The Umberto Veronesi MBCC will continue to be a relevant venue for an audience interested in the newest information regarding innovations that enhance patient care and understanding of the disease. Paolo Veronesi Aron Goldhirsch Scientific Committee: Bernardo Bonanni - Marco Colleoni - Giuseppe Curigliano - Viviana Galimberti - Mattia Intra - Roberto Orecchia - Virgilio Sacchini - Giuseppe Viale

Barberis Massimo Bardelli Alberto Bernier Jacques Bonanni Bernardo Burstein Harold Cassano Enrico Colleoni Marco Curigliano Giuseppe De Censi Andrea Denkert Carsten Di Leo Angelo Dubsky Peter Foiani Marco Galimberti Viviana Garber Judy Garusi Cristina Gentilini Oreste Gianni Luca Goldhirsch Aron Harris Jay Intra Mattia Jereczek-Fossa Barbara Alicja King Tari Leonardi Maria Cristina Marotti Lorenza Munzone Elisabetta Orecchia Roberto Partridge Ann Petit Jean Yves Pruneri Giancarlo Rietjens Mario Sacchini Virgilio Sapino Anna Serrano Davide Toesca Antonio Veronesi Paolo Viale Giuseppe Winer Eric Paul INTERNATIONAL INVITED FACULTY University of Turin Genolier Clinic E.O. Ospedali Galliera Charité University Azienda USL 4 Medical University of Vienna and St. Anna Clinic IFOM -Istituto FIRC di Oncologia Molecolare San Raffaele Hospital San Raffaele Hospital, European Society of Breast Cancer Specialists,, University of Turin,, Turin - Italy Genolier - Switzerland Genova - Italy Berlin - Germany Prato - Italy Lucerne - Switzerland Florence - Italy Turin - Italy

GENERAL INFORMATION Abstract deadline: 30th March 2017 Abstract submission Participants with new data relevant to the subjects of the conference may submit one abstract to be considered for e-poster presentation. Only papers whose abstracts have been reviewed and approved by the Scientific Committee will be presented as e-posters. - Abstracts must be written in English and the text should not exceed 2000 characters (title included). - The title should appear in capital letters. - For each author, type surname first followed by given name and initials (presenting author in capital letters). - List the affiliations after the authors list. - The full address with telephone number, fax number, and e-mail of the corresponding author must be provided. The latter will receive all the subsequent communications concerning the abstract. Once accepted, the full paper can be presented in 6 slides, containing the following sections: background, material methods, results, conclusions. All the slides must be sent to the Organising Secretariat (mbcc@ieo.it) within 15th May 2017, to be uploaded in the e-poster player. Please indicate your approval for publication in case the abstracts will be issued in a journal. Registration fees Delegates Associated members Residents in training (ID document and declaration from the hospital needed) Developing countries residents Early rate 400,00 300,00 200,00 200,00 Late rate 550,00 400,00 300,00 300,00 Online registration available in the website www.breastmilan.com The early rates will expire on the 24th April 2017 CME accreditation The will apply for CME credits to the accreditation Council of Oncology in Europe and to the Italian Ministry of Health. Official language: english

Thursday 22 June 2017 PROGRAMME 08.30 08.40 09.00-10.20 09.00 09.15 09.35 09.50 10.20 10.50-12.55 10.50 11.10 11.25 11.40 11.55 12.10 12.25 12.55 13.55-16.00 13.55 Welcome remarks - Aron Goldhirsch News from St.Gallen: Panel recommendations 2017 - Marco Colleoni High Risk of developing breast cancer Chair: Bernardo Bonanni - Judy Garber Clinical and metabolic risk assessment - Andrea De Censi Germline mutations: genetic predisposition - Judy Garber Pathological findings of high risk - Carsten Denkert Discussants: Massimo Barberis, Bernardo Bonanni, Andrea De Censi, Carsten Denkert, Judy Garber Coffee break In situ disease Chair: Giancarlo Pruneri - Virgilio Sacchini Pathology of Lobular and Ductal intraepthelial neoplasia - Giancarlo Pruneri Radiologic hurdles for DIN and LIN - Enrico Cassano State of the art surgery for intraepithelial lesions - Virgilio Sacchini How and when to irradiate operated intraepithelial lesions - M. Cristina Leonardi Plastic surgery and lipofilling in case of intraepithelial lesions - Jean Yves Petit Systemic Therapy of Intraepithelial neoplasia - Davide Serrano Discussants: Bernardo Bonanni, Enrico Cassano, M. Cristina Leonardi, Jean Yves Petit, Giancarlo Pruneri, Virgilio Sacchini, Davide Serrano Lunch Global approach to breast surgery Chair: Oreste Gentilini - Paolo Veronesi What do you need to know before facing breast operation for breast cancer - Anna Sapino

14.15 14.30 14.45 15.00 15.15 15.30 16.00 16.30-18.00 Axilla Dethroned? - Viviana Galimberti Long-term consequences of breast conservation vs. breast removal and reconstruction - Peter Dubsky All you want to know about intraoperative radiotherapy - Roberto Orecchia Breast surgery and beyond for special Patients - Mattia Intra Surgery for advanced disease: why and when? - Tari King Discussants: Peter Dubsky, Viviana Galimberti, Oreste Gentilini, Mattia Intra, Tari King, Roberto Orecchia, Anna Sapino, Paolo Veronesi Coffee break Breast Surgery live theater (author-commented videos) Chair: Viviana Galimberti - Mattia Intra 16.30 16.45 17.00 17.15 17.30 18.00 Oncoplastic Surgery - Mario Rietjens Radioguided occult lesion localization and sentinel node biopsy (SNOLL) - Viviana Galimberti Robotic Surgery - Antonio Toesca Surgery for lymphedema - Cristina Garusi Discussants: Viviana Galimberti, Cristina Garusi, Mattia Intra, Mario Rietjens, Antonio Toesca Adjourn Friday 23 June 2017 08.30 09.00-10.35 09.00 09.20 09.35 09.50 10.05 10.35 Panel: Eusoma Certification for Breast Centres: debate on process, details and relevance - Chair: Lorenza Marotti Radiation therapy: standards and beyond Chair: Jacques Bernier - Roberto Orecchia Standard of radiotherapy for breast cancer - Jay Harris Irradiation of the reconstructed breast - Barbara Alicja Jereczek-Fossa Re irradiation for cancer re-appearance - Maria Cristina Leonardi Radiotherapy in patient with autoimmune disorder - Giuseppe Curigliano Discussants: Jacques Bernier, Sandra Demaria, Jay Harris, Barbara A. Jereczek Fossa, M. Cristina Leonardi, Roberto Orecchia Coffee break

11.00-13.25 11.00 11.20 11.40 12.00 12.20 12.40 12.55 13.25 14.30-15.00 15.00 15.40-17.40 15.40 16.00 16.20 16.40 16.55 17.10 17.40 Adjuvant and neoadjuvant systemic therapies: standards and beyond Chair: Marco Colleoni - Eric Winer Type of disease and risk assessment in the choice of adjuvant systemic therapies (including choice of chemotherapy for lobular breast cancer) - Giuseppe Viale Innovation in adjuvant endocrine therapies for pre and postmenopausal patients - Marco Colleoni The special case of younger patients with breast cancer - Ann Partridge Chemotherapy for patients with HER2-positive and triple negative disease - Angelo Di Leo The evolving role of neoadjuvant treatments - Eric Winer Support and avoiding alopecia during adjuvant chemotherapy - Elisabetta Munzone Discussants: Marco Colleoni, Angelo Di Leo, Elisabetta Munzone, Ann Partridge, Giuseppe Viale, Eric Winer Lunch Spotlight Liquid biopsy: clinical implications - Alberto Bardelli EIO Award Keynote lecture - Judy Garber New targets and new drugs Chair: Harold Burstein - Giuseppe Curigliano Improving endocrine responsiveness - Harold Burstein Improving antiher2 responsiveness - Luca Gianni Enhancing immunogenicity and improving immune response - Giuseppe Curigliano The chapter of metronomic chemotherapies: from advanced breast cancer to the adjuvant setting - Marco Colleoni Targeting DNA repair - Marco Foiani Discussants: Harold Burstein, Marco Colleoni, Giuseppe Curigliano, Marco Foiani, Luca Gianni Conclusions

www.breastmilan.com Conference venue Auditorium GRUPPO 24 ORE Via Monte Rosa, 91 20149 Milano (area Fiera Milanocity) www.eventiquattro.com Organising Secretariat MZ Congressi srl Via Carlo Farini, 81 20159 Milano Tel. + 39 02 66802323 Fax. + 39 02 6686699 Email: mbcc@ieo.it Umberto Veronesi Milan Breast Cancer Conference