EB 2006 Genomics Symposium Health Disparities in Prostate and Breast Cancer: Genetic and Therapeutic Applications Monday April 3, 2006 2:00 p.m.-6:00 p.m. Moscone West Convention Center Room 2000
Welcome On behalf of the organizing committee, it is my pleasure to welcome you to the 2006 FASEB Experimental Biology Symposium on the Genomics of Health Disparities. The focus of this year s symposium, disparities in breast and prostate cancer incidence and mortality, is an area of grave national concern. Of the approximately 1.3 million invasive cancers diagnosed in 2003, racial/ethnic minorities accounted for a highly disproportionate number of these cancers. For example, population data indicate that African Americans suffer from a 10 percent higher incidence rate and a staggering 30% higher death rate for all cancers combined relative to whites. Particularly troubling is the fact that mortality to incidence ratios for some cancers, notably breast, have actually worsened over the past ten years. What are the extrinsic and intrinsic influences that are responsible for these disparities? How is the information gained from 30+ years of research into the molecular pathogenesis of cancer being utilized in understanding and addressing cancer disparities? What are the applications of genomics and proteomics in identifying at risk individuals for early intervention? The questions are multiple and complex. They demand answers if we are to improve health outcomes for a vast proportion of our population. We are indeed fortunate to have a distinguished faculty and panel of experts for this symposium who will not only provide insight into the multiple factors responsible for breast and prostate cancer disparities, but also present their cutting edge research geared at removing these inequities. Their work is both exciting and vital. We hope you take away critical new understanding as a result of today s platform presentations and associated poster session. Nancy L. Thompson, Ph.D. Professor (Research) Medicine and Pathology, Brown Medical School Associate Dean for Graduate and Postdoctoral Studies, Deputy Director, RI Hospital COBRE Center for Cancer Research Development EB 2006 Genomics Symposium 3
event schedule Health Disparities in Prostate and Breast Cancer: Genetic and Therapeutic Applications 2:00-2:05 PM Welcome and Introduction Dr. Sunny E. Ohia 2:05-2:20 PM Overview and Moderators Dr. John D. Carpten KEYNOTE PRESENTATIONS: 2:20-2:45 PM Dr. John D. Carpten Oncogenomics 2:45-3:10 PM Dr. Curtis Pettaway Prostate Cancer Mortality in African Americans: Insights Into Turning the Tide 3:10-3:35 PM Dr. Rick Kittles Prostate Cancer among African Americans: Is Genetics Driving the Disparity? 3:35-4:00 PM Dr. Ronda Henry-Tillman Disparities in Breast Cancer: Changing the Paradigm 4:00-4:25 PM Dr. Dione Farria Disparities in Breast Cancer Screening and Diagnosis 4:25-5:00 PM Interactive Discussion/Q&A 5:00-5:05 PM Introduction of Poster Presentations/ Closing Remarks 5:05-6:00 PM Poster Presentations/ Reception Mixer The symposium was organized by the FASEB MARC Program Advisory Board and sponsored by the FASEB Career Resources and MARC Program Office. Coordinated by: Dr. Sunny E. Ohia Dean and Professor of Pharmacology College of Pharmacy University of Houston, Texas Dr. Nancy Thompson Associate Dean for Graduate and Postdoctoral Studies Division of Biology and Medicine, Brown University Providence, Rhode Island 4 FASEB
MODERATOR: Dr. John D. Carpten Senior Investigator and Director Genetic Basis of Human Disease Division Head, Prostate Cancer Research Unit, TGen (Phoenix, Arizona) KEYNOTE SPEAKERS (PROSTATE CANCER): Dr. John D. Carpten Senior Investigator and Director Genetic Basis of Human Disease Division Head, Prostate Cancer Research Unit, TGen (Phoenix, Arizona) Dr. Curtis A. Pettaway Associate Professor Cancer Biology/Urology The University of Texas M. D. Anderson Cancer Center Dr. Rick Kittles Associate Professor Department of Molecular Virology, Immunology & Medical Genetics The Ohio State University, Human Cancer Genetics Program KEYNOTE SPEAKERS (BREAST CANCER): Dr. Ronda Henry-Tillman Associate Professor of Surgery University of Arkansas for Medical Sciences Dr. Dione Farria Co-Director Alvin J. Siteman Cancer Center Program for the Elimination of Cancer Disparities (PECaD), Assistant Professor of Radiology, Washington University School of Medicine The EB 2006/FASEB MARC Genomics Symposium is funded by a grant from the National Institute of General Medical Sciences, National Institutes of Health (T36-GM-08637). EB 2006 Genomics Symposium 5
ORGANIZER Dr. Sunny Ohia was appointed Dean, College of Pharmacy, University of Houston, Houston, Texas in October 2002. Dr. Ohia also holds the academic rank of professor of Pharmacology in the College. Dr. Ohia holds B.S. and M.S. degrees in pharmacology from the University of Ibadan, Nigeria and a Ph.D. in the same discipline from the University of Glasgow, Scotland, United Kingdom. He pursued postdoctoral research training in neuroscience from Memorial University of Newfoundland, Canada and an additional postdoctoral training in ophthalmology and visual sciences from University of Louisville Kentucky Lions Eye Center, Louisville. Prior to accepting the position at Houston, Dr. Ohia spent 11 years at Creighton University School of Pharmacy and Health Professions where he served as Chair, Department of Pharmacy Sciences for seven years and as an Associate Dean for Administration for four years. Dr. Ohia's research and teaching interests include the pharmacology of receptors that regulate neurotransmitter release and their signal transduction pathways in the eye. He has received research funding from both the National Institutes of Health (NIH) and the pharmaceutical industry. Dr. Ohia has authored several papers and currently serves as a research consultant to some pharmaceutical companies and as a reviewer on NIH Study Sections. He also serves on scientific advisory boards for Windber Research Institute, Pennsylvania and the Lambo Eye Institute, Nigeria. 6 FASEB
ORGANIZER Dr. Nancy L. Thompson is Associate Dean for Graduate and Postdoctoral Studies in the Division of Biology and Medicine as well as Professor of Medicine and Pathology at Brown University and a research oncologist in the Division of Medical Oncology, Rhode Island Hospital in Providence, RI. She also serves as Deputy Director of the NIH funded RI Hospital COBRE (Center of Biomedical Research Excellence) Center for Cancer Research Development. A major goal of the center is to mentor COBRE-funded junior investigators to independent status. Nancy received her research training at Rutgers University, Brown University and at the National Institutes of Health. She has a driving interest and background in career development issues, particularly for trainees, women and minority scientists as is exemplified by various leadership roles and activities. She is a member of the advisory board for the MARC (Minority Access to Research Careers) Program at FASEB and past chair of the American Society for Investigative Pathology s Committee on Career Development, Women and Minorities. She is also principal investigator of a U.S. Department of Education GAANN training grant in Pathobiology, which has partnered with the Graduate School at Brown and national Leadership Alliance Program to establish a pipeline for recruitment, training and mentoring minority PhD students entering careers in disease research. In her role as Associate Dean within Brown s Division of Biology and Medicine she is responsible for the recruitment, training, professional development and tracking of over 300 hundred trainees. Dr. Thompson s research expertise includes hepatocarcinogenesis, gene expression and the regulation and role of heterodimeric glycoprotein transporters in cell activation and cancer and has resulted in more than 50 research articles and book chapters. Her research has been funded by the American Cancer Society, National Institutes of Health, and the American Institute for Cancer Research. EB 2006 Genomics Symposium 7
moderator keynote speaker Prior to coming to TGen, Dr. John Carpten spent nine years at the National Institutes of Health, exploring the genetic basis for various human diseases. He currently directs the Genetic Basis of Human Disease research division at TGen. Throughout his career, he has made seminal discoveries in disease gene identification in cancer and other forms of human disease. Several research projects, which resulted in the discovery of genes involved in both hereditary and sporadic prostate cancer, were led by Dr. Carpten. He has sat on and participated in numerous scientific review boards and has performed scientific editorial review for a number of journals. He holds several patents and has published his work in high impact journals such as Science, Nature and Nature Genetics. He hopes to continue his work in the comprehensive genomic profiling of cancer. One area of extreme interest to Dr. Carpten is the identification of somatic changes that can confer resistance to cancer drugs. Research in this area will be critical in providing the appropriate treatments to individual cancer patients. Dr. Carpten will continue to bring his significant expertise in cancer genomics to bear on this issue to hopefully one day increase the life span or improve the quality of life for cancer patients. 8 FASEB
keynote speaker Dr. Curtis A. Pettaway is Associate Professor of Urology and Cancer Biology at The University of Texas M. D. Anderson Cancer Center in Houston, Texas. Dr. Pettaway s clinical and basic science research is centered on prostate cancer with an emphasis on high risk localized disease. The goal of his studies is to 1) further define serum and tissue markers of prostate cancer progression, 2) develop novel therapeutic strategies to cure locally advanced disease and 3) to reduce disparities in prostate cancer outcome among African Americans and the underserved. Dr. Pettaway s funded research involves defining the prognostic significance of assessing the expression of Matrix Metalloproteinases and E-cadherin in prostate cancer. In addition, through collaborative NIH funded research, Dr. Pettaway is exploring the role of diet and lifestyle in prostate cancer progression. He serves as the Clinical Director of the Neoadjuvant Trials Group that focuses on the integration of novel strategies such as chemotherapy, gene therapy, androgen ablation, and biologic agents with surgery and radiotherapy. Dr. Pettaway serves as the Principal Investigator of the Houston site for the African American Hereditary Prostate Cancer Study. This nationwide network of sites established through the Human Genome Research Institute and Howard University (Washington, DC) accrued African American prostate cancer families to define genetic abnormalities involved in hereditary prostate cancer in African Americans. He is the founder and director of the Prostate Outreach Project providing free education and early prostate cancer detection in the Houston community to African Americans and other underserved populations. EB 2006 Genomics Symposium 9
keynote speaker Dr. Rick Kittles received a B.S. in Biology from the Rochester Institute of Technology in 1989 and a Ph.D. in Biological Sciences from George Washington University in 1998. He then went to Howard University where he helped establish the National Human Genome Center at Howard University. As co-director of Molecular Genetics he directed large-scale, high throughput genotyping and DNA sequencing projects. Kittles coordinated a national cooperative network to study the genetics of hereditary prostate cancer in the African American community. He also co-founded African Ancestry, Inc., a private company that provides DNA testing services for tracing African genetic lineages to genealogists and the general public around the world. Dr. Kittles research interests are in genetic effects on diseases and complex traits such as prostate cancer and skin color. An important aspect of his work entails an appreciation of genetic variation and how it is partitioned across human populations. His work on tracing the genetic ancestry of African Americans has brought to focus many issues, new and old, which relate to race, ancestry, identity, and group membership. He has published numerous articles and book chapters on prostate cancer in the African American population, Race, and Health Disparities. Currently he is Associate Professor in the Department of Molecular Virology, Immunology and Medical Genetics at the Ohio State University Medical Center. 10 FASEB
keynote speaker Dr. Ronda Henry-Tillman is a surgical oncologist specializing in women s oncology at UAMS Medical Center. She is an Associate Professor in the Department of Surgery, and a fellow of the American College of Surgeons. She is Medical Director of the Women s Oncology Clinic, and the Director of Cancer Control at the Arkansas Cancer Research Center (ACRC). As Director, she heads efforts to reduce the mortality, health disparities and cancer burden of Arkansans. She has developed numerous interventions that target cancer disparities. Dr. Henry-Tillman has been recognized as a leader in cancer diagnosis and treatment. She has numerous publications, and has made national and international presentations on MRI and breast cancer staging and the advancements in breast cancer treatment, as well as cancer disparities interventions. She is federally funded in clinical research, with research interests prevalent in cancer education and awareness and community-participatory research. Dr. Henry-Tillman has been awarded several honors in the Cancer Control arena to include the Community Health Research Leadership Award from the National Cancer Institute and the Acknowledgements in Cancer Excellence Community Outreach Award from the American College of Surgeons. She was also recognized by her peers and awarded the Distinguished Faculty Award at Arkansas Cancer Research Center. Most recently, she was prestigiously honored as one of the Best Doctors in America. EB 2006 Genomics Symposium 11
keynote speaker Dr. Dione Farria joined Washington University as an Assistant Professor of Radiology in November, 1999 and as Adjunct Assistant Professor of Community Health at Saint Louis University School of Public Health in 2002. Dr. Farria received her MD from Harvard Medical School in 1989 and received her MPH from UCLA School of Public Health in 1997. She completed a diagnostic radiology residency at UCLA Medical School in 1994 and a General Preventive Medicine Residency in 1997. After a one year clinical fellowship in breast imaging at UCLA/Iris Cantor Center for Breast Imaging, she completed the Robert Wood Johnson Clinical Scholars Program on health services research methodology. She subsequently spent one year as an American Roentgen Ray Scholar. During this year, she completed women s imaging policy externships at the American College of Radiology, Food and Drug Administration, and the California Department of Radiologic Health. Her training was completed in 1998. In 2000, she was a recipient of the Department of Defense Career Development Award. She also received a 2004 Salute to Excellence in Health Care Award from the Saint Louis American Foundation. She is a fellow in the Society of Breast Imaging and the American College of Preventive Medicine. She is currently the principal investigator of a National Cancer Institute Community Networks Grant and the Washington University site principal investigator of the ACRIN Digital Mammography Imaging Screening Trial and ACRIN Breast Ultrasound Screening Trial for High Risk Women. She currently serves as Co-Director of the Program for the Elimination of Cancer Disparities (PECaD) for the Alvin J. Siteman Cancer Center. PECaD s mission is to reduce cancer disparities among African-Americans and other underserved populations in the local community. 12 FASEB
posters P1 P2 P3 Charvann Bailey, Meharry Medical College; Characterization of the mrna produced from the reverse activity of human BRCA2 gene promoter Jennifer Carter, University of North Carolina @ Chapel Hill; PPAR-gamma Regulation of the Plasminogen Activator System in Breast Tissue Athena Starlard-Davenport, University of Arkansas for Medical Sciences; Characterization of UDP-glucuronosyltransferases in normal and carcinogenic human breast tissues EB 2006 Genomics Symposium 13
special thanks We wish to express our sincere appeciation to the following for their time, effort, support and commitment to making this symposium possible. Organizers Dr. Sunny Ohia Dr. Nancy Thompson Moderator Dr. John Carpten Keynote Speakers Dr. John Carpten Dr. Curtis Pettaway Dr. Rick Kittles Dr. Ronda Henry-Tillman Dr. Dione Farria Contributors FASEB MARC Program and Career Resources Staff FASEB MARC Program Advisory Board Experimental Biology 2006 Executive Committee Ms. Pauline Minhinnett Ms. Carolyn Wahl Ms. Reola Moore Ms. Gwendolyn Woods Mr. Galen Perry Ms. Nidia Guzman Ms. Rebecca Santos 14 FASEB
FASEB MARC Program Office 9650 Rockville Pike Bethesda, MD 20814 PHONE: 301-634-7020 FAX: 301-634-7353 EMAIL: marc@faseb.org The EB2006/FASEB MARC Genonimcs Symposium is funded by a generous grant from the National Institute of General Medical Sciences, National Institutes of Health. [T36-GM-08637].