Acceptable antiarrhythmic therapy by monitoring, assessing its necessity and cardiac resynchronization (ICD-RCT) with an interval of one year

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FUNDATIA SENSIBLU Centrul de Consiliere CASA BLU Aleea Negru Voda nr. 4, Bl. C3A, Sc. 3, Et. 3, Ap. 43, Sector 3, București cod poștal 071313 tel/fax: 021-311-4636 cristina.horia@adpharma.com http://www.fundatiasensiblu.ro Persoana de contact PR: Ştefan Gabriel Georgscu Cubrain Studio Agency Coordonator Executive PR Specialist Mobile: +40.746.970.234 e-mail: stefan@donezdesign.org www.donezdesign.org Acceptable antiarrhythmic therapy by monitoring, assessing its necessity and cardiac resynchronization (ICD-RCT) with an interval of one year Project Donation Design transmitted, on 9 April 2013, the second call humanitarian humanitarian campaign Help Stephen, a fundraising appeal for a prominent leader, auxiliary teaching staff, Mr. Stefan Gabriel Georgescu, trainer of leaders and student at Faculty of Security and Defence, National Defence University "Carol I" National defense Ministry. Mr. Stephen Gabriel Georgescu was diagnosed in 2009 and 2010 with chordae rupture of grade III / IV, severe mitral insufficiency previously the central scalopului regurgitate inspiratory collapse completely and multiple transient strokes. Subsequently Stephen Gabriel Georgescu diagnosis was performed implantation loop recorder (ILR) - heart rate monitoring device which helped for 2 years at diagnosis, complex electrophysiological study and ablation catheters were used for diagnosis - treatment AVRNT with radiofrequency for treatment of various heart rhythm disorders. Long delay from the time of diagnosis and the high costs of hospitalization and 13 december 2013 1

treatment integration, Stefan Gabriel Georgescu entered the study with resynchronization implantation cardio stimulator in August 2012 in an already advanced stage of the disease, the condition health and deteriorated alarmingly. During the first year of synchronized cardiac treatment was considered, responder resynchronization therapy DDD bicameral type which, according to British cardiologists, is the only specific antiarrhythmic treatment proved to be effective in reducing the risk of sudden death of his fulfilling the following criteria: fatigue assessed by clinical improvement in work area, increase the distance traveled by at least 10 % in 6-minute walk test, the increase in LVEF by 5% and a decrease in left ventricular end-diastolic volume of at least 15 %, health improving its considerably, as confirmed by the fact that Mr. Stephen Gabriel Georgescu fully recovered activity and resuming his responsibilities. After the first year of synchronized cardiac treatment was considered, responder resynchronization therapy DDD bicameral type which, according to British cardiologists, is the only specific antiarrhythmic treatment proved to be effective in reducing the risk of sudden death of his fulfilling the following criteria: improvement fatigue assessed by the clinical work area, increase the distance traveled by at least 10% in 6-minute walk test, the increase in LVEF by 5% and a decrease in left ventricular end-diastolic volume of at least 15% of its health improving considerably, confirmed that Mr. Stefan Gabriel Georgescu fully recovered activity and resuming his responsibilities. During the fourth stage of resynchronization achieved aritmology clinic on November 29, 2013 in London, develop mitral insufficiency and marked shortening of left ventricular filling by modifications, access routes angle probes implanted on both arteries. Asynchrony between and intra-ventricular was now essential strengthening therapy, with a quite important pathophysiological process that directly depressed left ventricular function, and causing the re-synchronization LV remodeling, as a result of heart failure, by inducing an increased risk of morbidity and mortality. Patient being further international program of arrhythmias, which demonstrated the latest therapies performed that was in AV conduction and intra-ventricular delay further worsening LV dysfunction in patients with preexisting cardiomyopathy. Cardiac resynchronization therapies were applied in the first year of treatment at an interval of 6 months / year, expecting enforcing these resynchronization therapy and becoming visible after at least the first year of the first resynchronization performed. Treatment consists of a procedure resynchronization bicameral indefinitely complex, applying at an interval of one year as follows: for 2014 - the fifth resynchronization therapy bicameral 13 december 2013 2

type DDD - end of November (November 28 to 30 2014). Thus, to date, the cost of 3,700 pounds of annual private health insurance was 2014's likely because you've targeted those fully covered 2% of the funds raised Sensiblu Foundation. Thus, to date, the cost of private medical insurance 3,700 annual 2013 was possible because of you who have targeted 2% of the funds raised entirely covered Sensiblu Foundation. Currently expected effects of resynchronization therapy is long term and should become visible after at least the first year of the first resynchronization performed. Please pass on this message to colleagues and friends share it on your social networks so we can provide air transport costs and accommodation of 6 in 6 months / year, the continuation of the bicameral cardiac resynchronization therapy DDD type for Mr. Stefan Gabriel Georgescu. Continuing resynchronization therapy DDD bicameral type and surgery were made possible by fundraising campaign initiated first and second stage treatment by project design and subsequently Donation Sensiblu Foundation. Please note that these treatments are the latest generation cardiac resynchronization and ensuring only chance of survival in these patients with DDD pacemakers type permanent bicameral, with the latest available technologies and improve existing therapies, reducing unnecessary stimulation of intact atrio-ventricular conduction in patients, for which there were no specific cardiac resynchronization therapy effective in the last thirty years, for the treatment of ventricular arrhythmias. There is no reason to treat asymptomatic ventricular arrhythmias in the absence of these potential benefits. On May 15, 2013 Mr. Stefan Gabriel Georgescu, was admitted to the clinic to be taken into account and made a clinico-biological revaluation, after which it received from leaving the hospital and the medical certificate issued definitive negative opinion the Institute of Emergency for Cardiovascular Diseases "CC Iliescu", Bucharest, following diagnosis: Pacing to work effectively with functional disorders small iatrogenic complete heart block. Ablation of the slow pathway that cannot be controlled in Romania. The patient cannot be questioned in the country. We cannot control this device" is irreversible and past IC NYHA class III criteria for admission to medical and psychosocial disabilities. Inclusion criteria were patients with heart failure refractory to maximal medical treatment was in NYHA functional class III -IV who remain symptomatic despite optimal resynchronization therapy, LV ejection fraction (EF % ) 40 % critical, end-diastolic diameter LV > 29 mm, decreased right ventricular systolic diameter > 39mm, AS increased size > 31mm, narrow QRS escape rhythm and effective refractory node- atrio-ventricular 400/200ms. 13 december 2013 3

Remember that this cardio stimulator permanent bicameral type INGENIO J173 DR DDD is the next generation being purchased only in conjunction with a Latitude Communicator (Patient Management System), manufactured by Boston Scientific. According authorized representative in Romania Medison Pharma acquisition system programmer and LATITUDE Communicator has not been imported, distributed or used in Romania until now, they being made only in certain regions through a phased plan launched by Boston Scientific and Medison Pharma only through authorized channels. Data provided by Boston Scientific medical devices are not part of those contained in the National Cardiology in 2013 the Ministry of Health through the lengthy process of "realesed". Until now, dedicated to ensuring cost medical treatment and surgery resynchronization have amounted to over 227,000 being covered from various sources of funding, including funds raised in the campaign conducted humanitarian initial 2010 Sensiblu Foundation. Humanitarian Campaign Help Stephen!, The project design and subsequently Donation Sensiblu Foundation, Mr Stephen Gabriel Georgescu continues by appealing to the general public by press agencies, his friends, NGOs, academic institutions, colleagues, the business and to all who can support with any financial contribution on further medical checks in the UK. Thank you so much everyone who donated and organizational donors who are with Mr. Stefan Gabriel Georgescu for travel expenses and accommodation in the UK, prinvind continue resynchronization therapy DDD bicameral type : BursaBinelui.ro (through online donations platform BCR), Comunicatedepresa.ro Association Sports Club EduSport ( organizing charity skating courses), Microsoft Romania, Total PR, Digital PR. Senior partners active humanitarian campaign "Help Stephen! are Sensiblu Foundation and Donation project design, making the area an integrated communication campaign Goodwill. As a result of the project, the Design Foundation Donation Sensiblu sprijint him last year to cover the huge costs of treatment for heart disease that is being continued with him and one of those people who went less pleasant moments in life, managing to keep a smile and optimism. We can help and support Mr. Stefan Georgescu, using the following methods of donation. Donations can be made in Romania following accounts: TERMS OF DONATION: 13 december 2013 4

By the Internet Banking: ACCOUNT LEI: RO04 RZBR 0000 0600 1402 6424 ACCOUNT GBP: RO10 RZBR 0000 0600 1511 9021 ACCOUNT EURO: RO37 RZBR 0000 0600 1498 9816 By money order / individual contributions: At the same accounts, but adding the following: Account Holder: STEPHEN GABRIEL GEORGESCU SWIFT CODE: RZBRROBU Bank: Raiffeisen Bank - Bucharest Branch Agency ENPS Square Regiment no. 1, Sector 1, Bucharest Contacts humanitarian campaign to raise funds: donezdesign.org Cristina CĂRĂMIDĂ Senior Designer E-mail: cristina@donezdesign.org Daniel MOVILEANU Senior Designer & PM E-mail: daniel@donezdesign.org Thank you so much everyone who donated in the past three years we have supported in the first (2012 ), the second stage of treatment ( 2013) and are with Mr. Stefan Gabriel Georgescu at this time : [ 2013 ] - The Foundation Sensiblu donate Design, Faculty of communication and Public Relations - SNSPA Bucharest ( and administrative staff of the Bucharest SNSPA donations and all faculties of communication in the country who have supported us, everyone who took notice on blogs and their websites those who have supported us through social networks ) and BursaBinelui.ro ( for online donations platform BCR ) Comunicatedepresa.ro Association Sports Club EduSport ( organizing charity skating courses ), Microsoft Romania, Total PR, Digital PR, [2012 ] - the main partners of the campaign : "Help Stephen " were Sensiblu Donation Foundation Design Association Pro Vita - Valley poplar, Faculty of Communication and Public Relations - SNSPA Bucharest, Children's Heart Association, [2011 ] - a & D Pharma, the Association of Children's Heart ; [ 2010 ] - Wunderman Romania, Microsoft Romania, Syscom Digital, Mira Telecom, Blaupunkt, Asebuss - Institute of Management and Business, Siemens Romania, ELKO Tech Romania, Richter Gedeon 13 december 2013 5

Romania, Volksbank Romania, Orange Romania Faculty of Physics - University of Bucharest, Ernst & Young, Raiffeisen Bank Romania, Danone Romania, UniCreditŢiriac Bank Romania, European Commission Brussels - Belgium, European Organization for Nuclear Research - Switzerland, IFIN -HH, Keppler Rom Info, School "Gregory Prince Ghica "no. 30 Class I- VIII, Piraeus Bank Romania, BCR Romania - Erste Bank, TifinMBA Romania, A & D Pharma, AlliantzTiriac Insurance Romania, University of Bucharest, McCann Ericksson Romania, Tiffin University Business Club, Citibank Romania, Strike Advertising, Petrom - OMV Knoxcris Serv, TotalSoft Syngerta Romania, IPSOS Romania, Fundeni Parish Lady ( with the support of the Romanian Patriarchate ) Sensiblu Foundation, PayPal Romania, Parish Park Plumbuita DigiSign Romania, Autonomous Nuclear Activities - SITON ; Thank journalists and media partners : Comunicatedepresa.ro, Cancan, Antena 3, Romanian Radio Society, Antena 2, Antena 1, Comunicarepublica.ro, Heart Children infoong.ro, 121.ro ( Sensational Women Community ) Careers Magazine Online No Surprises Agency, EventBazar Magazine, Career, Start -up, Centruldepresă.ro, Total PR, Digital PR. ###################### Despre Donezdesign.org Donez Design este un proiect unic de responsabilitate sociala dezvoltat de CUBRAIN. Prin proiectul Donez Design punem la dispozitie serviciile noastre de grafica si design in scop caritabil. Beneficiarul unui proiect plateste serviciile grafice prin donatie, bani sau produse, catre copii din Valea Screzii sau catre comunitate. Despre Fundatia Sensiblu Fundatia Sensiblu a fost infiintata in 2002 la initiativa companiei A&D Pharma de a sprijini in mod activ persoanele aflate in dificultate si reprezinta una din modalitatile prin care compania se implica in viata comunitatii. Inca de la inceputul activitatii sale, Fundatia Sensiblu s-a implicat in sustinerea femeilor si copiilor, victime ale violentei domestice prin programul CASA BLU. Fundatia Sensiblu desfasoara periodic actiuni umanitare si contribuie in mod constant cu donatii in bani sau donatii in obiecte, menite sa aline suferinta diferitelor categorii sociale defavorizate. Fundatia Sensiblu este singura organizatie non-guvernamentala din Bucuresti care activeaza in domeniul prevenirii violentei domestice, deruland in fiecare an campanii de informare si sensibilizare a opiniei publice, precum Panglicile Albe, Sa oprim violenta impotriva femeii!, 16 Zile Internationale de Activism Impotriva Violentei asupra Femeii. Misiunea Fundatiei Sensiblu 13 december 2013 6

Fundatia Sensiblu isi propune sa se implice activ in a raspunde nevoilor cu care se confrunta diferite categorii de persoane (copii institutionalizati, copii ai strazii, femei si copii victime ale violentei domestice, batrani, persoane cu handicap, precum si alte persoane aflate in incapacitatea de a se ajuta singure), sustinandu-le si oferindu- le resurse pentru a-si putea construi o viata armonioasa din punct de vedere fizic, psihic si social. Valorile Fundatiei Sensiblu sunt grija, implicarea, respectul, transparenta, integritatea si responsabilitatea. Programul Casa Blu Programul CASA BLU raspunde nevoilor femeilor si copiilor, victime ale violentei domestice, prin serviciile de consiliere sociala, psihologica si juridica, reprezentarea in instanta, suportul financiar, serviciile de adapost, sprijinul pentru gasirea unui loc de munca si, cel mai important, le asigura starea de confort emotional necesar unui nou inceput. In cadrul programului CASA BLU functioneaza un centru de consiliere, cu adresa publica, la serviciile caruia apeleaza femeile si copiii, atat direct, cat si prin intermediul partenerilor din program si a altor organizatii non-guvernamentale cu programe similare, precum si un adapost, cu adresa confidentiala, in care femeile si copiii se simt in siguranta si pot fi gazduiti intre 1 si 6 luni. In centrul de consiliere, specialistii Fundatiei Sensiblu, asistenti sociali, psihologi, juristi, avocati, ofera suport imediat, pentru depasirea situatiei de criza, iar pe termen lung, sprijina persoanele asistate sa capete si sa dezvolte abilitati necesare unei vieti noi, ferite de violenta. 13 december 2013 7