Hyun Kee Kim, M.S. Curriculum Vitae August, 2012 Ⅰ. Personal Information Address - Office. Researcher Molecular Genetic Laboratory, Research Institute of Medical Science, College of Medicine, The Catholic University of Korea, 505, Banpodong, Seochoku, Seoul, 137-040, Korea Ⅱ. Academic Experience 1996~1997 Sherborne School International Study Centre Sherborne, Dorset, England GCSE s (Middle School) 1997~1998 Edward Greene s Tutorial College Oxford, England A- Level s (High School) 1998~1999 Oxford Tutorial College Oxford, England A- Level s (High School) 1999~2000 University of Durham Durham, England Biomedical science (Diploma) 2000~2002 University of Surrey Guildford, Surrey Medical Microbiology (Bsci Honor) Undergraduate Transferred to Glasgow of Glasgow 2002~2006 University of Glasgow Glasgow, Scotland 1
Neuroscience (Bsci Honor Undergraduate, Msci Honor Postgraduate) Abroad Bibliography 1. (S, 2.296) Wan Kyunn Whang, Hyung Soon Park, InHye Ham, Mihyun Oh, Hong Namkoong, Hyun Kee Kim, Dong Whi Hwang, Soo Young Hur, Tae Eung Kim, Yong Gyu Park, Jae-Ryong Kim and Jin Woo Kim. Methyl gallate and chemicals structurally related to methyl gallate protect human umbilical vein endothelial cells from oxidative stress. Exp. Mol. Med., Vol. 37, No. 4, pp. 343-352, 2005. 2. (S, 2.296) Wan Kyunn Whang, Hyung Soon Park, InHye Ham, Mihyun Oh, Hong Namkoong, Hyun Kee Kim, Dong Whi Hwang, Soo Young Hur, Tae Eung Kim, Yong Gyu Park, Jae-Ryong Kim and Jin Woo Kim. Natural compounds, fraxin and chemicals structurally related to fraxin protect cells from oxidative stress. Exp. Mol. Med., Vol. 37, No. 5, pp. 436-446, 2005. 3. (S, 6.612) Y-J Chung, T-M Kim, D-W Kim, H Namkoong, HK Kim, S-A Ha,, S Kim, SM Shin, J-H Kim, Y-J Lee, H-M Kang, and J W Kim. Gene expression signatures associated with the resistance to imatinib. Leukemia, Vol. 20, pp. 1542-1550, 2006. 4. (S, 2.694) Goang-Won Cho, Seung Min Shin, Hong Namkoong, Hyun Kee Kim, Seon-Ah Ha, Soo Young Hur, Tae Eung Kim, Young-Gyu Chai, Jin Woo Kim. The phosphatidylinositol 3-kinase/Akt pathway regulates the HCCR-1 oncogene expression. Gene, Vol. 384, pp. 18-26, 2006. 5. (S, 2.359) Hong Namkoong, Seung Min Shin, Hyun Kee Kim, Seon-Ah Ha, Goang Won Cho, Soo Young Hur, Tae Eung Kim, and Jin Woo Kim. The bone morphogenetic protein antagonist gremlin is overexpressed in human cancers and interacts with YWHAH protein. BMC Cancer, Vol. 6, No. 74, pp. 1-13, 2006. 6. (S, 13.092) Seung Min Shin, Yeun Jun Chung, Seong Tack Oh, Hae Myung Jeon, Lae Jeong Hwang, Hong Namkoong, Hyun Kee Kim, Goang Won Cho, Soo Young Hur, Tae Eung Kim, Youn Soo Lee, Yong Gyu Park, Jesang Ko, and Jin Woo Kim. HCCR-1 Interacting Molecule "Deleted in Polyposis 1" Plays a Tumor Suppressor 2
Role in Colon Carcinogenesis. Gastroenterology, Vol. 130, No. 7, pp. 2074-2086, 2006. 7. (S, 1.89) Joung Wook Lee, Hong Namkoong, Hyun Kee Kim, Sanghee Kim, Dong Whi Hwang, Hae Ri Na, Seon-Ah Ha, Jae-Ryong Kim,and Jin Woo Kim. Fibrinogen gamma-a chain precursor in CSF: a candidate biomarker for Alzheimer's disease. BMC Neurology, Vol. 7, No. 14, pp. 1-6, 2007. 8.(S, 3.16) Goang-Won Cho, Seung Min Shin, Hyun Kee Kim, Seon-Ah Ha, Sanghee Kim, Joo-Hee Yoon, Soo Young Hur, Tae Eung Kim and Jin Woo Kim. HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis. BMC Cell Biology., Vol. 8, No. 50, pp. 1-12, 2007. 9. (S, 4.693) Seon-Ah Ha, Seung Min Shin, Yong Jin Lee, Sanghee Kim, Hyun Kee Kim, Hong Namkoong, Heejeong Lee, Youn Soo Lee, Young-Seok Cho, Yong Gyu Park, Hae Myung Jeon, Changkyu Oh and Jin Woo Kim. HCCRBP-1 directly interacting with HCCR-1 induces tumorigenesis through p53 stabilization. Int J Cancer, Vol. 122, pp. 501-508, 2008. 10. (S, 2.092) Sang Min Jung, KiBeom Lee, Joung Wook Lee, Hong Namkoong, Hyun Kee Kim, Sanghee Kim, Hae Ri Na, Seon-Ah Ha, Jae-Ryong Kim, Jesang Ko, Jin Woo Kim. Both plasma retinol-binding protein and haptoglobin precursor allele 1 in CSF: Candidate biomarkers for the progression of normal to mild cognitive impairment to Alzheimer's disease. Neuroscience Letter, Vol. 436, pp. 153-157, 2008. 11. (S, 3.08) Seon-Ah Ha, Youn Soo Lee, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Sang Seol Jung and Jin Woo Kim. Oncoprotein HCCR-1 expression in breast cancer is well correlated with known breast cancer prognostic factors including the HER2 overexpression, p53 mutation, and ER/PR status. BMC Cancer, Vol. 9, No. 51, pp. 1-6, 2009. 12. (S, 5.114) Seon-Ah Ha, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Hong Namkoong, Youn Soo Lee, Hae Joo Kim, Sang Min Jung, Yu Sun Lee, Yeun Jun Chung, Yong Gyu Park, Sang Seol Jung, Jin Woo Kim. Dual action of apolipoprotein 3
E-interacting HCCR-1 oncoprotein and its implication for breast cancer and obesity. J. Cellular Molecular Medicine, Vol 13, No. 2, pp.1-8, 2009. 13. (S, 2.81) Goang-Won Cho, Mi-Hwa Kim, Seung Hyun Kim, Seon-Ah Ha, Hyun Kee Kim, Sanghee Kim, Jin W Kim. TCF/beta-catenin plays an important role in HCCR-1 oncogene expression. BMC Molecular Biology, 2009, 10:42 14. (S, 2.056) Youn Soo Lee, Seon-Ah Ha, Hae Joo Kim, Seung Min Shin, Hyun Kee Kim, Sanghee Kim, Chang Suk Kang, Kyo Young Lee, Oak Kee Hong, Seung-Hwan Lee, Hyuk-Sang Kwon, Bong-Yun Cha, Jin Woo Kim. Minichromosome maintenance protein 3 is a candidate proliferation marker in papillary thyroid carcinoma. Experimental Molecular Pathology, 88, 138-142, 2010. 15. (S, 2.654) Seon-Ah Ha, Hyun K Kim, Jinah Yoo, Sanghee Kim, Seung M Shin, Youn S Lee, Soo Y Hur, Yong W Kim, Tae E Kim, Yeun J Chung, Shin S Jeun, Dong W Kim, Yong G Park, Jin Kim, Soon Y Shin, Young Han Lee, Jin Woo Kim. Transdifferentiation-inducing HCCR-1 oncogene. BMC Cell Biol. 2010 Jun 30;11:49. (HKK is a co-first author) 16. (S, 2.026) Peng Jirun, Guoxin Zhang, Hyun Kee Kim, SeonAh Ha, Jin Zhongtian, Qiao Shishi, Cui Zhuqingqing, Gong Lei, Jinah Yoo, Sanghee Kim, Yong Gyu Park, Jing Wang, Yang Yang, Zekuan Xu, Zuhu Huang, Yun Kyung Lee, Eun Young Song and Jin Woo Kim. Clinical utility of alpha fetoprotein and HCCR-1, alone or in combination, in patients with hepatitis, liver cirrhosis and hepatocellular carcinoma. Disease Marker, 2011,30, 307-315. (HKK is a co-first author) 17. (S, ) T-M Kim, S-A Ha, HK Kim, J Yoo, S Kim, S-H Yim, S-H Jung, D-W Kim, Y-J Chung and JW Kim. Gene expression signatures associated with the in vitro resistance to two tyrosine kinase inhibitors, nilotinib and imatinib. Blood Cancer Journal (2011) 1, e32; doi:10.1038/bcj.2011.32 (Epub ahead of print). (HKK is a cofirst author) 18. (S, 2.026) Guoxin Zhang, Seon-Ah Ha, Hyun K. Kim, Jinah Yoo, Sanghee Kim, Youn S. Lee, Soo Y. Hur, Yong W. Kim, Tae E. Kim, Yong G. Park, Jing Wang, Yang Yang, Zekuan Xu, Eun Y. Song, Zuhu Huang, Peng Jirun, Jin Zhongtian, Qiao Shishi, Cui Zhuqingqing, Gong Lei, and Jin W. Kim. Combined analysis of AFP and HCCR-1 4
as an useful serological marker for small hepatocellular carcinoma: a prospective cohort study. Disease Marker, 2012, 32, 265-271. (HKK is a co-first author) 19. (S, 10.614) Peng Jirun, Guoxin Zhang, Seon-Ah Ha, Hyun Kee Kim, Jinah Yoo, Sanghee Kim, Jin Zhongtian, Cui Zhuqingqing, Youn Soo Lee, Gi Hwan Gong, Joo Hee Yoon, Hae Nam Lee, Sa Jin Kim, Tae Eung Kim, Eun Young Song, Yun Kyung Lee, Yong Gyu Park, Jin Woo Kim. HCCR-1 for detecting small hepatocellular carcinoma latent in a cirrhotic liver: a prospective cohort study. Gut, Jul 31, 2012 (Epub ahead of print). (HKK is a co-first author) 20. (S, 4.351) Minsoo Kim, Soomin Yoon, Sukmook Lee, Seon Ah Ha, Hyun Kee Kim, Jin Woo Kim, Junho Chung. Gremlin-1 Induces BMP-Independent Tumor Cell Proliferation, Migration, and Invasion. Plos One, April 2012 Volume 7 Issue 4 e35100. (Epub ahead of print). 21. (S, 3.265) Seon Ah Ha, Hyun Kee Kim, Jin Ah Yoo, Sanghee Kim, Seung Min Shin, Gi-Hwan Gong, Yun Kyung Lee and Jin Woo Kim. HCCRBP-3 Induces Tumorigenesis Through Direct Interaction with HCCR-1 in Human Cancers. Molecular carcinogenesis Jul 31, 2012 (Epub ahead of print). (HKK &JAY are co-first authors) 22. (S, 2.418) The Prognostic Potential of Keratin 18 in the Breast Cancer Associated with the Tumor Dedifferentiation, and the Loss of Estrogen and Progesterone Receptors. Seon-Ah Ha, Hyun Kee Kim, Youn Soo Lee, JinahYoo, Sanghee Kim, Youn Kyung Lee, and Jin Woo Kim. Cancer Biomarkers 2012, 10:219-231. (HKK is a co-first author) 23. (S, 3.15) Kyou-Hoon Han, Si-Hyung Lee, Seon-Ah Ha, Hyun Kee Kim, CheWook Lee, Do-Hyoung Kim, Kee Hwan Gong, JinAh Yoo, Sanghee Kim, and Jin Woo Kim. The functional and structural characterization of a novel oncogene GIG47 involved in the breast tumorigenesis. BMC Cancer 12:274, 2012. (HKK is a co-first author) 5