PRODUCT TECHNICAL DOSSIER N-ACETYL-D-GLUCOSAMINE (VEGAN)

PRODUCT TECHNICAL DOSSIER N-ACETYL-D-GLUCOSAMINE (VEGAN) Product Code: P1409 Raw Material Full Name: N-Acetyl-D-Glucosamine Raw Material Full Botanical/Chemical/Latin/Trade Name/Synonyms: N-Acetyl-D-Glucosamine This material is Food Grade Food Grade CAS Number: 134451-94-8 EC/EINECS Number: 231-368-2 Molecular Formula: C8H15NO6 Limit/Range/Specification: 98% - 102% Specific Rotation: 39 o 43 o Chloride: <1.0% ph Value: 5.5 7.5 Product Code: P1409 Version: 1 Page 1 of 13

Loss on Drying: <0.5% Residue on Ignition: <0.1% Bulk Density: >0.40g/ml Mesh Size: 100% Pass 100 mesh Melting Point: 196 o C 205 o C Ironic Salt: <10ppm Country of Origin: China Country of Origin of the Manufacture: China Base Source/Start Material: Fermented from glucose from corn Material is: 100% Compound Ingredients: None Shelf Life from Date of Manufacture: 2 years Storage Conditions: This material is to be stored in a tightly sealed bag/container and to be kept in a cool place away from moisture and direct sunlight Product Code: P1409 Version: 1 Page 2 of 13

Appearance: Powder Colour: White to off white Flavour/Taste: Characteristic Texture: Powder Odour: Characteristic Microbiological Test Total Viable Count: <500cfu/g Yeast & Moulds: <100cfu/g E.Coli: Negative Salmonella: Negative Metals Heavy Metals: <10ppm Lead (Pb): <2ppm Cadmium (Cd): <2ppm Product Code: P1409 Version: 1 Page 3 of 13

Arsenic (As): <0.5ppm There are no nuts in this recipe and are no nuts on site, however we cannot guarantee that the raw materials entering the site are nut free. Product Code: P1409 Version: 1 Page 4 of 13

INTOLERANCE DATA If No please give details Free from All Animal Products (Beef, Pork, Poultry or other) Free from Bovine Products or Derivatives by using hormones to increase milk yield in cows Free from Bone Meal Free from Peanuts and Peanut Derivatives (including possible cross contamination) Free from other Nut and Nut Derivatives Free from Nut Derived Oil Free from Sesame Seeds and Sesame Seed Derivatives Free from Poppy Seeds and Poppy Seed Derivatives Free from Sunflower Seeds and Sunflower Seeds Derivatives Free from other Seeds and Seed Derivatives Free from Milk and Milk Derivatives (including lactose) Free from Egg and Egg Derivatives Free from Cereals containing Gluten (wheat / rye / oats / barley/ spelt/ kamut or their hybridised strains) and Derivatives Free from Soya and Soya Derivatives Free from Maize and Maize Derivatives NO Starting material Free from Corn and Corn Derivatives NO Starting material Free from Lupin and Lupin Derivatives Free from Yeast and Yeast Derivatives Free from Cotton Seeds (Flour) and Cotton Seed Derivatives Free from Rice and Rice Derivatives Free from Mustard and Mustard Derivatives Free from Celery or Celery Derivatives Free from Celeriac or Celeriac Derivatives Free from Fruit and Fruit Derivatives Free from Vegetable and Vegetable Derivatives Free from Carrot and Carrot Derivatives Free from Legumes / Pulses Free from Fish and Fish Derivatives Free from Crustaceans / Molluscs and their Derivatives Free from Additives Free from Added Salt Free from Added Sugar Free from Antioxidants Free from Artificial Glutamates Free from Aspartame Free from Azo and Coal Tar Dyes Free from Benzoates (E210 / E219) Free from BHA / BHT (E320 / E321) Free from Caffeine Free from Cinnamon Free from Cocoa Free from Colours (Artificial / Nature Identical / Natural / Smoked) Free from Dextrose Free from Dioxins Free from Ethanol Product Code: P1409 Version: 1 Page 5 of 13

INTOLERANCE DATA If No please give details Free from Ethylene Oxide Free from Flavourings (Artificial / Nature Identical / Natural / Smoked) Free from Garlic Free from Gelatine Free from Glutamates (E620 to E625) Free from Histamine Free from Hickory Free from Honey Free from Lactose Free from Latex Free from MSG (Added and Naturally Occurring E621) Free from Nucleotides (E627, E630, E631, E635) Free from Polyols Free from Preservatives Free from Starch Products (Including Maltodextrin) Free from Sorbic Acid (E200, E203) Free from Sulphur Dioxide and Sulphites at levels above 10mg/kg or 10mg/litre expressed as SO 2 Free from Sulphites (E220, E228) Free from Sweeteners Free from Vannillin Suitable for Diabetics Suitable for Coeliacs Suitable for Ovo-Lacto Vegetarians Suitable for Vegans Kosher Certified NO Not certified Halal Certified NO Not certified Product Code: P1409 Version: 1 Page 6 of 13

CONFIRMATION OF BSE/TSE STATUS This is to certify that this product complies with all relevant current UK and EU Legislative requirements in regard to Transmissible Spongiform Encephalopathies (TSE) and Bovine Spongiform Encephalopathy (BSE) for human food, and so is free of TSE/BSE. This is also to certify that, during the course of their manufacture, the above-mentioned product did not come into contact with any materials, which could be derived from TSE/BSE risk materials. CONFIRMATION OF GM STATUS This is to certify that this product is not manufactured from GM raw materials and is therefore not subject to labelling under regulations 1829/2003/EC and 1830/2003/EC. CONFIRMATION OF NON IRRADIATION STATUS This is to certify that this product, whole or in part, has not been subjected to Ionising Radiation as per European Directives 1999/2/EC and 1000/3/EC. CONFIRMATION OF NANDROLONE STATUS This is to certify that this product, whole or in part, has not come into contact with Nandrolone or any of its precursors in any way. CONFIRMATION OF IOC PRODUCT STATUS This is to certify that this product, whole or in part, has not come into contact with any product/s, which is banned by the IOC (International Olympics Committee). CONFIRMATION OF ANIMAL TESTING STATUS This is to certify that all the products sold by Cambridge Commodities have not been tested on animals in any part of its manufacture in accordance with regulation 86/609/EEC. CONFIRMATION OF PESTICIDES STATUS This is to certify that the above-mentioned product complies with the regulation (EC) No.396/2005 of 23 rd February 2005 and commission Regulation (EU) No. 559/2011 of 7 th June 2011 amending annexes II and III of the above Regulation. Product Code: P1409 Version: 1 Page 7 of 13

Product Flow Chart Lyophilisation seed Slant culture Seed fermenter Primary fermentation Secondary fermentation Fermentation Fermentation broth Ceramic Membrane Filtration Filter liquor Ultrafiltration Concentration Crystallization & Separation Finished Product Product Code: P1409 Version: 1 Page 8 of 13

MATERIAL SAFETY DATA SHEET Section 1 Description PRODUCT NAME: PRODUCT CODE: Supplier: N-ACETYL-D-GLUCOSAMINE (VEGAN) P1409 Cambridge Commodities Limited 78 Lancaster Way, Ely, Cambridgeshire, CB6 3NW. Tel: 01353 667258. Email: mail@c-c-l.com Section 2 Ingredients/Identity Information Components % in Product CAS Number Formula EINECS Number N-acetyl-D-glucosamine 100 134451-94-8 C8H15NO6 231-368-2 Section 3 Possible Hazards Adverse Effects: Adverse effects may include nausea or other gastrointestinal upset. Possible allergic reaction to material inhaled ingested, or in contact with skin. Overdose Effects: n/f Acute: Possible eye, skin, gastrointestinal, and /or respiratory tract irritation. Chronic: Possible hypersensitisation. Medical Conditions Aggravated by Exposure: Hypersensitivity to material Cross Sensitivity : n/f Target organs: n/f For additional information on toxicity, see Section 11 Section 4 Emergency and First Aid Procedures Inhalation: May cause irritation. Remove to fresh air Eye: May cause irritation. Flush with copious quantities of water Skin: May cause irritation. Flush with copious quantities of water Ingestion: May cause irritation. Flush out mouth with water General First Aid Procedures: Remove from exposure. Remove from exposure. Remove contaminated clothing. Person developing serious hypersensitivity(anaphylactic) reactions must receive immediate medical attention. If person is not breathing, give artificial respiration. If breathing is difficult, give oxygen. Obtain medical attention. Product Code: P1409 Version: 1 Page 9 of 13

Section 4 Continued Note to Physicians Overdose Treatment: For current information about the treatment of overdose, consult a certified Regional Poison Control Center by Calling the number Listed in your local telephone directory Section 5 Fire and Hazard Data Extinguisher Media: Water spray, dry chemical,carbon dioxide, or foam as appropriate for surrounding fire and materials. Fire and Explosion Hazards: This material is assumed to be combustible. As with all dry powders, it is advisable to ground mechanical equipment in contact with dry material to dissipate the potential build-up of static electricity. Firefighting Procedures: As with all fires, evacuate personnel to a safe area, Firefighters should use self-contained breathing equipment and protective clothing. Section 6 Accidental release measures. Spill Response: Wear approved respiratory protection, chemically compatible gloves, and protective clothing. Wipe up spillage or collect spillage using a high efficiency vacuum cleaner. Avoid breathing dust. Place spillage in appropriately labeled container for disposal. Wash spill site. Section 7 Storage Handling: As a general rule, avoid all contact and inhalation of dust, mists, and /or vapors associated with the material. Wash thoroughly after handling. Storage: Store in tight container. This material should be handled and stored per label instructions to ensure product integrity. Store in desiccator. Section 8 Control Methods/Personal Protection Engineering Measures Respiratory Protection Provide sufficient mechanical (general and/or local exhaust) ventilation to maintain exposure below level of overexposure. Avoid inhalation and wear respirator if needed. 3M Dust respirator No. 8710 or 9900 is recommended, or a NIOSH/MSHA jointly approved dust respirator. Product Code: P1409 Version: 1 Page 10 of 13

Section 8 Control Methods/Personal Protection - Continued Hand/Body Protection Eye Protection Avoid contact and prolonged or repeated exposure. Wear resistant gloves. Wash thoroughly after handling. Protective clothing recommended. Wear safety glasses in compliance with OSHA regulations if needed. Section 9 Physical and Chemical Properties Physical state: Powder Colour: White to off white Melting Point: n/f Boiling Point: n/f Flash Point: n/f Autoignition Temperature: n/f Evaporation Rate: n/f Upper Flammability Limit: n/f Lower Flammability Limit: n/f Vapor Pressure: n/f Vapor Density: n/f Specific Gravity: n/f Solubility in water: n/f Fat solubility : n/f Other solubility : n/f Partition Coefficient: n-octabol/water: n/f Percent Volatile: n/f Reactivity in water: /f Explosive Properties: n/f Oxidizing Properties: n/f Section 10 Stability and Reactivity Condition to Avoid: Avoid exposure to moisture Incompatibilities: n/f Decomposition Products: When heated to decomposition, material emits toxic fumes of Sox and Na2o. Emits toxic fumes under fire conditions. Stable? Yes Hazardous Polymerization? NO Product Code: P1409 Version: 1 Page 11 of 13

Section 11 Toxicological Information Oral Rat: LD50:> 10 grams/kg Oral Mouse: LD50:> 10 grams/kg Other Toxicity Data: n/f Irritancy Data: n/f Corrosivity: n/f Sensitization Data: n/f Listed as Carcinogen by : NTP: No IARC No OSHA: No Other Carcinogenicity Data: No Mutagenicity Date: n/f Reproductive and Development Effects: Injection 1 ml of 2% N-acetyl-D-glucosamine in pregnant mice on day 9,10,or 11 of gestation produced an increase in cleft palate and tail abnormalities in the offspring. Oral administration of 5000 mg/kg to pregnant mice or rabbits did not produce adverse effects in the offspring. Section 12 Ecological Information Ecological Information: n/f Section 13 Disposal Considerations Disposal: Dispose of waste in accordance with all applicable National, Provincial, and local laws Section 14 Transport Information Shipping Name: n/f Class: n/f UN Number : n/f Packing Group : n/f Additional Transport Information: n/f Section 15 Regulatory Information China Regulatory Information: n/f International al Regulatory Information: n/f European Regulation This product is not classified according to the EU regulations. Reviews, Standards and Regulations Health & Safety at work act 1974. COSHH Regulations (1994). EH40 Occupational exposure limits. US Federal Regulations Not known. Product Code: P1409 Version: 1 Page 12 of 13

Section 16 Other Information This advice is given by Cambridge Commodities Ltd who accepts no legal liability for it. The information contained herein is based on the present state of our knowledge and is intended to describe our products from the point of view of safety requirements. It should not therefore be construed as guaranteeing specific properties. Individuals working with chemicals should consider all chemicals to be potentially hazardous even if their individual hazards may be uncharacterised or unknown. This Information provided in this document is subject to change and the batch specific Certificate of Analysis should always be referenced. To be used as per local legislation. Change History Version Change Customer Notification required Yes / No 1 First Issue N/A Created By: P. Barnhill Date: 08.07.14 Product Code: P1409 Version: 1 Page 13 of 13