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FUTURE DIRECTIONS IN PULMONARY AND CRITICAL CARE MEDICINE: 2016 Course DirectoRs Michael I. Lewis, MD and Jeremy A. Falk, MD Conference Location Medical Center Harvey Morse Auditorium South Tower, Plaza Level 8701 Gracie Allen Drive 90048 For the latest course information and to register visit csmc.edu/cme and click on CME courses.

Activity Information COURSE DESCRIPTION AND STATEMENT OF NEED This one-day live conference will provide the practicing clinician with the latest clinical and translational insights and advances in pulmonary and critical care medicine, presented by experts in the field. Program content will cover various lung diseases, including COPD, asthma, and idiopathic pulmonary fibrosis (IPF) and associated comorbidities. This state-of-the-art update will provide health care professionals with the clinical information needed to keep pace with rapid changes in research, technology and surgical advances, as well as practical strategies for treating and optimizing the care of patients. The program is divided into three sessions, each of which concludes with a panel discussion to allow participants to actively engage with faculty. Session 1 will explore new developments in COPD and asthma, the pathobiology of IPF and implications for therapy and new insights into drug-induced lung disease. Session 2 will detail the pathobiology of Acute Respiratory Distress Syndrome (ARDS), the management of refractory hypoxemia in the ICU and recommendations for the management of sepsis. Session 3 will examine device management and DVT and PE, present a new paradigm in PAH management, discuss approaches to mediastinal masses and lung cancer and update participants on interventional bronchoscopy. There is an urgent need to improve the delivery of evidenced-based care in Pulmonary and Critical Care Medicine. Join your colleagues in keeping abreast of important advancements and evidence-based practices that can improve the quality of patient care. TARGET AUDIENCE This educational activity is intended for pulmonary/critical care physicians, internists, cardiologists, thoracic surgeons, and healthcare professionals involved in the care of patients with pulmonary disorders. EDUCATIONAL OBJECTIVES Recognize the clinical manifestations of asthma and describe the current options for diagnosis, management and treatment Summarize the pathobiology of Acute Respiratory Distress Syndrome (ARDS) and evaluate current and emerging therapeutic options Evaluate indications and outcomes of devices and the implications for deep vein thrombosis (DVT) and pulmonary embolism (PE) Interpret the latest research in lung cancer and mediastinal masses and develop a systematic approach to diagnosis and treatment Identify the co-morbidities associated with IPF, hypersensitivity pneumonitis, and COPD and the strategies needed to address them Discuss interventional bronchoscopy for diagnostics, therapeutics and airway management Review recent updates in the management of pulmonary arterial hypertension (PAH) and select the most appropriate treatment option Describe the most current evidence based management approaches for sepsis ACCREDITATION Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. CREDIT DESIGNATION Medical Center designates this live activity for a maximum of 6.75 AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. NURSES The California State Board of Registered Nursing accepts courses approved by the ACCME for category 1 credit as meeting the continuing education requirements for license renewal. POLICY ON DISCLOSURE It is the policy of Medical Center to ensure balance, independence, objectivity, and scientific rigor in all of its educational activities. Medical Center assesses conflict of interest with its faculty, planners and managers of CME activities. Conflicts of interest that are identified are resolved by reviewing that presenter s content for fair balance and absence of bias, scientific objectivity of studies utilized in this activity, and patient care recommendations. While Medical Center endeavors to review faculty content, it remains the obligation of each physician or other healthcare practitioner to determine the applicability or relevance of the information provided from this course in his or her own practice. ACKNOWLEDGMENT OF COMMERCIAL SUPPORT Commercial support for this conference is pending and will be acknowledged at the meeting. PARKING Self-parking is available in the visitor parking lots P1, P2 (George Burns Road) or P4 (Sherbourne Drive).

Agenda FUTURE DIRECTIONS IN PULMONARY AND CRITICAL CARE MEDICINE: 2016 7:30 A.M. Registration & Breakfast 7:55 Welcome and Opening Remarks Michael I. Lewis, MD SESSION 1 Moderator: Zab Mosenifar, MD 8:00 What s New in COPD Gerard J. Criner, MD 8:30 What s New in Asthma Stephen C. Lazarus, MD 9:00 Pathobiology of IPF: Implications for Therapy Paul W. Noble, MD 9:30 Hypersensitivity Pneumonitis Joseph P. Lynch III, MD 10:00 Panel Discussion 10:15 Break & Exhibits SESSION 2 Moderator: Peter Chen, MD 10:30 Pathobiology of ARDS Peter Chen, MD 11:00 Management of Refractory Hypoxemia in the ICU Jeremy Falk, MD 11:30 A New Look at Sepsis Management Marin H. Kollef, MD 12:00 P.M. Panel Discussion 12:15 Lunch SESSION 3 Moderator: Victor Tapson, MD 1:10 Session 3 Opening Remarks Jeremy Falk, MD 1:15 Device Management of DVT and PE: Overview, Indications, Outcomes Victor Tapson, MD 1:45 New Paradigm in PAH Management Michael I. Lewis, MD 2:15 A Systematic Approach to the Diagnosis and Treatment of Mediastinal Masses Clark Fuller, MD 2:45 Personalized Treatment Approaches in Lung Cancer: An Update Ronald B. Natale, MD 3:15 Update on Interventional Bronchoscopy Harmik J. Soukiasian, MD, FACS 3:45 Panel Discussion 4:00 P.M. Adjourn

REGISTRATION FUTURE DIRECTIONS IN PULMONARY AND CRITICAL CARE MEDICINE: 2016 Registration Methods Online registration: csmc.edu/cme and click on CME Courses Mail form to: Medical Center Office of Continuing Medical Education Attn: Registration 8797 Beverly Boulevard, Suite #250 90048 Fax form to: 310-423-8596 For additional course or registration information call (310) 423-5548. Registration Fees Physician Allied Health *Resident/Fellow PROFESSIONAL Early Registration Received by 3/21/16 $125 $75 Free of Charge STANDARD Registration Received after 3/21/16 $150 $100 *Residents/Fellows are eligible to attend at no charge. In order to get your registration fee waived, please provide your institution and program directors contact information online during registration. If you have any questions, please email cme@cshs.org. Please print clearly Last Name First Name Degree Specialty Address City State Zip Phone Fax Email (required for all registrations) Check enclosed payable to CSMC for $ Please charge my credit card Visa MasterCard AmEx for $ CC Number CCV Exp Date / Authorized Signature How did you learn about this CME activity? Brochure/Other Printed Materials Website Email Internet Search Colleague Past Participant Internal Communication Other CONFIRMATION In order to receive a registration confirmation, please provide your e-mail address or fax number. If you do not receive a confirmation, please call 310-423-5548 to confirm your registration. REFUND POLICY All cancellations must be submitted in writing and refunds will be subject to a $50 administrative charge. No refunds will be given after March 25, 2016.

Faculty COURSE CO-DIRECTORS Michael I. Lewis, MD Director, Respiratory Therapy Jeremy A. Falk, MD Associate Director, Lung Transplant Center Fellowship Director Associate GUEST FACULTY Gerard J. Criner, MD Professor, Thoracic Medicine and Surgery Director, Medical Intensive Care Unit and Ventilator Rehabilitation Unit Co-Director, Center for Inflammation, Translational and Clinical Lung Research Temple University School of Medicine Philadelphia, PA Marin H. Kollef, MD, FACP, FCCP Professor, Medicine Division of Pulmonary and Critical Care Medicine Director, Medical Intensive Care Unit Washington University School of Medicine St. Louis, MO CEDARS-SINAI FACULTY Peter Chen, MD Director of Pulmonary and Critical Care Medicine Department of Medicine Associate Clark B. Fuller, MD Thoracic Surgeon Division of Thoracic Surgery Zab Mosenifar, MD Executive Vice Chair, Medicine Geri and Richard Brawerman Chair in Pulmonary and Critical Care Medicine Co-Medical Director, Women s Guild Lung Institute Ronald B. Natale, MD Medical Director of the Clinical Lung Cancer Program at the Women s Guild Lung Institute Stephen C. Lazarus, MD Professor, Department of Medicine, Director of the Training Program in Pulmonary and Critical Care Medicine Associate Director of the Adult Pulmonary Laboratory University of California San Francisco San Francisco, CA Joseph P. Lynch III, MD Professor of Clinical Medicine, Step VII, Division of Pulmonary, Critical Care Medicine, Allergy, and Clinical Immunology Director, Advanced Lung Disease and Lung Transplantation Associate Chief, Division of Pulmonary and Critical Care Medicine, Clinical Immunology, and Allergy David Geffen School of Medicine UCLA Paul W. Noble, MD Vera and Paul Guerin Family Distinguished Chair in Pulmonary Medicine Chair, Department of Medicine Director, Women s Guild Lung Institute Harmik J. Soukiasian, MD, FACS Chief, Division of Thoracic Surgery Associate Program Director, Cardiothoracic Surgery Residency Victor Tapson, MD Director, Venous Thromboembolism and Pulmonary Vascular Disease Research Program Director, Clinical Research, Women s Guild Lung Institute Associate Director,

8797 Beverly Blvd., Suite 250 90048 Register Now for: FUTURE DIRECTIONS IN PULMONARY AND CRITICAL CARE MEDICINE: 2016 Earn up to 6.75 AMA PRA Category 1 Credits NON-PROFIT ORG. U.S. POSTAGE PAID Permit #22328