SIGMA-ALDRICH MATERIAL SAFETY DATA SHEET Date Printed: 03/27/2008 Date Updated: 12/04/2006 Version 1.6 Section 1 - Product and Company Information Product Name TITANIUM(IV) OXIDE Product Number 72562 Brand FLUKA Company Address Technical Phone: 9058299500 Fax: 9058299292 Emergency Phone: 800-424-9300 Sigma-Aldrich Canada, Ltd 2149 Winston Park Drive Oakville ON L6H 6J8 CA Section 2 - Composition/Information on Ingredient Substance Name CAS # SARA 313 TITANIUM(IV) OXIDE 13463-67-7 No Formula O2Ti Synonyms A-Fil Cream * Atlas white titanium dioxide * Austiox R-CR 3 * Bayertitan * Baytitan * Brookite * Calcotone White T * C.I. 77891 * C.I. Pigment White 6 * Cosmetic White C47-5175 * Cosmetic White C47-9623 * C-Weiss 7 (German) * E 171 * Flamenco * Hombitan * Horse Head A-410 * Horse Head A-420 * Horse Head R-710 * KH 360 * Kronos * Kronos titanium dioxide * Levanox White RKB * NCI-C04240 * Pigment White 6 * Rayox * Runa RH20 * Rutiox CR * Tichlor * Tiofine * Tiona T.D. * Tioxide * Tipaque * Ti-Pure * Titafrance * Titandioxid (Swedish) * Titanium dioxide (ACGIH:OSHA) * Titanium peroxide * Titanox * Titanox 2010 * Titan White * Trioxide(S) * Tronox * Unitane * Unitane O-110 * Unitane O-220 * Unitane OR-150 * Unitane OR-340 * Unitane OR-342 * Unitane OR-350 * Unitane OR-540 * Unitane OR-640 * 1700 White * Zopaque * TITANIUM DIOXIDE * TITANIA RTECS Number: XR2275000 Section 3 - Hazards Identification HMIS RATING HEALTH: 0 FLAMMABILITY: 0 REACTIVITY: 0 NFPA RATING HEALTH: 0 FLAMMABILITY: 0 REACTIVITY: 0
For additional information on toxicity, please refer to Section 11. Section 4 - First Aid Measures ORAL EXPOSURE If swallowed, wash out mouth with water provided person is conscious. Call a physician. INHALATION EXPOSURE If inhaled, remove to fresh air. If breathing becomes difficult, call a physician. DERMAL EXPOSURE In case of contact, immediately wash skin with soap and copious amounts of water. EYE EXPOSURE In case of contact with eyes, flush with copious amounts of water for at least 15 minutes. Assure adequate flushing by separating the eyelids with fingers. Call a physician. Section 5 - Fire Fighting Measures FLASH POINT AUTOIGNITION TEMP FLAMMABILITY EXTINGUISHING MEDIA Suitable: Water spray. Carbon dioxide, dry chemical powder, or appropriate foam. FIREFIGHTING Protective Equipment: Wear self-contained breathing apparatus and protective clothing to prevent contact with skin and eyes. Specific Hazard(s): Emits toxic fumes under fire conditions. Section 6 - Accidental Release Measures PROCEDURE(S) OF PERSONAL PRECAUTION(S) Exercise appropriate precautions to minimize direct contact with skin or eyes and prevent inhalation of dust. METHODS FOR CLEANING UP Sweep up, place in a bag and hold for waste disposal. Avoid raising dust. Ventilate area and wash spill site after material pickup is complete. Section 7 - Handling and Storage HANDLING User Exposure: Avoid inhalation. Avoid contact with eyes, skin, and clothing. Avoid prolonged or repeated exposure. STORAGE Suitable: Keep tightly closed. Section 8 - Exposure Controls / PPE FLUKA - 72562 www.sigma-aldrich.com Page 2
ENGINEERING CONTROLS Safety shower and eye bath. Mechanical exhaust required. PERSONAL PROTECTIVE EQUIPMENT Respiratory: Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU). Respiratory protection is not required. Where protection from nuisance levels of dusts are desired, use type N95 (US) or type P1 (EN 143) dust masks. Hand: Protective gloves. Eye: Chemical safety goggles. GENERAL HYGIENE MEASURES Wash thoroughly after handling. EXPOSURE LIMITS, RTECS Country Source Type Value USA ACGIH TWA 10 MG/M3 USA MSHA Standard Remarks: Nuisance Particulates. USA OSHA. PEL 8H TWA 15 MG/M3, TOTAL DUST New Zealand OEL Remarks: check ACGIH TLV USA NIOSH LOWEST FEASIBLE CONCENTRATION EXPOSURE LIMITS Country Source Type Value Poland NDS 10 MG/M3 Poland NDSCh 30 MG/M3 Poland NDSP - Section 9 - Physical/Chemical Properties Appearance Physical State: Solid Color: White Form: Powder Odor: Odorless Property Value At Temperature or Pressure Molecular Weight 79.9 AMU ph 3.5-4.5 20 C Concentration: 40 g/l BP/BP Range MP/MP Range 1,850 C Freezing Point Vapor Pressure Vapor Density Saturated Vapor Conc. SG/Density 3.8 g/cm3 20 C Bulk Density Odor Threshold Volatile% VOC Content Water Content Solvent Content Evaporation Rate Viscosity Surface Tension Partition Coefficient Decomposition Temp. > 2,000 C FLUKA - 72562 www.sigma-aldrich.com Page 3
Flash Point Explosion Limits Flammability Autoignition Temp Refractive Index Optical Rotation Miscellaneous Data Solubility Solubility in Water:Insoluble. = not available Section 10 - Stability and Reactivity STABILITY Stable: Stable. Materials to Avoid: Strong acids. HAZARDOUS DECOMPOSITION PRODUCTS Hazardous Decomposition Products: Nature of decomposition products not known. HAZARDOUS POLYMERIZATION Hazardous Polymerization: Will not occur Section 11 - Toxicological Information ROUTE OF EXPOSURE Skin Contact: May cause skin irritation. Skin Absorption: May be harmful if absorbed through the skin. Eye Contact: May cause eye irritation. Inhalation: Material may be irritating to mucous membranes and upper respiratory tract. May be harmful if inhaled. Ingestion: May be harmful if swallowed. SENSITIZATION Sensitization: Will not occur SIGNS AND SYMPTOMS OF EXPOSURE To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated. TOXICITY DATA Oral Rat > 10,000 mg/kg LD50 Skin Rabbit > 10,000 mg/kg LD50 IRRITATION DATA Eyes Rabbit Remarks: No irritation effect Skin Rabbit Remarks: No irritation effect Skin Human 0.3 mg FLUKA - 72562 www.sigma-aldrich.com Page 4
3D I Remarks: Mild irritation effect CHRONIC EXPOSURE - CARCINOGEN Result: This product is or contains a component that is not classifiable as to its carcinogenicity based on its IARC, ACGIH, NTP, or EPA classification. Route of Application: Inhalation Dose: 250 MG/M3 Exposure Time: 6H/2Y- Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. Route of Application: Intramuscular Dose: 360 MG/KG Exposure Time: 2Y Result: Tumorigenic:Neoplastic by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Route of Application: Intramuscular Dose: 260 MG/KG Exposure Time: 84W Result: Tumorigenic:Equivocal tumorigenic agent by RTECS criteria. Blood:Lymphomas including Hodgkin's disease. Tumorigenic:Tumors at site or application. Route of Application: Inhalation Dose: 10 MG/M3 Exposure Time: 18H/2Y- Result: Tumorigenic:Carcinogenic by RTECS criteria. Lungs, Thorax, or Respiration:Tumors. IARC CARCINOGEN LIST Rating: Group 3 NTP CARCINOGEN LIST Rating: No evidence. Species: Mouse/rat Route: Feed ACGIH CARCINOGEN LIST Rating: A4 CHRONIC EXPOSURE - MUTAGEN Species: Mouse Route: Intraperitoneal Dose: 3 GM/KG FLUKA - 72562 www.sigma-aldrich.com Page 5
Exposure Time: 3D Mutation test: Micronucleus test Species: Hamster Dose: 5 UMOL/L Cell Type: ovary Mutation test: Micronucleus test Species: Hamster Dose: 500 MG/L Cell Type: lung Mutation test: DNA inhibition Species: Hamster Dose: 1 UMOL/L Cell Type: ovary Mutation test: Sister chromatid exchange Section 12 - Ecological Information ACUTE ECOTOXICITY TESTS Test Type: LC50 Fish Species: other fish Time: 96 h Value: > 1,000 mg/l Test Type: EC0 Daphnia Species: Daphnia magna Time: 48 h Value: 1,000 mg/l Section 13 - Disposal Considerations APPROPRIATE METHOD OF DISPOSAL OF SUBSTANCE OR PREPARATION Contact a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. Observe all federal, state, and local environmental regulations. Section 14 - Transport Information DOT Proper Shipping Name: None Non-Hazardous for Transport: This substance is considered to be non-hazardous for transport. IATA Non-Hazardous for Air Transport: Non-hazardous for air transport. Section 15 - Regulatory Information UNITED STATES REGULATORY INFORMATION SARA LISTED: No TSCA INVENTORY ITEM: Yes CANADA REGULATORY INFORMATION WHMIS Classification: This product has been classified in accordance with the hazard criteria of the CPR, and the MSDS contains all the information required by the CPR. FLUKA - 72562 www.sigma-aldrich.com Page 6
DSL: Yes NDSL: No Section 16 - Other Information DISCLAIMER For R&D use only. Not for drug, household or other uses. WARRANTY The above information is believed to be correct but does not purport to be all inclusive and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product with regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Sigma-Aldrich Inc., shall not be held liable for any damage resulting from handling or from contact with the above product. See reverse side of invoice or packing slip for additional terms and conditions of sale. Copyright 2008 Sigma-Aldrich Co. License granted to make unlimited paper copies for internal use only. FLUKA - 72562 www.sigma-aldrich.com Page 7