The Teleostei Immunoglobulin Heavy IGH Genes

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IMGT Locus in Focus Exp Clin Immunogenet 2000;17:148 161 Received: November 19, 1999 The Teleostei Immunoglobulin Heavy IGH Genes Sylvaine Artéro Marie-Paule Lefranc Laboratoire d ImmunoGénétique Moléculaire, CNRS, Université Montpellier II, Montpellier, France Key Words Teleostei W IMGT W Immunoglobulin W Heavy variable genes W Heavy joining genes W Heavy constant genes Abstract Teleostei Immunoglobulin Heavy IGH Genes, the eleventh report of the IMGT Locus in Focus section, comprises four tables: (1) Teleostei IGHV genes ; (2) Teleostei germline IGHJ genes ; (3) Teleostei IGHC genes and alleles ; (4) FR-IMGT and CDR-IMGT length of the Teleostei IGHV genes. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr: 8104) created in 1989 by Marie-Paule Lefranc, Université Montpellier II, CNRS, France. Introduction Copyright 2000 S. Karger AG, Basel Teleostei Immunoglobulin Heavy IGH Genes is the 11th report of the IMGT Locus in Focus section launched in the April 1998 issue of Experimental and Clinical Immunogenetics [1]. We have previously reported the complete repertoire of the human germline V and J genes of the immunoglobulin IGK and IGL and of the T cell receptor TRA loci [2 6], and that of the human germline V, D and J genes of the immunoglobulin IGH and of the T-cell receptor TRB loci [6 10]. This eleventh report on Teleostei Immunoglobulin Heavy IGH Genes describes the current data for 11 species of teleost fishes whose sequences are found in IMGT/LIGM-DB (fig. 1). It comprises four tables: (1) Teleostei IGHV genes ; (2) Teleostei germline IGHJ genes ; (3) Teleostei IGHC genes and alleles ; (4) FR-IMGT and CDR-IMGT length of the Teleostei IGHV genes. These tables are available at the IMGT Marie-Paule page from IMGT, the international ImMunoGeneTics database (http://imgt.cines.fr:8104) created in 1989 by Marie-Paule Lefranc, Université Montpellier II, CNRS, France [11, 12]. Teleostei IGH genes have a temporary designation based on the IMGT gene name nomenclature rules for the unmapped genes, the incomplete loci, or the cdnas in the absence of germline genes. Descriptions of functionality (functional, open reading frame, pseudogene) are according to the IMGT Scientific chart [11, 12], available at the IMGT Marie-Paule page. ABC Fax + 41 61 306 12 34 E-Mail karger@karger.ch www.karger.com 2000 S. Karger AG, Basel 0254 9670/00/0173 0148$17.50/0 Accessible online at: www.karger.com/journals/eci Prof. Marie-Paule Lefranc, Université Montpellier II Lab. d ImmunoGénétique Moléculaire, LIGM, UPR CNRS 1142, IGH 141, rue de la Cardonille, F 34396 Montpellier Cedex 5 (France) Tel. +33 4 99 61 99 65, Fax +33 4 99 61 99 01 E-Mail lefranc@ligm.igh.cnrs.fr, IMGT http://imgt.cines.fr:8104

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154 Exp Clin Immunogenet 480 Artéro/Lefranc Fig. 1. IMGT taxonomy tree of the Euteleostei present in IMGT/LIGM-DB. Note that the Ladyfish (Elops saurus) which does not belong to the Euteleostei but to the Elopomorpha [Order: Elopiformes; Family: Elopidae (tenpounders)] is not shown in that figure. T cell receptor sequences, but no immunoglobulin sequences, have been so far described for Sphoeroides nephelus.

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Acknowledgements We thank Valérie Contet for editorial work, Marianne Colonna, Mohamed Ben Mimoun, Christèle Jean and Chantal Ginestoux for the taxonomy figure, Véronique Giudicelli and Gérard Lefranc for helpful discussion. IMGT is funded by the European Union s BIOTECH programme (BIO4CT96-0037), the CNRS (Centre National de la Recherche Scientifique), and the MENRT (Ministère de l Education Nationale, de la Recherche et de la Technologie). Subventions have been received from ARC (Association pour la Recherche sur le Cancer), ARP (Association de la Recherche sur la Polyarthrite), FRM (Fondation pour la Recherche Médicale), Ligue Nationale contre le Cancer and the Région Languedoc-Roussillon. References 1 Lefranc MP: IMGT locus on focus. Exp Clin Immunogenet 1998;15:1 7. 2 Barbié V, Lefranc MP: The human immunoglobulin kappa variable (IGKV) genes and joining (IGKJ) segments. Exp Clin Immunogenet 1998;15:171 183. 3 Pallarès N, Frippiat JP, Giudicelli V, Lefranc MP: The human immunoglobulin lambda variable (IGLV) genes and joining (IGLJ) segments. Exp Clin Immunogenet 1998;15:8 18. 4 Scaviner D, Lefranc MP: The human T cell receptor alpha variable (TRAV) genes. Exp Clin Immunogenet 2000;17:83 92. 5 Scaviner D, Lefranc MP: The human T cell receptor alpha joining (TRAJ) genes. Exp Clin Immunogenet 2000;17:97 106. 6 Scaviner D, Barbié V, Ruiz M, Lefranc MP: Protein displays of the human immunoglobulin heavy, kappa and lambda variable and joining regions. Exp Clin Immunogenet 1999;16:234 240. 7 Pallarès N, Lefebvre S, Contet V, Matsuda F, Lefranc MP: The human immunoglobulin heavy variable (IGHV) genes. Exp Clin Immunogenet 1999;16:36 60. 8 Ruiz M, Pallarès N, Contet V, Barbié V, Lefranc MP: The human immunoglobulin heavy diversity (IGHD) and joining (IGHJ) segments. Exp Clin Immunogenet 1999;16:173 184. 9 Folch G, Lefranc MP: The human T cell receptor beta variable (TRBV) genes. Exp Clin Immunogenet 2000; 17:42 54. 10 Folch G, Lefranc MP: The human T cell receptor beta diversity (TRBD) and beta joining (TRBJ) genes. Exp Clin Immunogenet 2000;17:107 114. 11 Lefranc MP, Giudicelli V, Ginestoux C, Bodmer J, Müller W, Bontrop R, Lemaitre M, Malik A, Barbié V, Chaume D: IMGT, the international ImMunoGeneTics database. Nucl Acids Res 1999;27:209 212. 12 Ruiz M, Giudicelli V, Ginestoux C, Stoehr P, Robinson J, Bodmer J, Marsh S, Bontrop R, Lemaitre M, Lefranc G, Chaume D, Lefranc MP: IMGT, the international ImMuno- GeneTics database. Nucl Acids Res 2000;28:219 221. Teleostei IGH Genes Exp Clin Immunogenet 2000;17:148 161 161

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