Hematopoiesis Simplified: Part 1 Erythropoiesis Larry Johnson Texas A&M University
Hematopoiesis Simplified: Part 1 Erythropoiesis Objectives are to: Identify the developmental cells of erythropoiesis Characterize developmental changes in the cytoplasm and nucleus of these cells Bone marrow 32583 Blood vessel
19761 Bone marrow Blood in vessel
Peripheral blood 21 Erythrocytes Reticulocytes
Erythropoiesis Erythrocytes Reticulocytes No nucleus and red cytoplasm No nucleus and blue - grey cytoplasm Orthochromatophilic erythroblasts Polychromatophilic erythroblasts Dark, small, spherical nucleus blue grey cytoplasm Darkening, fractured,spherical nucleus and mixed pools of grey and blue cytoplasm Basophilic erythroblasts Proerythroblasts Fractured, spherical nucleus and thin rim of dark blue cytoplasm Uniformly light, spherical nucleus with thin rim of medium to dark blue cytoplasm
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Erythropoiesis Erythrocytes Proerythroblasts Reticulocytes Orthochromatophilic erythroblasts Basophilic erythroblasts Polychromatophilic erythroblasts Erythropoiesis
Orthochromatophilic erythroblasts Erythrocytes
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Polychromatophilic erythroblasts
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Basophilic erythroblast
Erythrocyte Proerythroblast Reticulocytes Orthochromatophilic erythroblast Basophilic erythroblast Polychromatophilic erythroblast Erythropoiesis
Proerythroblasts
Erythropoiesis Erythrocytes Orthochromatophilic erythroblasts Reticulocytes
Early orthochromatophilic erythroblasts Late polychromatophilic erythroblasts
Polychromatophilic erythroblasts Early polychromatophilic erythroblasts
Basophilic erythroblasts Proerythroblasts
Orthochromatophilic erythroblasts ut 112 RBCs Late polychromatophilic erythroblast Basophilic erythroblast platelets Reticulocyte Polychromatophilic erythroblast Eosinophil or basophil Erythrocytes Proerythroblast
Bone marrow Reticulocyte entering blood vessel 32583 Blood vessel
The End of Hematopoiesis Simplified: Part 1 Erythropoiesis
Granulopoiesis is next
Hematopoiesis Simplified: Part 2 Granulopoiesis Larry Johnson Texas A&M University
Hematopoiesis Simplified: Objectives are to: Part 2 Granulopoiesis Identify the developmental cells of granulopoiesis Characterize developmental changes in the 32583 cytoplasm and nucleus of these cells Bone marrow
19761 Bone marrow Blood Blood
32583 ` Bone marrow Developing granulocytes
21 Peripheral blood
Granulopoiesis Neutrophils Lobulated, dark nucleus, mature grey cytoplasm with small granules Neutrophilic band or stab cells Horse-shoe shaped, darkening nucleus, grey mature cytoplasm Neutrophilic metamyelocytes Neutrophilic myelocytes Promyelocytes Oval to kidney bean-shaped, indented nucleus, grey mature cytoplasm with a weak blue tent Large, oval, non-indented nucleus, large amount of cytoplasm with specific and non-specific granules Large, oval, non-indented nucleus, large amount of sky blue cytoplasm with non-specific granules
Granulopoiesis Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilic metamyelocytes
ut 112 Neutrophil Neutrophilic metamyelocytes Neutrophilic metamyelocyte Platelets Eosinophil or basophil Neutrophilic myelocytes
Neutrophils Promyelocytes Neutrophilic band cells Neutrophilic myelocytes Neutrophilic metamyelocytes Granulopoiesis
Neutrophilic metamyelocytes Lymphocytes Unknown nuclei Neutrophilic myelocytes Promyelocyte Neutrophilic myelocytes Lymphocytes Neutrophilic band cells Neutrophilic band cells Neutrophilic metamyelocytes Neutrophilic band cell
Neutrophils Neutrophilic band cells Granulopoiesis
Neutrophilic metamyelocytes Early neutrophilic metamyelocytes
Neutrophilic myelocytes
Late promyelocytes Promyelocyte
Neutrophilic metamyelocytes Unknown nuclei Neutrophilic myelocytes Neutrophilic band cells Neutrophilic metamyelocytes Orthochromatophilic erythroblasts Proerythroblast Eosinophils or basophils Orthochromatophilic erythroblasts
32583 Bone marrow White blood cell entering a blood vessel Blood vessel Blood vessel
he End of Hematopoiesis Simplified: Part 2 Granulopoiesis