MEADWESTLIDE Vs. Ceramide IIIB USA Head ffice Europe Asia Japan Elementis Specialties, Inc. Elementis Specialties Elementis Specialties, Inc. Elementis Japan KK P.. Box 700 Stolberger Straße 370 120 Jalan Kapar 27/89 15-14 Minaminisemba 1-Chome 329 Wyckoffs Mill Road 50933 Cologne, Germany 40400 Shah Alam Chou-Ku, saka Hightstown, NJ 08520 USA Malaysia 542-0081 Japan Tel.: +1 609 443 2500 Tel.: +49 221 2923 2000 Tel.: +60 3 5192 2887 Tel.: +81 6 6267 6211 Fax: +1 609 443 2422 Fax: +49 221 2923 2010 Fax: +60 3 5192 3887 Fax: +81 6 6267 6215
In Vivo Tissue Hydration Studies (comparative moisture retention for MEADWESTLIDE and ceramide IIIB): Methods The Delphin Moisture Meter SC was used to quantify moisture content in the stratum corneum (SC) by an electrical capacitance method. The measurement has no units, but is proportional to the dielectric constant of the surface layers of the skin, and increases as the skin becomes more hydrated. The DMM numbers are directly related to the skin s electrical capacitance measured as picofarads (pf). Simple creams containing 1% MEADWESTLIDE or 1% ceramide IIIB were applied to the upper arm and lower forearm. Readings were taken in triplicate at 0, 0.5, 2 and 4 hours. Results: As can be ssen in Figure 1, there is a significant increase in the hydration of the stratum corneum following the application of both MEADWESTLIDE and ceramide IIIB. However, the increase appears to be greater in the case of the MEADWESTLIDE and is sustained at least until the 4 hour measurement point.
Figure 1 Increase in Tissue Hydration As A Results of the Application of MEADWESTLIDE or Ceramide IIIB Tissue Hydration 50 45 40 35 Percent Increase 30 25 20 15 10 5 0 0.0 0.5 2.0 4.0 Hours Post-Application Ceramide IIIB Meadowestolide
Discussion: There are very sound biochemical mechanisms underlying the observed anti-aging effects of both MEADWESTLIDE and MEADWLACTNE. As mentioned in the Introduction, maintaining a physiologically correct balance of oil and water phases in our tissue is a key component to the improvement of the overall appearance and tone of the skin. Ceramides are a very important family of indigenous components within epidermal tissue. They serve several biochemical functions among which is the ability to act as an effective barrier against excessive loss of moisture. Consider the chemical structure of a ceramide, in this case Ceramide IIIB and the structure of MEADWESTLIDE. Figure 19 Chemical structure of Ceramide IIIB C H 3 H H H 3 C NH Figure 20 Chemical structure of MEADWESTLIDE C H 3 H 3 C H
There is a striking similarity between these molecules, particularly the spatial relationship between the extensive non-polar aliphatic chain and the more polar hydrophilic carboxy end. It is not surprising that the moisture retention (barrier) properties of ceramide are also evident for the MEADWESTLIDE. ne would expect the aliphatic portion of these molecules to be miscible in the more lipophilic aspects of the epidermis and contribute to the lipid character of this tissue while the hydrophilic end binds water and enriches the aqueous character of the skin. In both cases, the moisturization benefits of these compounds, which manifests itself as visual anti-aging effects, is derived from the dual lipophilic-hydrophilic activity within the same molecule. NTE: The information herein is currently believed to be accurate. We do not guarantee its accuracy. Purchasers shall not rely on statements herein when purchasing any products. Purchasers should make their own investigations to determine if such products are suitable for a particular use. The products discussed are sold without warranty, express or implied, including a warranty of merchantability and fitness for use. Purchasers will be subject to a separate agreement which will not incorporate this document. Copyright 2010, Elementis Specialties, Inc. All rights reserved. Copying and/or downloading of this document or information therein for republication is not allowed unless prior written agreement is obtained from Elementis Specialties, Inc. Trademark of Elementis Specialties, Inc. www.elementisspecialties.com v 11 th ctober 2010