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E UROPEAN FORMAT C. V. PERSONAL DATA First name Last name GIANLUCA CUSMA DOVICO GUATTERI Address Via Raffaello Sanzio, 21 20149 Milano (MI) - Italy Phone numbers mobile +39 329 / 6577343 E-mail gcdg@me.com Place of birth Rome, Italy Date of birth 08/01/1975 Linkedin: it.linkedin.com/pub/gianluca-cusmà-dovico-guatteri-m-d/40/43a/a29 Page 1 Gianluca Cusmà Dovico Guatteri

PRESENTATION I was born in Rome but moved very early to South America, Caracas and Margarita Island in Venezuela, because of my parent s work. There I completed Italian basic school programs. Definitively come back to Italy at sixteen, I completed high school studies in Milan and started Medical School at Milan University, obtaining in 2000 the Bachelor and Medical Degree. During my Residency in Orthopaedics and Traumatology, I began focusing on hip and knee surgery. After a 12 months fellowship in Mini-invasive solutions for Knee Replacement, I completed my residency in 2006 with a final thesis in Unicompartimental Knee Replacement. I was first Junior Consultant in Knee Surgery and then Consultant in Joint Replacement at the Hip and Knee Surgery Department of a poli-specialty private hospital in Milan (www.humanitas.it). From 2009 I has been involved in the R&D of the new GTS hip stem designed by Prof. Guido Grappiolo and produced by ZimmerBiomet (www.zimmerbiomet.it). For this company I already cover the role of Consultant for medical education, cadaver lab and hands on training for surgeons. For the Livio Sciutto Foundation (www.fondazione.it) that was founded by Prof. Lorenzo Spotorno in the 90 s, I m member of the scientific board: we are driving up some research programs in the field of biomechanics (in vivo interactions between hip and knee artrhoplasties), long term survivorship of hip replacements (first minimum 30 years survival study of a uncemented hip stem), ion related pathology (Italian survey metal on metal hip arthroplasties) and biomimetic scaffolds for bone reconstruction in revision arthroplasties. In the first 3 weeks of January 2016 I was present at the joint replacement department of Northern Jiangsu People's Hospital in China to train local surgeons in difficult primary and revision hip and knee cases and I received the Yangzhou Medical School Visiting Professor award. In February 2016 I was invited lecturer at the Master in Mini Invasive Hip Surgery organized by the Campus Biomedico University in Rome. From September 2016 I m Consultant in medical education and surgeons training for the MicroPort company (www.microport.com) with special address to the micro invasive SuperPath technique in hip replacement. From November 2016 I m the designer and project leader of a new unicompartimental knee prosthesis by Gruppo BioImpianti (www.bioimpianti.it), an Italian company leader in Central and South American market. Page 2 Gianluca Cusmà Dovico Guatteri

ACTUAL WORKING LOCATION From 2016 September Istituto di Cura Città di Pavia Gruppo Ospedaliero San Donato via Parco Vecchio, 27 27100 Pavia (PV) Head of Mini Invasive Orthopaedic Surgery Unit Surgical activity: Hip and Knee primary and revision Arthroplasty, performing about 300 joint replacements/year as first surgeon PREVIOUS WORK EXPERIENCE 2010 March 2016 August Center for Hip and Knee Surgery - Head Prof. Guido Grappiolo Istituto Clinico Humanitas IRCCS (www.humanitas.it) via Manzoni, 56 20090 - Rozzano (MI) Consultant in Joint Replacement Surgical activity: Hip and Knee primary and revision Arthroplasty, Hip and knee Arthroscopy and related, performing about 300 surgeries/year Research: Tribology, THA survivorship, THA innovative tecniques, TKA biomechanics, Interactions between Hip and Knee Replacements 2007 November - 2010 February Casa di Cura IGEA (www.casadicuraigea.it) via Marcona, 69 Milano Consultant in Knee Surgery Surgical activity: primary and revision Knee Arthroplasty, knee arthroscopy and ligament reconstruction, performing about 200 surgeries/year Research: Cartilage biological repair strategies, including growth factor and stem cells, Minimally Invasive Knee Artrhoplasty Page 3 Gianluca Cusmà Dovico Guatteri

2006 October 2007 October Center for Hip and Knee Surgery - head Prof. Lorenzo Spotorno Istituto Clinico Humanitas - via Manzoni, 56 20090 - Rozzano (MI) Sports Medicine and Arthroscopic Surgery Specialist Surgical activity: Knee Arthroscopy and Reconstructive, performing about 200 surgeries as first operator Research: Biomechanics, Minimally Invasive Knee Artrhoplasties 2004, July 2006, September Istituto Clinico Humanitas - via Manzoni, 56 20090 - Rozzano (MI) Knee Surgery head: Prof. Valerio Sansone Registrar Surgical activity: Knee Arthroscopy and Reconstructive, performing about 150 surgeries as first operator per year Research: Meniscal and Cartilage Repair, Double Bundle ACL reconstruction 2003, June 2004, June Istituto Ortopedico Galeazzi - via Galeazzi, 4-20161 Milano (MI) Center for Joint Replacement head: Prof. Sergio Romagnoli Registrar Surgical activity: Knee and Hip Reconstructive, performing about 50 surgeries as first operator Research: Navigation in THR and TKR, Gait Analysis 2001, March 2003, May Luigi Sacco General Hospital - via G.B.Grassi,74 20157 - Milano (MI) Orthopedics and Traumatology head: Prof. Roberto Franceschini Registrar Surgical activity: Lower Extremities Traumatology performing about 50 surgeries as first operator per year Page 4 Gianluca Cusmà Dovico Guatteri Emergency: Active frequency of the Trauma Centre Research: Sports Injuries Threatment

EDUCATION AND TRAINING s (from to) 1989-1994 High School Liceo Scientifico Leone XIII in Milano, Italy Title of qualification awarded Maturità Scientifica (50/60 final evaluation) s (from to) 1994 2000 University of Milano Faculty of Medicine and Surgery Principal subjects covered Final Thesys in Orthopedics with the coordination of Prof. Surace: Prevention and Treatment of post thraumatic algodistrophy Title of qualification awarded Doctor in Medicine and Surgery (108/110 final evaluation) (from to) 2001-2006 University of Milano Othopaedics Residency Principal subjects covered Title of qualification awarded Joint Care Surgery Final Thesys in Knee Replacement with the coordination of Prof. Sansone: Early results of the Oxford III unicompartmental knee replacement: a prospective study. Specialist in Orthopaedics and Thraumatology (70/70 final evaluation) FIRST IDIOM ITALIAN OTHER IDIOMS SPANISH ENGLISH reading excelent very good writing excelent very good oral expression excelent good PROFESSIONAL AND SCIENTIFIC SOCIETIES MEMBERSHIPS FONDAZIONE LIVIO SCIUTTO ONLUS (WWW.FONDAZIONE.IT) S.I.A. SOCIETA ITALIANA DI ARTROSCOPIA S.I.D.A. SOCIETA ITALIANA DELL ANCA E.H.S. EUROPEAN HIP SOCIETY I.S.T.A. INTERNATIONAL SOCIETY FOR TECHNOLOGY IN ARTHROPLASTY Page 5 Gianluca Cusmà Dovico Guatteri

PUBLISHED ORIGINAL PAPERS Gianluca Cusmà Guatteri M.D Management of severe CDH with THA and derotating/shortening osteotomy: our 20 years experience results J Bone Joint Surg Br 2012 94-B:(SUPP XXV) 34 LECTURES AT NATIONAL AND INTERNATIONAL MEETINGS IN LAST 5 YEARS 2010 ISTA CONGRESS (DUBAI UAE) Ø Management of severe CDH with THA and derotating/shortening osteotomy: our 20 years experience results 2012 AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS (LAS VEGAS USA): Ø Femur First Tecnique original video awarded as best original tecnique 2012 ISTA CONGRESS (BRUGES BELGIUM): Ø Femur First tecnique: an easy and safe way to match the safe zone in THA Ø Early results of the new GTS uncemented stem: outcome of first 570 consecutive cases 2012 SIOT CONGRESS (ROME ITALY) Ø COXALGIA MECCANICA DA CONFLITTO 2013 SHORT STEMS AND MODULAR NECKS HIP COURSE (UNIVERSITY OF BARCELONA SPAIN) Ø ADELANTE EL FEMUR 2013 XII CURSO DE CIRUGIA DE LA CADERA (UNIVERSITY OF BARCELONA SPAIN) Ø REVISION FEMORAL CON VASTAGOS CORTOS 2014 SIOT CONGRESS (ROME ITALY) Ø LA PROTESIZZAZIONE DELL ANCA DISPLASICA 2014 BARCELONA HIP MEETING: Ø OSTEOTOMÍA DE ACORTAMIENTO Y ATC EN LA DYSPLASIA TIPO 4 DE CROWE RESULTADOS A LARGO PLAZO Ø AUGMENTOS DE TANTALIO EN LAS REVISIONES DE CADERA 2015 2016 UNIVERSITA CAMPUS BIOMEDICO ROMA Ø CORSO DI PERFEZIONAMENTO POST LAUREA IN CHIRURGIA MINI INVASIVA DELL ANCA 2016 ZIMMERBIOMET WEBINAR. Ø LA GESTIONE DELLA PERDITA OSSEA NELLA REVISIONE D ANCA Page 6 Gianluca Cusmà Dovico Guatteri