CORSO DI AGGIORNAMENTO E.C.M.

CORSO DI AGGIORNAMENTO E.C.M.

RAZIONALE HIV Medicine is an ever-changing field: what today seems to be up-to-the-minute treatment often tomorrow is already out of date! Progress continues to be particularly rapid in the treatment of HIV disease and in the management of its complications. Although simpler antiretroviral combinations are now available and adherence to the treatment has improved, choosing the best treatment on an individual basis is often complex, particularly for those patients who failed first regimens. Furthermore, literature on the subject often produces incomplete or conflicting results. The ACHILLES advanced course will provide participants with the latest information as well as practical guidelines from an internationally-recognized panel of experts. Last but not least, the course will give young Italian clinicians an opportunity to share their own studies with the international faculty. COURSE OBJECTIVES To enable participants to acquire theoretical knowledge and to discuss the latest developments in the following areas: Early treatment for all infected persons as a means of preserving personal health and decreasing transmission Newer generation of ARV treatments including new integrate inhibitors Status and directions in HCV treatment HIV and aging: theoretical and practical issues HIV eradication: where do we stand on the cure? Update on HIV immunology and vaccine development Management of HIV-associated co-morbidities including cardiovascular disease HIV and cognition; the virus and the drugs; CNS penetration as an issue C.M.E. CREDITS Ministerial approval of credits for Doctors specialized in Infectious Diseases have been applied for: - ID Provider: 752 - Med Tech Science S.r.l. - ID Nr.: 752-53193 - CME Points: 21 1

PARTICIPATION SELECTION CRITERIA With regard to the next Achilles meeting, which will be held in Sextantio Albergo Diffuso (Santo Stefano di Sessanio AQ) on April 18/20 2013, we would like to inform you that we have selected 13 senior Italian Physicians. These senior MDs are to invite 13 junior MDs, who are fluent in English and specialized in Infectious Diseases. The junior Physicians will present their own slides and will give their talk. Achilles 2013 participants must be: II level Specialists; aged between 30-40; interested in direct comparison of their working environment with both national and international top medical centers; interested in discussion with leading national specialists in Infectious Diseases; work in accordance with recognized national and international guidelines; keen to study new approaches in treatment; speak English fluently. 2

Draft outline of the program for Achilles 2013 Topics (still in flux). Possible speakers as indicated, but this also can be moved around depending on interest. There will also be presentation from the Italian attendees interspersed throughout program. This year we will assign several talks in advance to be presented by an Italian participant as a regular lecture in the program. Speakers will be selected soon. DAY 1, APRIL 18 th 08.45 09.00 Welcome and Opening Remarks 09.00 10.00 Early treatment for all infected persons as a means of preserving personal health and decreasing transmission P. Volberding, J. Eron 10.00 10.30 Newer generation of ARV treatments including new integrate inhibitors J. Eron 11.00 11.30 Treatment cascade P. Volberding 12.00 13.00 Italian Speakers Presentations and General Discussion 13.00 14.30 Lunch 3

14.30 15.30 Status and directions in HCV treatment J. Eron, C.F. Perno 15.30 16.30 HIV and aging: theoretical and practical issues and role of inflammation S. Deeks, M. Lederman 16.30 17.30 HIV eradication: where do we stand on the cure? S. Deeks 17.30 18.30 Italian Speakers presentations and General Discussion DAY 2, APRIL 19 th 08.45 09.15 Update on HIV immunology and vaccine development D. Douek, M. Lederman, M. Clerici 09.15 10.30 Management of HIV-associated co-morbidities including cardiovascular disease J. Currier 10.30 11.30 HIV and cognition; the virus and the drugs; CNS penetration as an issue J. Currier 11.30 13.00 Panel discussion: New research opportunities 13.00 14.30 Lunch 4

14.30 16.00 Round table All faculty responds to Q&A 16.00 16.30 Panel discussion: Supporting early careers in HIV clinical research DAY 3, APRIL 20 th 08.30 10.00 CROI 2013 update J. Currier 10.00 11.30 The economics of HIV care: Challenges in US and Italy P. Volberding 11.30 12.30 Young Researchers presentations and General Discussion 12.30 13.00 Closing Remarks P. Volberding 5

COURSE COORDINATOR PAUL VOLBERDING Professor, UCSF Department of Medicine Chief, Director, UCSF AIDS Research Institute, Director of Research, UCSF Global Health Sciences, Co-Director, UCSF-GIVI Center for AIDS Research University of California San Francisco (USA) FACULTY 2013 MARIO CLERICI Professor Chair of Immunology University Medical School Milano (ITALY) JUDITH CURRIER UCLA Center for Clinical AIDS Research and Education (CARE) UCLA Medical Center (USA) Santa Monica (USA) DANIEL DOUEK MD, MRCP, Ph.D, Human Immunology Section Vaccine Research Center (VRC), NIAID, NIH Bethesda (USA) STEVEN G. DEEKS Professor of Medicine in Residence AIDS Research Institute University of California San Francisco (USA) 6

JOSEPH ERON Professor of Medicine, School of Medicine Director, Clinical Core, UNC Center for AIDS Research Associate Professor of Epidemiology, Gillings School of Global Public Healt North Carolina (USA) MICHAEL M. LEDERMAN Scott R. Inkley Professor of Medicine Professor of Pathology, Molecular Biology/Microbiology and Biomedical Ethics Case Western Reserve University Cleveland (OH) (USA) CARLO FEDERICO PERNO Direttore, UOC di Virologia Molecolare Dip. di Medicina di Lab. Policlinico Tor Vergata Roma (ITALY) GIULIANO RIZZARDINI Direttore UO Malattie Infettive 1^ Divisione Ospedale Luigi Sacco Milano (ITALY) 7

GENERAL INFORMATION LOCATION SEXTANTIO ALBERGO DIFFUSO Via Principe Umberto 67020 Santo Stefano di Sessanio, Italy Telefono 0862 899112 - Fax 0862 899656 ORGANIZING SECRETARIAT STUDIO CONGRESSI S.R.L. Viale Libertà, 17-27100 Pavia - ITALY Tel: +39 0382/21424 - Fax: +39 0382/303082 E-mail: info@studio-congressi.com Sito web: www.studio-congressi.com C.M.E. PROVIDER MED TECH SCIENCE S.R.L. (752) Viale Libertà, 17-27100 Pavia - ITALY Tel: +39 0382/33428 - Fax: +39 0382/303082 E-mail: ecm@medtechscience.com CON IL CONTRIBUTO NON CONDIZIONATO DI UN PARTICOLARE RINGRAZIAMENTO A: 8