Table 3 1 I07 13 rat 2.5 10 blood, liver, spleen anemia; hepatic inflamm.,siderosis of Kupffer cells, liver +spleen w. I07 13 dog 2.6 13.5 blood erythropoiesis; hematopoiesis in spleen I01 1972 52 dog 0.8 1.6 a.ph. I01 104 rat 0.5 5 liver periacinar hypertrophy I02 1990 52 dog 0.185 0.74 ChE RBC-ChE I02 1986 78 mouse 3 12 ChE, liver plasma + RBC-ChE; fatty changes; weight I02 1986 104 rat 0.05 0.25 ChE brain + RBC-ChE I03 1986 13 rat 3.4 17 glucose, food intake I03 1985 13 dog 10 50 liver, thyroid eosinophil. bodies in hepatocytes a.ph. liver + thyroid w. I03 1982 104 rat 0.89 9.8 thyroid hypertrophy + hyperplasia of epithelial cells, weight I03 1983 104 mouse 1.82 17.4 liver weight I03 1982 107 dog 2 20 liver bromosulphophthalein retention, bile duct hyperplasia, hypertrophy, weight I04 1982 8 (14) I04 12 (18) rat 1.4 (0.4) dog 0.5 (0.25) 1.6 ( - ) 1 (0.5) body weight inability to constrict pupils I04 1984 52 dog 0.25 0.5 eye, liver mydriasis; ALT, a.ph. I04 1986 95 mouse 4 8 mortality, + food I04 1986 105 rat 1.5 2 CNS tremor; I05 1969 12 rat 0.25 0.5 ChE plasma, RBC+ brain-che, b.w. I05 1961 12 dog 0.05 0.125 ChE plasma-che I05 1975/63 52 dog 0.08 0.125 ChE plasma-che I05 1990 102 mouse 0.015 0.15 ChE plasma-che I05 1963 104 rat 0.15 0.25 ChE RBC + plasma-che I06 1984 52 dog 0.025 0.125 ChE brain + RBC-ChE I06 1979 104 rat 0.05 0.15 ChE brain + RBC-ChE I07 1984 52 dog 0.72 1.44 blood, spleen reticulocyt.; iron pigments in spleen, liver, kidney, spleen w. I07 1984 104 rat 1 10 blood, bone, theeth anemia; fluoration of bones + theeth I07 1984 104 mouse 5.9 59 blood anemia, Heinz bodies, bilirub. protein I08 1971 13 rat 0.07 0.21 ChE plasma-che I08 1971 (1988) 13 dog 0.03 (0.01) 0.15 (0.3) ChE plasma-che I08 1989 52 dog 0.01 0.03 ChE plasma-che (1989) (52) (0.12) (2.4) I08 1975 104 rat 0.05 0.15 ChE plasma-che I08 1989 104 mouse 0.9 4.5 ChE plasma + RBC-ChE I09 1984 52 dog 5 15 liver pnod, cholesterol in liver; I09 1992 104 mouse 114 470 liver, urinary bladder adenoma, weight; ALAT, albumin; hyperplasia of epithel. I09 1984 106 rat 8.2 42 blood, urinary bladder, ovary, liver eosinoph., lymphocyt. AST, protein; hyperplasia of urinary bladder; ovary w. I10 1982 52 dog 5 15 CNS, gastrointest. tremor, incoordination, hypersens. gait abnormality; fluid feces, b.w. I10 1982 104 rat 7.5 75 liver, kidney, spleen, lung aminopyrine-n-dem., SER-prolif., weight; cholest., TG, BUN; kidney, spleen, lung w.
Table 3 2 I10 1989 104 mouse 40 160 blood, liver anemia; liver weight; I11 1976 13 rat 1 5 liver hypertrophy I11 1976 13 dog 5 50 liver weight I11 1982 52 dog 5 100 liver, adrenal cellular swelling, weight; focal degeneration with inflammatory changes in cortex, lipid accumulation in zona reticul. a.ph.; I11 52 mouse 37.5 150 liver, kidney aminopyridinedemethyl.,eosino. of hepatocytes, SER-prolif. liver + kidney w. I11 1978 104 rat 5 25 CNS, ovary tremor; glucose; ovary w. I12 1973 13 rat 5 15 blood anemia I12 1973 13 dog 2.5 7.5 blood, ChE anemia, plasma + RBC-ChE I13 1976 104 rat 19.1 60.2 liver weight; I13 1976 104 dog 37.5 115 liver hepatomegaly, weight; cholest ALAT, a.ph.; emesis, I13 1978 104 mouse 89.9 268 liver adenomas, weight I14 1970 13 rat 0.14 0.42 ChE plasma + RBC-ChE (8) (0.03) (0.06) I14 1970 13 dog 0.04 0.14 ChE plasma + RBC-ChE I14 1984 52 dog 0.05 0.2 ChE brain, plasma + RBC-ChE I14 1984 105 rat 0.12 0.29 ChE brain, plasma + RBC-ChE I14 1984 106 mouse 0.67 3.4 lung interstitial pneumony, weight I15 1980 13 rat 0.1 1 ChE plasma, RBC + brain-che I15 1973 13 dog 0.025 0.25 ChE plasma + RBC-ChE I15 1977 104 rat 0.05 0.44 ChE RBC + plasma-che I15 1977 104 dog 0.09 0.45 ChE plasma-che I15 1978 108 mouse 0.15 1.4 ChE plasma-che I16 1986 13 rat 7.2 21.3 spleen abs. +rel. weight I16 1980 (1984) 13 (52) dog 7 (2.8) 14 (7) CNS, gastrointestine, liver tremor, ataxia, emesis, salivation, diarrhoea, AST I16 1984 52 dog 2.8 7 CNS tremor I16 1973 104 rat 1.25 6.26 liver weight; (1986) (113) (7.2) (21.3) I16 1985 104 mouse 15 60 CNS, blood, brain, kidney, liver hyperactivity; RBC-parameter, AST, ALAT, BUN; brain + kidney w. I17 1984 52 dog 1.39 13.9 body weight + food intake I17 1987 104 mouse 1.03 10.3 ChE RBC-ChE; food intake I17 1987 107 rat 0.3 3 ChE, kidney plasma, RBC + brain-che urine ph I18 1981 52 dog < 0.01 0.01 ChE plasma + RBC-ChE I18 1984 104 rat 0.025 0.25 ChE plasma + RBC-ChE I19 1983 4 rat 12 120 liver ALAT, AST I19 1983 4 dog 350 no effect I19 1984 13 rat 8 80 liver AST, ALAT I19 1985 13 dog 3.5 35 gastrointestine slight focal gastritis I19 52 dog 3.2 17 liver weight I19 1987 78 mouse 2.25 11.25 liver nodular hyperplasia, adenomas, cell necrosis, bile duct + Kupffer cell proliferat, hypertrophy. I19 1987 107 rat 5.4 27 lymphatic system, liver ALAT, AST, OCT; hemangiomas in mesenteric nodes I20 1984 13 rat 7.5 17.5 blood, kidney anemia, BUN, + food I20 1985 13 dog 0.5 1.5 CNS.,thyroid tremor, weight; TG
Table 3 3 I20 1986 52 dog 0.5 2 CNS, gastrointest. mortality; ataxia, fluid feces, body w. I20 1986 104 rat 1.25 5 kidney urinary vol.; I20 1986 104 mouse 5 20 body weight I21 1976 13 rat 1 2.5 CNS hypersensitivity, body weight g. I21 1976 13 dog 1 2.5 eye, gastrointestine diarrhoea I22 1972 13 rat 50 250 liver, kidney liver + kidney w. (1977) (26) (20) (100) I22 1972 13 dog 12.5 125 liver a.ph., weight I23 1973 13 rat 0.6 2.4 blood, liver, adrenal RBC; necrotic cells in liver + inflammation; adrenal w. I23 1974 13 dog 0.84 1.64 liver a.ph., ALAT, pitted surface I23 1985 52 dog 2 10 blood, liver MHb, sulphemoglobin; macrophages and Kupffer cell siderosis I23 1984 91 mouse 2.4 12 blood, liver, spleen MHb, sulphemogl.; siderocytosis in Kupffer cells and in spleen I23 1975 104 rat 1.43 5.8 blood MHb, ALAT I24 1987 13 rat < 1.5 1.5 ChE, heart RBC-ChE, heart rate, temp. I24 1987 13 dog 0.6 2.4 blood Hb I25 4 rat 0.5 2 ChE RBC + plasma-che I25 4 dog 0.05 0.5 ChE plasma + RBC- ChE I25 1990 104 rat 3.4 10 ChE, blood RBC-ChE, anemia, reticulocyt ALAT cholest., glucose I25 1980 104 dog 0.125 0.375 ChE plasma-che I25 1989 104 mouse 10 30 ChE plasma-che, ALAT I26 1989 52 dog 0.57 1.7 CNS tonic spasm of abdominal and cheek muscle; + food I26 1989 104 rat 0.6 3 kidney enlarged kidney and lumbar nodes, glomerulonephritis, aneurysm, I26 1988 104 mouse 0.84 2.5 lung, ovary mortality, lung + ovary w. I27 1987 52 rat 0.025 0.05 ChE brain + plasma-che, chromadacryorrhea, lacrimation, alopecia I27 1986 52 dog <0.015 0.015 ChE plasma-che I28 1974/86 96 mouse 30 40 I28 1992/71 104 rat 12.5 18 food intake I28 1971 104 dog 1.8 4 blood erythroid/myeloid ratio I29 1961 13 rat 0.1 0.15 ChE RBC + brain-che I29 1961 13 dog 0.5 1 ChE plasma + RBC-ChE (1985) (52) (0.1) (2.5) I29 1990 13 mouse 0.15 5.9 ChE epididyma plasma, RBC + brain-che vacuolative epididymal degenerat. I29 1985 52 dog 0.1 2.5 ChE.,blood brain, plasma +RBC-ChE, anemia, ALAT; vomiting I29 1986 104 rat 0.05 1.5 CNS, ChE, skin, liver, lung tremor; brain + plasma-che; dermatitis of tail; inflammatory changes in liver + lung I29 1992 104 mouse 0.1 1.1 ChE, testes, gastrointestine brain, plasma + RBC-ChE; epididyma degeneration; mucosal hyperplasia in duodenum I30 1975 13 rat < 7 7 kidney a.ph., kidney w. I30 1975 13 dog 12.5 no effect I30 1976 13 mouse 57.2 180 liver, blood necrotic foci, album, bilirub. leucocyt., neutroph. I31 1966 9 rat 0.5 1 ChE plasma + RBC-ChE
Table 3 4 I31 1957 12 dog 0.125 0.25 ChE RBC-ChE I31 1990 52 dog 0.15 0.75 ChE, gastrointest. RBC-ChE; diarrhoea I31 1987 104 rat 0.25 0.75 ChE brain + plasma-che I31 1985 104 mouse 0.7 2.8 ChE RBC, plasma + brain-che I32 1988 52 dog 0.03 0.06 ChE, gastrointes. plasma-che; diarrhoea I32 1965 104 rat 0.125 no effect I33 1983 52 dog 0.036 0.36 ChE brain, plasma + RBC-ChE I33 1988 91 mouse 0.24 3.5 ChE brain + plasma-che I33 1988 104 rat 0.05 0.35 ChE brain, plasma + RBC-ChE; I34 1967 13 rat 0.05 5 ChE ChE I34 1967 13 dog 0.025 0.075 ChE plasma + RBC-ChE I34 1986 52 dog 0.025 1 ChE RBC + plasma-che I34 1982 104 rat 0.05 0.5 ChE RBC + plasma-che; cholest. I34 1984 104 mouse 0.03 0.3 ChE plasma-che I35 1962 13 dog 0.3 1 ChE plasma + RBC-ChE I35 1957 15 rat 0.25 1 ChE plasma + RBC-ChE I35 1971 104 rat 0.24 2.4 ChE, liver plasma + RBC-ChE; vacuoles in hepatocytes I35 1971 104 dog 0.008 0.08 ChE RBC-ChE I36 13 rat 3 12 body weight gain I36 1971 13 dog 0.25 1 heart, kidney heart rate; hyperglycemia, glucosuria, adrenal effects, vomitis I36 1973 104 rat 2.8 11.2 CNS convulsion, excitable, nervous I36 1971 104 dog 0.25 1.0 CNS depression; temperature I37 1984 13 rat 5 10 nervous system tremor, Ca2+, K+ I37 1984 13 dog 2.5 5 nervous system tremor, ataxia I37 1985 52 dog 1.5 3 CNS, blood tremor; platelets, Na+, Cl- I37 1988 104 rat 2.3 4.6 CNS tremor I37 1986 104 mouse 7.6 30 CNS tremor, clonic convulsion I38 1976 13 rat 5 20 kidney weight I38 13 dog 1.25 12.5 CNS, gastrointestine tremor, ataxia, incoordination, hyperaesthesia, diarrhoea, b.w. I38 1982/82 52 dog 7.5 15 vomitis, I38 1982 101 mouse 60 240 blood, liver anemia, thrombocyt.; weight I38 1981 (1981) 104 (104) rat 7.5 (5.0) 50 (50) kidney, liver BUN; liver + kidney w. I39 1989 13 rat 14 60 plasma protein, body weight I39 1990 13 dog 7.5 22.5 liver pnod, food intake I39 1990 52 dog 15 37 liver cyt.p-450; cholest., food I39 1991 104 rat 5.7 17.1 thyroid mineralisation of follicles I39 1991 104 mouse 66 208 + water consumpt. I40 1 968 13 rat 0.5 1 ChE plasma + RBC-ChE I40 1975 13 dog 0.0125 0.075 ChE plasma + RBC-ChE I41 1970 13 rat 0.4 4 ChE plasma, RBC+ brain-che, b.w I41 1970 13 dog < 2 2 ChE plasma + RBC-ChE I41 1976 80 mouse 0.5 25 ChE plasma + RBC-ChE I41 1974 104 rat 0.5 2.5 ChE plasma-che I41 1973 104 dog 0.5 2 ChE plasma-che I42 1984 52 dog 0.128 1.25 ChE brain, plasma + RBC-ChE I42 1992 91 mouse < 0.5 5 ChE brain + plasma-che
Table 3 5 I42 1984 117 rat 0.027 0.23 ChE brain, plasma + RBC-ChE I43 1978 4 rat 0.15 1.5 ChE plasma, RBC and brain-che; I43 1992 4 dog 0.1 3.9 ChE plasma-che I43 1991 4 mouse 0.2 2 ChE plasma-che I43 1993/65 52 dog 0.1 1.0 ChE plasma-che I43 1980 104 rat 0.15 1.5 ChE plasma + RBC + brain-che I43 1993 104 mouse 0.2 5 ChE plasma-che I44 1988 13 rat 0.025 0.25 ChE plasma + RBC-ChE I44 1988 13 dog 0.003 0.017 ChE plasma-che I45 1979 13 rat 1 25 ChE, ovary, liver, kidney, brain plasma, RBC + brain-che brain + ovary, liver, kidney w. I45 1981 26 dog 1.25 12.5 ChE plasma-che I46 1983 52 dog 4 16 CNS, thymus gastrointestine locomotor impairment; thymus weight;, vomitis, fluid feces I46 1983 100 mouse 45.5 182 a.ph., ALAT; I46 1983 104 rat 2.4 7.2 bone fluor concentr.; I47 1989 8 mouse 0.14 0.7 ChE plasma-che I47 1970 13 rat 0.56 1.8 ChE plasma-che I47 1973 13 dog 0.01 0.036 ChE plasma-che I47 1977 104 dog 0.003 0.6 ChE plasma + RBC-ChE, weight I47 1992 104 mouse 0.47 2.5 ChE plasma-che I47 1977 104 rat 0.75 3.75 ChE plasma + RBC-ChE I48 1982 13 rat 3 9 liver weight, body weight I48 1984 13 dog 2.3 9.9 CNS tremor, ataxia, mortality I49 1985 13 rat 0.025 0.5 ChE plasma-che I49 1989 13 dog 0.01 0.22 ChE plasma + RBC-ChE I49 1987 13 mouse < 0.5 0.5 ChE plasma-che I49 1988 104 rat 0.01 0.25 ChE plasma-che I49 1974 104 dog 0.03 0.1 ChE plasma-che I50 1979 13 rat 0.5 2.5 ChE RBC-ChE I50 1974 13 dog 0.5 2.5 ChE RBC-ChE I50 1981 104 rat 0.34 0.78 ChE, eye brain-che; lenticular opacity I50 1980 104 dog 0.6 3 water consumpt. I50 1981 104 mouse 8 40 kidney weight; I51 1990 13 rat 0.1 1 ChE plasma-che I51 1990 13 dog 0.1 10 ChE plasma + RBC-ChE I52 1985/85 13 rat 0.7 2.8 ChE blood + brain-che I52 1987/87 13 dog 2.5 2.83 plasma + RBC-ChE, salivation I52 1983 52 dog 0.25 0.5 ChE, testis plasma-che; testicul. degenerat. I52 1979 104 rat 1 5 ChE brain, plasma + RBC-ChE I52 1980 104 mouse 3 18 ChE brain-che I53 1988 13 rat 9.5 38.9 CNS mortality, uncoordinate movement general cond.; body weight I53 1987 13 dog 2.3 13 CNS, gastrointestine uncoordinate movement, emesis, diarrhoea; body weight gain